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The map label for this gene is uvrC

Identifier: 238920172

GI number: 238920172

Start: 2184927

End: 2186759

Strand: Reverse

Name: uvrC

Synonym: NT01EI_2281

Alternate gene names: 238920172

Gene position: 2186759-2184927 (Counterclockwise)

Preceding gene: 238920173

Following gene: 238920171

Centisome position: 57.36

GC content: 58.97

Gene sequence:

>1833_bases
GTGAGTGAGCGCTTTGATGCGGTCGCCTTTCTAAAGACGGTGACCAACCAACCGGGTGTATACCGGATGTACGATGCCGG
GGCAGAGGTTATTTATGTCGGCAAGGCGAAAGATCTCAAAAAACGCCTCTCCAGCTACTTCCGCTGCCAGCTTGCCAGTC
GCAAAACCGAAGCTCTTGTACGTCAGATAGCCCAGATCGACGTGACCGTGACCCACACGGAAACAGAGGCGCTGCTGCTG
GAGCACAATTACATCAAGCGTTACCAACCCCGCTATAACGTGCTGCTGCGTGACGACAAATCCTACCCTCTGATCTTTCT
CAGCGCCGATCGCCACCCGCGTTTGGCGGTACACCGCGGCGCTAGGCGCGCCCGTGGTGACTATTTTGGCCCCTTTCCCA
ACGCGAACGCGGTGCGTGAGACGCTGGCCCTGCTGCAGAAGCTATTCCCCATTCGCCAGTGTGAAGACAGCGTCTACCGC
AATCGTTCACGTCCCTGCCTGCAATACCAGATCCAGCGCTGTCTGGGGCCCTGCGTCACCGGGCTGGTCAACGATGGGGA
GTATGCCCGTCAGGTGGAGTATGTGCGGCTGTTCCTCTCCGGGAAGGACAGCCAGGTGATCGACGCGCTGGTGGCCAGAA
TGGAGGAGGCCAGCCGGGCGCTGCGCTTTGAGGAGGCCGCGCGGCTGCGCGATCAGATCCAGGCGGTGCGGAGGGTGACC
GAGCGCCAGTTTATCTCCGGCGATCACGAGGATATCGACGTGATCGGCGTCGCCTTTGAGGCGGGGATGGCCTGTATCCA
TGTGCTGTTTATTCGTCATGGGCAGGTGCTGGGCAGCCGTAGCTACTTTCCACGGGTTCCCGCCGGTACGACGCTGGCTG
AGGTACTGCAGACCTTTGTCGGCCAGTTTTACCTGCAGGGCAGCCAGATACGTACGCTGCCGGGGGAGATCCTGATCGAC
TTTCTCCTGCCGGATCGCAAGCTGCTGGCGGACTCTATCAGCGAACTGGCCGGGCGGAGGATCCCTATTCAGTCACAGCC
GCGCGGCGATCGTGCCCGTTACCTTAAGCTGGCGCGTACCAACGCAGTAACGGCCCTGAACAGCAAGCTCTCCCAGCAGT
CGACCATTCTGCAGCGTCTGGTGCAGCTGGAGCAGGTGCTGCAACGGGCGGATATTCAACGCATGGAGTGTTTTGATATC
AGTCATACCATGGGGGAGGAGACAGTGGCCTCCTGCGTGGTATTCGATCGCAATGGACCGCTGCGCAGTGAATACCGGCG
CTATAATATCAAGGGTATCACCCCGGGAGATGACTATGCCGCCATGGACCAGGTGCTGCGTCGTCGCTATGACAAGGCAC
TGAACGAAGAGAAGATCCCCGACATTATTTTTATCGACGGCGGCAAGGGGCAGCTGGGGCAGGCTAAGCAGGTGTTTGCT
GAACTGGAGGTGCCTTGGGATACACATCGCCCGCTGCTGCTGGGAATTGCCAAAGGGAGCGATCGCAAGGCGGGGTTGGA
GACGCTGTTCTTTGAGGCGCAGGGGGAGGGATTCTCCCTGCCGCCAGACTCACCGGCGCTACATTTGATCCAGCATATCC
GCGATGAGTCGCACAACCATGCGATCGCCGGCCATCGGAAGAGAAGGGCTAAGGTACGCAGCACCAGCGCGCTTGAGTCT
ATTGAAGGCATTGGGCCCAAGCGGCGCCAGTTGCTGCTCAAATATATGGGCGGAATGCAACCGCTGCGCGATGCCAGTAT
TGATGAGATTGCAAAAGTGCCCGGTATTTCAGCCGCATTGGCGGAAAAGATCCACTATGCATTGAAACAATGA

Upstream 100 bases:

>100_bases
CGTTACCGCATGTTCAGCAAGCTGAACATCAGCGGGGATGTCGAGTTAACCCACCTGGCTATCCGTCACGGGCTGTGCAA
CGCAGAGAAAATCTTGAGCA

Downstream 100 bases:

>100_bases
GGGCGTTGTAGCAACATAAACGCAGTATCCACGAAAGGAAGATCGTCACAGTACTATGCGATTAAATATCCCCACGTTAT
TAACGCTGTTTCGCGTTATA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSERFDAVAFLKTVTNQPGVYRMYDAGAEVIYVGKAKDLKKRLSSYFRCQLASRKTEALVRQIAQIDVTVTHTETEALLL
EHNYIKRYQPRYNVLLRDDKSYPLIFLSADRHPRLAVHRGARRARGDYFGPFPNANAVRETLALLQKLFPIRQCEDSVYR
NRSRPCLQYQIQRCLGPCVTGLVNDGEYARQVEYVRLFLSGKDSQVIDALVARMEEASRALRFEEAARLRDQIQAVRRVT
ERQFISGDHEDIDVIGVAFEAGMACIHVLFIRHGQVLGSRSYFPRVPAGTTLAEVLQTFVGQFYLQGSQIRTLPGEILID
FLLPDRKLLADSISELAGRRIPIQSQPRGDRARYLKLARTNAVTALNSKLSQQSTILQRLVQLEQVLQRADIQRMECFDI
SHTMGEETVASCVVFDRNGPLRSEYRRYNIKGITPGDDYAAMDQVLRRRYDKALNEEKIPDIIFIDGGKGQLGQAKQVFA
ELEVPWDTHRPLLLGIAKGSDRKAGLETLFFEAQGEGFSLPPDSPALHLIQHIRDESHNHAIAGHRKRRAKVRSTSALES
IEGIGPKRRQLLLKYMGGMQPLRDASIDEIAKVPGISAALAEKIHYALKQ

Sequences:

>Translated_610_residues
MSERFDAVAFLKTVTNQPGVYRMYDAGAEVIYVGKAKDLKKRLSSYFRCQLASRKTEALVRQIAQIDVTVTHTETEALLL
EHNYIKRYQPRYNVLLRDDKSYPLIFLSADRHPRLAVHRGARRARGDYFGPFPNANAVRETLALLQKLFPIRQCEDSVYR
NRSRPCLQYQIQRCLGPCVTGLVNDGEYARQVEYVRLFLSGKDSQVIDALVARMEEASRALRFEEAARLRDQIQAVRRVT
ERQFISGDHEDIDVIGVAFEAGMACIHVLFIRHGQVLGSRSYFPRVPAGTTLAEVLQTFVGQFYLQGSQIRTLPGEILID
FLLPDRKLLADSISELAGRRIPIQSQPRGDRARYLKLARTNAVTALNSKLSQQSTILQRLVQLEQVLQRADIQRMECFDI
SHTMGEETVASCVVFDRNGPLRSEYRRYNIKGITPGDDYAAMDQVLRRRYDKALNEEKIPDIIFIDGGKGQLGQAKQVFA
ELEVPWDTHRPLLLGIAKGSDRKAGLETLFFEAQGEGFSLPPDSPALHLIQHIRDESHNHAIAGHRKRRAKVRSTSALES
IEGIGPKRRQLLLKYMGGMQPLRDASIDEIAKVPGISAALAEKIHYALKQ
>Mature_609_residues
SERFDAVAFLKTVTNQPGVYRMYDAGAEVIYVGKAKDLKKRLSSYFRCQLASRKTEALVRQIAQIDVTVTHTETEALLLE
HNYIKRYQPRYNVLLRDDKSYPLIFLSADRHPRLAVHRGARRARGDYFGPFPNANAVRETLALLQKLFPIRQCEDSVYRN
RSRPCLQYQIQRCLGPCVTGLVNDGEYARQVEYVRLFLSGKDSQVIDALVARMEEASRALRFEEAARLRDQIQAVRRVTE
RQFISGDHEDIDVIGVAFEAGMACIHVLFIRHGQVLGSRSYFPRVPAGTTLAEVLQTFVGQFYLQGSQIRTLPGEILIDF
LLPDRKLLADSISELAGRRIPIQSQPRGDRARYLKLARTNAVTALNSKLSQQSTILQRLVQLEQVLQRADIQRMECFDIS
HTMGEETVASCVVFDRNGPLRSEYRRYNIKGITPGDDYAAMDQVLRRRYDKALNEEKIPDIIFIDGGKGQLGQAKQVFAE
LEVPWDTHRPLLLGIAKGSDRKAGLETLFFEAQGEGFSLPPDSPALHLIQHIRDESHNHAIAGHRKRRAKVRSTSALESI
EGIGPKRRQLLLKYMGGMQPLRDASIDEIAKVPGISAALAEKIHYALKQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=79.1803278688525, Blast_Score=1028, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_EDWI9 (C5BH21)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933687.1
- ProteinModelPortal:   C5BH21
- GeneID:   7960859
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2281
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69067; Mature: 68936

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERFDAVAFLKTVTNQPGVYRMYDAGAEVIYVGKAKDLKKRLSSYFRCQLASRKTEALV
CCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
RQIAQIDVTVTHTETEALLLEHNYIKRYQPRYNVLLRDDKSYPLIFLSADRHPRLAVHRG
HHHHHHCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCHHHHHC
ARRARGDYFGPFPNANAVRETLALLQKLFPIRQCEDSVYRNRSRPCLQYQIQRCLGPCVT
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GLVNDGEYARQVEYVRLFLSGKDSQVIDALVARMEEASRALRFEEAARLRDQIQAVRRVT
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERQFISGDHEDIDVIGVAFEAGMACIHVLFIRHGQVLGSRSYFPRVPAGTTLAEVLQTFV
HHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCHHHHHHHHHH
GQFYLQGSQIRTLPGEILIDFLLPDRKLLADSISELAGRRIPIQSQPRGDRARYLKLART
HHHHCCCCCEECCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
NAVTALNSKLSQQSTILQRLVQLEQVLQRADIQRMECFDISHTMGEETVASCVVFDRNGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHEEEECCCCC
LRSEYRRYNIKGITPGDDYAAMDQVLRRRYDKALNEEKIPDIIFIDGGKGQLGQAKQVFA
CHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHH
ELEVPWDTHRPLLLGIAKGSDRKAGLETLFFEAQGEGFSLPPDSPALHLIQHIRDESHNH
HHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCC
AIAGHRKRRAKVRSTSALESIEGIGPKRRQLLLKYMGGMQPLRDASIDEIAKVPGISAAL
CHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHH
AEKIHYALKQ
HHHHHHHHCC
>Mature Secondary Structure 
SERFDAVAFLKTVTNQPGVYRMYDAGAEVIYVGKAKDLKKRLSSYFRCQLASRKTEALV
CCHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
RQIAQIDVTVTHTETEALLLEHNYIKRYQPRYNVLLRDDKSYPLIFLSADRHPRLAVHRG
HHHHHHCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCHHHHHC
ARRARGDYFGPFPNANAVRETLALLQKLFPIRQCEDSVYRNRSRPCLQYQIQRCLGPCVT
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GLVNDGEYARQVEYVRLFLSGKDSQVIDALVARMEEASRALRFEEAARLRDQIQAVRRVT
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERQFISGDHEDIDVIGVAFEAGMACIHVLFIRHGQVLGSRSYFPRVPAGTTLAEVLQTFV
HHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCHHHHHHHHHH
GQFYLQGSQIRTLPGEILIDFLLPDRKLLADSISELAGRRIPIQSQPRGDRARYLKLART
HHHHCCCCCEECCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
NAVTALNSKLSQQSTILQRLVQLEQVLQRADIQRMECFDISHTMGEETVASCVVFDRNGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHEEEECCCCC
LRSEYRRYNIKGITPGDDYAAMDQVLRRRYDKALNEEKIPDIIFIDGGKGQLGQAKQVFA
CHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHH
ELEVPWDTHRPLLLGIAKGSDRKAGLETLFFEAQGEGFSLPPDSPALHLIQHIRDESHNH
HHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCC
AIAGHRKRRAKVRSTSALESIEGIGPKRRQLLLKYMGGMQPLRDASIDEIAKVPGISAAL
CHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHH
AEKIHYALKQ
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA