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The map label for this gene is deoR [H]

Identifier: 238920429

GI number: 238920429

Start: 2438671

End: 2439435

Strand: Direct

Name: deoR [H]

Synonym: NT01EI_2540

Alternate gene names: 238920429

Gene position: 2438671-2439435 (Clockwise)

Preceding gene: 238920428

Following gene: 238920430

Centisome position: 63.97

GC content: 55.16

Gene sequence:

>765_bases
ATGGAAGCCCGGCGTTACGATCGTATCAACCGCCTGTCCCAGGCACTGAAACGTACCGATAAGCTGCACCTGAAAGATGC
GGCCGAATTGCTTAATGTCTCTGAAATGACGGTACGCCGCGACCTGGCAGCCCAGAACGGCGACGTGGTATTACTGGGGG
GCTACGTCGTGCTCGATCCCAAAATCCACCAGAGCGTGCGCTACTTTGTCAGCGATCAGCAGGAGCGGCGGGTCAAAGAG
AAACGCCATATCGGAGCCCTGGCCGCCCAACAGGTACAGGAAGATGACGTGGTATTTTTTGACTGCGGCACTACGGTTCC
CTTTATCATTGATGCTATTGATGAACAGAGGCATTTTACCGGCATCTGCTATTCGCTCAATACCTTCATGGCCCTTCAGA
GCAAGCCCCACTGCCGGGTGATCCTGTGCGGCGGTATTTTTAACCCGGACAGTGCCATTTTTGCCACCAGTGATGGGATC
AGCGAACTGGACAACCTGTGTCCAACCCTGGCCTTTATCTCTGCGGCAGGCATCTCGGTACAGCAGGGAGCCACCTGTTA
CAACCTGGACGAAATCGCGATCAAGCGTAAAGCAATGCTGCGTGCCAACCGCACGCTACTGATTGCCGACGCCAGCAAGT
TTGGCGAAGTCCGCAGTGCCTGGATAGCGCCGCTGGAAAACTTCAGTACGCTGATCGCCGATCAGGCGCCACACGGCGAG
CTGAAAGCATACCTTAACGCCCATAAGGTTCAGTTACTGTACTGA

Upstream 100 bases:

>100_bases
GCATCGCCAGGGTGGCAGATTACCCTGTGCTGCAAATTTTTACGGCCAGCGACGATGAGCTACTGCACGCCATTCACAGA
ATCATTTAACGAGAGAGATT

Downstream 100 bases:

>100_bases
GGCCTATTCCGCCGTCGTGCGCGACGGCATCCCCCTCTTCAGCATCGGTTCGTGGGGTTTACGTCTATTTTTTTCCAGCA
CCGCCTCTCCCCATAATCGA

Product: transcriptional regulator, DeoR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MEARRYDRINRLSQALKRTDKLHLKDAAELLNVSEMTVRRDLAAQNGDVVLLGGYVVLDPKIHQSVRYFVSDQQERRVKE
KRHIGALAAQQVQEDDVVFFDCGTTVPFIIDAIDEQRHFTGICYSLNTFMALQSKPHCRVILCGGIFNPDSAIFATSDGI
SELDNLCPTLAFISAAGISVQQGATCYNLDEIAIKRKAMLRANRTLLIADASKFGEVRSAWIAPLENFSTLIADQAPHGE
LKAYLNAHKVQLLY

Sequences:

>Translated_254_residues
MEARRYDRINRLSQALKRTDKLHLKDAAELLNVSEMTVRRDLAAQNGDVVLLGGYVVLDPKIHQSVRYFVSDQQERRVKE
KRHIGALAAQQVQEDDVVFFDCGTTVPFIIDAIDEQRHFTGICYSLNTFMALQSKPHCRVILCGGIFNPDSAIFATSDGI
SELDNLCPTLAFISAAGISVQQGATCYNLDEIAIKRKAMLRANRTLLIADASKFGEVRSAWIAPLENFSTLIADQAPHGE
LKAYLNAHKVQLLY
>Mature_254_residues
MEARRYDRINRLSQALKRTDKLHLKDAAELLNVSEMTVRRDLAAQNGDVVLLGGYVVLDPKIHQSVRYFVSDQQERRVKE
KRHIGALAAQQVQEDDVVFFDCGTTVPFIIDAIDEQRHFTGICYSLNTFMALQSKPHCRVILCGGIFNPDSAIFATSDGI
SELDNLCPTLAFISAAGISVQQGATCYNLDEIAIKRKAMLRANRTLLIADASKFGEVRSAWIAPLENFSTLIADQAPHGE
LKAYLNAHKVQLLY

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=254, Percent_Identity=51.9685039370079, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1790753, Length=238, Percent_Identity=27.3109243697479, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI226510968, Length=207, Percent_Identity=29.951690821256, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789519, Length=233, Percent_Identity=24.0343347639485, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789829, Length=257, Percent_Identity=25.6809338521401, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789059, Length=229, Percent_Identity=27.0742358078603, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787540, Length=223, Percent_Identity=26.0089686098655, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28339; Mature: 28339

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEARRYDRINRLSQALKRTDKLHLKDAAELLNVSEMTVRRDLAAQNGDVVLLGGYVVLDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECC
KIHQSVRYFVSDQQERRVKEKRHIGALAAQQVQEDDVVFFDCGTTVPFIIDAIDEQRHFT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHH
GICYSLNTFMALQSKPHCRVILCGGIFNPDSAIFATSDGISELDNLCPTLAFISAAGISV
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEE
QQGATCYNLDEIAIKRKAMLRANRTLLIADASKFGEVRSAWIAPLENFSTLIADQAPHGE
CCCCCEECHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LKAYLNAHKVQLLY
HHHHHCCCEEEEEC
>Mature Secondary Structure
MEARRYDRINRLSQALKRTDKLHLKDAAELLNVSEMTVRRDLAAQNGDVVLLGGYVVLDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECC
KIHQSVRYFVSDQQERRVKEKRHIGALAAQQVQEDDVVFFDCGTTVPFIIDAIDEQRHFT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHH
GICYSLNTFMALQSKPHCRVILCGGIFNPDSAIFATSDGISELDNLCPTLAFISAAGISV
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEE
QQGATCYNLDEIAIKRKAMLRANRTLLIADASKFGEVRSAWIAPLENFSTLIADQAPHGE
CCCCCEECHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LKAYLNAHKVQLLY
HHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]