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The map label for this gene is fabB [H]

Identifier: 238920615

GI number: 238920615

Start: 2618488

End: 2619699

Strand: Reverse

Name: fabB [H]

Synonym: NT01EI_2727

Alternate gene names: 238920615

Gene position: 2619699-2618488 (Counterclockwise)

Preceding gene: 238920617

Following gene: 238920614

Centisome position: 68.72

GC content: 59.49

Gene sequence:

>1212_bases
ATGAAACGTGCAGTGATTACTGGCTTGGGTATTGTTTCCAGTATCGGTAACAACCAGCAGGAGGTGCTGGCGTCTCTGAA
AGAAGGGCGTTCGGGGATCACCTTTGCGCCTGAACTGCAGGAGGCCGGCATGCGTAGCCAGGTCTGGGGCAATATCAAGC
TGGATACCGCTGGCCTGATCGACCGTAAGGTGATGCGTTTTATGAGCGATGCATCGATCTACGCCTATCTGTCGATGCAG
GAAGCGATCAAGGACTCCGGTCTGAGCGACGATATGGTTTCCAATAACCGTACCGGCCTGATCGTGGGTTCCGGCGGCGG
CTCTCCGCGTAACCAGGTCGCTGGCGCTGACGGTATGCGCGCCCGCGGTATTCGCGGCGTGGGGCCGTATATGGTGACCA
AGGCCATGGCCTCCGGCGTTTCCGCCTGCCTGGCCACGCCATTTAAAATCCGCGGTGTCAACTACTCCATCAGCTCCGCC
TGTGCTACATCGGCTCACTGCATCGGCAACGCCGTTGAGATGATCCAGCTGGGCAAACAGGACGTGGTCTTCGCCGGCGG
CGGTGAGGAAATGTGCTGGGAGCTGGCCTGTGAGTTCGATGCCATGGGAGCCCTGTCCACCCATTACAACGATGCGCCGG
AAAAGGCCTCCCGGACCTATGATGCCAAGCGCGACGGTTTTGTCATTTCCGGCGGCGGCGGTATCGTGGTCGTTGAAGAG
CTGGAGCACGCGCTGGCGCGCGGCGCGCACATTTATGCCGAAATCGTCGGCTACGGTGCAACCTCCGATGGCTATGACAT
GGTGGCGCCGTCAGGTGAAGGTGCGGCGCGCTGCATGCAGATGGCGATGCAGGGGCTGGATAAGCCGGTGGATTATCTGA
ACGTACATGGCACCTCCACCATGGTGGGCGACGTGAAAGAGTTGGGCGCCATCCGTGAAGTCTTTGGTGACCGTACGCCG
GCTATCTCCTCTACCAAGGCGATGACTGGCCATGCGCTGGGGGCTGCGGGGGTACACGAAGCCATCTACACCCTGCTGAT
GCTGGAGCACGGCTTTATCGCGCCGAGCATCAACATTGAAGAGCTGGATGAGCAGGCCACCGGGATGGATATTGTTACCG
CCACCACTGAGCGAGAGCTGGATGTGGTGATGTCCAACAGTTTCGGCTTTGGCGGCACCAACGCGACGCTGGTGATGCGC
AAGTACAAATAA

Upstream 100 bases:

>100_bases
CTGGTTTTACCAGCGCTGATCGGACTTGCCTCGGCGTACAGGTGTACGCTAAAGTGCGTGGCGAATCCCGAATGATAAAA
ATTTTTTCAAGAGGTAAGAA

Downstream 100 bases:

>100_bases
CGCCGGAGACCGGTGCCAGAAAAACCCGCCGCGGCGGGTTTTTTTATACCTGGCATCTGTCTTCTGAATAGGTAACACTG
ATAAGGGCGGGATGTCTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRAVITGLGIVSSIGNNQQEVLASLKEGRSGITFAPELQEAGMRSQVWGNIKLDTAGLIDRKVMRFMSDASIYAYLSMQ
EAIKDSGLSDDMVSNNRTGLIVGSGGGSPRNQVAGADGMRARGIRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CATSAHCIGNAVEMIQLGKQDVVFAGGGEEMCWELACEFDAMGALSTHYNDAPEKASRTYDAKRDGFVISGGGGIVVVEE
LEHALARGAHIYAEIVGYGATSDGYDMVAPSGEGAARCMQMAMQGLDKPVDYLNVHGTSTMVGDVKELGAIREVFGDRTP
AISSTKAMTGHALGAAGVHEAIYTLLMLEHGFIAPSINIEELDEQATGMDIVTATTERELDVVMSNSFGFGGTNATLVMR
KYK

Sequences:

>Translated_403_residues
MKRAVITGLGIVSSIGNNQQEVLASLKEGRSGITFAPELQEAGMRSQVWGNIKLDTAGLIDRKVMRFMSDASIYAYLSMQ
EAIKDSGLSDDMVSNNRTGLIVGSGGGSPRNQVAGADGMRARGIRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CATSAHCIGNAVEMIQLGKQDVVFAGGGEEMCWELACEFDAMGALSTHYNDAPEKASRTYDAKRDGFVISGGGGIVVVEE
LEHALARGAHIYAEIVGYGATSDGYDMVAPSGEGAARCMQMAMQGLDKPVDYLNVHGTSTMVGDVKELGAIREVFGDRTP
AISSTKAMTGHALGAAGVHEAIYTLLMLEHGFIAPSINIEELDEQATGMDIVTATTERELDVVMSNSFGFGGTNATLVMR
KYK
>Mature_403_residues
MKRAVITGLGIVSSIGNNQQEVLASLKEGRSGITFAPELQEAGMRSQVWGNIKLDTAGLIDRKVMRFMSDASIYAYLSMQ
EAIKDSGLSDDMVSNNRTGLIVGSGGGSPRNQVAGADGMRARGIRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CATSAHCIGNAVEMIQLGKQDVVFAGGGEEMCWELACEFDAMGALSTHYNDAPEKASRTYDAKRDGFVISGGGGIVVVEE
LEHALARGAHIYAEIVGYGATSDGYDMVAPSGEGAARCMQMAMQGLDKPVDYLNVHGTSTMVGDVKELGAIREVFGDRTP
AISSTKAMTGHALGAAGVHEAIYTLLMLEHGFIAPSINIEELDEQATGMDIVTATTERELDVVMSNSFGFGGTNATLVMR
KYK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=33.9712918660287, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=29.2537313432836, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=38.3233532934132, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=83.7037037037037, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=37.2262773722628, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.4916067146283, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=40.377358490566, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI212642053, Length=359, Percent_Identity=27.8551532033426, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=365, Percent_Identity=25.7534246575342, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=31.057268722467, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=38.3333333333333, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=27.810650887574, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=27.810650887574, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=23.3644859813084, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42472; Mature: 42472

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGLGIVSSIGNNQQEVLASLKEGRSGITFAPELQEAGMRSQVWGNIKLDTAGLI
CCCEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCHHHCCCCHHHCCCEEECCHHHH
DRKVMRFMSDASIYAYLSMQEAIKDSGLSDDMVSNNRTGLIVGSGGGSPRNQVAGADGMR
HHHHHHHHCCCCEEEEEEHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
ARGIRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSACATSAHCIGNAVEMIQLGKQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGGEEMCWELACEFDAMGALSTHYNDAPEKASRTYDAKRDGFVISGGGGIVVVEE
CEEEECCCHHHHHHHHHCHHHCCCHHHCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEIVGYGATSDGYDMVAPSGEGAARCMQMAMQGLDKPVDYLNVHGTST
HHHHHHCCCCEEEEHEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHEEECCCCH
MVGDVKELGAIREVFGDRTPAISSTKAMTGHALGAAGVHEAIYTLLMLEHGFIAPSINIE
HHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
ELDEQATGMDIVTATTERELDVVMSNSFGFGGTNATLVMRKYK
HHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKRAVITGLGIVSSIGNNQQEVLASLKEGRSGITFAPELQEAGMRSQVWGNIKLDTAGLI
CCCEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCHHHCCCCHHHCCCEEECCHHHH
DRKVMRFMSDASIYAYLSMQEAIKDSGLSDDMVSNNRTGLIVGSGGGSPRNQVAGADGMR
HHHHHHHHCCCCEEEEEEHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
ARGIRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSACATSAHCIGNAVEMIQLGKQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGGEEMCWELACEFDAMGALSTHYNDAPEKASRTYDAKRDGFVISGGGGIVVVEE
CEEEECCCHHHHHHHHHCHHHCCCHHHCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEIVGYGATSDGYDMVAPSGEGAARCMQMAMQGLDKPVDYLNVHGTST
HHHHHHCCCCEEEEHEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHEEECCCCH
MVGDVKELGAIREVFGDRTPAISSTKAMTGHALGAAGVHEAIYTLLMLEHGFIAPSINIE
HHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
ELDEQATGMDIVTATTERELDVVMSNSFGFGGTNATLVMRKYK
HHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]