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The map label for this gene is manA [H]

Identifier: 238919975

GI number: 238919975

Start: 1999072

End: 2000250

Strand: Direct

Name: manA [H]

Synonym: NT01EI_2079

Alternate gene names: 238919975

Gene position: 1999072-2000250 (Clockwise)

Preceding gene: 238919973

Following gene: 238919976

Centisome position: 52.44

GC content: 62.09

Gene sequence:

>1179_bases
ATGCAAAAGATGAACAATGCCATACAGCACTATGCCTGGGGCAGCCACGACGCACTGAGCAAACTTTATGGCATCGCTAA
CCCGGATAACCAACCGATGGCCGAGCTGTGGATGGGAGCCCACCCGTTAAACAGCTCCCGGGTACAGGATGCGCGCGGCA
CCAGCCTAAGTCTGCGCGATCAAATCGCCGCCGATCCTCGCGCCCAGCTGGGCGATGCCGTCGCCCGGCGCTTTGGCGAG
CTGCCGTTCCTGTTTAAGGTGCTGTGCGCAGCCCAGCCGCTCTCCATTCAGGTACATCCCAATAAGCACGCCGCCGAAGC
CGGCTTTGCGCGCGAAGAGGCCGCCGGCATCGCGCGAAATGCCCCGAACCGTAACTACAAGGATGCCAACCATAAACCGG
AGCTGGTGTATGCGCTAACCCCTTTTGCAGCGATGAACGGCTTTCGCGAATTCGACCAGATAGCTACCCTGCTGCAACCA
CTGGCCGATGCCCACCCGGATATCGCCGCTTTTATCGCCCACCCGGGTGCCGACACGCTGCGGGCCCTGTTTGCCAATTT
GCTCAATATGCAGGGGGAGGCAAAAGCCCATGCACTGCGCCGCCTGCGCGAGGAGATGGCCCACCAGCAAGGCGAGGTCT
GGGACACCCTGCGCGCCATTGCCCCTATTTACCCGGATGACAGCGGCCTGTTCTCTCCACTGCTGCTGAATGTGATAGTG
CTGGCGCCGGGCCAGGCCATGTTCCTGGATGCCGAAACACCCCACGCCTATCTGCACGGCGTCGGCCTGGAGGTCATGGC
CAATTCGGATAACGTACTGCGCGCCGGCCTGACCCCGAAATATATCGATGTCACCGAGCTGCTGAAGAGCGTCCGCTTCA
TCGCCACACCACCCGACAAGCTGCTGACGGCGCCGTGCACCTCCGGCGCGGAGACCCGTTTCCCCGTGCCGGTCGCCGAT
TTTGCCTTTGCGGTCCATACGCTGAGCGCACAGCCGCAGCCGCTGCATCAGGAGAGCGCCGCCGTGCTGTTTTGCATCCG
TGGAGAGGCCCGGCTGCAGCAGGGGGCACAGACGCTGATCCTGCACGCCGGCGAGTCCTGCTATCTCAGTGCCGCAGACC
GCCAGGTTTCGGTGACCGGTCACGGAGAGCTGGCGCGTATTTTTAATCAGTTAGATTAA

Upstream 100 bases:

>100_bases
AATGCCTTCGCCATTTAGATGATCAATCCCCTTGCCGAGGCGGGGGCAGTTCCTGTTTACTGAAGAAAATTCACATTTCA
CTGACTCGCGGAACCGACAG

Downstream 100 bases:

>100_bases
TTTTCAACGAATTATTTGCCAATTACGCCCCCTTGCCCCCACAATAAAAACGCCTGCGGGCGTTTTTTTACCTTCCGGCA
CCGATGCGCTTGAAACCGGT

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQKMNNAIQHYAWGSHDALSKLYGIANPDNQPMAELWMGAHPLNSSRVQDARGTSLSLRDQIAADPRAQLGDAVARRFGE
LPFLFKVLCAAQPLSIQVHPNKHAAEAGFAREEAAGIARNAPNRNYKDANHKPELVYALTPFAAMNGFREFDQIATLLQP
LADAHPDIAAFIAHPGADTLRALFANLLNMQGEAKAHALRRLREEMAHQQGEVWDTLRAIAPIYPDDSGLFSPLLLNVIV
LAPGQAMFLDAETPHAYLHGVGLEVMANSDNVLRAGLTPKYIDVTELLKSVRFIATPPDKLLTAPCTSGAETRFPVPVAD
FAFAVHTLSAQPQPLHQESAAVLFCIRGEARLQQGAQTLILHAGESCYLSAADRQVSVTGHGELARIFNQLD

Sequences:

>Translated_392_residues
MQKMNNAIQHYAWGSHDALSKLYGIANPDNQPMAELWMGAHPLNSSRVQDARGTSLSLRDQIAADPRAQLGDAVARRFGE
LPFLFKVLCAAQPLSIQVHPNKHAAEAGFAREEAAGIARNAPNRNYKDANHKPELVYALTPFAAMNGFREFDQIATLLQP
LADAHPDIAAFIAHPGADTLRALFANLLNMQGEAKAHALRRLREEMAHQQGEVWDTLRAIAPIYPDDSGLFSPLLLNVIV
LAPGQAMFLDAETPHAYLHGVGLEVMANSDNVLRAGLTPKYIDVTELLKSVRFIATPPDKLLTAPCTSGAETRFPVPVAD
FAFAVHTLSAQPQPLHQESAAVLFCIRGEARLQQGAQTLILHAGESCYLSAADRQVSVTGHGELARIFNQLD
>Mature_392_residues
MQKMNNAIQHYAWGSHDALSKLYGIANPDNQPMAELWMGAHPLNSSRVQDARGTSLSLRDQIAADPRAQLGDAVARRFGE
LPFLFKVLCAAQPLSIQVHPNKHAAEAGFAREEAAGIARNAPNRNYKDANHKPELVYALTPFAAMNGFREFDQIATLLQP
LADAHPDIAAFIAHPGADTLRALFANLLNMQGEAKAHALRRLREEMAHQQGEVWDTLRAIAPIYPDDSGLFSPLLLNVIV
LAPGQAMFLDAETPHAYLHGVGLEVMANSDNVLRAGLTPKYIDVTELLKSVRFIATPPDKLLTAPCTSGAETRFPVPVAD
FAFAVHTLSAQPQPLHQESAAVLFCIRGEARLQQGAQTLILHAGESCYLSAADRQVSVTGHGELARIFNQLD

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=378, Percent_Identity=34.1269841269841, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=63.6828644501279, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71997620, Length=397, Percent_Identity=30.4785894206549, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17557650, Length=343, Percent_Identity=30.0291545189504, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320839, Length=406, Percent_Identity=30.0492610837438, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI21356061, Length=391, Percent_Identity=30.690537084399, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42659; Mature: 42659

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKMNNAIQHYAWGSHDALSKLYGIANPDNQPMAELWMGAHPLNSSRVQDARGTSLSLRD
CCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEHHH
QIAADPRAQLGDAVARRFGELPFLFKVLCAAQPLSIQVHPNKHAAEAGFAREEAAGIARN
HHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCHHHHHCCHHHHHHHHHCC
APNRNYKDANHKPELVYALTPFAAMNGFREFDQIATLLQPLADAHPDIAAFIAHPGADTL
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
RALFANLLNMQGEAKAHALRRLREEMAHQQGEVWDTLRAIAPIYPDDSGLFSPLLLNVIV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LAPGQAMFLDAETPHAYLHGVGLEVMANSDNVLRAGLTPKYIDVTELLKSVRFIATPPDK
CCCCCEEEEECCCCCHHHCCCCEEEEECCCCEEECCCCCCEECHHHHHHHHHEECCCCHH
LLTAPCTSGAETRFPVPVADFAFAVHTLSAQPQPLHQESAAVLFCIRGEARLQQGAQTLI
HEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHCCCCEEE
LHAGESCYLSAADRQVSVTGHGELARIFNQLD
EECCCCEEEEECCCEEEEECCHHHHHHHHHCC
>Mature Secondary Structure
MQKMNNAIQHYAWGSHDALSKLYGIANPDNQPMAELWMGAHPLNSSRVQDARGTSLSLRD
CCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEHHH
QIAADPRAQLGDAVARRFGELPFLFKVLCAAQPLSIQVHPNKHAAEAGFAREEAAGIARN
HHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCHHHHHCCHHHHHHHHHCC
APNRNYKDANHKPELVYALTPFAAMNGFREFDQIATLLQPLADAHPDIAAFIAHPGADTL
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
RALFANLLNMQGEAKAHALRRLREEMAHQQGEVWDTLRAIAPIYPDDSGLFSPLLLNVIV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LAPGQAMFLDAETPHAYLHGVGLEVMANSDNVLRAGLTPKYIDVTELLKSVRFIATPPDK
CCCCCEEEEECCCCCHHHCCCCEEEEECCCCEEECCCCCCEECHHHHHHHHHEECCCCHH
LLTAPCTSGAETRFPVPVADFAFAVHTLSAQPQPLHQESAAVLFCIRGEARLQQGAQTLI
HEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHCCCCEEE
LHAGESCYLSAADRQVSVTGHGELARIFNQLD
EECCCCEEEEECCCEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]