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The map label for this gene is galM [H]

Identifier: 238920731

GI number: 238920731

Start: 2735891

End: 2736943

Strand: Direct

Name: galM [H]

Synonym: NT01EI_2844

Alternate gene names: 238920731

Gene position: 2735891-2736943 (Clockwise)

Preceding gene: 238920730

Following gene: 238920733

Centisome position: 71.76

GC content: 67.05

Gene sequence:

>1053_bases
ATGCTAACCCCAGCGCCACAGTATGAGACCGCGCCGGACGGCGCCCCCTTTCAGTTCACCGCGCTGCACAACGCCCGGGG
CAGCACGCTGCTGCTGATGGACTGGGGAGCAACCTGGCTCTCCTGTCGCCTGGCGCTGCCCGGCGGGCAGGCGCGCGAGG
TGCTGCTCGGCTGCCAGCGCGCCGGGCAATACCCGCAGCAGCAGGCCTTTCTGGGCGCCACCGTGGGACGCTATGCCAAC
CGGATCGCCCTCGCCCGCTACACCCGCCAGGGGAAAACCGTCGTACTGCAGCCCAGCCAGAGCGTCAATCAACTGCACGG
CGGACCGCAAGGGTTTGACAAGTGCCGCTGGCAGCGGGTCGCCTGCGATGCGCGATCGGTGACCTACCGGCTGGACTCAC
CCGACGGCGATCAGGGCTATCCCGGCAACCTGAGGGTAGAGACCCGCTATGCCCTCAGCGACGACGATCGGGTCGAGATC
CGCTGGCAGGCCAGCGTCGATCGCGCCTGCCCGGTCTGTCTGACCAACCATGCCTACTTTAATCTGGACGGCGAGGCGCA
GACCGATGCGCTGGCGCAGCGCCTGCAGCTGAACGCCGATCGCTACCTGCCGGTGGATGAGGCAGGGATCCCCTGCGCAC
CGCTGACCGACGTGTCAGGCAGCGGAATGGACTTTCGCCAGGCCAAACGGTTGGGGCAGGATCTGCTCAGGGATGCCGAC
CAGCAGCGAGCTAAGGGCTATGACCACGCCTATCTGCTGCAGGCGCGCTGCGCCGACGGCGCCTATCCCGCCGCCGTACT
GAGCGCCGCCGATGGCCGGGTTAGCCTACGGCTGTACACCAACGCTCCGGCACTGCAGCTCTACAGCGGGAATTTCCTTG
CAGGCACCCCCGACCGCCGCGGTGGCCACTATGCCGACTATGCCGGCGTGGCGCTGGAGAGCGAGTTTTTACCCGACAGC
CCCAACCATCCGGAATGGCCACAGCCCGACTGCATGCTGCAGCCCGGCGAGACCTACCGGGCTTTTACCCACTATCAGTT
CAGACTGCGCTGA

Upstream 100 bases:

>100_bases
TGGTCGAGCCGGTACGCGCCGCCGTCGCCCGTGACTACGCTGGCCGTACCGGCCTGAAGGAAACTTTTTACGTCTGTCAG
CCCTCGGCGGGAGCCAGCGT

Downstream 100 bases:

>100_bases
GAGCTACCACCGCGCGCGACGGCACATCCGTCCGCGCGGTGATGGCAGGCTCGGGGCACCTCAGCGCCAGAAGAACCAGG
CGAACAGGCTGAGTGCAACG

Product: galactose mutarotase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MLTPAPQYETAPDGAPFQFTALHNARGSTLLLMDWGATWLSCRLALPGGQAREVLLGCQRAGQYPQQQAFLGATVGRYAN
RIALARYTRQGKTVVLQPSQSVNQLHGGPQGFDKCRWQRVACDARSVTYRLDSPDGDQGYPGNLRVETRYALSDDDRVEI
RWQASVDRACPVCLTNHAYFNLDGEAQTDALAQRLQLNADRYLPVDEAGIPCAPLTDVSGSGMDFRQAKRLGQDLLRDAD
QQRAKGYDHAYLLQARCADGAYPAAVLSAADGRVSLRLYTNAPALQLYSGNFLAGTPDRRGGHYADYAGVALESEFLPDS
PNHPEWPQPDCMLQPGETYRAFTHYQFRLR

Sequences:

>Translated_350_residues
MLTPAPQYETAPDGAPFQFTALHNARGSTLLLMDWGATWLSCRLALPGGQAREVLLGCQRAGQYPQQQAFLGATVGRYAN
RIALARYTRQGKTVVLQPSQSVNQLHGGPQGFDKCRWQRVACDARSVTYRLDSPDGDQGYPGNLRVETRYALSDDDRVEI
RWQASVDRACPVCLTNHAYFNLDGEAQTDALAQRLQLNADRYLPVDEAGIPCAPLTDVSGSGMDFRQAKRLGQDLLRDAD
QQRAKGYDHAYLLQARCADGAYPAAVLSAADGRVSLRLYTNAPALQLYSGNFLAGTPDRRGGHYADYAGVALESEFLPDS
PNHPEWPQPDCMLQPGETYRAFTHYQFRLR
>Mature_350_residues
MLTPAPQYETAPDGAPFQFTALHNARGSTLLLMDWGATWLSCRLALPGGQAREVLLGCQRAGQYPQQQAFLGATVGRYAN
RIALARYTRQGKTVVLQPSQSVNQLHGGPQGFDKCRWQRVACDARSVTYRLDSPDGDQGYPGNLRVETRYALSDDDRVEI
RWQASVDRACPVCLTNHAYFNLDGEAQTDALAQRLQLNADRYLPVDEAGIPCAPLTDVSGSGMDFRQAKRLGQDLLRDAD
QQRAKGYDHAYLLQARCADGAYPAAVLSAADGRVSLRLYTNAPALQLYSGNFLAGTPDRRGGHYADYAGVALESEFLPDS
PNHPEWPQPDCMLQPGETYRAFTHYQFRLR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=320, Percent_Identity=37.5, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI1786971, Length=347, Percent_Identity=57.6368876080692, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17557428, Length=332, Percent_Identity=29.2168674698795, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI115533334, Length=332, Percent_Identity=29.2168674698795, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319493, Length=320, Percent_Identity=24.0625, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=23.876404494382, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24668278, Length=336, Percent_Identity=32.7380952380952, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24583720, Length=336, Percent_Identity=30.952380952381, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24668282, Length=338, Percent_Identity=30.1775147928994, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24641876, Length=343, Percent_Identity=26.530612244898, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38690; Mature: 38690

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPAPQYETAPDGAPFQFTALHNARGSTLLLMDWGATWLSCRLALPGGQAREVLLGCQR
CCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHH
AGQYPQQQAFLGATVGRYANRIALARYTRQGKTVVLQPSQSVNQLHGGPQGFDKCRWQRV
HCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCCHHHHHHCCCCCCHHHHHHHHH
ACDARSVTYRLDSPDGDQGYPGNLRVETRYALSDDDRVEIRWQASVDRACPVCLTNHAYF
CCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCEEEECCEEE
NLDGEAQTDALAQRLQLNADRYLPVDEAGIPCAPLTDVSGSGMDFRQAKRLGQDLLRDAD
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QQRAKGYDHAYLLQARCADGAYPAAVLSAADGRVSLRLYTNAPALQLYSGNFLAGTPDRR
HHHHCCCCCEEEEEEECCCCCCCHHHEECCCCEEEEEEEECCCEEEEECCCEEECCCCCC
GGHYADYAGVALESEFLPDSPNHPEWPQPDCMLQPGETYRAFTHYQFRLR
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEEEEEC
>Mature Secondary Structure
MLTPAPQYETAPDGAPFQFTALHNARGSTLLLMDWGATWLSCRLALPGGQAREVLLGCQR
CCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHH
AGQYPQQQAFLGATVGRYANRIALARYTRQGKTVVLQPSQSVNQLHGGPQGFDKCRWQRV
HCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCCHHHHHHCCCCCCHHHHHHHHH
ACDARSVTYRLDSPDGDQGYPGNLRVETRYALSDDDRVEIRWQASVDRACPVCLTNHAYF
CCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCEEEECCEEE
NLDGEAQTDALAQRLQLNADRYLPVDEAGIPCAPLTDVSGSGMDFRQAKRLGQDLLRDAD
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QQRAKGYDHAYLLQARCADGAYPAAVLSAADGRVSLRLYTNAPALQLYSGNFLAGTPDRR
HHHHCCCCCEEEEEEECCCCCCCHHHEECCCCEEEEEEEECCCEEEEECCCEEECCCCCC
GGHYADYAGVALESEFLPDSPNHPEWPQPDCMLQPGETYRAFTHYQFRLR
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]