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The map label for this gene is cycA [H]

Identifier: 238920478

GI number: 238920478

Start: 2482714

End: 2484132

Strand: Direct

Name: cycA [H]

Synonym: NT01EI_2589

Alternate gene names: 238920478

Gene position: 2482714-2484132 (Clockwise)

Preceding gene: 238920477

Following gene: 238920482

Centisome position: 65.12

GC content: 57.29

Gene sequence:

>1419_bases
ATGGAGAAACGATCTACAGCGGCAACAAAGCAACGCGACACGACGTCCGACGGACACCTGCAGCGTAATCTTAATAACCG
CCATATTCAGCTCATTGCCATCGGGGGCGCTATCGGAACCGGCCTGTTTATGGGCTCCGGAAAAACCATCAGCCTGGCCG
GACCATCTATTATTTTCGTTTATATGATTATCGGATTTATGCTTTTTTTTGTAATGCGGGCAATGGGCGAACTACTGCTC
TCCAACCTGGAGTATAAATCCTTCAGCGATTTCGCCACCGATCTACTCGGTGCCCGCGCCGGTTATTTTACCGGATGGAC
CTACTGGTTTTGCTGGGTCGTCACCGGTATGGCCGACGTAGTCGCCATTACCGCCTATGCCCACTTCTGGTTTCCTCATC
TGGCTGACTGGATTATTTCGCTCTCCTGTGTCGTACTGCTGCTCTCGCTCAATCTGGTCACGGTTAAAATGTTCGGTGAA
ACCGAATTTTGGTTCGCGATGATTAAAATCGTCGCCATTATCGCCCTGATCCTGATCGGGCTGGGCATGGCCATCGGCGG
CTTTCGCGCCCCTTCCGGTGAGCAGGCTGCCTTCAGCAACCTGTGGCACGGCGGCCTCTTTCCCCACGGGATCGGTGGTT
TCTTCGCCGGATTTCAGATCGCAGTCTTCGCCTTTGTCGGCATTGAGCTGGTTGGCACCACGGCGGCGGAAACCCGCGAT
CCGCAACGCGTGCTCCCCAGAGCAATCAATGCGATACCGCTGCGTATCATCATGTTCTATGTACTGGCTCTGTGCACCAT
CATGATCGTTACCCCCTGGCAGCAAGTGGTGCCCGACAAGAGCCCCTTTGTGGAGCTGTTTATCCTGGCCGGGCTGCCGG
CCGCAGCGGGGATCATCAACTTTGTGGTGCTGACCTCAGCAGCCTCCTCCGCCAACAGCGGTATCTTTTCGACCAGCCGC
ATGCTTTACGGACTGGCAAAAAGCGGCCTGGCCCCCGCCCGCTTCGCCCGTCTGTCCCGTCAATCGGTGCCCGCCTCCGG
GCTGTTTTTCTCCTGCCTGTGCCTAATGGGGGGCGTCGTGCTGCTCTATCTGATCCCCAACGTGATCACCGTCTTTACCC
TGATCACCACCGTCTCGGCCGTGCTGTTTATGTTCGTCTGGTCGATCATTCTGTGTAGCTACCTGGTCTATCGCCGCCGC
TATCCGCAGCGACACGCCGCCTCGGGCTACAAGATGCCGCTGGGCCGCGTTATGTGCTGGATCTGTCTCGCCTTTCTGTT
TGGTGTACTGATCCTGCTCACGCTGGAAACCGATACGCGCCAGGCGTTGATGGTCACGCCGCTGTGGTTTATCGCGCTGG
CTATCGGCTGGCGTTTCACCCAGCGTCCCCCGGCGCTTTCCTGTGACGAGGCCGCCTAA

Upstream 100 bases:

>100_bases
CTACTATCGTTAACGGAGGACGGCCACAGGGTATAACTGTCGCAAGAAGCGAACCGTCGGATCCACGCATTTCGAACAGC
TCACTCGGGGGAGAGCAGAC

Downstream 100 bases:

>100_bases
AAAAATAGGGGAGCCTCCCGGCTCCCCCACACGCTATCATTCAAATGACTATGCCGTTTTCGTCACCCGCTCCTGTGGTG
CAACATCTGGACGCTTGAGC

Product: proline-specific permease ProY

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MEKRSTAATKQRDTTSDGHLQRNLNNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLL
SNLEYKSFSDFATDLLGARAGYFTGWTYWFCWVVTGMADVVAITAYAHFWFPHLADWIISLSCVVLLLSLNLVTVKMFGE
TEFWFAMIKIVAIIALILIGLGMAIGGFRAPSGEQAAFSNLWHGGLFPHGIGGFFAGFQIAVFAFVGIELVGTTAAETRD
PQRVLPRAINAIPLRIIMFYVLALCTIMIVTPWQQVVPDKSPFVELFILAGLPAAAGIINFVVLTSAASSANSGIFSTSR
MLYGLAKSGLAPARFARLSRQSVPASGLFFSCLCLMGGVVLLYLIPNVITVFTLITTVSAVLFMFVWSIILCSYLVYRRR
YPQRHAASGYKMPLGRVMCWICLAFLFGVLILLTLETDTRQALMVTPLWFIALAIGWRFTQRPPALSCDEAA

Sequences:

>Translated_472_residues
MEKRSTAATKQRDTTSDGHLQRNLNNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLL
SNLEYKSFSDFATDLLGARAGYFTGWTYWFCWVVTGMADVVAITAYAHFWFPHLADWIISLSCVVLLLSLNLVTVKMFGE
TEFWFAMIKIVAIIALILIGLGMAIGGFRAPSGEQAAFSNLWHGGLFPHGIGGFFAGFQIAVFAFVGIELVGTTAAETRD
PQRVLPRAINAIPLRIIMFYVLALCTIMIVTPWQQVVPDKSPFVELFILAGLPAAAGIINFVVLTSAASSANSGIFSTSR
MLYGLAKSGLAPARFARLSRQSVPASGLFFSCLCLMGGVVLLYLIPNVITVFTLITTVSAVLFMFVWSIILCSYLVYRRR
YPQRHAASGYKMPLGRVMCWICLAFLFGVLILLTLETDTRQALMVTPLWFIALAIGWRFTQRPPALSCDEAA
>Mature_472_residues
MEKRSTAATKQRDTTSDGHLQRNLNNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLL
SNLEYKSFSDFATDLLGARAGYFTGWTYWFCWVVTGMADVVAITAYAHFWFPHLADWIISLSCVVLLLSLNLVTVKMFGE
TEFWFAMIKIVAIIALILIGLGMAIGGFRAPSGEQAAFSNLWHGGLFPHGIGGFFAGFQIAVFAFVGIELVGTTAAETRD
PQRVLPRAINAIPLRIIMFYVLALCTIMIVTPWQQVVPDKSPFVELFILAGLPAAAGIINFVVLTSAASSANSGIFSTSR
MLYGLAKSGLAPARFARLSRQSVPASGLFFSCLCLMGGVVLLYLIPNVITVFTLITTVSAVLFMFVWSIILCSYLVYRRR
YPQRHAASGYKMPLGRVMCWICLAFLFGVLILLTLETDTRQALMVTPLWFIALAIGWRFTQRPPALSCDEAA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=22.6890756302521, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI115648063, Length=457, Percent_Identity=24.507658643326, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=457, Percent_Identity=24.507658643326, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI181337167, Length=318, Percent_Identity=22.9559748427673, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=74.5614035087719, Blast_Score=705, Evalue=0.0,
Organism=Escherichia coli, GI48994972, Length=436, Percent_Identity=43.1192660550459, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=38.6516853932584, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1786789, Length=461, Percent_Identity=37.0932754880694, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1786602, Length=449, Percent_Identity=40.7572383073497, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI87081915, Length=469, Percent_Identity=36.0341151385927, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=34.3283582089552, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788480, Length=439, Percent_Identity=37.129840546697, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789017, Length=449, Percent_Identity=31.1804008908686, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI2367353, Length=385, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=358, Percent_Identity=24.5810055865922, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=444, Percent_Identity=22.0720720720721, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=385, Percent_Identity=23.6363636363636, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324924, Length=418, Percent_Identity=33.0143540669856, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=412, Percent_Identity=31.7961165048544, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=412, Percent_Identity=30.3398058252427, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=411, Percent_Identity=28.4671532846715, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324990, Length=423, Percent_Identity=28.8416075650118, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=30.2272727272727, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=29.1237113402062, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=418, Percent_Identity=27.0334928229665, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=420, Percent_Identity=25, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=438, Percent_Identity=28.0821917808219, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319824, Length=420, Percent_Identity=26.1904761904762, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=417, Percent_Identity=25.6594724220624, Blast_Score=136, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=441, Percent_Identity=25.8503401360544, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=25.6723716381418, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321053, Length=395, Percent_Identity=27.0886075949367, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322967, Length=383, Percent_Identity=27.6762402088773, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=392, Percent_Identity=25.765306122449, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320364, Length=466, Percent_Identity=22.9613733905579, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550968, Length=409, Percent_Identity=26.4058679706601, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921172, Length=409, Percent_Identity=26.4058679706601, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667468, Length=384, Percent_Identity=22.9166666666667, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51772; Mature: 51772

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRSTAATKQRDTTSDGHLQRNLNNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFV
CCCCHHHHHHCCCCCCCCHHHHCCCCCEEEEEEECCHHHHHEEECCCCEEEECCHHHHHH
YMIIGFMLFFVMRAMGELLLSNLEYKSFSDFATDLLGARAGYFTGWTYWFCWVVTGMADV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VAITAYAHFWFPHLADWIISLSCVVLLLSLNLVTVKMFGETEFWFAMIKIVAIIALILIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHH
LGMAIGGFRAPSGEQAAFSNLWHGGLFPHGIGGFFAGFQIAVFAFVGIELVGTTAAETRD
HHHHHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
PQRVLPRAINAIPLRIIMFYVLALCTIMIVTPWQQVVPDKSPFVELFILAGLPAAAGIIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGIFSTSRMLYGLAKSGLAPARFARLSRQSVPASGLFFSCLCLMGGVV
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLYLIPNVITVFTLITTVSAVLFMFVWSIILCSYLVYRRRYPQRHAASGYKMPLGRVMCW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHH
ICLAFLFGVLILLTLETDTRQALMVTPLWFIALAIGWRFTQRPPALSCDEAA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKRSTAATKQRDTTSDGHLQRNLNNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFV
CCCCHHHHHHCCCCCCCCHHHHCCCCCEEEEEEECCHHHHHEEECCCCEEEECCHHHHHH
YMIIGFMLFFVMRAMGELLLSNLEYKSFSDFATDLLGARAGYFTGWTYWFCWVVTGMADV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VAITAYAHFWFPHLADWIISLSCVVLLLSLNLVTVKMFGETEFWFAMIKIVAIIALILIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHH
LGMAIGGFRAPSGEQAAFSNLWHGGLFPHGIGGFFAGFQIAVFAFVGIELVGTTAAETRD
HHHHHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
PQRVLPRAINAIPLRIIMFYVLALCTIMIVTPWQQVVPDKSPFVELFILAGLPAAAGIIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGIFSTSRMLYGLAKSGLAPARFARLSRQSVPASGLFFSCLCLMGGVV
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLYLIPNVITVFTLITTVSAVLFMFVWSIILCSYLVYRRRYPQRHAASGYKMPLGRVMCW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHH
ICLAFLFGVLILLTLETDTRQALMVTPLWFIALAIGWRFTQRPPALSCDEAA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]