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The map label for this gene is sdaC [H]

Identifier: 238920430

GI number: 238920430

Start: 2440301

End: 2441593

Strand: Direct

Name: sdaC [H]

Synonym: NT01EI_2541

Alternate gene names: 238920430

Gene position: 2440301-2441593 (Clockwise)

Preceding gene: 238920429

Following gene: 238920431

Centisome position: 64.01

GC content: 54.83

Gene sequence:

>1293_bases
ATGGACACCACTCAGACTGGTACTATTGCTTCTACCTCCGGTTCCAAGAGTGCCTGGCGTAAGTCAGATACTATGTGGAT
GTTGGGCCTGTACGGTACAGCCATCGGCGCGGGCGTTCTGTTCCTGCCGATCAACGCCGGCGTCGGCGGCCTGATTCCGC
TGATCATCATGGCGATCCTGGCGTTCCCCATGACATTCTTTGCCCACCGCGGTCTGACCCGCTTCGTGCTGTCCGGCAAA
AAACCGGGCGAAGATATCACTGAAGTGGTCGAGGAACACTTCGGCATTGGCGCGGGTAAACTGATAACCCTGCTGTACTT
CTTCGCTATCTACCCTATCTGCCTGGTATACAGCGTAGCGATCACCAATACCGTGGAAAGCTTCATCACTCACCAGCTGG
GTATGAGCGCACCGCCGCGTATCATCCTGTCCCTGATTCTGATCCTGGGCCTGATGACCATCGTCCGCTTCGGTGAGCAT
CTGATTGTGAAGGTGATGAGCATCCTGGTATATCCGTTCGTTGCCGTTCTGATGCTGCTGGCCCTGTATCTGATCCCGAA
CTGGAACAGCGCCATCTTCGACAGCGCAGCCATCGCCAGCTCTGCCTCCGGCAGCGGCCTGTGGATGACCCTGTGGCTGG
CTATCCCGGTTATGGTGTTCTCCTTCAACCACTCTCCTATCATCTCCGCTTTCGCCGTTGCCAAGCGTGAAGAGTATGGT
GATGAGCTGGCTGAGAAAAAGTGCTCCAAAATCCTGAGCTACGCACACATCATGATGGTACTGACCGTTATGTTCTTCGT
GTTCAGCTGTGTACTGAGCCTGTCTCCGGCCGACCTGGCCGAAGCCAAAGCCCAGAACCTCTCCATCCTGTCGTATCTGG
CCAACCACTTTAATACGCCGGTTATCGCCTTCGCTGCACCGATCATTGCGTTCGTTGCCATCACCAAATCTTTCCTGGGC
CACTACCTGGGTGCCCGTGAAGGCTTCAACGGTCTGGTCATCAAATCACTGCGTGGCCGCGGTAAGAGCATCGAAATTGG
CAAACTGAACAAAATCACTGCTCTGTTCATGCTGATCACCACCTGGGTTGTGGCCACCCTGAACCCATCCATTCTGGGGA
TGATTGAAACCCTGGGCGGTCCGGTTATCGCGATGATCCTGTTCCTGATGCCGATGTACGCCATTAACAAGGTACCGGCC
ATGCGCAAGTACAGCGGCCACATCAGCAACGTCTTCGTTGTGATTATGGGCCTGATTGCCATCTCTGCAATCCTGTATAC
CCTGTTCGGTTAA

Upstream 100 bases:

>100_bases
TCATTAGGAATTATTAACTCACTCAGTTCCCTGATTGAGTGTCTGTCGGCCTTAGAGCGGGCAGACCGATCAGAACAAAT
GTGTTCAATTTGGAGACCCT

Downstream 100 bases:

>100_bases
TAACAGTAACAGCCCGACCGGTGCGGCTTCCGCACCGGTCGTTTTTTTATCCTGGCAACAGTTTCAATTTCCAGCCTTGA
TAAATCATTGGAGGCGATAT

Product: serine transporter family protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDTTQTGTIASTSGSKSAWRKSDTMWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAILAFPMTFFAHRGLTRFVLSGK
KPGEDITEVVEEHFGIGAGKLITLLYFFAIYPICLVYSVAITNTVESFITHQLGMSAPPRIILSLILILGLMTIVRFGEH
LIVKVMSILVYPFVAVLMLLALYLIPNWNSAIFDSAAIASSASGSGLWMTLWLAIPVMVFSFNHSPIISAFAVAKREEYG
DELAEKKCSKILSYAHIMMVLTVMFFVFSCVLSLSPADLAEAKAQNLSILSYLANHFNTPVIAFAAPIIAFVAITKSFLG
HYLGAREGFNGLVIKSLRGRGKSIEIGKLNKITALFMLITTWVVATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPA
MRKYSGHISNVFVVIMGLIAISAILYTLFG

Sequences:

>Translated_430_residues
MDTTQTGTIASTSGSKSAWRKSDTMWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAILAFPMTFFAHRGLTRFVLSGK
KPGEDITEVVEEHFGIGAGKLITLLYFFAIYPICLVYSVAITNTVESFITHQLGMSAPPRIILSLILILGLMTIVRFGEH
LIVKVMSILVYPFVAVLMLLALYLIPNWNSAIFDSAAIASSASGSGLWMTLWLAIPVMVFSFNHSPIISAFAVAKREEYG
DELAEKKCSKILSYAHIMMVLTVMFFVFSCVLSLSPADLAEAKAQNLSILSYLANHFNTPVIAFAAPIIAFVAITKSFLG
HYLGAREGFNGLVIKSLRGRGKSIEIGKLNKITALFMLITTWVVATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPA
MRKYSGHISNVFVVIMGLIAISAILYTLFG
>Mature_430_residues
MDTTQTGTIASTSGSKSAWRKSDTMWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAILAFPMTFFAHRGLTRFVLSGK
KPGEDITEVVEEHFGIGAGKLITLLYFFAIYPICLVYSVAITNTVESFITHQLGMSAPPRIILSLILILGLMTIVRFGEH
LIVKVMSILVYPFVAVLMLLALYLIPNWNSAIFDSAAIASSASGSGLWMTLWLAIPVMVFSFNHSPIISAFAVAKREEYG
DELAEKKCSKILSYAHIMMVLTVMFFVFSCVLSLSPADLAEAKAQNLSILSYLANHFNTPVIAFAAPIIAFVAITKSFLG
HYLGAREGFNGLVIKSLRGRGKSIEIGKLNKITALFMLITTWVVATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPA
MRKYSGHISNVFVVIMGLIAISAILYTLFG

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=430, Percent_Identity=85.5813953488372, Blast_Score=727, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=442, Percent_Identity=52.262443438914, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=36.9829683698297, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI145693183, Length=421, Percent_Identity=26.3657957244656, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789961, Length=404, Percent_Identity=25.4950495049505, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46613; Mature: 46613

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTQTGTIASTSGSKSAWRKSDTMWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAIL
CCCCCCCCEECCCCCCHHHHCCCCEEHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
AFPMTFFAHRGLTRFVLSGKKPGEDITEVVEEHFGIGAGKLITLLYFFAIYPICLVYSVA
HHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ITNTVESFITHQLGMSAPPRIILSLILILGLMTIVRFGEHLIVKVMSILVYPFVAVLMLL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALYLIPNWNSAIFDSAAIASSASGSGLWMTLWLAIPVMVFSFNHSPIISAFAVAKREEYG
HHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DELAEKKCSKILSYAHIMMVLTVMFFVFSCVLSLSPADLAEAKAQNLSILSYLANHFNTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
VIAFAAPIIAFVAITKSFLGHYLGAREGFNGLVIKSLRGRGKSIEIGKLNKITALFMLIT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
TWVVATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPAMRKYSGHISNVFVVIMGLIA
HHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHH
ISAILYTLFG
HHHHHHHHCC
>Mature Secondary Structure
MDTTQTGTIASTSGSKSAWRKSDTMWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAIL
CCCCCCCCEECCCCCCHHHHCCCCEEHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
AFPMTFFAHRGLTRFVLSGKKPGEDITEVVEEHFGIGAGKLITLLYFFAIYPICLVYSVA
HHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ITNTVESFITHQLGMSAPPRIILSLILILGLMTIVRFGEHLIVKVMSILVYPFVAVLMLL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALYLIPNWNSAIFDSAAIASSASGSGLWMTLWLAIPVMVFSFNHSPIISAFAVAKREEYG
HHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DELAEKKCSKILSYAHIMMVLTVMFFVFSCVLSLSPADLAEAKAQNLSILSYLANHFNTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
VIAFAAPIIAFVAITKSFLGHYLGAREGFNGLVIKSLRGRGKSIEIGKLNKITALFMLIT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
TWVVATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPAMRKYSGHISNVFVVIMGLIA
HHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHH
ISAILYTLFG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]