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The map label for this gene is nuoM [H]

Identifier: 238920556

GI number: 238920556

Start: 2562261

End: 2563784

Strand: Reverse

Name: nuoM [H]

Synonym: NT01EI_2668

Alternate gene names: 238920556

Gene position: 2563784-2562261 (Counterclockwise)

Preceding gene: 238920557

Following gene: 238920555

Centisome position: 67.25

GC content: 58.99

Gene sequence:

>1524_bases
ATGTTATTACCTTGGCTAATTCTTATCCCGCTGATTGGCGGCCTGCTGTCCTGGCAGGGCGAGCGTCTGGGGCTGAAAGC
GCCGCGCTGGATTGCGCTGCTGGCCATGGGCCTGACGCTGGTGCTGTCGCTCTACCTGTGGCTGCAGGGCAACTATGGCC
TGACTCAGGCGGCGGGTATTCCGCAGTGGCAGTCCAGCTTTATGGTGCCGTGGATCCCGAGCCTGGGCATCTCTTTCCAC
CTGGCGCTCGACGGTCTGTCACTGCTGATGGTGGTGCTTACCGCGCTGCTGGGGGTGCTGGCCATCCTCTGCTCCTGGAA
TGAGATCCATAGGTATCAGGGTTTCTTCCACCTTAACCTGCTGTGGATCCTGGCAGGGGTATTCGGCGTCTTCCTGGCCA
TCGACATGTTCCTGTTCTTCTTCTTCTGGGAAATGATGCTGGTGCCGATGTACTTCCTGATCGCCCTGTGGGGCCATAAG
GGATCCGACGGCAAGACGCGTATTACCGCGGCGACCAAGTTCTTCATCTATACCCAGGCCAGCGGTCTGGTGATGCTGAT
CGCCATCTTCGGCCTGGTGTGGGTGCACTACAACGCCACCGGGGTGCTGAGCTTTGACTATGAGGTACTGCTCAATACGC
CGATGAGCCACACGGTGCAGTATCTGCTGATGCTGGGTTTCTTTATCTCCTTTGCGGTGAAGATGCCGGTGGTGCCGCTA
CACGGCTGGTTGCCGGACGCGCACAGTCAGGCGCCGACCGCAGGCTCCGTCGACCTGGCCGGTATCCTGCTGAAGACCGC
CGCCTACGGCCTACTGCGCTTCAGCCTGCCGCTGTTCCCGCAGGCGTCGCACGAATTTGCGCCGATTGCGATGGCTCTGG
GGGTGATCGGGATTTTCTACGGCGCCTGGATGGCTTATATCCAGACGGATATTAAACGCCTGATTGCCTATACCTCGGTA
TCGCACATGGGCTTTGTGATGATCGCCATCTACTCCGGCAGCCAGCTGGCGTTCCAGGGGGCGGTGGTACAGATGATCGC
GCATGGCCTCTCTGCCGCCGGGCTGTTCATCATTACCGGTCAGCTGTATGAGCGTCTGCATACCCGCGATCTGCGCGAGA
TGGGGGGCCTGTGGGGGCGTCTGAAGTATCTGCCTGCGCTATCGCTGTTTTTCGCGGTGGCGACCCTGGGAATGCCGGGT
ACCGGGAACTTTGTCGGTGAATTTATGATTATGTTCGGCAGCTTCCAGGTGGTGCCGGTAACGACGGTGGTCGCCAGCTT
TGGTCTGGTATTTGCGTCTGTCTATTCGCTGGTAATGATGCAGCGCGCTTACTACGGTGTGCCAAAGTCAGACCAACCCT
TGGCCAATCTGAGCGTGCGTGAGCTGTCGCTCATTCTGCTGCTGGTGGTACTGCTGGTACTGCTGGGGATCTTCCCGCAG
CCGGTGCTGGACACCTCCAGCGCGGCGATGGGCAATATTCAGCATTGGTTCGCTTCTGCTTCAACTTTAACCACAAGGCC
GTAA

Upstream 100 bases:

>100_bases
CGCTGTTGTTATTGGTTAAGTGAATCTCGTTAAAGCGGGTGAGGGGACGACCCCTGTCTCCTCCGTTTGAATGTATTCAG
AATAAGGGAAACCAAACGCC

Downstream 100 bases:

>100_bases
ATCGCCATGACAATAACTCCTCAAAATCTGATCGCACTGCTACCGCTGTTGATCGTCGGATTGACGGTGGTGGTTGTGAT
GCTGTGCATTGCGTGGCGAC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M; NUO13 [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MLLPWLILIPLIGGLLSWQGERLGLKAPRWIALLAMGLTLVLSLYLWLQGNYGLTQAAGIPQWQSSFMVPWIPSLGISFH
LALDGLSLLMVVLTALLGVLAILCSWNEIHRYQGFFHLNLLWILAGVFGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHK
GSDGKTRITAATKFFIYTQASGLVMLIAIFGLVWVHYNATGVLSFDYEVLLNTPMSHTVQYLLMLGFFISFAVKMPVVPL
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPQASHEFAPIAMALGVIGIFYGAWMAYIQTDIKRLIAYTSV
SHMGFVMIAIYSGSQLAFQGAVVQMIAHGLSAAGLFIITGQLYERLHTRDLREMGGLWGRLKYLPALSLFFAVATLGMPG
TGNFVGEFMIMFGSFQVVPVTTVVASFGLVFASVYSLVMMQRAYYGVPKSDQPLANLSVRELSLILLLVVLLVLLGIFPQ
PVLDTSSAAMGNIQHWFASASTLTTRP

Sequences:

>Translated_507_residues
MLLPWLILIPLIGGLLSWQGERLGLKAPRWIALLAMGLTLVLSLYLWLQGNYGLTQAAGIPQWQSSFMVPWIPSLGISFH
LALDGLSLLMVVLTALLGVLAILCSWNEIHRYQGFFHLNLLWILAGVFGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHK
GSDGKTRITAATKFFIYTQASGLVMLIAIFGLVWVHYNATGVLSFDYEVLLNTPMSHTVQYLLMLGFFISFAVKMPVVPL
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPQASHEFAPIAMALGVIGIFYGAWMAYIQTDIKRLIAYTSV
SHMGFVMIAIYSGSQLAFQGAVVQMIAHGLSAAGLFIITGQLYERLHTRDLREMGGLWGRLKYLPALSLFFAVATLGMPG
TGNFVGEFMIMFGSFQVVPVTTVVASFGLVFASVYSLVMMQRAYYGVPKSDQPLANLSVRELSLILLLVVLLVLLGIFPQ
PVLDTSSAAMGNIQHWFASASTLTTRP
>Mature_507_residues
MLLPWLILIPLIGGLLSWQGERLGLKAPRWIALLAMGLTLVLSLYLWLQGNYGLTQAAGIPQWQSSFMVPWIPSLGISFH
LALDGLSLLMVVLTALLGVLAILCSWNEIHRYQGFFHLNLLWILAGVFGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHK
GSDGKTRITAATKFFIYTQASGLVMLIAIFGLVWVHYNATGVLSFDYEVLLNTPMSHTVQYLLMLGFFISFAVKMPVVPL
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPQASHEFAPIAMALGVIGIFYGAWMAYIQTDIKRLIAYTSV
SHMGFVMIAIYSGSQLAFQGAVVQMIAHGLSAAGLFIITGQLYERLHTRDLREMGGLWGRLKYLPALSLFFAVATLGMPG
TGNFVGEFMIMFGSFQVVPVTTVVASFGLVFASVYSLVMMQRAYYGVPKSDQPLANLSVRELSLILLLVVLLVLLGIFPQ
PVLDTSSAAMGNIQHWFASASTLTTRP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=362, Percent_Identity=33.1491712707182, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI251831117, Length=275, Percent_Identity=29.4545454545455, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788613, Length=510, Percent_Identity=81.7647058823529, Blast_Score=816, Evalue=0.0,
Organism=Escherichia coli, GI1788831, Length=494, Percent_Identity=27.3279352226721, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788827, Length=347, Percent_Identity=27.3775216138329, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788614, Length=504, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693160, Length=436, Percent_Identity=26.3761467889908, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788829, Length=343, Percent_Identity=25.6559766763848, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55860; Mature: 55860

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPWLILIPLIGGLLSWQGERLGLKAPRWIALLAMGLTLVLSLYLWLQGNYGLTQAAGI
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PQWQSSFMVPWIPSLGISFHLALDGLSLLMVVLTALLGVLAILCSWNEIHRYQGFFHLNL
CCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHH
LWILAGVFGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKGSDGKTRITAATKFFIYTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECC
SGLVMLIAIFGLVWVHYNATGVLSFDYEVLLNTPMSHTVQYLLMLGFFISFAVKMPVVPL
CHHHHHHHHHHHHHHHCCCCEEEEECHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCEEC
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPQASHEFAPIAMALGVIGIFY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
GAWMAYIQTDIKRLIAYTSVSHMGFVMIAIYSGSQLAFQGAVVQMIAHGLSAAGLFIITG
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHEEHH
QLYERLHTRDLREMGGLWGRLKYLPALSLFFAVATLGMPGTGNFVGEFMIMFGSFQVVPV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEHHH
TTVVASFGLVFASVYSLVMMQRAYYGVPKSDQPLANLSVRELSLILLLVVLLVLLGIFPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PVLDTSSAAMGNIQHWFASASTLTTRP
CCCCCCCHHHCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLLPWLILIPLIGGLLSWQGERLGLKAPRWIALLAMGLTLVLSLYLWLQGNYGLTQAAGI
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PQWQSSFMVPWIPSLGISFHLALDGLSLLMVVLTALLGVLAILCSWNEIHRYQGFFHLNL
CCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHH
LWILAGVFGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKGSDGKTRITAATKFFIYTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECC
SGLVMLIAIFGLVWVHYNATGVLSFDYEVLLNTPMSHTVQYLLMLGFFISFAVKMPVVPL
CHHHHHHHHHHHHHHHCCCCEEEEECHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCEEC
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPQASHEFAPIAMALGVIGIFY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
GAWMAYIQTDIKRLIAYTSVSHMGFVMIAIYSGSQLAFQGAVVQMIAHGLSAAGLFIITG
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHEEHH
QLYERLHTRDLREMGGLWGRLKYLPALSLFFAVATLGMPGTGNFVGEFMIMFGSFQVVPV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEHHH
TTVVASFGLVFASVYSLVMMQRAYYGVPKSDQPLANLSVRELSLILLLVVLLVLLGIFPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PVLDTSSAAMGNIQHWFASASTLTTRP
CCCCCCCHHHCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]