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The map label for this gene is hisD [H]

Identifier: 238920454

GI number: 238920454

Start: 2457116

End: 2458426

Strand: Direct

Name: hisD [H]

Synonym: NT01EI_2565

Alternate gene names: 238920454

Gene position: 2457116-2458426 (Clockwise)

Preceding gene: 238920453

Following gene: 238920455

Centisome position: 64.45

GC content: 66.97

Gene sequence:

>1311_bases
ATGATCCGCTTTGATACGCTTATCCAATGGGACGACTGTAGCCCCGAACAGCAGCACTGCCTGCTACAGCGCCCGGCGAT
CGCCAGCGCCGCGCAAATCAGTGCAAACGTTGAGGCGATCATCGCCCAGGTTCGCCACGACGGTGATGCGGCGCTGCATC
GCCTCAGCCAACGCTTTGACCGGGAGGCACCTGCCATCCTGCGCGTTTCACGTCAGATCCGCGACGTCGCCGGCGACAGT
CTGCCCGACGCACTGACCCGCGCCATGGGCCAGGCGGCCAAGAATATTGAGGTCTTTCATCGCGCCCAGTGCCCGGCCCC
TGTCGAGGTCGAAACCCAGCCCGGCGTCTGCTGCCGCCAGATCTCCCGCGCACTGGACACCGTCGGCCTGTATATTCCCG
GCGGCAGCGCCCCGTTGCTCTCCACGGTGCTGATGCTGGGGATCCCGGCCCGCGTGGCGCAGTGCCGTAGAGTGATCCTC
TGCTCACCACCGCCGATTGACCCGGCGATCCTCTACGCCGCACGCCTGTGCGGCATCGACGAAATTTTTCAGGTCGGCGG
CGCGCAAGCAATCGCCGCCATGGCCTTCGGAACCGAATCCGTCCCCCGCGTCGACAAAATCTTTGGCCCCGGAAACGCCT
ATGTCACCGAGGCCAAACGGCAGGTCAGCCAAAGCCCTCGGGGCGCCGCCATCGATATGCCCGCCGGCCCCTCCGAGGTG
CTGGTGATCGCCGATTCCGGAGCCAACCCGGAGTTTATCGCCGCCGATCTGCTCTCCCAGGCGGAGCATGGCCCCGACTC
ACAGGTGCTCCTGCTGACGCCCGATGCCCCGCTGGCCCGCCGGGTCGCCGAACGGGTCAAGGCGCAGCTTGCCCTCCTGC
CACGCGCTGACATCGCCCGCCAGGCGCTGGCGCAGAGCCGCCTGATCGTCACCCGTTCGCTGGCGCAGTGCATCGAGATC
AGCAACCGCTATGGGCCGGAGCACCTCATCATTCAAACCCGCGACGCCGAGGCGTGGCTCGATGCCATCACCAGCGCTGG
CTCCGTGTTTCTGGGCGACTGGTCGCCCGAATCCGCGGGGGACTATGCCTCCGGCACCAATCACGTGCTGCCGACCTACG
GCTACACCGCCACCCACTCCAGTCTGGGGCTGGCAGATTTCCAGAAACGCATGACCGTCCAACGCCTCAGCCCCGCAGGC
CTGCTGACGCTGGCCCCGACGGTCGAGGCCATGGCGCAGGCTGAGTGCCTTGACGCCCACGCCAACGCCGTCCGCCTGCG
GGTCGCCGCCATCCGGGAGAGCCAATCATGA

Upstream 100 bases:

>100_bases
AGCAGCGAAACCCTGTTCTGGGAAACCATGGAGCAGCTCAAGGCTCTGGGGGCCAGCTCGATCCTGGTACTGCCGATTGA
AAAGATGATGGAGTGACGCC

Downstream 100 bases:

>100_bases
AGCCGATAACCGCACTGGCGCGGGAAAACATACAGCGCCTGACCCCCTACCAGTCCGCCCGACGCCTCGGTGGCAGCGGC
GACGTCTGGCTCAATGCCAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MIRFDTLIQWDDCSPEQQHCLLQRPAIASAAQISANVEAIIAQVRHDGDAALHRLSQRFDREAPAILRVSRQIRDVAGDS
LPDALTRAMGQAAKNIEVFHRAQCPAPVEVETQPGVCCRQISRALDTVGLYIPGGSAPLLSTVLMLGIPARVAQCRRVIL
CSPPPIDPAILYAARLCGIDEIFQVGGAQAIAAMAFGTESVPRVDKIFGPGNAYVTEAKRQVSQSPRGAAIDMPAGPSEV
LVIADSGANPEFIAADLLSQAEHGPDSQVLLLTPDAPLARRVAERVKAQLALLPRADIARQALAQSRLIVTRSLAQCIEI
SNRYGPEHLIIQTRDAEAWLDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATHSSLGLADFQKRMTVQRLSPAG
LLTLAPTVEAMAQAECLDAHANAVRLRVAAIRESQS

Sequences:

>Translated_436_residues
MIRFDTLIQWDDCSPEQQHCLLQRPAIASAAQISANVEAIIAQVRHDGDAALHRLSQRFDREAPAILRVSRQIRDVAGDS
LPDALTRAMGQAAKNIEVFHRAQCPAPVEVETQPGVCCRQISRALDTVGLYIPGGSAPLLSTVLMLGIPARVAQCRRVIL
CSPPPIDPAILYAARLCGIDEIFQVGGAQAIAAMAFGTESVPRVDKIFGPGNAYVTEAKRQVSQSPRGAAIDMPAGPSEV
LVIADSGANPEFIAADLLSQAEHGPDSQVLLLTPDAPLARRVAERVKAQLALLPRADIARQALAQSRLIVTRSLAQCIEI
SNRYGPEHLIIQTRDAEAWLDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATHSSLGLADFQKRMTVQRLSPAG
LLTLAPTVEAMAQAECLDAHANAVRLRVAAIRESQS
>Mature_436_residues
MIRFDTLIQWDDCSPEQQHCLLQRPAIASAAQISANVEAIIAQVRHDGDAALHRLSQRFDREAPAILRVSRQIRDVAGDS
LPDALTRAMGQAAKNIEVFHRAQCPAPVEVETQPGVCCRQISRALDTVGLYIPGGSAPLLSTVLMLGIPARVAQCRRVIL
CSPPPIDPAILYAARLCGIDEIFQVGGAQAIAAMAFGTESVPRVDKIFGPGNAYVTEAKRQVSQSPRGAAIDMPAGPSEV
LVIADSGANPEFIAADLLSQAEHGPDSQVLLLTPDAPLARRVAERVKAQLALLPRADIARQALAQSRLIVTRSLAQCIEI
SNRYGPEHLIIQTRDAEAWLDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATHSSLGLADFQKRMTVQRLSPAG
LLTLAPTVEAMAQAECLDAHANAVRLRVAAIRESQS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=432, Percent_Identity=67.5925925925926, Blast_Score=593, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=44.1527446300716, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46613; Mature: 46613

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRFDTLIQWDDCSPEQQHCLLQRPAIASAAQISANVEAIIAQVRHDGDAALHRLSQRFD
CCEECCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
REAPAILRVSRQIRDVAGDSLPDALTRAMGQAAKNIEVFHRAQCPAPVEVETQPGVCCRQ
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHH
ISRALDTVGLYIPGGSAPLLSTVLMLGIPARVAQCRRVILCSPPPIDPAILYAARLCGID
HHHHHHHCEEEECCCCCHHHHHHHHHCCCHHHHHCCEEEEECCCCCCHHHHHHHHHCCHH
EIFQVGGAQAIAAMAFGTESVPRVDKIFGPGNAYVTEAKRQVSQSPRGAAIDMPAGPSEV
HHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCE
LVIADSGANPEFIAADLLSQAEHGPDSQVLLLTPDAPLARRVAERVKAQLALLPRADIAR
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
QALAQSRLIVTRSLAQCIEISNRYGPEHLIIQTRDAEAWLDAITSAGSVFLGDWSPESAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCC
DYASGTNHVLPTYGYTATHSSLGLADFQKRMTVQRLSPAGLLTLAPTVEAMAQAECLDAH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHH
ANAVRLRVAAIRESQS
HHHHEEHHHHHHCCCC
>Mature Secondary Structure
MIRFDTLIQWDDCSPEQQHCLLQRPAIASAAQISANVEAIIAQVRHDGDAALHRLSQRFD
CCEECCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
REAPAILRVSRQIRDVAGDSLPDALTRAMGQAAKNIEVFHRAQCPAPVEVETQPGVCCRQ
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHH
ISRALDTVGLYIPGGSAPLLSTVLMLGIPARVAQCRRVILCSPPPIDPAILYAARLCGID
HHHHHHHCEEEECCCCCHHHHHHHHHCCCHHHHHCCEEEEECCCCCCHHHHHHHHHCCHH
EIFQVGGAQAIAAMAFGTESVPRVDKIFGPGNAYVTEAKRQVSQSPRGAAIDMPAGPSEV
HHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCE
LVIADSGANPEFIAADLLSQAEHGPDSQVLLLTPDAPLARRVAERVKAQLALLPRADIAR
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
QALAQSRLIVTRSLAQCIEISNRYGPEHLIIQTRDAEAWLDAITSAGSVFLGDWSPESAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCC
DYASGTNHVLPTYGYTATHSSLGLADFQKRMTVQRLSPAGLLTLAPTVEAMAQAECLDAH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHH
ANAVRLRVAAIRESQS
HHHHEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA