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The map label for this gene is melR [H]

Identifier: 238919675

GI number: 238919675

Start: 1720668

End: 1721609

Strand: Reverse

Name: melR [H]

Synonym: NT01EI_1776

Alternate gene names: 238919675

Gene position: 1721609-1720668 (Counterclockwise)

Preceding gene: 238919679

Following gene: 238919673

Centisome position: 45.16

GC content: 62.74

Gene sequence:

>942_bases
ATGGGGGAGAGTCACCACAAAGACGCAGCCACAGGGCTGATGTGCAACAGCACCGACCCACAGCAGCACAGCCCACTGAT
GCTCTATTCCGAGCACCAGCCCCTGGCGATCGCACTCTGTTCACCGCAGGCGATGGCCGCCAGCCACTGGCATGCCCAGG
TCGAGCTCAATATTCCTTTCGACGGCGCGATAGGCTACCGCATTCACGATCGGCAGCTGCGCATCCCGCAGGGACATATT
GCCCTGTTCTGGGCCTGTACCCCCCACCGTCTCGTCGATCCGGGGCACTGTCGCCACATGGCCCTGCTCAGCCTGCCCAT
GCATCTGTTGCTCTCCTGGCCGTTAGATCCGCAGCTGCTCAGCCAGATTACCCACGGCAGAGTATTGACATCTGCGCACC
CGACCCGGCTAACGCCCGTTGAGATTGGGCGTTGGCAGCAGGATCTGCAGAGCCCATGCCCGCAGATGCGGCAGCTGGCC
AGCGATGAAATCCTGCTAATGCTAAAGCGCTTGAGCCTCTCCGGCTGGCACGCCCTGCAGCCCGGTGGCGACGATCCGCG
CGCGGGCAACGGCCAGGGGCTCTCACGCCATGCCCTGTTCTACGTCGGCCAGATGCTGACCTTCACTGCCGCCCACTACG
ATCGCGCGCTGACGATAGAGCAGGTTGCCCGGCACGTCGGCCTCAACGCCCACTATGCGATGGGACTGTTCCAGCGGGTG
ATGCAGATGACGATGAAGCAGTATATTACCGCCATGCGCATCAACCACGTCCGGGCGCTTCTGAGCGACACCGACAGAAC
GGTCCTCGATATCGCGCTCACGGCAGGGTTCAGCTCCAGCAGCCGCTTTTACAGCACCTTCAGTAAATACACCGGAATGT
CGCCGCAGCAGTACCGTCGGCTGGCGCGTACAGGCGCAACGCACCCTCCACCGGCGGATTAG

Upstream 100 bases:

>100_bases
CCAGGCTAGAGACAGCGCGGCAGTGTTCCGCCGGGACGTCCGCCAGGGAGCGCGGCACCCTTATCTCTATCTCTGCCGCA
GCGGGATCCGGAGGAAAACC

Downstream 100 bases:

>100_bases
TTTATGATCCTCGTGGCGGGAGAGCATCGCGAACCGGCGTATTGAAACAATGAACCCTCTGAGCCCACGCGGGAAAATCG
ACAATGACGCAGAGAAAGGC

Product: DNA-binding transcriptional regulator MelR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MGESHHKDAATGLMCNSTDPQQHSPLMLYSEHQPLAIALCSPQAMAASHWHAQVELNIPFDGAIGYRIHDRQLRIPQGHI
ALFWACTPHRLVDPGHCRHMALLSLPMHLLLSWPLDPQLLSQITHGRVLTSAHPTRLTPVEIGRWQQDLQSPCPQMRQLA
SDEILLMLKRLSLSGWHALQPGGDDPRAGNGQGLSRHALFYVGQMLTFTAAHYDRALTIEQVARHVGLNAHYAMGLFQRV
MQMTMKQYITAMRINHVRALLSDTDRTVLDIALTAGFSSSSRFYSTFSKYTGMSPQQYRRLARTGATHPPPAD

Sequences:

>Translated_313_residues
MGESHHKDAATGLMCNSTDPQQHSPLMLYSEHQPLAIALCSPQAMAASHWHAQVELNIPFDGAIGYRIHDRQLRIPQGHI
ALFWACTPHRLVDPGHCRHMALLSLPMHLLLSWPLDPQLLSQITHGRVLTSAHPTRLTPVEIGRWQQDLQSPCPQMRQLA
SDEILLMLKRLSLSGWHALQPGGDDPRAGNGQGLSRHALFYVGQMLTFTAAHYDRALTIEQVARHVGLNAHYAMGLFQRV
MQMTMKQYITAMRINHVRALLSDTDRTVLDIALTAGFSSSSRFYSTFSKYTGMSPQQYRRLARTGATHPPPAD
>Mature_312_residues
GESHHKDAATGLMCNSTDPQQHSPLMLYSEHQPLAIALCSPQAMAASHWHAQVELNIPFDGAIGYRIHDRQLRIPQGHIA
LFWACTPHRLVDPGHCRHMALLSLPMHLLLSWPLDPQLLSQITHGRVLTSAHPTRLTPVEIGRWQQDLQSPCPQMRQLAS
DEILLMLKRLSLSGWHALQPGGDDPRAGNGQGLSRHALFYVGQMLTFTAAHYDRALTIEQVARHVGLNAHYAMGLFQRVM
QMTMKQYITAMRINHVRALLSDTDRTVLDIALTAGFSSSSRFYSTFSKYTGMSPQQYRRLARTGATHPPPAD

Specific function: Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790559, Length=291, Percent_Identity=61.8556701030928, Blast_Score=383, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008917
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 35039; Mature: 34908

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGESHHKDAATGLMCNSTDPQQHSPLMLYSEHQPLAIALCSPQAMAASHWHAQVELNIPF
CCCCCCCHHHCCEEECCCCCCCCCCEEEEECCCCEEEEEECCHHHHHCCCEEEEEEECCC
DGAIGYRIHDRQLRIPQGHIALFWACTPHRLVDPGHCRHMALLSLPMHLLLSWPLDPQLL
CCCCCEEEECCEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
SQITHGRVLTSAHPTRLTPVEIGRWQQDLQSPCPQMRQLASDEILLMLKRLSLSGWHALQ
HHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCEEEC
PGGDDPRAGNGQGLSRHALFYVGQMLTFTAAHYDRALTIEQVARHVGLNAHYAMGLFQRV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHH
MQMTMKQYITAMRINHVRALLSDTDRTVLDIALTAGFSSSSRFYSTFSKYTGMSPQQYRR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHH
LARTGATHPPPAD
HHHCCCCCCCCCC
>Mature Secondary Structure 
GESHHKDAATGLMCNSTDPQQHSPLMLYSEHQPLAIALCSPQAMAASHWHAQVELNIPF
CCCCCCHHHCCEEECCCCCCCCCCEEEEECCCCEEEEEECCHHHHHCCCEEEEEEECCC
DGAIGYRIHDRQLRIPQGHIALFWACTPHRLVDPGHCRHMALLSLPMHLLLSWPLDPQLL
CCCCCEEEECCEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
SQITHGRVLTSAHPTRLTPVEIGRWQQDLQSPCPQMRQLASDEILLMLKRLSLSGWHALQ
HHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCEEEC
PGGDDPRAGNGQGLSRHALFYVGQMLTFTAAHYDRALTIEQVARHVGLNAHYAMGLFQRV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHH
MQMTMKQYITAMRINHVRALLSDTDRTVLDIALTAGFSSSSRFYSTFSKYTGMSPQQYRR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHH
LARTGATHPPPAD
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]