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The map label for this gene is caiT [H]

Identifier: 238920834

GI number: 238920834

Start: 2849002

End: 2850525

Strand: Reverse

Name: caiT [H]

Synonym: NT01EI_2960

Alternate gene names: 238920834

Gene position: 2850525-2849002 (Counterclockwise)

Preceding gene: 238920835

Following gene: 238920833

Centisome position: 74.77

GC content: 57.87

Gene sequence:

>1524_bases
ATGAAGACTGAAAATAGCAGCCGGAAAACAGGGATAGAGCCCAAAGTCTTTTTCCCGTCTTTGATTATTGTTGCGTTACT
TTGCTACCTGACCATTCGCGATTTGGATGCCTCCAACGCGGTGATTAACTCGGTATTTAACTACATCACCTATTCATGGG
GTTGGGCCTTCGAGTGGTACATGGTGGTGATGCTGGGCGGGTGGTTCTGGCTGATCTTTGGCCCCTTTGCCCAACGCCGT
CTGGGGGATGAGGCGCCGGAGTTCAGCACTGTCAGCTGGATCTTCATGATGTTCGCCTCCTGTACCTCTGCGGCGGTCCT
GTTCTGGGGCTCCATCGAAATTTATTACTATGTCGCCACGCCGCCGTTTGGCCTGACGCCGTTCTCCAACACCGCCAAAG
AGATGGGGCTGGCCTATAGCCTGTTCCACTGGGGGCCGCTGCCGTGGGCGACCTACAGCTTCCTGGCCGTGGCCTTTGGT
TACTTCCTGTTCGTGCGCAAAATCAGCGTAGTCCGCCCCAGTGGCACCCTGGTCGCGCTGATGGGCGAGAAGCGCTGCAA
CGGCCTGTTCGGCGTGGTGGTCGATAACCTGTATCTGGTTGCGTTGATCCTGGCGATGGGGACCAGTCTGGGGCTGGCGA
CACCGCTGGTGACCGAATGTATCCAGTATCTGTTCGGCGTGCCGCATACGCTGGAGCTGGATGCGCTGATCATCTGCTGC
TGGATCGTCTTTAACGCCGTGTGCGTCGCCTTTGGCCTGCAGAAAGGGGTCAAGGTGGCCAGCGACGTGCGTAACTACCT
GAGTATCATCGTTCTGGCGTGGGTCCTGATCATCGGTGCCACCAGCTTCACCGTTAACTACTTCACCGACTCCGTCGGGG
TGCTGCTGATGAACGTCGGCCGGATGCTGTTCTACACCGATGCCGTCGGCAAGAGCGGCTTCCCGCAGGCCTGGACCGTG
TTCTACTGGGCATGGTGGATCGTGTACGGCATCCAGATGTGTATCTTCCTGGCCCGTATCTCCAAAGGCCGTACCGTGCG
TCAGCTGTGCCTGGGGATGGTCGGCGGTCTGACGGCGTCGACCTGGCTGCTGTGGACCATTCTGGGCAGCAACACCCTCT
CTCTGATGAACAACAGCGTGGTCGATCTGCCGAAGACCATCGAAACCCACGGCGTGGCCCGCGCCATCATTGAAACCTGG
GCCGCGCTGCCACTGAGTACGGCAACCATGTGGGCGTTCTTCATCCTGTGCTTTATCGCCACCGTGACCCTGATTAACGC
CTGCTCCTACACCCTGGCGATGTCGACCTGTAAAGAGGCCAGCGGCTATCAGGAACCGCCGATCTGGGTGCGCGTAGGCT
GGTCCATTCTGGTGGGGATCATCGGCATCATCCTGTTGGCTCTGGGCGGACTGAAGCCGATTCAGACGGCGATCATCGCC
GGCGGCTGCCCGCTGTTCTTTGTCAACATATTGATAACCATATCGTTCTTGAAAGATGCCAAGTCCACGTACTGGAAATA
TTAA

Upstream 100 bases:

>100_bases
GCCAACGTATGTTTTACATACGCTGACGTGGCTTATTCAGAACCTTTACACTTAACGTGATCATGGAGAGGTATGCCTTT
CCATGAGGGAAGATACGTAA

Downstream 100 bases:

>100_bases
CCCGTTAATTTGCCAAACAAGAGGTCTGACACATGGATTTTACACTGACTGACGAGCAGGAGCTGTTCGTTGCCGGGATT
CGCGATCTGATGGCGCAGGA

Product: L-carnitine/gamma-butyrobetaine antiporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKTENSSRKTGIEPKVFFPSLIIVALLCYLTIRDLDASNAVINSVFNYITYSWGWAFEWYMVVMLGGWFWLIFGPFAQRR
LGDEAPEFSTVSWIFMMFASCTSAAVLFWGSIEIYYYVATPPFGLTPFSNTAKEMGLAYSLFHWGPLPWATYSFLAVAFG
YFLFVRKISVVRPSGTLVALMGEKRCNGLFGVVVDNLYLVALILAMGTSLGLATPLVTECIQYLFGVPHTLELDALIICC
WIVFNAVCVAFGLQKGVKVASDVRNYLSIIVLAWVLIIGATSFTVNYFTDSVGVLLMNVGRMLFYTDAVGKSGFPQAWTV
FYWAWWIVYGIQMCIFLARISKGRTVRQLCLGMVGGLTASTWLLWTILGSNTLSLMNNSVVDLPKTIETHGVARAIIETW
AALPLSTATMWAFFILCFIATVTLINACSYTLAMSTCKEASGYQEPPIWVRVGWSILVGIIGIILLALGGLKPIQTAIIA
GGCPLFFVNILITISFLKDAKSTYWKY

Sequences:

>Translated_507_residues
MKTENSSRKTGIEPKVFFPSLIIVALLCYLTIRDLDASNAVINSVFNYITYSWGWAFEWYMVVMLGGWFWLIFGPFAQRR
LGDEAPEFSTVSWIFMMFASCTSAAVLFWGSIEIYYYVATPPFGLTPFSNTAKEMGLAYSLFHWGPLPWATYSFLAVAFG
YFLFVRKISVVRPSGTLVALMGEKRCNGLFGVVVDNLYLVALILAMGTSLGLATPLVTECIQYLFGVPHTLELDALIICC
WIVFNAVCVAFGLQKGVKVASDVRNYLSIIVLAWVLIIGATSFTVNYFTDSVGVLLMNVGRMLFYTDAVGKSGFPQAWTV
FYWAWWIVYGIQMCIFLARISKGRTVRQLCLGMVGGLTASTWLLWTILGSNTLSLMNNSVVDLPKTIETHGVARAIIETW
AALPLSTATMWAFFILCFIATVTLINACSYTLAMSTCKEASGYQEPPIWVRVGWSILVGIIGIILLALGGLKPIQTAIIA
GGCPLFFVNILITISFLKDAKSTYWKY
>Mature_507_residues
MKTENSSRKTGIEPKVFFPSLIIVALLCYLTIRDLDASNAVINSVFNYITYSWGWAFEWYMVVMLGGWFWLIFGPFAQRR
LGDEAPEFSTVSWIFMMFASCTSAAVLFWGSIEIYYYVATPPFGLTPFSNTAKEMGLAYSLFHWGPLPWATYSFLAVAFG
YFLFVRKISVVRPSGTLVALMGEKRCNGLFGVVVDNLYLVALILAMGTSLGLATPLVTECIQYLFGVPHTLELDALIICC
WIVFNAVCVAFGLQKGVKVASDVRNYLSIIVLAWVLIIGATSFTVNYFTDSVGVLLMNVGRMLFYTDAVGKSGFPQAWTV
FYWAWWIVYGIQMCIFLARISKGRTVRQLCLGMVGGLTASTWLLWTILGSNTLSLMNNSVVDLPKTIETHGVARAIIETW
AALPLSTATMWAFFILCFIATVTLINACSYTLAMSTCKEASGYQEPPIWVRVGWSILVGIIGIILLALGGLKPIQTAIIA
GGCPLFFVNILITISFLKDAKSTYWKY

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=503, Percent_Identity=75.9443339960239, Blast_Score=809, Evalue=0.0,
Organism=Escherichia coli, GI1788102, Length=430, Percent_Identity=28.1395348837209, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786506, Length=511, Percent_Identity=26.027397260274, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 56272; Mature: 56272

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTENSSRKTGIEPKVFFPSLIIVALLCYLTIRDLDASNAVINSVFNYITYSWGWAFEWY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
MVVMLGGWFWLIFGPFAQRRLGDEAPEFSTVSWIFMMFASCTSAAVLFWGSIEIYYYVAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEC
PPFGLTPFSNTAKEMGLAYSLFHWGPLPWATYSFLAVAFGYFLFVRKISVVRPSGTLVAL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
MGEKRCNGLFGVVVDNLYLVALILAMGTSLGLATPLVTECIQYLFGVPHTLELDALIICC
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
WIVFNAVCVAFGLQKGVKVASDVRNYLSIIVLAWVLIIGATSFTVNYFTDSVGVLLMNVG
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHH
RMLFYTDAVGKSGFPQAWTVFYWAWWIVYGIQMCIFLARISKGRTVRQLCLGMVGGLTAS
HHHEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHH
TWLLWTILGSNTLSLMNNSVVDLPKTIETHGVARAIIETWAALPLSTATMWAFFILCFIA
HHHHHHHHCCCHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TVTLINACSYTLAMSTCKEASGYQEPPIWVRVGWSILVGIIGIILLALGGLKPIQTAIIA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHC
GGCPLFFVNILITISFLKDAKSTYWKY
CCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTENSSRKTGIEPKVFFPSLIIVALLCYLTIRDLDASNAVINSVFNYITYSWGWAFEWY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
MVVMLGGWFWLIFGPFAQRRLGDEAPEFSTVSWIFMMFASCTSAAVLFWGSIEIYYYVAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEC
PPFGLTPFSNTAKEMGLAYSLFHWGPLPWATYSFLAVAFGYFLFVRKISVVRPSGTLVAL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
MGEKRCNGLFGVVVDNLYLVALILAMGTSLGLATPLVTECIQYLFGVPHTLELDALIICC
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
WIVFNAVCVAFGLQKGVKVASDVRNYLSIIVLAWVLIIGATSFTVNYFTDSVGVLLMNVG
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHH
RMLFYTDAVGKSGFPQAWTVFYWAWWIVYGIQMCIFLARISKGRTVRQLCLGMVGGLTAS
HHHEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHH
TWLLWTILGSNTLSLMNNSVVDLPKTIETHGVARAIIETWAALPLSTATMWAFFILCFIA
HHHHHHHHCCCHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TVTLINACSYTLAMSTCKEASGYQEPPIWVRVGWSILVGIIGIILLALGGLKPIQTAIIA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHC
GGCPLFFVNILITISFLKDAKSTYWKY
CCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA