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The map label for this gene is cobC [H]

Identifier: 238919605

GI number: 238919605

Start: 1661297

End: 1661896

Strand: Direct

Name: cobC [H]

Synonym: NT01EI_1704

Alternate gene names: 238919605

Gene position: 1661297-1661896 (Clockwise)

Preceding gene: 238919604

Following gene: 238919608

Centisome position: 43.58

GC content: 66.17

Gene sequence:

>600_bases
ATGGAGCTCTATCTGGTTCGTCACGGTGAGACTCAGGCCAATCGGGATGGCCTCTACTGCGGCAGCAGCGATGTGGCGCT
GACGCCGCAGGGACTCCAACAGGCGCAGGCCGTGGCGCATCAGCTGCAGGGGGTCGCGTTCGACGCCGCCTATGCCAGCC
GCCTGCGGCGTACCCAGCAGACCCTGCGCCCCATCATCGGCGCGTTGGGGCAGTTTCACGTCCATGCGGGGCTCGATGAG
ATCAACTTTGGTGAATGGGAGCTGTGTCATCACCGCGATCTGGCGCGCCAGCAGAGCGCAGCCTATCGCGCCTGGTGCGA
CGATTGGCGCAGCGCTGTGCCACCGGGCGGCGAGGGGTTCGCCGGCTTTAGCGCCCGGGTGGAGGCGGTGCTGGCAGAGC
TGCTGGCGCGTCACGAGGGCCAGCGGGTGCTGGTGGTTTCACATCAGGGGGTGCTCTCTCTGCTGTGCGCCCGTCTGCTG
GGCATGGCGGCGGAGAACATGTGGCACTTCTCATTCAGCCAGGGCAGCCACAGTCTGATCGCGGTCCGACAGGGGTTTGC
GGTGATGCGTAGCCTTAACGATCGCAGCGCGGTGAACTAG

Upstream 100 bases:

>100_bases
CATCAATATGCGGCTGGGGGGGCAGACCGGGGATACGCTGGGTGCGGCAAACGAGCTGTTTGCGCTGGTATTTCTGCTGT
CGCTGTACTGAGTGGGTCCC

Downstream 100 bases:

>100_bases
CGGCCGCGGCGCGGGATTACCAGTCGATGCCTTTCTGCGCCTTGACGCCAGCGTTGAAGGCATGTTTTTCCGGGCGGATT
TCACTGACGGTATCGGCCAG

Product: phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MELYLVRHGETQANRDGLYCGSSDVALTPQGLQQAQAVAHQLQGVAFDAAYASRLRRTQQTLRPIIGALGQFHVHAGLDE
INFGEWELCHHRDLARQQSAAYRAWCDDWRSAVPPGGEGFAGFSARVEAVLAELLARHEGQRVLVVSHQGVLSLLCARLL
GMAAENMWHFSFSQGSHSLIAVRQGFAVMRSLNDRSAVN

Sequences:

>Translated_199_residues
MELYLVRHGETQANRDGLYCGSSDVALTPQGLQQAQAVAHQLQGVAFDAAYASRLRRTQQTLRPIIGALGQFHVHAGLDE
INFGEWELCHHRDLARQQSAAYRAWCDDWRSAVPPGGEGFAGFSARVEAVLAELLARHEGQRVLVVSHQGVLSLLCARLL
GMAAENMWHFSFSQGSHSLIAVRQGFAVMRSLNDRSAVN
>Mature_199_residues
MELYLVRHGETQANRDGLYCGSSDVALTPQGLQQAQAVAHQLQGVAFDAAYASRLRRTQQTLRPIIGALGQFHVHAGLDE
INFGEWELCHHRDLARQQSAAYRAWCDDWRSAVPPGGEGFAGFSARVEAVLAELLARHEGQRVLVVSHQGVLSLLCARLL
GMAAENMWHFSFSQGSHSLIAVRQGFAVMRSLNDRSAVN

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=197, Percent_Identity=49.746192893401, Blast_Score=193, Evalue=6e-51,
Organism=Escherichia coli, GI1790856, Length=165, Percent_Identity=33.9393939393939, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 21890; Mature: 21890

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYLVRHGETQANRDGLYCGSSDVALTPQGLQQAQAVAHQLQGVAFDAAYASRLRRTQQ
CEEEEEECCCCCCCCCCCEECCCCCEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TLRPIIGALGQFHVHAGLDEINFGEWELCHHRDLARQQSAAYRAWCDDWRSAVPPGGEGF
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AGFSARVEAVLAELLARHEGQRVLVVSHQGVLSLLCARLLGMAAENMWHFSFSQGSHSLI
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCHHH
AVRQGFAVMRSLNDRSAVN
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MELYLVRHGETQANRDGLYCGSSDVALTPQGLQQAQAVAHQLQGVAFDAAYASRLRRTQQ
CEEEEEECCCCCCCCCCCEECCCCCEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TLRPIIGALGQFHVHAGLDEINFGEWELCHHRDLARQQSAAYRAWCDDWRSAVPPGGEGF
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AGFSARVEAVLAELLARHEGQRVLVVSHQGVLSLLCARLLGMAAENMWHFSFSQGSHSLI
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCHHH
AVRQGFAVMRSLNDRSAVN
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]