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The map label for this gene is nuoL [H]

Identifier: 238920557

GI number: 238920557

Start: 2563862

End: 2565706

Strand: Reverse

Name: nuoL [H]

Synonym: NT01EI_2669

Alternate gene names: 238920557

Gene position: 2565706-2563862 (Counterclockwise)

Preceding gene: 238920558

Following gene: 238920556

Centisome position: 67.3

GC content: 60.54

Gene sequence:

>1845_bases
ATGAATCTACTCTATTTAACCATTCTGCTGCCGCTGCTGGGATTTCTGATCCTGGCCTTTTCCCGCGGCCGTCTGTCGGA
GAAGCACACCGCGATCATCGGGGTCGGATCCGTCGGTCTGGCTGCGCTGGTCACCCTGTACGTCGGTGCTGACTTTCTGA
GTCACAATGCGGCCGGTGCGGCCTATAACCAGCATCTGTGGAACTGGATAGCGGTCGGTAACTTTACCATTCCGGTGACC
CTCAGCCTGGATGGCCTGTCGCTGACCATGCTGTCGGTGGTGACCGGTGTCGGCTTCCTGATCCACCTGTTCGCCTCATG
GTATATGCGCGGGGAGGAGGGCTACTCGCGCTTCTTCGCCTATACCAACCTGTTTATCGCCAGCATGGTGGTACTGGTGC
TGGCTGATAACCTGATGCTGATGTATCTGGGCTGGGAAGGGGTGGGGTTGTGCAGCTATCTGTTGATCGGATTCTACTAC
AGCAATCCGGCCAACGGCGCGGCGGCGATGAAGGCGTTCATCGTCACCCGCGTCGGCGACGTGTTCCTGGCCATCGGGCT
GTTTATCCTCTATCACCAGCTGGGTACCCTGAATATCCGTGAGCTGATGATCCTGGCGCCGCAGCAGCTGGCGGTCGGTT
CGCCTGTCATTACCTGGGCGACCCTGATGCTGCTGGGCGGCGCAGTGGGTAAATCGGCCCAGCTGCCGTTGCAGACCTGG
CTTGCCGATGCCATGGCCGGTCCGACGCCGGTCTCTGCCCTGATCCACGCCGCGACTATGGTGACCGCCGGGGTGTACCT
GATCGCCCGGACCCATGGCCTGTTCGTGATGGCACCGGAGGTGCTGCATCTGGTGGGCATTATCGGTGCCGTTACGCTGG
TGTTGGCCGGTTTTGCTGCGCTGGTACAGACGGACATCAAGCGGGTGCTGGCCTATTCAACCATGAGCCAGATAGGCTAT
ATGTTCCTAGCGCTGGGCGTGCAGGCCTGGGACGCCGCGATTTTCCATCTGATGACTCACGCCTTCTTTAAGGCGCTGCT
GTTCCTCTCATCCGGCTCGGTTATTCTGGCCTGCCACCATGAGCAGAACATCTTCAAGATGGGGGGACTGCGCCACAAGC
TGCCGTTGACCTACCTGTGTTTCCTGGTGGGCGGTGGTGCCCTGGCAGCGCTGCCGCTGGTCACAGCCGGCTTCTACAGT
AAGGATGAGATCTTGTGGGGCGCGCTGGCCTCGGGCCATGTCAACCTGATGATGGCCGGGCTTATCGGCGCCTTCCTGAC
CTCGCTGTATACCTTCCGGATGATCTTCATCGTGTTCCACGGCGAGGCGCATACCCAGGCCCATGAGGTGAAGGGGCTGA
GCCACCATCTGCCGCTGATCGTGCTGATGATCCTCTCCACCTTCATCGGGGCGCTGATCACCCCGCCGCTGACAGGGGTG
CTGCCCGCCATGCCGCAAGGTGAAGGGGGCAAGGTGATGCTGGAGGTGGTATCGGCCATCGTCGCCATCGCCGGGGTACT
GCTGGCCGCGCGTCTCTATCTGGGGCAGCGCACTCTGGTCAATGGCATTGCCAACAGCGCGCCGGGACGTTTTCTCTCCA
CGTGGTGGTTCCATGCCTGGGGATTCGACTGGCTGTACCGGCAGATCTTTATTAAGCCATTTAAGGCCATCGCCTGGCTG
CTGCAGCGTGATCCGCTCGATCGCATGATGAACCTGTTTGCGCTGGTGGCCCGCTTGGGAAACCGCGTTCTGGCCGTCAG
CGAAAACGGGCAGCTGCGCTGGTATGCAGCGTCGATGGGTGTTGGGGCAGTGGTCATTCTGGCGCTGTTGTTATTGGTTA
AGTGA

Upstream 100 bases:

>100_bases
GCCTGGCGGCGGCGGAGGCCTCTATCGGCCTGGCGCTGTTGCTACAGCTGCATCGTCGCCGCAACACCCTGAATATTGAT
ACTGTCAGTGAGATGCGCGG

Downstream 100 bases:

>100_bases
ATCTCGTTAAAGCGGGTGAGGGGACGACCCCTGTCTCCTCCGTTTGAATGTATTCAGAATAAGGGAAACCAAACGCCATG
TTATTACCTTGGCTAATTCT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MNLLYLTILLPLLGFLILAFSRGRLSEKHTAIIGVGSVGLAALVTLYVGADFLSHNAAGAAYNQHLWNWIAVGNFTIPVT
LSLDGLSLTMLSVVTGVGFLIHLFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLMLMYLGWEGVGLCSYLLIGFYY
SNPANGAAAMKAFIVTRVGDVFLAIGLFILYHQLGTLNIRELMILAPQQLAVGSPVITWATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFVMAPEVLHLVGIIGAVTLVLAGFAALVQTDIKRVLAYSTMSQIGY
MFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRHKLPLTYLCFLVGGGALAALPLVTAGFYS
KDEILWGALASGHVNLMMAGLIGAFLTSLYTFRMIFIVFHGEAHTQAHEVKGLSHHLPLIVLMILSTFIGALITPPLTGV
LPAMPQGEGGKVMLEVVSAIVAIAGVLLAARLYLGQRTLVNGIANSAPGRFLSTWWFHAWGFDWLYRQIFIKPFKAIAWL
LQRDPLDRMMNLFALVARLGNRVLAVSENGQLRWYAASMGVGAVVILALLLLVK

Sequences:

>Translated_614_residues
MNLLYLTILLPLLGFLILAFSRGRLSEKHTAIIGVGSVGLAALVTLYVGADFLSHNAAGAAYNQHLWNWIAVGNFTIPVT
LSLDGLSLTMLSVVTGVGFLIHLFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLMLMYLGWEGVGLCSYLLIGFYY
SNPANGAAAMKAFIVTRVGDVFLAIGLFILYHQLGTLNIRELMILAPQQLAVGSPVITWATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFVMAPEVLHLVGIIGAVTLVLAGFAALVQTDIKRVLAYSTMSQIGY
MFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRHKLPLTYLCFLVGGGALAALPLVTAGFYS
KDEILWGALASGHVNLMMAGLIGAFLTSLYTFRMIFIVFHGEAHTQAHEVKGLSHHLPLIVLMILSTFIGALITPPLTGV
LPAMPQGEGGKVMLEVVSAIVAIAGVLLAARLYLGQRTLVNGIANSAPGRFLSTWWFHAWGFDWLYRQIFIKPFKAIAWL
LQRDPLDRMMNLFALVARLGNRVLAVSENGQLRWYAASMGVGAVVILALLLLVK
>Mature_614_residues
MNLLYLTILLPLLGFLILAFSRGRLSEKHTAIIGVGSVGLAALVTLYVGADFLSHNAAGAAYNQHLWNWIAVGNFTIPVT
LSLDGLSLTMLSVVTGVGFLIHLFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLMLMYLGWEGVGLCSYLLIGFYY
SNPANGAAAMKAFIVTRVGDVFLAIGLFILYHQLGTLNIRELMILAPQQLAVGSPVITWATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFVMAPEVLHLVGIIGAVTLVLAGFAALVQTDIKRVLAYSTMSQIGY
MFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRHKLPLTYLCFLVGGGALAALPLVTAGFYS
KDEILWGALASGHVNLMMAGLIGAFLTSLYTFRMIFIVFHGEAHTQAHEVKGLSHHLPLIVLMILSTFIGALITPPLTGV
LPAMPQGEGGKVMLEVVSAIVAIAGVLLAARLYLGQRTLVNGIANSAPGRFLSTWWFHAWGFDWLYRQIFIKPFKAIAWL
LQRDPLDRMMNLFALVARLGNRVLAVSENGQLRWYAASMGVGAVVILALLLLVK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=481, Percent_Identity=36.5904365904366, Blast_Score=260, Evalue=3e-69,
Organism=Escherichia coli, GI1788614, Length=603, Percent_Identity=76.2852404643449, Blast_Score=932, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=487, Percent_Identity=32.2381930184805, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1788827, Length=363, Percent_Identity=30.3030303030303, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788831, Length=332, Percent_Identity=30.1204819277108, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788613, Length=478, Percent_Identity=28.2426778242678, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI2367154, Length=288, Percent_Identity=31.25, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI145693160, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66377; Mature: 66377

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLYLTILLPLLGFLILAFSRGRLSEKHTAIIGVGSVGLAALVTLYVGADFLSHNAAGA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCC
AYNQHLWNWIAVGNFTIPVTLSLDGLSLTMLSVVTGVGFLIHLFASWYMRGEEGYSRFFA
HHHHHHHHHEEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YTNLFIASMVVLVLADNLMLMYLGWEGVGLCSYLLIGFYYSNPANGAAAMKAFIVTRVGD
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VFLAIGLFILYHQLGTLNIRELMILAPQQLAVGSPVITWATLMLLGGAVGKSAQLPLQTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFVMAPEVLHLVGIIGAVTLVLAGFAA
HHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHH
LVQTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
EQNIFKMGGLRHKLPLTYLCFLVGGGALAALPLVTAGFYSKDEILWGALASGHVNLMMAG
CCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHH
LIGAFLTSLYTFRMIFIVFHGEAHTQAHEVKGLSHHLPLIVLMILSTFIGALITPPLTGV
HHHHHHHHHHHHHHHHHEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHC
LPAMPQGEGGKVMLEVVSAIVAIAGVLLAARLYLGQRTLVNGIANSAPGRFLSTWWFHAW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GFDWLYRQIFIKPFKAIAWLLQRDPLDRMMNLFALVARLGNRVLAVSENGQLRWYAASMG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCC
VGAVVILALLLLVK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MNLLYLTILLPLLGFLILAFSRGRLSEKHTAIIGVGSVGLAALVTLYVGADFLSHNAAGA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCC
AYNQHLWNWIAVGNFTIPVTLSLDGLSLTMLSVVTGVGFLIHLFASWYMRGEEGYSRFFA
HHHHHHHHHEEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YTNLFIASMVVLVLADNLMLMYLGWEGVGLCSYLLIGFYYSNPANGAAAMKAFIVTRVGD
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VFLAIGLFILYHQLGTLNIRELMILAPQQLAVGSPVITWATLMLLGGAVGKSAQLPLQTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFVMAPEVLHLVGIIGAVTLVLAGFAA
HHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHH
LVQTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
EQNIFKMGGLRHKLPLTYLCFLVGGGALAALPLVTAGFYSKDEILWGALASGHVNLMMAG
CCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHH
LIGAFLTSLYTFRMIFIVFHGEAHTQAHEVKGLSHHLPLIVLMILSTFIGALITPPLTGV
HHHHHHHHHHHHHHHHHEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHC
LPAMPQGEGGKVMLEVVSAIVAIAGVLLAARLYLGQRTLVNGIANSAPGRFLSTWWFHAW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GFDWLYRQIFIKPFKAIAWLLQRDPLDRMMNLFALVARLGNRVLAVSENGQLRWYAASMG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCC
VGAVVILALLLLVK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]