Click here to switch to the map view.

The map label for this gene is serS

Identifier: 238920371

GI number: 238920371

Start: 2372101

End: 2373393

Strand: Reverse

Name: serS

Synonym: NT01EI_2481

Alternate gene names: 238920371

Gene position: 2373393-2372101 (Counterclockwise)

Preceding gene: 238920372

Following gene: 238920368

Centisome position: 62.26

GC content: 58.39

Gene sequence:

>1293_bases
ATGCTAGATCCCAATTTGCTGCGTAATGAGCTAGACGCAGTCGCCGAAAAACTGGCTCGCCGAGGCTATAAACTGGATGT
TGACACACTGCGTCAACAGGAAGAACGCCGTAAAGTGCTGCAGGTAGAAACGGAGTCCCTGCAGGCTGAGCGTAACTCGC
GATCCAAATCGATCGGTGCGGCGAAAGCGCGCGGTGAGGATATTGAACCGTTGCGCCGTGAAGTCAACGAATTGGGTGAA
AAGCTGGATGCCGCCAAGGCCGAGCTGGATCGGCTGCAGCAGGAAATCCGCGATCTGGCGCTCTCTATCCCCAACCTGCC
GGATGACTCCGTGCCGGTCGGTCGTGATGAGAACGATAACCAGGAGATCTGCCGCTGGGGTGAGCCGCGCAGCTACAATT
TTGATGTCCGTGATCACGTCACTCTGGGTGAAATGGCCGAGGGCCTGGATTTCGCCGCGGCCGTGAAGTTGACCGGTGCC
CGCTTTGTGGTAATGAAAGGTCAGATCGCCCGTATGCACCGTGCCTTGGCCCAGTTTATGCTGGATCTGCACACGGAGCA
GCATGGCTACCTGGAAACCTATGTGCCGTATCTGGTCAACCACGATACCCTGTACGGTACTGGTCAGCTGCCGAAGTTCG
GCGCGGATCTGTTCCACACCCGTCCGCTGGAAGAAGAGGCCGACAGCAGCATCTATGCGCTGATCCCGACCGCCGAAGTA
CCGGTAACCAACCTGGTGCGCGGTGAGATCCTGGAAGAGAGTGCGCTGCCGCTGAAGATGACCGCCCATACCCCGTGCTT
CCGCTCTGAGGCTGGCTCCTATGGTCGCGATACCCGCGGTCTGATCCGTATGCACCAGTTCGATAAGGTTGAGCTGGTAC
AGATCGTCCGTCCGGAGGACTCGATGGCGGCGCTGGAAGAGCTGACCGCGCACGCGGAGAAAGTGCTGCAGCTGCTGAAT
CTGCCGTACCGCAAGGTGCTGCTGTGCACCGGCGACATGGGCTTTGGCTCCAGCAAGACCTACGATCTGGAGGTCTGGGT
TCCGGCGCAGAACACCTATCGTGAAATTTCCTCCTGCTCCAATATGTGGGATTTCCAGGCGCGCCGTATGCAGGCCCGCT
ACCGCAGCAAAGATGACAAGAAGCCGCGCCTGGTGCATACCCTGAACGGCTCTGGTCTGGCGGTGGGGCGCACCCTGGTC
GCTGTGATGGAAAACTATCAGCAGGCTGATGGCCGCATTCAGGTACCTGAAGCGCTGCGCCCATATATGAACGGTTTAGA
ATATATCGGTTAA

Upstream 100 bases:

>100_bases
TGTGAAGAAATCCGCTTTGCATTGAGCGCACTGCCGCAGATGTGGCTATCGCCTTGATGTATTGTTTATTAAAAACCCCT
CAATAATTCACAGGATTAGC

Downstream 100 bases:

>100_bases
TCCGTTAACCTCTTATTCTCTGCCAGTAAACCCCGCATAGCGGCTGAGGGATCCCCATAAATCAGTGCTAATAAACCAGC
ACCATATTTTGGTAGGTTCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLDPNLLRNELDAVAEKLARRGYKLDVDTLRQQEERRKVLQVETESLQAERNSRSKSIGAAKARGEDIEPLRREVNELGE
KLDAAKAELDRLQQEIRDLALSIPNLPDDSVPVGRDENDNQEICRWGEPRSYNFDVRDHVTLGEMAEGLDFAAAVKLTGA
RFVVMKGQIARMHRALAQFMLDLHTEQHGYLETYVPYLVNHDTLYGTGQLPKFGADLFHTRPLEEEADSSIYALIPTAEV
PVTNLVRGEILEESALPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQIVRPEDSMAALEELTAHAEKVLQLLN
LPYRKVLLCTGDMGFGSSKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARYRSKDDKKPRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIQVPEALRPYMNGLEYIG

Sequences:

>Translated_430_residues
MLDPNLLRNELDAVAEKLARRGYKLDVDTLRQQEERRKVLQVETESLQAERNSRSKSIGAAKARGEDIEPLRREVNELGE
KLDAAKAELDRLQQEIRDLALSIPNLPDDSVPVGRDENDNQEICRWGEPRSYNFDVRDHVTLGEMAEGLDFAAAVKLTGA
RFVVMKGQIARMHRALAQFMLDLHTEQHGYLETYVPYLVNHDTLYGTGQLPKFGADLFHTRPLEEEADSSIYALIPTAEV
PVTNLVRGEILEESALPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQIVRPEDSMAALEELTAHAEKVLQLLN
LPYRKVLLCTGDMGFGSSKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARYRSKDDKKPRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIQVPEALRPYMNGLEYIG
>Mature_430_residues
MLDPNLLRNELDAVAEKLARRGYKLDVDTLRQQEERRKVLQVETESLQAERNSRSKSIGAAKARGEDIEPLRREVNELGE
KLDAAKAELDRLQQEIRDLALSIPNLPDDSVPVGRDENDNQEICRWGEPRSYNFDVRDHVTLGEMAEGLDFAAAVKLTGA
RFVVMKGQIARMHRALAQFMLDLHTEQHGYLETYVPYLVNHDTLYGTGQLPKFGADLFHTRPLEEEADSSIYALIPTAEV
PVTNLVRGEILEESALPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQIVRPEDSMAALEELTAHAEKVLQLLN
LPYRKVLLCTGDMGFGSSKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARYRSKDDKKPRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIQVPEALRPYMNGLEYIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=375, Percent_Identity=34.4, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI8923421, Length=412, Percent_Identity=27.1844660194175, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI225579074, Length=353, Percent_Identity=28.328611898017, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=86.2790697674419, Blast_Score=778, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=334, Percent_Identity=33.5329341317365, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=336, Percent_Identity=29.4642857142857, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=408, Percent_Identity=32.1078431372549, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=388, Percent_Identity=31.4432989690722, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=373, Percent_Identity=33.2439678284182, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737985, Length=371, Percent_Identity=30.4582210242588, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_EDWI9 (C5BE90)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933886.1
- GeneID:   7958819
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2481
- OMA:   ENGYTEV
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48728; Mature: 48728

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 291-291 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPNLLRNELDAVAEKLARRGYKLDVDTLRQQEERRKVLQVETESLQAERNSRSKSIGA
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AKARGEDIEPLRREVNELGEKLDAAKAELDRLQQEIRDLALSIPNLPDDSVPVGRDENDN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QEICRWGEPRSYNFDVRDHVTLGEMAEGLDFAAAVKLTGARFVVMKGQIARMHRALAQFM
HHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYLETYVPYLVNHDTLYGTGQLPKFGADLFHTRPLEEEADSSIYALIPTAEV
HHHHCCCCCHHHHHHHHHHCCCCEECCCCCCCCCHHHHCCCCCCHHHCCCEEEEECCCCC
PVTNLVRGEILEESALPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQIVRPED
CHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHCCCEEEHEEECCCH
SMAALEELTAHAEKVLQLLNLPYRKVLLCTGDMGFGSSKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHH
NMWDFQARRMQARYRSKDDKKPRLVHTLNGSGLAVGRTLVAVMENYQQADGRIQVPEALR
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECHHHHH
PYMNGLEYIG
HHHHHHHCCC
>Mature Secondary Structure
MLDPNLLRNELDAVAEKLARRGYKLDVDTLRQQEERRKVLQVETESLQAERNSRSKSIGA
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AKARGEDIEPLRREVNELGEKLDAAKAELDRLQQEIRDLALSIPNLPDDSVPVGRDENDN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QEICRWGEPRSYNFDVRDHVTLGEMAEGLDFAAAVKLTGARFVVMKGQIARMHRALAQFM
HHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYLETYVPYLVNHDTLYGTGQLPKFGADLFHTRPLEEEADSSIYALIPTAEV
HHHHCCCCCHHHHHHHHHHCCCCEECCCCCCCCCHHHHCCCCCCHHHCCCEEEEECCCCC
PVTNLVRGEILEESALPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQIVRPED
CHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHCCCEEEHEEECCCH
SMAALEELTAHAEKVLQLLNLPYRKVLLCTGDMGFGSSKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHH
NMWDFQARRMQARYRSKDDKKPRLVHTLNGSGLAVGRTLVAVMENYQQADGRIQVPEALR
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECHHHHH
PYMNGLEYIG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA