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The map label for this gene is folC [H]

Identifier: 238920605

GI number: 238920605

Start: 2609983

End: 2611254

Strand: Reverse

Name: folC [H]

Synonym: NT01EI_2717

Alternate gene names: 238920605

Gene position: 2611254-2609983 (Counterclockwise)

Preceding gene: 238920606

Following gene: 238920604

Centisome position: 68.5

GC content: 65.96

Gene sequence:

>1272_bases
ATGAATACGCTTCCTACGCCATTGGCAACCTCTCCGCTTTCCACCTGGCTTGACTACCTTGAAAACCTGCACAGTAAGAG
CATCGATCTCGGTCTGGATCGCGTACGCCACGTAGCGCAGCGCCTGGACCTACTGACGCCGGCCCCGGTAGTGTATACCG
TCGCGGGAACGAACGGGAAAGGGACGACCTGCCGTACGCTGGAGGCGATCCTGATGGCAGCTGGCTATCGGGTTGGGGTT
TATGGCTCGCCGCACCTGCTGCACTATCGTGAGCGGGTGCGCATCCAGCACCGCGAGCTGGACGATGCGGCACATGCCGC
CGCCTTTGCCGCCGTTGAGGCGGGGCGCGACGGTGTATCGCTGACCTATTTCGAATTCGGCACGCTGGCCGCGTTGTACC
TGTTTAAGCAGGCGGCGCTGGATGCGGTGATCCTGGAGGTCGGCCTCGGCGGCCGCCTGGATGCGACCAACATCGTGGAT
CCCAGCGTCGCGGTGGTGACCAGCATCGCGCTGGATCACACCGACTGGCTGGGCGATACGCGGGAGAGCATCGGCCGTGA
GAAGGCCGGTATCTTCCGCGACGCGGCGCCGGCGGTGGTTGGCGAACCCGATATGCCGGACTCGATTGGCGCGGTCGCGC
AGGCGTGTGGTGCTCATCTTCTGCGACGCGGCGTGGACTGGGATTTCAGCGTAGAGGCACAGGGATGGCGCTGGCACGAT
GCTACGCGCCATGTTGAGGGGCTGCCGCTGCCTCAGGTGCCGCTGGCCAACGCGGCGACGGCGCTGACGGCGCTCAGCTA
TGGGCCGCTGCCGGTCGATGACGCGGCGATCCGTCAGGGGCTGCGCGATGCGGTGCTGCCGGGGCGCTTTCAGCAGCTGT
CGGAGTCGCCGCGCCTGATCCTGGACGTCGCACACAATCCCCATGCGGCGGCCTATCTGGCCCAGCGTCTGCGCACGTTG
CCGCAGCGCGGCCGCCTGCGCATGGTGATCGGTATGCTCTCGGACAAGGATATCGCCGGTACGCTGGCCTGCCTGATACC
GCTGGTTGACCAGTGGTACTGTGCACCGCTGGAGGGACCGCGCGGTGCGGCGGTCCTGGCGTTAATGGCGCACCTGCCCG
CTGATGCCCAAACGTTTGGCGGGGTTGAGCTGGCCTGGCGCCAGGCGATGGCCGATGCGGCCGCCGACGATACGGTGGTG
GTCTGTGGTTCCTTCCATACGGTTGCTCACGTAATGGCAGCCCTCGCGTCAGGAGAGACGGGTGGCAAGTAA

Upstream 100 bases:

>100_bases
GGCGTATGGCAGGTCCATACGCCGTGCATCTTTGGCAACCGGCGCCACTCCGCGGCCGGTTACATTCCGCAATCGGTTTT
ATTATGGGACGTAAAACAGC

Downstream 100 bases:

>100_bases
GTTTCAGAACCGATTGGTCGGTACGGTGATCCTGGTGGCGCTGGGGGTGATCATTCTGCCCGGCCTGCTGGATGGTCAGA
AAAAGCATTATCAGGATGAG

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNTLPTPLATSPLSTWLDYLENLHSKSIDLGLDRVRHVAQRLDLLTPAPVVYTVAGTNGKGTTCRTLEAILMAAGYRVGV
YGSPHLLHYRERVRIQHRELDDAAHAAAFAAVEAGRDGVSLTYFEFGTLAALYLFKQAALDAVILEVGLGGRLDATNIVD
PSVAVVTSIALDHTDWLGDTRESIGREKAGIFRDAAPAVVGEPDMPDSIGAVAQACGAHLLRRGVDWDFSVEAQGWRWHD
ATRHVEGLPLPQVPLANAATALTALSYGPLPVDDAAIRQGLRDAVLPGRFQQLSESPRLILDVAHNPHAAAYLAQRLRTL
PQRGRLRMVIGMLSDKDIAGTLACLIPLVDQWYCAPLEGPRGAAVLALMAHLPADAQTFGGVELAWRQAMADAAADDTVV
VCGSFHTVAHVMAALASGETGGK

Sequences:

>Translated_423_residues
MNTLPTPLATSPLSTWLDYLENLHSKSIDLGLDRVRHVAQRLDLLTPAPVVYTVAGTNGKGTTCRTLEAILMAAGYRVGV
YGSPHLLHYRERVRIQHRELDDAAHAAAFAAVEAGRDGVSLTYFEFGTLAALYLFKQAALDAVILEVGLGGRLDATNIVD
PSVAVVTSIALDHTDWLGDTRESIGREKAGIFRDAAPAVVGEPDMPDSIGAVAQACGAHLLRRGVDWDFSVEAQGWRWHD
ATRHVEGLPLPQVPLANAATALTALSYGPLPVDDAAIRQGLRDAVLPGRFQQLSESPRLILDVAHNPHAAAYLAQRLRTL
PQRGRLRMVIGMLSDKDIAGTLACLIPLVDQWYCAPLEGPRGAAVLALMAHLPADAQTFGGVELAWRQAMADAAADDTVV
VCGSFHTVAHVMAALASGETGGK
>Mature_423_residues
MNTLPTPLATSPLSTWLDYLENLHSKSIDLGLDRVRHVAQRLDLLTPAPVVYTVAGTNGKGTTCRTLEAILMAAGYRVGV
YGSPHLLHYRERVRIQHRELDDAAHAAAFAAVEAGRDGVSLTYFEFGTLAALYLFKQAALDAVILEVGLGGRLDATNIVD
PSVAVVTSIALDHTDWLGDTRESIGREKAGIFRDAAPAVVGEPDMPDSIGAVAQACGAHLLRRGVDWDFSVEAQGWRWHD
ATRHVEGLPLPQVPLANAATALTALSYGPLPVDDAAIRQGLRDAVLPGRFQQLSESPRLILDVAHNPHAAAYLAQRLRTL
PQRGRLRMVIGMLSDKDIAGTLACLIPLVDQWYCAPLEGPRGAAVLALMAHLPADAQTFGGVELAWRQAMADAAADDTVV
VCGSFHTVAHVMAALASGETGGK

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=364, Percent_Identity=31.043956043956, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI66932984, Length=364, Percent_Identity=31.043956043956, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1788654, Length=418, Percent_Identity=66.5071770334928, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17553150, Length=318, Percent_Identity=29.874213836478, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17553148, Length=317, Percent_Identity=29.9684542586751, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71984923, Length=317, Percent_Identity=29.9684542586751, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323760, Length=348, Percent_Identity=27.2988505747126, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324815, Length=179, Percent_Identity=35.195530726257, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24641571, Length=208, Percent_Identity=32.2115384615385, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581568, Length=177, Percent_Identity=32.2033898305085, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 45163; Mature: 45163

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLPTPLATSPLSTWLDYLENLHSKSIDLGLDRVRHVAQRLDLLTPAPVVYTVAGTNGK
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
GTTCRTLEAILMAAGYRVGVYGSPHLLHYRERVRIQHRELDDAAHAAAFAAVEAGRDGVS
CCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LTYFEFGTLAALYLFKQAALDAVILEVGLGGRLDATNIVDPSVAVVTSIALDHTDWLGDT
EEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCHH
RESIGREKAGIFRDAAPAVVGEPDMPDSIGAVAQACGAHLLRRGVDWDFSVEAQGWRWHD
HHHHCHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECC
ATRHVEGLPLPQVPLANAATALTALSYGPLPVDDAAIRQGLRDAVLPGRFQQLSESPRLI
HHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCEE
LDVAHNPHAAAYLAQRLRTLPQRGRLRMVIGMLSDKDIAGTLACLIPLVDQWYCAPLEGP
EEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCC
RGAAVLALMAHLPADAQTFGGVELAWRQAMADAAADDTVVVCGSFHTVAHVMAALASGET
CHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCC
GGK
CCC
>Mature Secondary Structure
MNTLPTPLATSPLSTWLDYLENLHSKSIDLGLDRVRHVAQRLDLLTPAPVVYTVAGTNGK
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
GTTCRTLEAILMAAGYRVGVYGSPHLLHYRERVRIQHRELDDAAHAAAFAAVEAGRDGVS
CCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LTYFEFGTLAALYLFKQAALDAVILEVGLGGRLDATNIVDPSVAVVTSIALDHTDWLGDT
EEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCHH
RESIGREKAGIFRDAAPAVVGEPDMPDSIGAVAQACGAHLLRRGVDWDFSVEAQGWRWHD
HHHHCHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECC
ATRHVEGLPLPQVPLANAATALTALSYGPLPVDDAAIRQGLRDAVLPGRFQQLSESPRLI
HHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCEE
LDVAHNPHAAAYLAQRLRTLPQRGRLRMVIGMLSDKDIAGTLACLIPLVDQWYCAPLEGP
EEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCC
RGAAVLALMAHLPADAQTFGGVELAWRQAMADAAADDTVVVCGSFHTVAHVMAALASGET
CHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCC
GGK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]