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The map label for this gene is cusR [H]

Identifier: 238920016

GI number: 238920016

Start: 2042307

End: 2042990

Strand: Direct

Name: cusR [H]

Synonym: NT01EI_2120

Alternate gene names: 238920016

Gene position: 2042307-2042990 (Clockwise)

Preceding gene: 238920011

Following gene: 238920017

Centisome position: 53.57

GC content: 58.33

Gene sequence:

>684_bases
GTGAAAATACTGATCGTTGAAGATGAGGTAAAAACCGGGAAATATCTGTGTAAGGGATTGACAGAGGCGGGATTTGTCGC
CGATCTCACCGACAATGGTTTAACGGGATACCACCTGGCGATGACCGCCAGCTATGACCTGATCATCCTCGATATTCTGC
TGCCAGACGTCAATGGCTGGGATATCGTGCGCATGCTGCGCAACGCCAATCAGGGGATGCCGATCCTGCTGCTGAGCGCG
CTGGGCACCATCGAGCAGCGGGTAAAGGGGTTGGAACTCGGCGCCGACGATTACCTGGTCAAACCCTTCGCCTTCGCCGA
GCTCTTGGCGCGGGTGAGAACCCTGCTGCGACGCGGCAACACGCACATCCCCGAAAGTCAGTTGCACGTGGCCGATCTCA
GCCTGGATCTCCTCTCCAGAAAGGTGACCCGCAGCGGTAAGCGCATTACGCTGACGGGTAAGGAGTTCACCCTGCTGGAG
TTTTTCATCCGCCATCAGGGGGAAGTTCTGCCCCGCTCCCTGATCGCCTCGCAGGTCTGGGACATGAACTTCGACAGCGA
CACCAACGCCATCGACGTGGCCGTAAAGCGACTGCGGGCGAAGATCGACCTCGACTTCGAGCCTAAGCTGATCCAGACGG
TGCGCGGCGTCGGCTATCTGCTTGAGGCGCCGGATGAGTGTTAA

Upstream 100 bases:

>100_bases
GACAGGAAAATGACAAAGCTGTCATTTTCCTGCACATTGATTGATCTGGCCCGCAACCCATCTACAATGGCCGGGAGGTC
ATGAGATAACGGAGCTCAGG

Downstream 100 bases:

>100_bases
GCGCGTGCGACGCCCTATCTCCCTGGCAGCCCGCCTGACCCTGACCATCTCGCTGGCGACCAGCCTCGCCTTCGCCCTGT
TCACCTGGATCATGATCTAC

Product: DNA-binding transcriptional activator CusR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKILIVEDEVKTGKYLCKGLTEAGFVADLTDNGLTGYHLAMTASYDLIILDILLPDVNGWDIVRMLRNANQGMPILLLSA
LGTIEQRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNTHIPESQLHVADLSLDLLSRKVTRSGKRITLTGKEFTLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDLDFEPKLIQTVRGVGYLLEAPDEC

Sequences:

>Translated_227_residues
MKILIVEDEVKTGKYLCKGLTEAGFVADLTDNGLTGYHLAMTASYDLIILDILLPDVNGWDIVRMLRNANQGMPILLLSA
LGTIEQRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNTHIPESQLHVADLSLDLLSRKVTRSGKRITLTGKEFTLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDLDFEPKLIQTVRGVGYLLEAPDEC
>Mature_227_residues
MKILIVEDEVKTGKYLCKGLTEAGFVADLTDNGLTGYHLAMTASYDLIILDILLPDVNGWDIVRMLRNANQGMPILLLSA
LGTIEQRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNTHIPESQLHVADLSLDLLSRKVTRSGKRITLTGKEFTLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDLDFEPKLIQTVRGVGYLLEAPDEC

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=86.6666666666667, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=50.2283105022831, Blast_Score=223, Evalue=7e-60,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=35.8407079646018, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=35.4978354978355, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.6363636363636, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=33.6322869955157, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=34.5291479820628, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=35.4978354978355, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=34.051724137931, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.3636363636364, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=31.1965811965812, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.3185840707965, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25393; Mature: 25393

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEVKTGKYLCKGLTEAGFVADLTDNGLTGYHLAMTASYDLIILDILLPDVNGW
CEEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCH
DIVRMLRNANQGMPILLLSALGTIEQRVKGLELGADDYLVKPFAFAELLARVRTLLRRGN
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
THIPESQLHVADLSLDLLSRKVTRSGKRITLTGKEFTLLEFFIRHQGEVLPRSLIASQVW
CCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDLDFEPKLIQTVRGVGYLLEAPDEC
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHEECCCCCC
>Mature Secondary Structure
MKILIVEDEVKTGKYLCKGLTEAGFVADLTDNGLTGYHLAMTASYDLIILDILLPDVNGW
CEEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCH
DIVRMLRNANQGMPILLLSALGTIEQRVKGLELGADDYLVKPFAFAELLARVRTLLRRGN
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
THIPESQLHVADLSLDLLSRKVTRSGKRITLTGKEFTLLEFFIRHQGEVLPRSLIASQVW
CCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDLDFEPKLIQTVRGVGYLLEAPDEC
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]