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The map label for this gene is hisG

Identifier: 238920453

GI number: 238920453

Start: 2456212

End: 2457111

Strand: Direct

Name: hisG

Synonym: NT01EI_2564

Alternate gene names: 238920453

Gene position: 2456212-2457111 (Clockwise)

Preceding gene: 238920450

Following gene: 238920454

Centisome position: 64.43

GC content: 62.33

Gene sequence:

>900_bases
ATGTTGGACAAAACACGTTTACGCATCGCCATGCAAAAATCTGGCCGTCTGAGCGAAGACTCGCAGGCGCTGCTGGCCCG
CTGCGGGATCAAAATCAACCTGCATCAGCAGCGACTGATCGCCTTCGCCGAAAATATGCCCATCGACATCCTGCGGGTGC
GCGATGACGATATTCCCGGCCTGGTGATGGATGGCGTGGTTGACCTGGGCATCATCGGCGAGAACGTGCTGGAAGAGGAG
CTGCTCACCCGGCGGGCCCAGGGTGACGATCCGCGCTATACCCTGCTACGGCGCCTCGACTTCGGTGCCTGCCGCCTCTC
CCTGGCCATGCCCATCGATGCAGCCTATGACGGTGCCCGCGGTCTGCAGGACTGCCGCATCGCCACCTCTTATCCCCACC
TGCTCAAGCGCTATCTGGATGGGCAGGGCGTCCGCTTCAAATCCTGTCTGCTCAACGGCTCGGTAGAGGTTGCCCCGCGC
GCCGGATTGGCCGATGCCATCTGCGATCTGGTCTCCACCGGTGCCACCCTTGAGGCCAACGGCCTGCGCGAGGTCGAGGT
TATCTACCGCTCCAAGGCCTGCCTGATTCAGCGCGACGGCGAGATGCCTCCCGCCAAGCAGGCGCTGATCGAACGCCTAA
TGACCCGGATTCAAGGGGTGATCCAGGCGCGGGAGTCCAAATACATCATGTTGCACGCGCCGAGCGATCGTCTGGAAGAG
ATTATGGCGCTGCTGCCGGGGGCTGAGCGCCCGACCCTGCTGCCGCTGGCCGGTGACAAGCGCCGCGTCGCTATGCACAT
GGTCAGCAGCGAAACCCTGTTCTGGGAAACCATGGAGCAGCTCAAGGCTCTGGGGGCCAGCTCGATCCTGGTACTGCCGA
TTGAAAAGATGATGGAGTGA

Upstream 100 bases:

>100_bases
GATGTGAAAAAGCCCTCGGAAGATCTTCTTCCGAGGGCTTTTTTGTTGTTCATCATTCACGGGCGCCGCGGCGCCGGCTG
GGGAATACAGGAGTAACACC

Downstream 100 bases:

>100_bases
CGCCATGATCCGCTTTGATACGCTTATCCAATGGGACGACTGTAGCCCCGAACAGCAGCACTGCCTGCTACAGCGCCCGG
CGATCGCCAGCGCCGCGCAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLDKTRLRIAMQKSGRLSEDSQALLARCGIKINLHQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEE
LLTRRAQGDDPRYTLLRRLDFGACRLSLAMPIDAAYDGARGLQDCRIATSYPHLLKRYLDGQGVRFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMPPAKQALIERLMTRIQGVIQARESKYIMLHAPSDRLEE
IMALLPGAERPTLLPLAGDKRRVAMHMVSSETLFWETMEQLKALGASSILVLPIEKMME

Sequences:

>Translated_299_residues
MLDKTRLRIAMQKSGRLSEDSQALLARCGIKINLHQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEE
LLTRRAQGDDPRYTLLRRLDFGACRLSLAMPIDAAYDGARGLQDCRIATSYPHLLKRYLDGQGVRFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMPPAKQALIERLMTRIQGVIQARESKYIMLHAPSDRLEE
IMALLPGAERPTLLPLAGDKRRVAMHMVSSETLFWETMEQLKALGASSILVLPIEKMME
>Mature_299_residues
MLDKTRLRIAMQKSGRLSEDSQALLARCGIKINLHQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEE
LLTRRAQGDDPRYTLLRRLDFGACRLSLAMPIDAAYDGARGLQDCRIATSYPHLLKRYLDGQGVRFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMPPAKQALIERLMTRIQGVIQARESKYIMLHAPSDRLEE
IMALLPGAERPTLLPLAGDKRRVAMHMVSSETLFWETMEQLKALGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=85.61872909699, Blast_Score=523, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=30.3030303030303, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_EDWI9 (C5BG10)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933968.1
- GeneID:   7961752
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2564
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33249; Mature: 33249

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKTRLRIAMQKSGRLSEDSQALLARCGIKINLHQQRLIAFAENMPIDILRVRDDDIPG
CCCCHHHEEEECCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEELLTRRAQGDDPRYTLLRRLDFGACRLSLAMPIDAAYDGAR
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCHHHCCCCC
GLQDCRIATSYPHLLKRYLDGQGVRFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
CHHHCEECCCCHHHHHHHHCCCCCEEHHHHCCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREVEVIYRSKACLIQRDGEMPPAKQALIERLMTRIQGVIQARESKYIMLHAPSDRLEE
CCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IMALLPGAERPTLLPLAGDKRRVAMHMVSSETLFWETMEQLKALGASSILVLPIEKMME
HHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MLDKTRLRIAMQKSGRLSEDSQALLARCGIKINLHQQRLIAFAENMPIDILRVRDDDIPG
CCCCHHHEEEECCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEELLTRRAQGDDPRYTLLRRLDFGACRLSLAMPIDAAYDGAR
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCHHHCCCCC
GLQDCRIATSYPHLLKRYLDGQGVRFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
CHHHCEECCCCHHHHHHHHCCCCCEEHHHHCCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREVEVIYRSKACLIQRDGEMPPAKQALIERLMTRIQGVIQARESKYIMLHAPSDRLEE
CCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IMALLPGAERPTLLPLAGDKRRVAMHMVSSETLFWETMEQLKALGASSILVLPIEKMME
HHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA