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The map label for this gene is add

Identifier: 238919977

GI number: 238919977

Start: 2002081

End: 2003082

Strand: Direct

Name: add

Synonym: NT01EI_2081

Alternate gene names: 238919977

Gene position: 2002081-2003082 (Clockwise)

Preceding gene: 238919976

Following gene: 238919980

Centisome position: 52.52

GC content: 62.38

Gene sequence:

>1002_bases
ATGATCGATTCGCGTTTTCCCCTGATTGACCTACACCGCCATCTTGATGGCAACATCCGGCCACAAACCATTCTAGAGCT
GGGACAACAGTATCGGCTGGCGCTGCCGGCGAATGAGCTGGAGGCCCTGCGCCCCCATGTCCAAATCAGCGATTCGGTAC
CGGATCTGGTCAGCTTTCTGCAAAAGCTGGACTGGGGCGTCGCCGTTCTGGCCACCCTGGATGCCTGCCGCCGGGTAGCC
TACGAAAACGTTGAAGATCTGAAGCGCGCAGGTATCGATTATGCCGAGCTGCGCTTCTCCCCCTACTACATGGCGCAGCG
CCACGGCCTGCCTCTGCAGGGGGTGGTTGAAGCCATCATTGACGGCGTCAGCGCCGCCTCGCGCGACGTCGGCGTTCCGG
TCAAACTGATTGGGATCATGAGCCGCACCTTTGGCCAAGAGGCCTGCCGCCAGGAGCTGGAGGCACTGCTGAGCGGCCGC
GAGCGGATCGCCGCACTGGATCTGGCCGGTGACGAGCTGGGCTTCCCGGGCGATCTGTTTAGGTCGCACTTTACCCGGGC
GCGTGACGCAGGATGGCACATTACAGTACACGCCGGCGAAGCCGCGGGGGCGGAAAGCATCTGGCAGGCCATCCGCGAAC
TGGGTGCCGAACGCATTGGCCACGGTGTGAATGCGATCCAGGATGCACGCCTGATGGATTATCTGGCGGAGCACGCCATC
GGCGTGGAGGCCTGCCTGACCTCCAACCTGCAGACCAGTACGGTGCCCTCTTTGGCACAGCATCCGCTGAAGCATTTCCT
GCAACACGGCATTATCGCTAACCTCAACACGGATGACCCGGCGGTGGAAGGGATTGAGCTGCGTCACGAATACCAGACAG
CCGCACCGGCGGCAGGCCTGAGCGCCGAGCAAATCCGCCAGGCGCAGTACAACGGCCTGAGCATGGCTTTCCTGAGCCCG
GCGGAGAAACAGGTGCTGCGCGACGCCAAGCAGATGTGCTAA

Upstream 100 bases:

>100_bases
GGTGATCAAAATCACATTCTTATGTAATTAGATGGTTATTTACTTCGCGTTGTTTTTATACTGTTGCGCACCTTAAGCAA
AATAATTGAGAGTGCCCATC

Downstream 100 bases:

>100_bases
CTCCCCAGGACACTCTGGGAGCGTGCTATTCAGCGCGCTCCGGCGCCTGACAACGGCGGGCGTAGCGCTGGGCCAGCCAG
GCACAGACCATCAGCTGCAA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIDSRFPLIDLHRHLDGNIRPQTILELGQQYRLALPANELEALRPHVQISDSVPDLVSFLQKLDWGVAVLATLDACRRVA
YENVEDLKRAGIDYAELRFSPYYMAQRHGLPLQGVVEAIIDGVSAASRDVGVPVKLIGIMSRTFGQEACRQELEALLSGR
ERIAALDLAGDELGFPGDLFRSHFTRARDAGWHITVHAGEAAGAESIWQAIRELGAERIGHGVNAIQDARLMDYLAEHAI
GVEACLTSNLQTSTVPSLAQHPLKHFLQHGIIANLNTDDPAVEGIELRHEYQTAAPAAGLSAEQIRQAQYNGLSMAFLSP
AEKQVLRDAKQMC

Sequences:

>Translated_333_residues
MIDSRFPLIDLHRHLDGNIRPQTILELGQQYRLALPANELEALRPHVQISDSVPDLVSFLQKLDWGVAVLATLDACRRVA
YENVEDLKRAGIDYAELRFSPYYMAQRHGLPLQGVVEAIIDGVSAASRDVGVPVKLIGIMSRTFGQEACRQELEALLSGR
ERIAALDLAGDELGFPGDLFRSHFTRARDAGWHITVHAGEAAGAESIWQAIRELGAERIGHGVNAIQDARLMDYLAEHAI
GVEACLTSNLQTSTVPSLAQHPLKHFLQHGIIANLNTDDPAVEGIELRHEYQTAAPAAGLSAEQIRQAQYNGLSMAFLSP
AEKQVLRDAKQMC
>Mature_333_residues
MIDSRFPLIDLHRHLDGNIRPQTILELGQQYRLALPANELEALRPHVQISDSVPDLVSFLQKLDWGVAVLATLDACRRVA
YENVEDLKRAGIDYAELRFSPYYMAQRHGLPLQGVVEAIIDGVSAASRDVGVPVKLIGIMSRTFGQEACRQELEALLSGR
ERIAALDLAGDELGFPGDLFRSHFTRARDAGWHITVHAGEAAGAESIWQAIRELGAERIGHGVNAIQDARLMDYLAEHAI
GVEACLTSNLQTSTVPSLAQHPLKHFLQHGIIANLNTDDPAVEGIELRHEYQTAAPAAGLSAEQIRQAQYNGLSMAFLSP
AEKQVLRDAKQMC

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=343, Percent_Identity=31.1953352769679, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI226693318, Length=341, Percent_Identity=24.3401759530792, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1787910, Length=328, Percent_Identity=72.2560975609756, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI32565969, Length=335, Percent_Identity=29.2537313432836, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17538512, Length=334, Percent_Identity=28.7425149700599, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115537133, Length=327, Percent_Identity=23.2415902140673, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324188, Length=282, Percent_Identity=26.9503546099291, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645260, Length=332, Percent_Identity=24.6987951807229, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_EDWI9 (C5BDE0)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933492.1
- GeneID:   7959059
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2081
- OMA:   PYYMAMN
- ProtClustDB:   CLSK2813238
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 36574; Mature: 36574

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 200-200 BINDING 14-14 BINDING 16-16 BINDING 170-170 BINDING 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSRFPLIDLHRHLDGNIRPQTILELGQQYRLALPANELEALRPHVQISDSVPDLVSFL
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHEECCCHHHHHHHCCCCEECCCHHHHHHHH
QKLDWGVAVLATLDACRRVAYENVEDLKRAGIDYAELRFSPYYMAQRHGLPLQGVVEAII
HHHCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHH
DGVSAASRDVGVPVKLIGIMSRTFGQEACRQELEALLSGRERIAALDLAGDELGFPGDLF
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCHHHH
RSHFTRARDAGWHITVHAGEAAGAESIWQAIRELGAERIGHGVNAIQDARLMDYLAEHAI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GVEACLTSNLQTSTVPSLAQHPLKHFLQHGIIANLNTDDPAVEGIELRHEYQTAAPAAGL
HHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCC
SAEQIRQAQYNGLSMAFLSPAEKQVLRDAKQMC
CHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDSRFPLIDLHRHLDGNIRPQTILELGQQYRLALPANELEALRPHVQISDSVPDLVSFL
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHEECCCHHHHHHHCCCCEECCCHHHHHHHH
QKLDWGVAVLATLDACRRVAYENVEDLKRAGIDYAELRFSPYYMAQRHGLPLQGVVEAII
HHHCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHH
DGVSAASRDVGVPVKLIGIMSRTFGQEACRQELEALLSGRERIAALDLAGDELGFPGDLF
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCHHHH
RSHFTRARDAGWHITVHAGEAAGAESIWQAIRELGAERIGHGVNAIQDARLMDYLAEHAI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GVEACLTSNLQTSTVPSLAQHPLKHFLQHGIIANLNTDDPAVEGIELRHEYQTAAPAAGL
HHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCC
SAEQIRQAQYNGLSMAFLSPAEKQVLRDAKQMC
CHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA