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The map label for this gene is putP [H]

Identifier: 238920019

GI number: 238920019

Start: 2045297

End: 2046094

Strand: Reverse

Name: putP [H]

Synonym: NT01EI_2123

Alternate gene names: 238920019

Gene position: 2046094-2045297 (Counterclockwise)

Preceding gene: 238920021

Following gene: 238920018

Centisome position: 53.67

GC content: 61.03

Gene sequence:

>798_bases
ATGAGCACGCCCATGTTGGTGACATTCTGTATCTATATCCTGGGGATGATCCTGATCGGCTTCCTCGCCTGGCGATCGAC
GAACAACTTCGATGATTATATTCTCGGCGGGCGCCGGCTCGGCCCCTTCGTCACCGCACTGTCGGTCGGGGCATCGGGCA
TGAGCGGCTGGCTGCTGATGGGCCTGCCCGGCGCGGTATTCATCGCCGGTATCTCGGAGAGCTGGATCGTCATCGGTCTG
ACGCTGGGCGCCTGGCTGAACTGGCGGCTGGTGGCGGGGCGACTGCGGGTACACACGGAGGCGAACAATAACGCGCTGAC
CCTGCCGGACTATTTTACCGCCCGTTTCGCCGATGGCAGCCGTCTATTACGCATTATCTCTGCCCTGGTGATCCTGCTGT
TTTTCACCATCTATTGCGCTTCCGGGATCGTGGCCGGCGCCCGCCTGTTTGAGAGCACCTTCGGCATGAGCTACCAGACG
GCGCTGTGGGCCGGGGCGGCGGCGACCATCATTTATACCTTTATCGGCGGTTTCCTGGCGGTCAGCTGGACCGACACAGT
GCAGGCGATACTGATGGTCTTCGCCCTGATCCTGACGCCGGTGATGGTGATAATCGCCGTCGGCGGCGTCGACGATGCGC
TGCTGGTGATCAGGCAGAAAAGCATTGAGAGACGTCGATATGCTGAAGGGGCTAAATCTGGTCGCTATCCTCTCGTTGCT
GGGCTGGGGGCTGGGGCTACTTTGGCCAGCCGCATATCCTGGCCCGTTTTATGGCGGCCGACTCGCACCATAGCCTGA

Upstream 100 bases:

>100_bases
TTGGCGGGGAACGGCTGGATGGGAACGTCCGCCGACGATGCCCCGATGGCGACTTCATGGCTGGCCCGGTGTGCCAGACG
AGACTTTCGGGAGAGTGGTA

Downstream 100 bases:

>100_bases
TTAATGCCCGGCGTATCAGCATGACCTGGACGGTCTTCTGTCTGCTCGGTGCCGTCTCCGTTGGTTTCTTCGGTATCGCC
TACTTTACCAACCATCCTGC

Product: sodium/proline symporter

Products: NA

Alternate protein names: Proline permease; Propionate transporter [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSTPMLVTFCIYILGMILIGFLAWRSTNNFDDYILGGRRLGPFVTALSVGASGMSGWLLMGLPGAVFIAGISESWIVIGL
TLGAWLNWRLVAGRLRVHTEANNNALTLPDYFTARFADGSRLLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYQT
ALWAGAAATIIYTFIGGFLAVSWTDTVQAILMVFALILTPVMVIIAVGGVDDALLVIRQKSIERRRYAEGAKSGRYPLVA
GLGAGATLASRISWPVLWRPTRTIA

Sequences:

>Translated_265_residues
MSTPMLVTFCIYILGMILIGFLAWRSTNNFDDYILGGRRLGPFVTALSVGASGMSGWLLMGLPGAVFIAGISESWIVIGL
TLGAWLNWRLVAGRLRVHTEANNNALTLPDYFTARFADGSRLLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYQT
ALWAGAAATIIYTFIGGFLAVSWTDTVQAILMVFALILTPVMVIIAVGGVDDALLVIRQKSIERRRYAEGAKSGRYPLVA
GLGAGATLASRISWPVLWRPTRTIA
>Mature_264_residues
STPMLVTFCIYILGMILIGFLAWRSTNNFDDYILGGRRLGPFVTALSVGASGMSGWLLMGLPGAVFIAGISESWIVIGLT
LGAWLNWRLVAGRLRVHTEANNNALTLPDYFTARFADGSRLLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYQTA
LWAGAAATIIYTFIGGFLAVSWTDTVQAILMVFALILTPVMVIIAVGGVDDALLVIRQKSIERRRYAEGAKSGRYPLVAG
LGAGATLASRISWPVLWRPTRTIA

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of propionate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=206, Percent_Identity=46.6019417475728, Blast_Score=200, Evalue=1e-51,
Organism=Escherichia coli, GI1787251, Length=230, Percent_Identity=84.7826086956522, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI87082237, Length=216, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790503, Length=204, Percent_Identity=26.9607843137255, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24645928, Length=179, Percent_Identity=30.7262569832402, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 28651; Mature: 28520

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPMLVTFCIYILGMILIGFLAWRSTNNFDDYILGGRRLGPFVTALSVGASGMSGWLLM
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
GLPGAVFIAGISESWIVIGLTLGAWLNWRLVAGRLRVHTEANNNALTLPDYFTARFADGS
CCCCEEEEEECCCCEEEEEEEHHHHHHHEEEECEEEEEEECCCCEEECCCHHHHHHCCHH
RLLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYQTALWAGAAATIIYTFIGGFLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHE
VSWTDTVQAILMVFALILTPVMVIIAVGGVDDALLVIRQKSIERRRYAEGAKSGRYPLVA
ECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
GLGAGATLASRISWPVLWRPTRTIA
ECCCCHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure 
STPMLVTFCIYILGMILIGFLAWRSTNNFDDYILGGRRLGPFVTALSVGASGMSGWLLM
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
GLPGAVFIAGISESWIVIGLTLGAWLNWRLVAGRLRVHTEANNNALTLPDYFTARFADGS
CCCCEEEEEECCCCEEEEEEEHHHHHHHEEEECEEEEEEECCCCEEECCCHHHHHHCCHH
RLLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYQTALWAGAAATIIYTFIGGFLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHE
VSWTDTVQAILMVFALILTPVMVIIAVGGVDDALLVIRQKSIERRRYAEGAKSGRYPLVA
ECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
GLGAGATLASRISWPVLWRPTRTIA
ECCCCHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3302614; 8905232; 9278503; 1400239; 3325781; 3053687; 3053649; 1567896; 8119910 [H]