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The map label for this gene is nhaB

Identifier: 238919533

GI number: 238919533

Start: 1587880

End: 1589454

Strand: Reverse

Name: nhaB

Synonym: NT01EI_1629

Alternate gene names: 238919533

Gene position: 1589454-1587880 (Counterclockwise)

Preceding gene: 238919535

Following gene: 238919532

Centisome position: 41.69

GC content: 57.84

Gene sequence:

>1575_bases
ATGACAATCACATATACCCAGGCCTTCGCGAAGAACTTCCTCGGTAATGCGCCAGGCTGGTACAAAATCGCTATTCTGGC
CTTTTTAATCATCAACCCACTGGTTTTTTCCCTCAGCCCTTTCTACGCCGGCTGGCTGTTGGTGATCGAGTTTATCTTCA
CCCTGGCTATGGCGCTAAAGTGCTACCCCTTGCAACCGGGCGGCCTGTTAGCGCTGGAGGCCGTATTTATCGGAATGACC
AGCCCAGAGAAGATCGCCCATGAGGTGGCCGCTAACCTGGAAGTACTGCTGCTACTGATTTTCATGGTAGCCGGTATCTA
TTTTATGAAGCAGCTGCTGCTGTTTGTATTCACCAAGCTACTGCTTAACATCCGCTCGAAAATAGTCCTATCGCTGGCCT
TTTGTCTGGCGGCGGCGTTCCTGTCCGCCTTTCTCGATGCCCTGACGGTGATCGCCGTTGTCATCAGCGTCGCGGTGGGA
TTCTATGGCATCTATCATCAGGTCGCCTCTGGCGGTGGCAGCAACGTGGCGCTCAGCGACGATAGCCTCCTGACCGACAG
CGCCAAACGCGATGCCCTCGATCAGTTCCGCGCCTTTCTGCGCAGTCTGCTGATGCATGCCGGCGTCGGCACCGCCCTCG
GCGGCGTCATGACCATGGTCGGTGAGCCGCAGAACCTGATCATCGCCAAAAATGCCGACTGGCATTTTGTGTCGTTTCTG
CTGCGCATGGCTCCGGTTACCGTACCGGTCTTCTGCTGCGGTATCCTCACCTGTTACCTGGTCGAGCGATTTTCCCTGTT
CGGCTACGGCGCTCAACTGCCGGATCGCGTACGTCAAATCCTGCTCAACTTCGATCGGGAGAGTACCAACAGCCGCAGCC
GCCAGGATAAGCTGCGCCTGATGATACAGGCCCTGGTCGGCGTCTGGCTGGTGAGCGCACTGGCCTTCCACCTGGCTGAG
GTTGGGCTGATCGGGCTGAGCGTGATCGTACTGGTTACGTCACTGTGCGGGGTCACCGACGAGCACCTGATCGGCAAGGC
ATTTCAGGAGTCTCTACCCTTCACCGCGCTGCTCACCGTGTTCTTCTCCATCGTGGCGGTGATCATCGATCAGCACCTGT
TTACCCCGGTGATCCAGTTTGTGCTGCAGTCACCACCGGATCGTCAGCTGACCTTGTTCTATCTGTTCAACGGCCTGCTC
TCGTCGATCTCCGATAACGTCTTTGTCGGTACGGTCTACATTCACGAGGCTAAGGCGGCGCTGGAGTCTGGCGCTATCTC
CCTGAAACAGTTCGAACTGCTGGCTGTCGCCATTAACACCGGCACCAATCTGCCGTCGGTAGCGACTCCCAACGGTCAGG
CCGCGTTCCTGTTCCTGCTGACCTCCGCGCTGGCGCCGTTGATCCGTCTCTCCTATGGGCGCATGGTCTGGATGGCGCTG
CCCTATACGGTGGTGATGACGCTGGTGGGTCTGCTGTGCGTTATCTTCACGCTTGAACCGGCAACGCAGCTCATGTCCCA
GTGGCATCTACTGACCCTGCCGCCGGCCCAGGACGTACTCAGCAGCGGGCTATAA

Upstream 100 bases:

>100_bases
TATAGTCTAATAATTTCCCGGCAAAGATATTCTCCGTTCCGCTTTCTGGGATCGCAGCCGATACCGGCAAATCACATAAG
AAATCAGGTTTAACAACGTT

Downstream 100 bases:

>100_bases
CTCCCGCACGTCGCGCATTTCAGATAATTTTTTCTGGCAGTGTGCAGGCAATGGTTTACACTGATTACACCTTTTGTGAC
ATGGAAATCGGGTTATGTTG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MTITYTQAFAKNFLGNAPGWYKIAILAFLIINPLVFSLSPFYAGWLLVIEFIFTLAMALKCYPLQPGGLLALEAVFIGMT
SPEKIAHEVAANLEVLLLLIFMVAGIYFMKQLLLFVFTKLLLNIRSKIVLSLAFCLAAAFLSAFLDALTVIAVVISVAVG
FYGIYHQVASGGGSNVALSDDSLLTDSAKRDALDQFRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKNADWHFVSFL
LRMAPVTVPVFCCGILTCYLVERFSLFGYGAQLPDRVRQILLNFDRESTNSRSRQDKLRLMIQALVGVWLVSALAFHLAE
VGLIGLSVIVLVTSLCGVTDEHLIGKAFQESLPFTALLTVFFSIVAVIIDQHLFTPVIQFVLQSPPDRQLTLFYLFNGLL
SSISDNVFVGTVYIHEAKAALESGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMAL
PYTVVMTLVGLLCVIFTLEPATQLMSQWHLLTLPPAQDVLSSGL

Sequences:

>Translated_524_residues
MTITYTQAFAKNFLGNAPGWYKIAILAFLIINPLVFSLSPFYAGWLLVIEFIFTLAMALKCYPLQPGGLLALEAVFIGMT
SPEKIAHEVAANLEVLLLLIFMVAGIYFMKQLLLFVFTKLLLNIRSKIVLSLAFCLAAAFLSAFLDALTVIAVVISVAVG
FYGIYHQVASGGGSNVALSDDSLLTDSAKRDALDQFRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKNADWHFVSFL
LRMAPVTVPVFCCGILTCYLVERFSLFGYGAQLPDRVRQILLNFDRESTNSRSRQDKLRLMIQALVGVWLVSALAFHLAE
VGLIGLSVIVLVTSLCGVTDEHLIGKAFQESLPFTALLTVFFSIVAVIIDQHLFTPVIQFVLQSPPDRQLTLFYLFNGLL
SSISDNVFVGTVYIHEAKAALESGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMAL
PYTVVMTLVGLLCVIFTLEPATQLMSQWHLLTLPPAQDVLSSGL
>Mature_523_residues
TITYTQAFAKNFLGNAPGWYKIAILAFLIINPLVFSLSPFYAGWLLVIEFIFTLAMALKCYPLQPGGLLALEAVFIGMTS
PEKIAHEVAANLEVLLLLIFMVAGIYFMKQLLLFVFTKLLLNIRSKIVLSLAFCLAAAFLSAFLDALTVIAVVISVAVGF
YGIYHQVASGGGSNVALSDDSLLTDSAKRDALDQFRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKNADWHFVSFLL
RMAPVTVPVFCCGILTCYLVERFSLFGYGAQLPDRVRQILLNFDRESTNSRSRQDKLRLMIQALVGVWLVSALAFHLAEV
GLIGLSVIVLVTSLCGVTDEHLIGKAFQESLPFTALLTVFFSIVAVIIDQHLFTPVIQFVLQSPPDRQLTLFYLFNGLLS
SISDNVFVGTVYIHEAKAALESGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTVVMTLVGLLCVIFTLEPATQLMSQWHLLTLPPAQDVLSSGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=507, Percent_Identity=75.7396449704142, Blast_Score=748, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_EDWI9 (C5B9W2)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933048.1
- GeneID:   7961957
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1629
- OMA:   CFLVEKF
- ProtClustDB:   PRK09547
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 57120; Mature: 56988

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c01c160)-; HASH(0x1ce941e0)-; HASH(0x1bd726f8)-; HASH(0x4085c2e4)-; HASH(0x1cc9c0ac)-; HASH(0x1ce8bcc8)-; HASH(0x1cbe12c0)-; HASH(0x1a714214)-; HASH(0x1ce8ef9c)-; HASH(0x1ca4b6bc)-; HASH(0x1ce8bbc0)-; HASH(0x1bc6b5cc)-; HASH(0x1cc63c54)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITYTQAFAKNFLGNAPGWYKIAILAFLIINPLVFSLSPFYAGWLLVIEFIFTLAMALK
CEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
CYPLQPGGLLALEAVFIGMTSPEKIAHEVAANLEVLLLLIFMVAGIYFMKQLLLFVFTKL
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLNIRSKIVLSLAFCLAAAFLSAFLDALTVIAVVISVAVGFYGIYHQVASGGGSNVALSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
DSLLTDSAKRDALDQFRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKNADWHFVSFL
CCHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
LRMAPVTVPVFCCGILTCYLVERFSLFGYGAQLPDRVRQILLNFDRESTNSRSRQDKLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH
MIQALVGVWLVSALAFHLAEVGLIGLSVIVLVTSLCGVTDEHLIGKAFQESLPFTALLTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHH
FFSIVAVIIDQHLFTPVIQFVLQSPPDRQLTLFYLFNGLLSSISDNVFVGTVYIHEAKAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHH
LESGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMAL
HHHCCCHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYTVVMTLVGLLCVIFTLEPATQLMSQWHLLTLPPAQDVLSSGL
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCCHHHHHCCCH
>Mature Secondary Structure 
TITYTQAFAKNFLGNAPGWYKIAILAFLIINPLVFSLSPFYAGWLLVIEFIFTLAMALK
EEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCCHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA