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The map label for this gene is guaA

Identifier: 238921023

GI number: 238921023

Start: 3033546

End: 3035123

Strand: Reverse

Name: guaA

Synonym: NT01EI_3153

Alternate gene names: 238921023

Gene position: 3035123-3033546 (Counterclockwise)

Preceding gene: 238921024

Following gene: 238921022

Centisome position: 79.61

GC content: 62.36

Gene sequence:

>1578_bases
ATGACGCAAAATATTCATCAAGATCGTATCCTGATCCTGGATTTCGGTTCACAGTACACCCAGTTATTGGCCCGTCGCGT
GCGTGAAATCGGCGTTTACTGCGAGCTGTGGGCATGGGATGTCAGCGAAGCGCAGATCCGCGACTTCAATCCCAGTGGCA
TCATTCTGTCCGGCGGTCCGGAGAGCACCACCGAAGCCGGCAGCCCCCGTGCGCCGGAGTATGTGTTCCAGGCGGGCGTC
CCGGTACTGGGCGTCTGCTACGGCATGCAGACCATGGCCATGCAGCTGGGCGGCCGCGTGGAGAGCTCCACCGAGCGCGA
GTTTGGCTATGCCAAGGTAGAGGTCACGGCGCCGGGCCGTCTGTTCGACGGCATTCAGGACGCCCTTAGCGCCGACGGTA
ACGCCGTGCTGGACGTGTGGATGAGCCACGGTGACAAAGTGACGGCGATCCCGTCTGACTTCACCACCGTCGCCAGCACC
GAAACCTGCCCGTATGCCATTATGGCCAACGAAGCAAAACGCTTCTACGGCGTGCAGTTCCACCCGGAGGTTACCCATAC
CCATCAGGGTCAGCATATGCTGCAGCGCTTTGTGCTGGAGATCTGTGGCTGCGCTGCGCTGTGGACCCCGGCCACCATCA
TCGAAGACGCCGTCGTCCGCATGCGTGAGCAGATCGGCGACGACGAGGTGATCCTCGGCCTGTCCGGCGGCGTGGACTCT
TCTGTCACCGCGCTGCTGCTGCACCGCGCCATCGGCAAGCGCCTGACCTGCGTCTTTGTGGACAACGGCCTGCTGCGCCT
GAACGAAGCCGAGCAGGTGATGGATATGTTTGGCGATCGGTTCGGTCTGAACATCATTCACGTCAACGCCGAAGCGCGCT
TCCTCTCGGCGCTGTCCGGCATCGCCGACCCGGAAGCCAAGCGCAAGACCATCGGGCGGGTCTTCGTCGAGGTATTCGAT
GAAGAGGCGGCCAAGCTGCCCCAGGTCAAGTGGCTGGCGCAGGGCACCATCTACCCGGACGTGATCGAGTCCGCCGCCTC
TGCCACCGGCAAGGCGCATGTGATCAAGTCGCACCACAACGTGGGCGGCCTGCCGGAGGAGATGAAGCTGGGTCTGGTCG
AGCCGCTGAAGGAGCTGTTTAAGGATGAAGTGCGCAAGATCGGTCTGGAGCTGGGGCTGCCGTACGACATGCTGTACCGC
CACCCGTTCCCGGGGCCGGGTCTGGGCGTGCGCGTGCTGGGTGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGCCGCGC
CGATGCCATCTTCATCGAAGAGCTGCACAAGGCCGACCTGTATAACAAGGTGAGCCAGGCGTTTACCGTCTTCCTGCCGG
TGCGCTCCGTCGGCGTTATGGGCGATGGCCGTAAGTATGACTGGGTGGTCTCCCTGCGTGCGGTGGAAACCATCGACTTC
ATGACCGCGCACTGGGCACACCTGCCCTATGACTTCCTGGGCCGTGTTTCCAACCGCATCATCAACGAGGTCAACGGCAT
CTCCCGCGTGGTGTACGATATCTCCGGCAAGCCGCCGGCCACCATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
CCGTCTGGGTTCCTAACCCGACGAGCCGGGCCCGGTGCAGCGCCGGGCCCGCTGAGTTTGTACCGTTTTGCCCGATCAAT
TTGCCAATACAGAGCCCCTA

Downstream 100 bases:

>100_bases
TCCGTTAACGTTTTTCTGCCGTTAACTGCCGTGAAAAACAACACTAACCGCCTTGATTAACAGGTGGTTTTTTTGTTTTT
TACCCTTGGTATCCATCAAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTQNIHQDRILILDFGSQYTQLLARRVREIGVYCELWAWDVSEAQIRDFNPSGIILSGGPESTTEAGSPRAPEYVFQAGV
PVLGVCYGMQTMAMQLGGRVESSTEREFGYAKVEVTAPGRLFDGIQDALSADGNAVLDVWMSHGDKVTAIPSDFTTVAST
ETCPYAIMANEAKRFYGVQFHPEVTHTHQGQHMLQRFVLEICGCAALWTPATIIEDAVVRMREQIGDDEVILGLSGGVDS
SVTALLLHRAIGKRLTCVFVDNGLLRLNEAEQVMDMFGDRFGLNIIHVNAEARFLSALSGIADPEAKRKTIGRVFVEVFD
EEAAKLPQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPEEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MTQNIHQDRILILDFGSQYTQLLARRVREIGVYCELWAWDVSEAQIRDFNPSGIILSGGPESTTEAGSPRAPEYVFQAGV
PVLGVCYGMQTMAMQLGGRVESSTEREFGYAKVEVTAPGRLFDGIQDALSADGNAVLDVWMSHGDKVTAIPSDFTTVAST
ETCPYAIMANEAKRFYGVQFHPEVTHTHQGQHMLQRFVLEICGCAALWTPATIIEDAVVRMREQIGDDEVILGLSGGVDS
SVTALLLHRAIGKRLTCVFVDNGLLRLNEAEQVMDMFGDRFGLNIIHVNAEARFLSALSGIADPEAKRKTIGRVFVEVFD
EEAAKLPQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPEEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
>Mature_524_residues
TQNIHQDRILILDFGSQYTQLLARRVREIGVYCELWAWDVSEAQIRDFNPSGIILSGGPESTTEAGSPRAPEYVFQAGVP
VLGVCYGMQTMAMQLGGRVESSTEREFGYAKVEVTAPGRLFDGIQDALSADGNAVLDVWMSHGDKVTAIPSDFTTVASTE
TCPYAIMANEAKRFYGVQFHPEVTHTHQGQHMLQRFVLEICGCAALWTPATIIEDAVVRMREQIGDDEVILGLSGGVDSS
VTALLLHRAIGKRLTCVFVDNGLLRLNEAEQVMDMFGDRFGLNIIHVNAEARFLSALSGIADPEAKRKTIGRVFVEVFDE
EAAKLPQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPEEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFM
TAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=568, Percent_Identity=34.8591549295775, Blast_Score=295, Evalue=9e-80,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=88, Blast_Score=963, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=34.4827586206897, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=34.4827586206897, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=34.4827586206897, Blast_Score=286, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=48.7619047619048, Blast_Score=525, Evalue=1e-150,
Organism=Drosophila melanogaster, GI281365319, Length=563, Percent_Identity=35.5239786856128, Blast_Score=298, Evalue=7e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_EDWI9 (C5BER5)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934538.1
- ProteinModelPortal:   C5BER5
- GeneID:   7958671
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3153
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58166; Mature: 58035

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 181-181 ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNIHQDRILILDFGSQYTQLLARRVREIGVYCELWAWDVSEAQIRDFNPSGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHCCCCCCEEEEECCC
ESTTEAGSPRAPEYVFQAGVPVLGVCYGMQTMAMQLGGRVESSTEREFGYAKVEVTAPGR
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCH
LFDGIQDALSADGNAVLDVWMSHGDKVTAIPSDFTTVASTETCPYAIMANEAKRFYGVQF
HHHHHHHHHCCCCCCEEHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCHHHHCCEEE
HPEVTHTHQGQHMLQRFVLEICGCAALWTPATIIEDAVVRMREQIGDDEVILGLSGGVDS
CCCCCCCCCHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVTALLLHRAIGKRLTCVFVDNGLLRLNEAEQVMDMFGDRFGLNIIHVNAEARFLSALSG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCCHHCCEEEEECCHHHHHHHHHC
IADPEAKRKTIGRVFVEVFDEEAAKLPQVKWLAQGTIYPDVIESAASATGKAHVIKSHHN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPEEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TQNIHQDRILILDFGSQYTQLLARRVREIGVYCELWAWDVSEAQIRDFNPSGIILSGGP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHCCCCCCEEEEECCC
ESTTEAGSPRAPEYVFQAGVPVLGVCYGMQTMAMQLGGRVESSTEREFGYAKVEVTAPGR
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCH
LFDGIQDALSADGNAVLDVWMSHGDKVTAIPSDFTTVASTETCPYAIMANEAKRFYGVQF
HHHHHHHHHCCCCCCEEHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCHHHHCCEEE
HPEVTHTHQGQHMLQRFVLEICGCAALWTPATIIEDAVVRMREQIGDDEVILGLSGGVDS
CCCCCCCCCHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVTALLLHRAIGKRLTCVFVDNGLLRLNEAEQVMDMFGDRFGLNIIHVNAEARFLSALSG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCCHHCCEEEEECCHHHHHHHHHC
IADPEAKRKTIGRVFVEVFDEEAAKLPQVKWLAQGTIYPDVIESAASATGKAHVIKSHHN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPEEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA