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The map label for this gene is trpC [H]

Identifier: 238919590

GI number: 238919590

Start: 1649288

End: 1650718

Strand: Reverse

Name: trpC [H]

Synonym: NT01EI_1689

Alternate gene names: 238919590

Gene position: 1650718-1649288 (Counterclockwise)

Preceding gene: 238919591

Following gene: 238919589

Centisome position: 43.3

GC content: 65.62

Gene sequence:

>1431_bases
ATGTCACCGCCCTGGCCGCCCGCGGCTGACCACACACAGCGCAAGGAGCCTATCATGACGCAACCCTCACCATTGCCCGC
CAGCCTGCTGAGCCGCATCATCGCCGATAAACGGCGCTGGATCGCCGCCCGTGAACGGCAACAGCCGCTGTCAGGCTTTC
AACCAACCCTGCAGCGCAGCGAGCGCGACTTTCACCGGGCGCTCAGCGGGACGCCACGCGCGCTGATCCTGGAGTGTAAA
AAAGCATCGCCATCGCGCGGGCTGATCCGGGCGGACTTTGATCCACAGGCTATCGCACGGGTATATCGCGATCATGCCGC
CGCCATCTCGGTCTTAACCGACGGTGACTATTTTCAGGGTGACTTCCGCTTTCTGCGCACGGTAAGTGACATTGTCACGC
AACCGGTACTGTGTAAAGACTTTATCCTCTCGCCTTACCAGGTCTATCTGGCGCGCCACTACCGCGCCGATGCCATCCTG
TTGATGCTCTCCGTACTGGACGATACGCAGTATCGTCAGCTGGCCGCCGTGGCTACGACGCTGAATATGGGGATCCTCAC
CGAGGTCAGTACCCCCACCGAAATGGCACGCGCCGTCGCGCTGGGCGCCAGGGCGATCGGCATCAATAACCGTAATCTAC
ACGATCTCAGCGTCGATCCCGGGCGCACCCGGCATCTCGCGGCGCTGGCACCGCCGGGCGCGACACTTATCGCCGAGTCC
GGTATCCGCAGCCACGCCCAAGTCCGCGATCTGGGCCGCCTGGTGCAGGGCTTTCTGATCGGCAGCGCGCTGATGTCCCA
GCCCGATCTGCGCAGCGCCGTCTGTCGTCTGCGCTTTGGCGACAATAAGGTCTGCGGCCTGACCCGCCCTGAGGACGCGG
TCAGCGCGCTGTGCGCCGGCGCCGTCTACGGCGGCCTGATCTTCGTGGCCGACTCGCCGCGCTACGTCGATATCGCCACC
GCCCGCGGCATTATCTCGGCCGCCCCGCTGCGGTACGTCGGGGTCTTTCGCGATGCCAAGCCCGCCAGCGTTGCGCTGGC
CGCAGAACGCCTGGCTCTGCACGCCGTTCAACTGCACGGCAGCGAAGATCAGGCCTACATTGATAGCCTGCGTCCGCTGT
TACCGGCGGCCTGTCGGATCTGGAAGGCGCTGCCGGTCAGCGATGCCCTGCCCACAGAGCGCCTGCGTCACGTCGATCGC
TACCTGCTTGACGGCGCCCGCCCCGGCAGCGGACGCCCCTTTGACTGGCGCCTGCTGGACGGACATCCCCTGGGCAACAT
CATGCTGGCCGGGGGGATCGGCGCCGATAACTGCCGCGCAGCGGCTGACCTCGGCGCGCTGGGTCTCGATTTTAACTCCG
CCGTGGAGTCCTCTCCCGGGCGTAAAGACCCCGGCAAACTCCGTGCGGCCTTCCAGGCGCTGCTCGCCTGA

Upstream 100 bases:

>100_bases
GCCAACGTGGCGCTGTTGCTGCGCCTGTTCGGCCAGCGCGATCTGGCTGCTAACGCCCGCCAGGCGCTGGATGTCCTGCG
CAGCGGACGGGCCTATCACT

Downstream 100 bases:

>100_bases
GACGCTACCACCGTTTTTATGACTGACAGGAAGATGACATGAGCTTACTGAATCCCTATTTCGGCGAATTTGGCGGCAGG
TTTGTGCCGCAAATTCTGAT

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSPPWPPAADHTQRKEPIMTQPSPLPASLLSRIIADKRRWIAARERQQPLSGFQPTLQRSERDFHRALSGTPRALILECK
KASPSRGLIRADFDPQAIARVYRDHAAAISVLTDGDYFQGDFRFLRTVSDIVTQPVLCKDFILSPYQVYLARHYRADAIL
LMLSVLDDTQYRQLAAVATTLNMGILTEVSTPTEMARAVALGARAIGINNRNLHDLSVDPGRTRHLAALAPPGATLIAES
GIRSHAQVRDLGRLVQGFLIGSALMSQPDLRSAVCRLRFGDNKVCGLTRPEDAVSALCAGAVYGGLIFVADSPRYVDIAT
ARGIISAAPLRYVGVFRDAKPASVALAAERLALHAVQLHGSEDQAYIDSLRPLLPAACRIWKALPVSDALPTERLRHVDR
YLLDGARPGSGRPFDWRLLDGHPLGNIMLAGGIGADNCRAAADLGALGLDFNSAVESSPGRKDPGKLRAAFQALLA

Sequences:

>Translated_476_residues
MSPPWPPAADHTQRKEPIMTQPSPLPASLLSRIIADKRRWIAARERQQPLSGFQPTLQRSERDFHRALSGTPRALILECK
KASPSRGLIRADFDPQAIARVYRDHAAAISVLTDGDYFQGDFRFLRTVSDIVTQPVLCKDFILSPYQVYLARHYRADAIL
LMLSVLDDTQYRQLAAVATTLNMGILTEVSTPTEMARAVALGARAIGINNRNLHDLSVDPGRTRHLAALAPPGATLIAES
GIRSHAQVRDLGRLVQGFLIGSALMSQPDLRSAVCRLRFGDNKVCGLTRPEDAVSALCAGAVYGGLIFVADSPRYVDIAT
ARGIISAAPLRYVGVFRDAKPASVALAAERLALHAVQLHGSEDQAYIDSLRPLLPAACRIWKALPVSDALPTERLRHVDR
YLLDGARPGSGRPFDWRLLDGHPLGNIMLAGGIGADNCRAAADLGALGLDFNSAVESSPGRKDPGKLRAAFQALLA
>Mature_475_residues
SPPWPPAADHTQRKEPIMTQPSPLPASLLSRIIADKRRWIAARERQQPLSGFQPTLQRSERDFHRALSGTPRALILECKK
ASPSRGLIRADFDPQAIARVYRDHAAAISVLTDGDYFQGDFRFLRTVSDIVTQPVLCKDFILSPYQVYLARHYRADAILL
MLSVLDDTQYRQLAAVATTLNMGILTEVSTPTEMARAVALGARAIGINNRNLHDLSVDPGRTRHLAALAPPGATLIAESG
IRSHAQVRDLGRLVQGFLIGSALMSQPDLRSAVCRLRFGDNKVCGLTRPEDAVSALCAGAVYGGLIFVADSPRYVDIATA
RGIISAAPLRYVGVFRDAKPASVALAAERLALHAVQLHGSEDQAYIDSLRPLLPAACRIWKALPVSDALPTERLRHVDRY
LLDGARPGSGRPFDWRLLDGHPLGNIMLAGGIGADNCRAAADLGALGLDFNSAVESSPGRKDPGKLRAAFQALLA

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=449, Percent_Identity=59.6881959910913, Blast_Score=545, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322638, Length=272, Percent_Identity=35.6617647058824, Blast_Score=127, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 51581; Mature: 51450

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPWPPAADHTQRKEPIMTQPSPLPASLLSRIIADKRRWIAARERQQPLSGFQPTLQRS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ERDFHRALSGTPRALILECKKASPSRGLIRADFDPQAIARVYRDHAAAISVLTDGDYFQG
HHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCH
DFRFLRTVSDIVTQPVLCKDFILSPYQVYLARHYRADAILLMLSVLDDTQYRQLAAVATT
HHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHH
LNMGILTEVSTPTEMARAVALGARAIGINNRNLHDLSVDPGRTRHLAALAPPGATLIAES
HCCCCEEECCCHHHHHHHHHHHHHEEECCCCCCEECCCCCCCCCEEEEECCCCCCEEECC
GIRSHAQVRDLGRLVQGFLIGSALMSQPDLRSAVCRLRFGDNKVCGLTRPEDAVSALCAG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCEECCCCCHHHHHHHHHH
AVYGGLIFVADSPRYVDIATARGIISAAPLRYVGVFRDAKPASVALAAERLALHAVQLHG
HHHCCEEEEECCCCEEEEHHHCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEECC
SEDQAYIDSLRPLLPAACRIWKALPVSDALPTERLRHVDRYLLDGARPGSGRPFDWRLLD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
GHPLGNIMLAGGIGADNCRAAADLGALGLDFNSAVESSPGRKDPGKLRAAFQALLA
CCCCCCEEEECCCCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
SPPWPPAADHTQRKEPIMTQPSPLPASLLSRIIADKRRWIAARERQQPLSGFQPTLQRS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ERDFHRALSGTPRALILECKKASPSRGLIRADFDPQAIARVYRDHAAAISVLTDGDYFQG
HHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCH
DFRFLRTVSDIVTQPVLCKDFILSPYQVYLARHYRADAILLMLSVLDDTQYRQLAAVATT
HHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHH
LNMGILTEVSTPTEMARAVALGARAIGINNRNLHDLSVDPGRTRHLAALAPPGATLIAES
HCCCCEEECCCHHHHHHHHHHHHHEEECCCCCCEECCCCCCCCCEEEEECCCCCCEEECC
GIRSHAQVRDLGRLVQGFLIGSALMSQPDLRSAVCRLRFGDNKVCGLTRPEDAVSALCAG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCEECCCCCHHHHHHHHHH
AVYGGLIFVADSPRYVDIATARGIISAAPLRYVGVFRDAKPASVALAAERLALHAVQLHG
HHHCCEEEEECCCCEEEEHHHCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEECC
SEDQAYIDSLRPLLPAACRIWKALPVSDALPTERLRHVDRYLLDGARPGSGRPFDWRLLD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
GHPLGNIMLAGGIGADNCRAAADLGALGLDFNSAVESSPGRKDPGKLRAAFQALLA
CCCCCCEEEECCCCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]