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The map label for this gene is trpE [H]

Identifier: 238919593

GI number: 238919593

Start: 1652332

End: 1653906

Strand: Reverse

Name: trpE [H]

Synonym: NT01EI_1692

Alternate gene names: 238919593

Gene position: 1653906-1652332 (Counterclockwise)

Preceding gene: 238919597

Following gene: 238919592

Centisome position: 43.38

GC content: 65.97

Gene sequence:

>1575_bases
ATGCCTCAGGCCAAAACCGCCGTGACCGTATTAACCCGCAGCGCCGCTTACTCCGCGGATCCTACGCTGCTTTTTGAACA
ACTGTGCGCCCAGCGCCCGGCGACGCTGCTGCTGGAATCTGCCGATATCGCCAGTAAGCACCACCTGAAAAGTCTCCTGA
TCATCGACAGCGCCCTGCGTATTACCGCGCGCGGGCGGGAGGTCACGCTGGAGTCCTTAAGCGCCAACGGCGCAGCCCTG
CTGACCACCCTGCGCCATACCCTGCCTCCAGACGTAGCCTGTACGTGCCAGCCCCACGGTTGTACGCTCACCTTTCCCGC
GCAGGACAATGAGCAGGATGAAGACAGCCGGCTGCACACCCTGTCGGTATTTGACGCCCTGCGAACTCTGCTTACCTGCC
AGCCAACGCCTGACGCCGAGCCGGAGGCCATGTTGCTCGGCGGCCTGTTCGCCTATGATCTGGTCGCTGGCTTTGAGCCC
TTGCCACAGCTCAGCGCAGGGCCGCGCTGCCCCGATCTCTGCTTTTATCTGGCCGAAACCCTACTGATCCTCGACCATCG
TCAGGGCAGCGCCCGCCTGCAGGCCAGCCTCTTCAGCGCCGCATCGGATGAGCATCAGCGCCTGCAGCGGCGTCTGGATA
CCCTGCTGACGGAGATGCTGCGCCCCTTCAAGACAGCGCCCGTTGCGCCCTGCCCGGCGTTAAAGGTCGAGGTCGATCGG
GATGATGAGGCGTTCGCTACGATCGTCCGCGACATGCAGCGCGCCATTCTCGCCGGCGACATTTTTCAGGCGGTGCCCTC
ACGCCGCTTCACACTGCCGTGTCCCGCGCCGCTGGCTGCCTACCGCCAGCTGAAGCAGAGTAATCCCAGCCCTTACATGT
TCTTCATGCAGGATCAGGACTTCACGCTGTTCGGCGCCTCGCCGGAGAGTGCCCTGAAATACGATGCCGACAGCCGACGG
GTCGAAATCTACCCCATCGCGGGCACCCGGCCGCGCGGGCGGCGCGCCGACGGCAGCATCGATCGCGATCTCGATGGCCG
GCTGGAGCTGGACATGCGCAGCGATCCCAAAGAGCTGGCCGAACACCTGATGCTGGTCGATCTGGCGCGCAACGATCTGG
CGCGGATCTGTGAGCCGGGCTCACGCTACGTCGCCGAGCTGACCAACGTGGATCGCTACTCCGTAGTGATGCATCTGGTC
TCCCGGGTCGTCGGCACCCTGCGCGCCGATCTCGACGCGCTGCATGCCTACCGTGCCTGCATGAACATGGGCACCCTGAG
CGGTGCCCCCAAAGTGCGCGCCATGCAGCTGATCGCCGCCTGCGAGCGGCGCCGGCGCGGCAGCTACGGCGGTGCCGTCG
GCTACCTGACGGCCCGCGGCGATTTGGACACCTGCATCGTTATCCGCGCCGCCTACGTAGAGGACGGCGTCGCCAGCGTA
CAGGCCGGCGCCGGCGTGGTGCTGGACTCCCAGCCTCAGGCGGAGGCCGATGAAACCCGCAGCAAGGCCCGGGCGGTGCT
GAACGCCATCGCGGCGGCGCACCCGAACGCCCCCCAGCCGCAAGGAGCGATCTGA

Upstream 100 bases:

>100_bases
CGGAATAAGCGCGCAGAAACCGTACGCCTGCGTTATTACCGCCCGCATAATGCGGGCTTTTTTATGTCCGCGCCGTGTAT
GACCGTCAGGGAGCTATTCT

Downstream 100 bases:

>100_bases
TGGCCGACGTCTTACTGCTCGACAATATTGACTCATTTACTTACAACCTGGTCGATCAGCTGCGCAGCGGCGGTCATCGG
GTGGTTATCTACCGTAACAG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MPQAKTAVTVLTRSAAYSADPTLLFEQLCAQRPATLLLESADIASKHHLKSLLIIDSALRITARGREVTLESLSANGAAL
LTTLRHTLPPDVACTCQPHGCTLTFPAQDNEQDEDSRLHTLSVFDALRTLLTCQPTPDAEPEAMLLGGLFAYDLVAGFEP
LPQLSAGPRCPDLCFYLAETLLILDHRQGSARLQASLFSAASDEHQRLQRRLDTLLTEMLRPFKTAPVAPCPALKVEVDR
DDEAFATIVRDMQRAILAGDIFQAVPSRRFTLPCPAPLAAYRQLKQSNPSPYMFFMQDQDFTLFGASPESALKYDADSRR
VEIYPIAGTRPRGRRADGSIDRDLDGRLELDMRSDPKELAEHLMLVDLARNDLARICEPGSRYVAELTNVDRYSVVMHLV
SRVVGTLRADLDALHAYRACMNMGTLSGAPKVRAMQLIAACERRRRGSYGGAVGYLTARGDLDTCIVIRAAYVEDGVASV
QAGAGVVLDSQPQAEADETRSKARAVLNAIAAAHPNAPQPQGAI

Sequences:

>Translated_524_residues
MPQAKTAVTVLTRSAAYSADPTLLFEQLCAQRPATLLLESADIASKHHLKSLLIIDSALRITARGREVTLESLSANGAAL
LTTLRHTLPPDVACTCQPHGCTLTFPAQDNEQDEDSRLHTLSVFDALRTLLTCQPTPDAEPEAMLLGGLFAYDLVAGFEP
LPQLSAGPRCPDLCFYLAETLLILDHRQGSARLQASLFSAASDEHQRLQRRLDTLLTEMLRPFKTAPVAPCPALKVEVDR
DDEAFATIVRDMQRAILAGDIFQAVPSRRFTLPCPAPLAAYRQLKQSNPSPYMFFMQDQDFTLFGASPESALKYDADSRR
VEIYPIAGTRPRGRRADGSIDRDLDGRLELDMRSDPKELAEHLMLVDLARNDLARICEPGSRYVAELTNVDRYSVVMHLV
SRVVGTLRADLDALHAYRACMNMGTLSGAPKVRAMQLIAACERRRRGSYGGAVGYLTARGDLDTCIVIRAAYVEDGVASV
QAGAGVVLDSQPQAEADETRSKARAVLNAIAAAHPNAPQPQGAI
>Mature_523_residues
PQAKTAVTVLTRSAAYSADPTLLFEQLCAQRPATLLLESADIASKHHLKSLLIIDSALRITARGREVTLESLSANGAALL
TTLRHTLPPDVACTCQPHGCTLTFPAQDNEQDEDSRLHTLSVFDALRTLLTCQPTPDAEPEAMLLGGLFAYDLVAGFEPL
PQLSAGPRCPDLCFYLAETLLILDHRQGSARLQASLFSAASDEHQRLQRRLDTLLTEMLRPFKTAPVAPCPALKVEVDRD
DEAFATIVRDMQRAILAGDIFQAVPSRRFTLPCPAPLAAYRQLKQSNPSPYMFFMQDQDFTLFGASPESALKYDADSRRV
EIYPIAGTRPRGRRADGSIDRDLDGRLELDMRSDPKELAEHLMLVDLARNDLARICEPGSRYVAELTNVDRYSVVMHLVS
RVVGTLRADLDALHAYRACMNMGTLSGAPKVRAMQLIAACERRRRGSYGGAVGYLTARGDLDTCIVIRAAYVEDGVASVQ
AGAGVVLDSQPQAEADETRSKARAVLNAIAAAHPNAPQPQGAI

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=514, Percent_Identity=68.0933852140078, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1788114, Length=365, Percent_Identity=31.7808219178082, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87082077, Length=465, Percent_Identity=25.3763440860215, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=377, Percent_Identity=36.3395225464191, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324361, Length=556, Percent_Identity=23.3812949640288, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57116; Mature: 56985

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQAKTAVTVLTRSAAYSADPTLLFEQLCAQRPATLLLESADIASKHHLKSLLIIDSALR
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHEEEECCHHHHHHHHHHHHHHHHHHE
ITARGREVTLESLSANGAALLTTLRHTLPPDVACTCQPHGCTLTFPAQDNEQDEDSRLHT
EEECCCEEEEEHHCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCCCCHHHHHH
LSVFDALRTLLTCQPTPDAEPEAMLLGGLFAYDLVAGFEPLPQLSAGPRCPDLCFYLAET
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
LLILDHRQGSARLQASLFSAASDEHQRLQRRLDTLLTEMLRPFKTAPVAPCPALKVEVDR
HHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
DDEAFATIVRDMQRAILAGDIFQAVPSRRFTLPCPAPLAAYRQLKQSNPSPYMFFMQDQD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCEEEEEECCC
FTLFGASPESALKYDADSRRVEIYPIAGTRPRGRRADGSIDRDLDGRLELDMRSDPKELA
EEEECCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
EHLMLVDLARNDLARICEPGSRYVAELTNVDRYSVVMHLVSRVVGTLRADLDALHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAACERRRRGSYGGAVGYLTARGDLDTCIVIRAAYVEDGVASV
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEHHHHCCHHHH
QAGAGVVLDSQPQAEADETRSKARAVLNAIAAAHPNAPQPQGAI
HCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PQAKTAVTVLTRSAAYSADPTLLFEQLCAQRPATLLLESADIASKHHLKSLLIIDSALR
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHEEEECCHHHHHHHHHHHHHHHHHHE
ITARGREVTLESLSANGAALLTTLRHTLPPDVACTCQPHGCTLTFPAQDNEQDEDSRLHT
EEECCCEEEEEHHCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCCCCHHHHHH
LSVFDALRTLLTCQPTPDAEPEAMLLGGLFAYDLVAGFEPLPQLSAGPRCPDLCFYLAET
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
LLILDHRQGSARLQASLFSAASDEHQRLQRRLDTLLTEMLRPFKTAPVAPCPALKVEVDR
HHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
DDEAFATIVRDMQRAILAGDIFQAVPSRRFTLPCPAPLAAYRQLKQSNPSPYMFFMQDQD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCEEEEEECCC
FTLFGASPESALKYDADSRRVEIYPIAGTRPRGRRADGSIDRDLDGRLELDMRSDPKELA
EEEECCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
EHLMLVDLARNDLARICEPGSRYVAELTNVDRYSVVMHLVSRVVGTLRADLDALHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAACERRRRGSYGGAVGYLTARGDLDTCIVIRAAYVEDGVASV
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEHHHHCCHHHH
QAGAGVVLDSQPQAEADETRSKARAVLNAIAAAHPNAPQPQGAI
HCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11371633; 4598537; 366432; 7007652 [H]