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The map label for this gene is uvrY [H]

Identifier: 238920173

GI number: 238920173

Start: 2186752

End: 2187408

Strand: Reverse

Name: uvrY [H]

Synonym: NT01EI_2282

Alternate gene names: 238920173

Gene position: 2187408-2186752 (Counterclockwise)

Preceding gene: 238920176

Following gene: 238920172

Centisome position: 57.38

GC content: 52.82

Gene sequence:

>657_bases
TTGATCAGCGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATCCGACGCATTCTTGAAGATATCAAAGGGAT
TAAAGTGGTAGGCGAGGCGCAGTGCGGCGAAGATGCAGTGAAGTGGTGCCGTAATAACTGTGCAGATATCATATTGATGG
ACATGAACATGCCGGGCATCGGCGGGCTGGAGGCTACACGTAAGATCCTGCGGGTAAAATCGGATATAAAAGTCATCATG
CTGACCATTCATACGGAAAATCCGCTGCCGGCGAAGGTGATGCAGGCCGGTGCGTTCGGCTATCTGAGCAAAGGGGCTGC
GCCACAGGAGATGATCAGCGCGATCCGGGCGGTATACGCCGGTCAGCGCTATATCGCTTCTGATATTGCTCAGCAGATGG
CGCTGAGCCAGCTGACGCCGCAGGGAGATTCCCCGTTTGGATCTCTGTCCGAGCGCGAGTTGCAAATTATGCTGATGATC
ACTAAAGGCAGCAAGGTGACAGAGATTTCTGAGCAGCTGAATCTGAGTCCAAAAACAGTAAACAGCTATCGTTACCGCAT
GTTCAGCAAGCTGAACATCAGCGGGGATGTCGAGTTAACCCACCTGGCTATCCGTCACGGGCTGTGCAACGCAGAGAAAA
TCTTGAGCAGTGAGTGA

Upstream 100 bases:

>100_bases
AATAACATTTACACTATTCATTCTTTTGGCGAAAAACAGTAGACTTAGTCTGTTTAGTATAAAAGTATGCTGTTGTTTCC
TCTAGCTGGGAGATTCATCT

Downstream 100 bases:

>100_bases
GCGCTTTGATGCGGTCGCCTTTCTAAAGACGGTGACCAACCAACCGGGTGTATACCGGATGTACGATGCCGGGGCAGAGG
TTATTTATGTCGGCAAGGCG

Product: response regulator UvrY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRNNCADIILMDMNMPGIGGLEATRKILRVKSDIKVIM
LTIHTENPLPAKVMQAGAFGYLSKGAAPQEMISAIRAVYAGQRYIASDIAQQMALSQLTPQGDSPFGSLSERELQIMLMI
TKGSKVTEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLCNAEKILSSE

Sequences:

>Translated_218_residues
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRNNCADIILMDMNMPGIGGLEATRKILRVKSDIKVIM
LTIHTENPLPAKVMQAGAFGYLSKGAAPQEMISAIRAVYAGQRYIASDIAQQMALSQLTPQGDSPFGSLSERELQIMLMI
TKGSKVTEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLCNAEKILSSE
>Mature_218_residues
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRNNCADIILMDMNMPGIGGLEATRKILRVKSDIKVIM
LTIHTENPLPAKVMQAGAFGYLSKGAAPQEMISAIRAVYAGQRYIASDIAQQMALSQLTPQGDSPFGSLSERELQIMLMI
TKGSKVTEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLCNAEKILSSE

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=84.7926267281106, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=35, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=31.7073170731707, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=26.865671641791, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788546, Length=215, Percent_Identity=26.5116279069767, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=27.1844660194175, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787473, Length=188, Percent_Identity=31.9148936170213, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23988; Mature: 23988

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRNNCADIILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCC
GGLEATRKILRVKSDIKVIMLTIHTENPLPAKVMQAGAFGYLSKGAAPQEMISAIRAVYA
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
GQRYIASDIAQQMALSQLTPQGDSPFGSLSERELQIMLMITKGSKVTEISEQLNLSPKTV
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCHH
NSYRYRMFSKLNISGDVELTHLAIRHGLCNAEKILSSE
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRNNCADIILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCC
GGLEATRKILRVKSDIKVIMLTIHTENPLPAKVMQAGAFGYLSKGAAPQEMISAIRAVYA
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
GQRYIASDIAQQMALSQLTPQGDSPFGSLSERELQIMLMITKGSKVTEISEQLNLSPKTV
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCHH
NSYRYRMFSKLNISGDVELTHLAIRHGLCNAEKILSSE
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]