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The map label for this gene is fhs [H]

Identifier: 238919980

GI number: 238919980

Start: 2005109

End: 2006839

Strand: Direct

Name: fhs [H]

Synonym: NT01EI_2084

Alternate gene names: 238919980

Gene position: 2005109-2006839 (Clockwise)

Preceding gene: 238919977

Following gene: 238919981

Centisome position: 52.6

GC content: 65.11

Gene sequence:

>1731_bases
ATGATATCCTGCTGCGAACCGATGCCCTCATCCCAGCCTGCCCTGCTGCCGATCGCCACCATTGCCGCCAAAATCGGCAT
CGCCACCGAAGCCCTGATCCCCTATGGCCACTATGCGGCCAAGGTGGATATGCGGCAGCTCACGCCCCGCCCCCCACGAG
GTAAACTGATCCTGGTCTCCAGCATCACCCCCACGCCGCTCGGCGAAGGGAAAACCGTCACGACCCTAGGCCTGAGCCAA
GGGCTGAACCATCTGGGGCACAGCGCTATCGCCTGTATCCGCCAGCCCAGCCTTGGCCCGGTGTTCGGCGTTAAGGGCGG
AGCCGCCGGCGGCGGTGCGTCGCAGGTGCTGCCGATGGAGCAGCTCAATCTGCATCTGACCGGCGATATCCACGCCATCA
GCGCCGCGCATAACCTGGCCGCGGCGGCGCTCGATGCCCGACTGTTCCACGAACAGCGCCTGGGCGATGCGTTCACTGCC
CAGAGCGGGCTGCAGCGCCTGGATATCGACCCCCTGCGCATCGTCTGGAAGCGGGTGATGGACCATAACGATCGGGCGCT
GCGCAGCATTGACGTTGGCGTCGGCGGTGGCAATAACGGCGTGCCGCGCCACGATGGCTTTGATATCAGCGCAGCCTCGG
AACTGATGGCCATTCTGGCGCTCTCCGACGGTCTGGCCGATATGCGTACGCGCATCGGCAAGGTGATCCTGGCCTATTCC
CTGCAAGGTGCGCCGATCACCGCGGAGGATCTGCAGGTGGCCGGTGCCATGACCGTCGTGATGAAAGCGGCGATCCACCC
GACCCTGATGCAGAGCAGCGAGCAGACGCCGGTGCTGATCCACGCGGGTCCCTTCGCCAATATCGCCCATGGCAACTCCT
CCGTGCTGGCCGATAGACTGGCCCTGCAACTGGCCGACTATGTGGTCACCGAAGCGGGCTTCGGCTCCGACATGGGAATG
GAGAAGTTCTTCAATATCAAATATCGCCAGTCGGGGATCGCCCCCTCCTGCGTGGTGCTGGTCGCCACGCTGCGCAGCCT
GAAAGCCAACAGCGGGCAGTTCAATATGAAGCCGGGACAGGCGCTGCCGGAAGAGGTGAAGCAGCCGAACGCCGATCTGC
TGCGCACCGGCTGTGAAAACCTGGGCTGGCATATCGCCAACGCCCGCCGCTATGGTCTGCCGGTGGTTATCGCCGTCAAC
CGCTGGCCGGAAGATACGCCGCAGGAGCTGGCCATACTGCGCGACTATGCGCTCAGCGCCGGCGCATTCGGCGTCGAATT
CAGCGAAGCCTTTGCTCTCGGCGGGCGCGGCGCGGCGCGCCTGGCAGCCTGCGTCACCGATGCCTGCAGCCAGGCGGCCC
AGGTCAACCTGCTCTACCCGGACGCTATGCCGCTGGCAGAGAAGCTGCAGACCCTGGCGCACAGCTACGGCGCCAGCCAT
GCCGAGCTGACAGTGCAGGCGCAGCAGGAGCTGGATGCGCTGGAGCAGGCCGGCTTTGGCCACCTGCCGCTGTGCATGGC
AAAGACCCCGCTCTCCATCAGCGCCGATCCGGCGTTGAAAAACGCCCCGCGCGGATTTGTGCTGCCCATCCGCAGCCTGC
AGGTCTCCGCCGGTGCCGGGTTTATCCGCGCCTATGCCGGTAACATCATGACGATGCCGGGGCTCAGCACCCTGCCGGCC
TACCGCCACATCGATATCGACGCCGACGGCAATACCGTTGGACTAAGCTAA

Upstream 100 bases:

>100_bases
GCCCGTCCAGGCGTATAATCGATGCCGCTCAGCCCACTTAGCGGCCTGCTGCCGGCAGCGCCTGTGTTTACTCTGTTTAT
ATAAAGGATCACGACACACC

Downstream 100 bases:

>100_bases
CGCCCGCCCCCGATCCCTGCTCCCTCCGGCGCCGGGATCGGGTATACTCCCCCGCATTCGCCCTTTTATCCGGTATTGCA
TACGATGAAAACTGACCGTA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MISCCEPMPSSQPALLPIATIAAKIGIATEALIPYGHYAAKVDMRQLTPRPPRGKLILVSSITPTPLGEGKTVTTLGLSQ
GLNHLGHSAIACIRQPSLGPVFGVKGGAAGGGASQVLPMEQLNLHLTGDIHAISAAHNLAAAALDARLFHEQRLGDAFTA
QSGLQRLDIDPLRIVWKRVMDHNDRALRSIDVGVGGGNNGVPRHDGFDISAASELMAILALSDGLADMRTRIGKVILAYS
LQGAPITAEDLQVAGAMTVVMKAAIHPTLMQSSEQTPVLIHAGPFANIAHGNSSVLADRLALQLADYVVTEAGFGSDMGM
EKFFNIKYRQSGIAPSCVVLVATLRSLKANSGQFNMKPGQALPEEVKQPNADLLRTGCENLGWHIANARRYGLPVVIAVN
RWPEDTPQELAILRDYALSAGAFGVEFSEAFALGGRGAARLAACVTDACSQAAQVNLLYPDAMPLAEKLQTLAHSYGASH
AELTVQAQQELDALEQAGFGHLPLCMAKTPLSISADPALKNAPRGFVLPIRSLQVSAGAGFIRAYAGNIMTMPGLSTLPA
YRHIDIDADGNTVGLS

Sequences:

>Translated_576_residues
MISCCEPMPSSQPALLPIATIAAKIGIATEALIPYGHYAAKVDMRQLTPRPPRGKLILVSSITPTPLGEGKTVTTLGLSQ
GLNHLGHSAIACIRQPSLGPVFGVKGGAAGGGASQVLPMEQLNLHLTGDIHAISAAHNLAAAALDARLFHEQRLGDAFTA
QSGLQRLDIDPLRIVWKRVMDHNDRALRSIDVGVGGGNNGVPRHDGFDISAASELMAILALSDGLADMRTRIGKVILAYS
LQGAPITAEDLQVAGAMTVVMKAAIHPTLMQSSEQTPVLIHAGPFANIAHGNSSVLADRLALQLADYVVTEAGFGSDMGM
EKFFNIKYRQSGIAPSCVVLVATLRSLKANSGQFNMKPGQALPEEVKQPNADLLRTGCENLGWHIANARRYGLPVVIAVN
RWPEDTPQELAILRDYALSAGAFGVEFSEAFALGGRGAARLAACVTDACSQAAQVNLLYPDAMPLAEKLQTLAHSYGASH
AELTVQAQQELDALEQAGFGHLPLCMAKTPLSISADPALKNAPRGFVLPIRSLQVSAGAGFIRAYAGNIMTMPGLSTLPA
YRHIDIDADGNTVGLS
>Mature_576_residues
MISCCEPMPSSQPALLPIATIAAKIGIATEALIPYGHYAAKVDMRQLTPRPPRGKLILVSSITPTPLGEGKTVTTLGLSQ
GLNHLGHSAIACIRQPSLGPVFGVKGGAAGGGASQVLPMEQLNLHLTGDIHAISAAHNLAAAALDARLFHEQRLGDAFTA
QSGLQRLDIDPLRIVWKRVMDHNDRALRSIDVGVGGGNNGVPRHDGFDISAASELMAILALSDGLADMRTRIGKVILAYS
LQGAPITAEDLQVAGAMTVVMKAAIHPTLMQSSEQTPVLIHAGPFANIAHGNSSVLADRLALQLADYVVTEAGFGSDMGM
EKFFNIKYRQSGIAPSCVVLVATLRSLKANSGQFNMKPGQALPEEVKQPNADLLRTGCENLGWHIANARRYGLPVVIAVN
RWPEDTPQELAILRDYALSAGAFGVEFSEAFALGGRGAARLAACVTDACSQAAQVNLLYPDAMPLAEKLQTLAHSYGASH
AELTVQAQQELDALEQAGFGHLPLCMAKTPLSISADPALKNAPRGFVLPIRSLQVSAGAGFIRAYAGNIMTMPGLSTLPA
YRHIDIDADGNTVGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=602, Percent_Identity=48.3388704318937, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI36796743, Length=601, Percent_Identity=47.0881863560732, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI310124614, Length=87, Percent_Identity=45.9770114942529, Blast_Score=83, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=599, Percent_Identity=47.7462437395659, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568739, Length=599, Percent_Identity=47.7462437395659, Blast_Score=492, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321643, Length=619, Percent_Identity=46.6882067851373, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6319558, Length=617, Percent_Identity=45.2188006482982, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI62472483, Length=604, Percent_Identity=45.364238410596, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=604, Percent_Identity=45.364238410596, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24645718, Length=604, Percent_Identity=45.364238410596, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=604, Percent_Identity=45.364238410596, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60610; Mature: 60610

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISCCEPMPSSQPALLPIATIAAKIGIATEALIPYGHYAAKVDMRQLTPRPPRGKLILVS
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHCCCCCCCCCEEEEE
SITPTPLGEGKTVTTLGLSQGLNHLGHSAIACIRQPSLGPVFGVKGGAAGGGASQVLPME
CCCCCCCCCCCEEEEECHHHHHHHHCHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHH
QLNLHLTGDIHAISAAHNLAAAALDARLFHEQRLGDAFTAQSGLQRLDIDPLRIVWKRVM
HCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCCCHHHHHHHHHH
DHNDRALRSIDVGVGGGNNGVPRHDGFDISAASELMAILALSDGLADMRTRIGKVILAYS
CCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEE
LQGAPITAEDLQVAGAMTVVMKAAIHPTLMQSSEQTPVLIHAGPFANIAHGNSSVLADRL
CCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCEEEECCCCCEECCCCHHHHHHHH
ALQLADYVVTEAGFGSDMGMEKFFNIKYRQSGIAPSCVVLVATLRSLKANSGQFNMKPGQ
HHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCCC
ALPEEVKQPNADLLRTGCENLGWHIANARRYGLPVVIAVNRWPEDTPQELAILRDYALSA
CCCHHHHCCCHHHHHHHHHHCCEEEECCEECCCEEEEEECCCCCCCHHHHHHHHHHHHCC
GAFGVEFSEAFALGGRGAARLAACVTDACSQAAQVNLLYPDAMPLAEKLQTLAHSYGASH
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCC
AELTVQAQQELDALEQAGFGHLPLCMAKTPLSISADPALKNAPRGFVLPIRSLQVSAGAG
EEEEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCC
FIRAYAGNIMTMPGLSTLPAYRHIDIDADGNTVGLS
CHHHHCCCEEECCCCCCCCCEEEEEECCCCCEECCC
>Mature Secondary Structure
MISCCEPMPSSQPALLPIATIAAKIGIATEALIPYGHYAAKVDMRQLTPRPPRGKLILVS
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHCCCCCCCCCEEEEE
SITPTPLGEGKTVTTLGLSQGLNHLGHSAIACIRQPSLGPVFGVKGGAAGGGASQVLPME
CCCCCCCCCCCEEEEECHHHHHHHHCHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHH
QLNLHLTGDIHAISAAHNLAAAALDARLFHEQRLGDAFTAQSGLQRLDIDPLRIVWKRVM
HCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCCCHHHHHHHHHH
DHNDRALRSIDVGVGGGNNGVPRHDGFDISAASELMAILALSDGLADMRTRIGKVILAYS
CCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEE
LQGAPITAEDLQVAGAMTVVMKAAIHPTLMQSSEQTPVLIHAGPFANIAHGNSSVLADRL
CCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCEEEECCCCCEECCCCHHHHHHHH
ALQLADYVVTEAGFGSDMGMEKFFNIKYRQSGIAPSCVVLVATLRSLKANSGQFNMKPGQ
HHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCCC
ALPEEVKQPNADLLRTGCENLGWHIANARRYGLPVVIAVNRWPEDTPQELAILRDYALSA
CCCHHHHCCCHHHHHHHHHHCCEEEECCEECCCEEEEEECCCCCCCHHHHHHHHHHHHCC
GAFGVEFSEAFALGGRGAARLAACVTDACSQAAQVNLLYPDAMPLAEKLQTLAHSYGASH
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCC
AELTVQAQQELDALEQAGFGHLPLCMAKTPLSISADPALKNAPRGFVLPIRSLQVSAGAG
EEEEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCC
FIRAYAGNIMTMPGLSTLPAYRHIDIDADGNTVGLS
CHHHHCCCEEECCCCCCCCCEEEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA