Click here to switch to the map view.

The map label for this gene is trpD [H]

Identifier: 238919592

GI number: 238919592

Start: 1651697

End: 1652332

Strand: Reverse

Name: trpD [H]

Synonym: NT01EI_1691

Alternate gene names: 238919592

Gene position: 1652332-1651697 (Counterclockwise)

Preceding gene: 238919593

Following gene: 238919591

Centisome position: 43.34

GC content: 65.09

Gene sequence:

>636_bases
ATGGCCGACGTCTTACTGCTCGACAATATTGACTCATTTACTTACAACCTGGTCGATCAGCTGCGCAGCGGCGGTCATCG
GGTGGTTATCTACCGTAACAGCGTCGCGCCGGAAACCCTGCTGCGGCATCTGGATAGGTTGCACCAGCCACTGCTGATGC
TCTCCCCCGGCCCCGGCGCACCGGCTGACGCAGGCTGTATGCCCGCGCTGCTGCAAACGCTGTGTGGGCGCCTGCCCATC
ATCGGCATCTGTCTGGGACACCAGGCCATCGTCGAACACTATGGCGGCCAGGTCGATCGGGCGGAGGAAGTTCTGCACGG
GCGGGTCTGCGCCATCGAGCACGATGGCGAGGCCATGTTTCACGGCTTGCCGTCGCCACTGCCGGTAGCGCGCTACCACT
CACTGGCGGCCCGGTGCATTCCGGCCGATCTCTGCGTCAACGCCCACTTCCAGGGCATGGTCATGGCGGTACGCCACGAT
CGCCAGCGCGTCTGCGGCTTCCAGTTTCACCCGGAGTCGCTCCTTACGCCACAGGGCGCCCGGCTGCTGGATCAGAGCAT
CGACTGGGCCCGCGCCGCACAGCCCCAACCCCGATTGCCCTCCCTCAGCGCAGCGGAGGCCCCATCATGTCACTGA

Upstream 100 bases:

>100_bases
CTCAGGCGGAGGCCGATGAAACCCGCAGCAAGGCCCGGGCGGTGCTGAACGCCATCGCGGCGGCGCACCCGAACGCCCCC
CAGCCGCAAGGAGCGATCTG

Downstream 100 bases:

>100_bases
CCTCTGAGCATCTGACCATACTGGATAAGCTATACCGGGCACAGGTAATCAGCCGCGCGGAAAGCCAGCGGCTCTTTAGC
GCCATCGTGCACGGTCATCT

Product: anthranilate synthase component II

Products: NA

Alternate protein names: Glutamine amidotransferase; Anthranilate phosphoribosyltransferase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MADVLLLDNIDSFTYNLVDQLRSGGHRVVIYRNSVAPETLLRHLDRLHQPLLMLSPGPGAPADAGCMPALLQTLCGRLPI
IGICLGHQAIVEHYGGQVDRAEEVLHGRVCAIEHDGEAMFHGLPSPLPVARYHSLAARCIPADLCVNAHFQGMVMAVRHD
RQRVCGFQFHPESLLTPQGARLLDQSIDWARAAQPQPRLPSLSAAEAPSCH

Sequences:

>Translated_211_residues
MADVLLLDNIDSFTYNLVDQLRSGGHRVVIYRNSVAPETLLRHLDRLHQPLLMLSPGPGAPADAGCMPALLQTLCGRLPI
IGICLGHQAIVEHYGGQVDRAEEVLHGRVCAIEHDGEAMFHGLPSPLPVARYHSLAARCIPADLCVNAHFQGMVMAVRHD
RQRVCGFQFHPESLLTPQGARLLDQSIDWARAAQPQPRLPSLSAAEAPSCH
>Mature_210_residues
ADVLLLDNIDSFTYNLVDQLRSGGHRVVIYRNSVAPETLLRHLDRLHQPLLMLSPGPGAPADAGCMPALLQTLCGRLPII
GICLGHQAIVEHYGGQVDRAEEVLHGRVCAIEHDGEAMFHGLPSPLPVARYHSLAARCIPADLCVNAHFQGMVMAVRHDR
QRVCGFQFHPESLLTPQGARLLDQSIDWARAAQPQPRLPSLSAAEAPSCH

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787517, Length=214, Percent_Identity=65.8878504672897, Blast_Score=289, Evalue=9e-80,
Organism=Escherichia coli, GI1789760, Length=183, Percent_Identity=42.6229508196721, Blast_Score=144, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=182, Percent_Identity=40.1098901098901, Blast_Score=138, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324361, Length=212, Percent_Identity=27.8301886792453, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005940
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase; PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3 [H]

EC number: =4.1.3.27; =2.4.2.18 [H]

Molecular weight: Translated: 23031; Mature: 22900

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVLLLDNIDSFTYNLVDQLRSGGHRVVIYRNSVAPETLLRHLDRLHQPLLMLSPGPGA
CCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCC
PADAGCMPALLQTLCGRLPIIGICLGHQAIVEHYGGQVDRAEEVLHGRVCAIEHDGEAMF
CCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCHHC
HGLPSPLPVARYHSLAARCIPADLCVNAHFQGMVMAVRHDRQRVCGFQFHPESLLTPQGA
CCCCCCCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHCCCEECCHHHCCCCCH
RLLDQSIDWARAAQPQPRLPSLSAAEAPSCH
HHHHHHCCHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADVLLLDNIDSFTYNLVDQLRSGGHRVVIYRNSVAPETLLRHLDRLHQPLLMLSPGPGA
CCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCC
PADAGCMPALLQTLCGRLPIIGICLGHQAIVEHYGGQVDRAEEVLHGRVCAIEHDGEAMF
CCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCHHC
HGLPSPLPVARYHSLAARCIPADLCVNAHFQGMVMAVRHDRQRVCGFQFHPESLLTPQGA
CCCCCCCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHCCCEECCHHHCCCCCH
RLLDQSIDWARAAQPQPRLPSLSAAEAPSCH
HHHHHHCCHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7038627; 6283099; 9097039; 9278503; 4594441 [H]