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The map label for this gene is caiB [H]

Identifier: 238920832

GI number: 238920832

Start: 2846501

End: 2847721

Strand: Reverse

Name: caiB [H]

Synonym: NT01EI_2958

Alternate gene names: 238920832

Gene position: 2847721-2846501 (Counterclockwise)

Preceding gene: 238920833

Following gene: 238920831

Centisome position: 74.7

GC content: 60.61

Gene sequence:

>1221_bases
ATGTCTGACCGTCTGTCCATGCCCAAGTTTGGCCCGCTCTCCGGCCTGCGCGTCGTGTTTTCCGGCATCGAGATCGCCGG
TCCCTTTGCCGGACAAATGTTTGCCGAATGGGGCGCCGAAGTTATCTGGATCGAAAACGTCGCTTACGGGGATACGATCC
GGGTACAGCCCAACTATCCCCAGCTGTCGCGACGTAACCTGCACGCGCTGTCGCTGAATATTTTTAAGGATGAGGGACGC
GAAGCCTTCCTGCGCCTGATGGAGACCACCGATATTTTCATCGAGGCCAGCAAGGGCCCGGCCTTCGCCCGCCGCGGCAT
CACCGACGAGGTGCTGTGGGAGCGCAATAAAAAACTGGTGATCGCTCACCTGTCCGGCTTTGGCCAGTACGGCACGCCGG
AGTACACCAACCTGGCCGCCTATAACACCATCGCCCAGGCGTTCAGTGGCTATCTAATCCAGAACGGCGATAAAGATCAG
CCGATGCCGGCCTTCCCATATACCGCCGACTACTTCTCTGGCATGACGGTGACCACCGCTGCCTTGGCCGCCCTGCACAA
GGCACAGCAGACCGGCGTGGGCGAGAGCATCGATGTCGCCATGTATGAAGTGATGCTGCGCATGGGGCAGTACTTCATGA
TGGACTACTTCAACGGCGGCGAAATGTGTCCGCGCATGACCAAAGGCAAGGACCCCTACTACGCCGGCTGCGGCCTGTAT
CGGTGCAGCGACGGCTATATCGTGATGGAGCTGGTGGGGATCACCCAGATCCGTGAGATGTTCAACGATATCGGCCTGGC
GCATCTGCTGGATACGCCGGAGGTGCCGGAGGGCACCCAGCTTATCCACCGCATCGAATGCCCGCACGGCGAGCTGGTCG
AGGAGAAACTGGACGCCTGGCTGGCGCAGCACACCATCGCCGAGGTGCAGGCCCGCTTTGCCGGGCTGAAGATCGCCTGC
GCCAAGGTGCTGAACGTGGATGAGCTGGAAAGCAACCCGCAGTACGTGGCACGCGAGTCGATCACCACCTGGAAGGCCGT
TGATGGGCACACCTGTAAAGGCCCCAACGTGATGCCGAAGTTTAAACATCACCCGGGGCAGATTTGGCGCGGCATGCCGG
AGCATGGCATGGATACCGCGGCGATCCTGCACAGCATCGGTTATGACCAGATGGCGATCGACGCCCTGGTGGCGAAAGGG
CTGGCCAAGACCGGTCAGTAA

Upstream 100 bases:

>100_bases
GCAGACGGCCGCCGCGGCGACCGTCTGTCTGCCATGACACCCGGGATCAGCCTGTATGCCCGGCCCCGGGTCCGCTGATT
TTTTTAAGAAGGATCACGTT

Downstream 100 bases:

>100_bases
GGCCGTACTGCCGTTGTCTGCGTCGGGGGGCAACGGCATGGCACCATTAAACGGCGGTAGAGCATGGACATGATAGGGGA
ACGCCATCTGCGCCAGGCGT

Product: crotonobetainyl-CoA:carnitine CoA-transferase

Products: 4-(Trimethylammonio)But-2-Enoate; H2O; crotonobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSDRLSMPKFGPLSGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAYGDTIRVQPNYPQLSRRNLHALSLNIFKDEGR
EAFLRLMETTDIFIEASKGPAFARRGITDEVLWERNKKLVIAHLSGFGQYGTPEYTNLAAYNTIAQAFSGYLIQNGDKDQ
PMPAFPYTADYFSGMTVTTAALAALHKAQQTGVGESIDVAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLY
RCSDGYIVMELVGITQIREMFNDIGLAHLLDTPEVPEGTQLIHRIECPHGELVEEKLDAWLAQHTIAEVQARFAGLKIAC
AKVLNVDELESNPQYVARESITTWKAVDGHTCKGPNVMPKFKHHPGQIWRGMPEHGMDTAAILHSIGYDQMAIDALVAKG
LAKTGQ

Sequences:

>Translated_406_residues
MSDRLSMPKFGPLSGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAYGDTIRVQPNYPQLSRRNLHALSLNIFKDEGR
EAFLRLMETTDIFIEASKGPAFARRGITDEVLWERNKKLVIAHLSGFGQYGTPEYTNLAAYNTIAQAFSGYLIQNGDKDQ
PMPAFPYTADYFSGMTVTTAALAALHKAQQTGVGESIDVAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLY
RCSDGYIVMELVGITQIREMFNDIGLAHLLDTPEVPEGTQLIHRIECPHGELVEEKLDAWLAQHTIAEVQARFAGLKIAC
AKVLNVDELESNPQYVARESITTWKAVDGHTCKGPNVMPKFKHHPGQIWRGMPEHGMDTAAILHSIGYDQMAIDALVAKG
LAKTGQ
>Mature_405_residues
SDRLSMPKFGPLSGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAYGDTIRVQPNYPQLSRRNLHALSLNIFKDEGRE
AFLRLMETTDIFIEASKGPAFARRGITDEVLWERNKKLVIAHLSGFGQYGTPEYTNLAAYNTIAQAFSGYLIQNGDKDQP
MPAFPYTADYFSGMTVTTAALAALHKAQQTGVGESIDVAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLYR
CSDGYIVMELVGITQIREMFNDIGLAHLLDTPEVPEGTQLIHRIECPHGELVEEKLDAWLAQHTIAEVQARFAGLKIACA
KVLNVDELESNPQYVARESITTWKAVDGHTCKGPNVMPKFKHHPGQIWRGMPEHGMDTAAILHSIGYDQMAIDALVAKGL
AKTGQ

Specific function: Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-

COG id: COG1804

COG function: function code C; Predicted acyl-CoA transferases/carnitine dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CaiB/BaiF CoA-transferase family [H]

Homologues:

Organism=Homo sapiens, GI300863128, Length=418, Percent_Identity=24.1626794258373, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI42794625, Length=395, Percent_Identity=25.5696202531646, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI266456254, Length=408, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI300863124, Length=314, Percent_Identity=24.5222929936306, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI266458393, Length=269, Percent_Identity=27.1375464684015, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI266458397, Length=260, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786222, Length=402, Percent_Identity=86.318407960199, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI87082093, Length=364, Percent_Identity=23.9010989010989, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788717, Length=214, Percent_Identity=30.8411214953271, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32564160, Length=346, Percent_Identity=24.8554913294798, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115535051, Length=360, Percent_Identity=23.6111111111111, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648431, Length=290, Percent_Identity=25.5172413793103, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24585488, Length=206, Percent_Identity=26.2135922330097, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003673 [H]

Pfam domain/function: PF02515 CoA_transf_3 [H]

EC number: 2.8.3.- [C]

Molecular weight: Translated: 45093; Mature: 44962

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRLSMPKFGPLSGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAYGDTIRVQPNYP
CCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEECCCCC
QLSRRNLHALSLNIFKDEGREAFLRLMETTDIFIEASKGPAFARRGITDEVLWERNKKLV
CHHHCCEEEEEEEEECCCCHHHHHHHHHHCEEEEECCCCCHHHHCCCCHHHHHCCCCEEE
IAHLSGFGQYGTPEYTNLAAYNTIAQAFSGYLIQNGDKDQPMPAFPYTADYFSGMTVTTA
EEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHCCHHHHHH
ALAALHKAQQTGVGESIDVAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLY
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCEE
RCSDGYIVMELVGITQIREMFNDIGLAHLLDTPEVPEGTQLIHRIECPHGELVEEKLDAW
EECCCEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
LAQHTIAEVQARFAGLKIACAKVLNVDELESNPQYVARESITTWKAVDGHTCKGPNVMPK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHCCCEEECCCCCCCCCCCCCCC
FKHHPGQIWRGMPEHGMDTAAILHSIGYDQMAIDALVAKGLAKTGQ
CCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDRLSMPKFGPLSGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAYGDTIRVQPNYP
CCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEECCCCC
QLSRRNLHALSLNIFKDEGREAFLRLMETTDIFIEASKGPAFARRGITDEVLWERNKKLV
CHHHCCEEEEEEEEECCCCHHHHHHHHHHCEEEEECCCCCHHHHCCCCHHHHHCCCCEEE
IAHLSGFGQYGTPEYTNLAAYNTIAQAFSGYLIQNGDKDQPMPAFPYTADYFSGMTVTTA
EEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHCCHHHHHH
ALAALHKAQQTGVGESIDVAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLY
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCEE
RCSDGYIVMELVGITQIREMFNDIGLAHLLDTPEVPEGTQLIHRIECPHGELVEEKLDAW
EECCCEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
LAQHTIAEVQARFAGLKIACAKVLNVDELESNPQYVARESITTWKAVDGHTCKGPNVMPK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHCCCEEECCCCCCCCCCCCCCC
FKHHPGQIWRGMPEHGMDTAAILHSIGYDQMAIDALVAKGLAKTGQ
CCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Carnitine; L-carnitinyl-CoA [C]

Specific reaction: L-Carnitine = 4-(Trimethylammonio)But-2-Enoate + H2O. L-carnitinyl-CoA = H2O + crotonobetainyl-CoA [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA