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The map label for this gene is guaB [H]

Identifier: 238921024

GI number: 238921024

Start: 3035208

End: 3036674

Strand: Reverse

Name: guaB [H]

Synonym: NT01EI_3154

Alternate gene names: 238921024

Gene position: 3036674-3035208 (Counterclockwise)

Preceding gene: 238921026

Following gene: 238921023

Centisome position: 79.65

GC content: 63.26

Gene sequence:

>1467_bases
ATGCTACGTATTGTTAAAGAAGCCCTAACGTTTGATGATGTTCTCTTGGTTCCCGCCCATTCTACCGTTCTGCCGAACAC
CGCCGAACTTGGCACTCAGCTGACTGCCACTATTCACCTGAACATTCCTATGCTGTCCGCCGCCATGGACACCGTCACCG
AAGCGCGTCTGGCGATTGCGCTGGCGCAGGAAGGGGGCATTGGCTTTATCCATAAAAACATGCCCATCGAGCGCCAGGCC
GAAGAAGTCCGCCGGGTGAAGAAGCACGAGTCCGGCGTGGTGACCGACCCGCAGACCGTGACGCCGGGCACTACCTTGCG
CGAAGTGAAGGCCCTGACCGAGCGTAACGGCTTCGCCGGTTACCCGGTGGTGACGGAAGATAACCAGCTGGTGGGGATCA
TCACCGGCCGCGACGTACGCTTCGTGACTGACCTGGAGCAGCCGGTAACCGCGGTGATGACGCCGAAGGCGCGCCTGGTG
ACGGTGAAAGAGGGCGAAGCCCGCGACGTGGTGCTGCAGCGCATGCACGAAAAGCGCGTTGAGAAGGCCTTGGTGGTGGA
CGATAGCTTCCACCTGCGCGGCATGATCACCGTGAAAGATTTCCAGAAGGCCGAGCGCAAGCCGAACGCCTGTAAGGATG
AGCATGGCCGCCTGCGTGTCGGCGCCGCCGTCGGCGCCGGTGCCGGTAACGAAGAGCGCATCGCCGCGCTGGTCGAGGCC
GGCGTCGATGTGCTGCTGATCGACTCCTCTCACGGCCACTCCGAAGGTGTGCTGCAGCGCATTCGCGAAACCCGCGCTAA
ATTCCCGCAGCTGCAGATCATCGGCGGCAACGTTGCGACGGCCGCCGGCGCCAAGGCGCTGGCTGACGCGGGGGTGAACG
CCGTCAAAGTGGGTATCGGCCCGGGCTCTATCTGTACCACCCGTATCGTGACCGGCGTCGGTGTACCGCAGATCACTGCC
GTCTCTGACGCCGTCGCCGCCCTGGAGGGGACCGGCATTCCGGTGATCGCCGATGGCGGTATCCGTTTCTCCGGCGACAT
CGCCAAGGCGCTGGCCGCCGGCGCCGCCTGCGTCATGGTCGGCTCCATGCTGGCCGGGACCGAAGAGTCCCCGGGAGAGA
TCGAGCTGTATCAGGGGCGTTCCTTCAAGTCCTACCGTGGCATGGGCTCGCTGGGCGCGATGTCTAAGGGCTCCTCCGAC
CGTTACTTCCAGAGCGATAACGCCGCCGATAAACTGGTGCCGGAAGGCATCGAAGGGCGCGTGGCCTATAAGGGCCGTCT
GAAAGAGATCGTACACCAGCAGATGGGCGGCCTGCGCTCCTGCATGGGGCTGACCGGCTGTGCCACCATCGATGAGCTGC
GCACCAAGGCGCAGTTCGTGCGCATCACCGGCTCCGGTATTCAGGAGAGCCACGTGCACGACGTGACCATTACCAAAGAG
TCACCGAATTACCGTCTGGGTTCCTAA

Upstream 100 bases:

>100_bases
TATTTCTGAAAAAAATGCTGGAGGCAACCGATTTCGGCCTGTATAATGCCGCGGCAATATTAAATCTGGTTTGACCTTCC
TCTCTGGTGAGATATTGCCC

Downstream 100 bases:

>100_bases
CCCGACGAGCCGGGCCCGGTGCAGCGCCGGGCCCGCTGAGTTTGTACCGTTTTGCCCGATCAATTTGCCAATACAGAGCC
CCTAATGACGCAAAATATTC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLRIVKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIHLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMPIERQA
EEVRRVKKHESGVVTDPQTVTPGTTLREVKALTERNGFAGYPVVTEDNQLVGIITGRDVRFVTDLEQPVTAVMTPKARLV
TVKEGEARDVVLQRMHEKRVEKALVVDDSFHLRGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERIAALVEA
GVDVLLIDSSHGHSEGVLQRIRETRAKFPQLQIIGGNVATAAGAKALADAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAVAALEGTGIPVIADGGIRFSGDIAKALAAGAACVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRVAYKGRLKEIVHQQMGGLRSCMGLTGCATIDELRTKAQFVRITGSGIQESHVHDVTITKE
SPNYRLGS

Sequences:

>Translated_488_residues
MLRIVKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIHLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMPIERQA
EEVRRVKKHESGVVTDPQTVTPGTTLREVKALTERNGFAGYPVVTEDNQLVGIITGRDVRFVTDLEQPVTAVMTPKARLV
TVKEGEARDVVLQRMHEKRVEKALVVDDSFHLRGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERIAALVEA
GVDVLLIDSSHGHSEGVLQRIRETRAKFPQLQIIGGNVATAAGAKALADAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAVAALEGTGIPVIADGGIRFSGDIAKALAAGAACVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRVAYKGRLKEIVHQQMGGLRSCMGLTGCATIDELRTKAQFVRITGSGIQESHVHDVTITKE
SPNYRLGS
>Mature_488_residues
MLRIVKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIHLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMPIERQA
EEVRRVKKHESGVVTDPQTVTPGTTLREVKALTERNGFAGYPVVTEDNQLVGIITGRDVRFVTDLEQPVTAVMTPKARLV
TVKEGEARDVVLQRMHEKRVEKALVVDDSFHLRGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERIAALVEA
GVDVLLIDSSHGHSEGVLQRIRETRAKFPQLQIIGGNVATAAGAKALADAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAVAALEGTGIPVIADGGIRFSGDIAKALAAGAACVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRVAYKGRLKEIVHQQMGGLRSCMGLTGCATIDELRTKAQFVRITGSGIQESHVHDVTITKE
SPNYRLGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=486, Percent_Identity=40.7407407407407, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI217035146, Length=484, Percent_Identity=40.495867768595, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI156616279, Length=484, Percent_Identity=40.495867768595, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI34328928, Length=484, Percent_Identity=40.495867768595, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI34328930, Length=484, Percent_Identity=40.495867768595, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI217035152, Length=478, Percent_Identity=40.5857740585774, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI217035148, Length=484, Percent_Identity=39.6694214876033, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI217035150, Length=484, Percent_Identity=37.1900826446281, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=37.246963562753, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=91.1885245901639, Blast_Score=844, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.10407239819, Blast_Score=142, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=35, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=38.0614657210402, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=37.8995433789954, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=39.5112016293279, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6323585, Length=488, Percent_Identity=39.7540983606557, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=488, Percent_Identity=40.5737704918033, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=39.0173410404624, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=42.0168067226891, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=40.0826446280992, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=40.0826446280992, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=41.1764705882353, Blast_Score=292, Evalue=5e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51765; Mature: 51765

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIVKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIHLNIPMLSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHHHCCEEEEEEEECCHHHHHHHHHHHHHHEEEE
LAQEGGIGFIHKNMPIERQAEEVRRVKKHESGVVTDPQTVTPGTTLREVKALTERNGFAG
EECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
YPVVTEDNQLVGIITGRDVRFVTDLEQPVTAVMTPKARLVTVKEGEARDVVLQRMHEKRV
CCEEECCCCEEEEEECCCEEEEECCCCCHHEEECCCEEEEEECCCCHHHHHHHHHHHHHH
EKALVVDDSFHLRGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERIAALVEA
HHEEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKFPQLQIIGGNVATAAGAKALADAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCEEHHHCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAVAALEGTGIPVIADGGIRFSGDIAKALAAGAACVMV
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHHCHHHHHH
GSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
VAYKGRLKEIVHQQMGGLRSCMGLTGCATIDELRTKAQFVRITGSGIQESHVHDVTITKE
EEEHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHCCEEEEEEECCCCCCCCEEEEEEEEC
SPNYRLGS
CCCCCCCC
>Mature Secondary Structure
MLRIVKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIHLNIPMLSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHHHCCEEEEEEEECCHHHHHHHHHHHHHHEEEE
LAQEGGIGFIHKNMPIERQAEEVRRVKKHESGVVTDPQTVTPGTTLREVKALTERNGFAG
EECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
YPVVTEDNQLVGIITGRDVRFVTDLEQPVTAVMTPKARLVTVKEGEARDVVLQRMHEKRV
CCEEECCCCEEEEEECCCEEEEECCCCCHHEEECCCEEEEEECCCCHHHHHHHHHHHHHH
EKALVVDDSFHLRGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERIAALVEA
HHEEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKFPQLQIIGGNVATAAGAKALADAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCEEHHHCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAVAALEGTGIPVIADGGIRFSGDIAKALAAGAACVMV
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHHCHHHHHH
GSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
VAYKGRLKEIVHQQMGGLRSCMGLTGCATIDELRTKAQFVRITGSGIQESHVHDVTITKE
EEEHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHCCEEEEEEECCCCCCCCEEEEEEEEC
SPNYRLGS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]