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The map label for this gene is hexR [H]

Identifier: 238919510

GI number: 238919510

Start: 1568254

End: 1569123

Strand: Reverse

Name: hexR [H]

Synonym: NT01EI_1606

Alternate gene names: 238919510

Gene position: 1569123-1568254 (Counterclockwise)

Preceding gene: 238919518

Following gene: 238919509

Centisome position: 41.16

GC content: 55.98

Gene sequence:

>870_bases
ATGAATACGCTGGAAAAAATCCAGGCGAATCTGGATCAACTGAGTAAATCAGAACGCAAAGTCGCCGAGGTGATCCTCGC
AGTGCCGCAGACCGCCATCCACTCCAGTATCGCCACCCTGGCCAAGATGGCCGATGTCAGTGAGCCTACGGTAAACCGTT
TCTGCCGTCGGCTGGAAACGAAAGGGTTTCCGGATTTTAAACTGCATCTGGCACAGAGCCTTGCCAACGGAACCCCTTAC
GTTAACCGCAACGTTGAAGAGAACGACAGTGTCGACGCCTATACCAGCAAGATCTTCGAGTCGGCAATGGCTGGCCTGGA
GATGGCCAAAAACCACCTGGATATGGTCACCATCAACCGCGCGGTCGACCTGCTGACCCAGGCAAAGAAAATTTCTTTCT
TCGGCCTTGGCGCCTCCGCCGCCGTGGCCCATGATGCCATGAACAAATTTTTCCGCTTCAACATCCCGGTGGTCTACTTT
GACGACATCGTCATGCAGCGCATGAGCTGCATGAACTCCAACGAGGGTGATGTGGTGGTTCTGATCTCCCACACCGGGCG
TACCAAAAGTCTGGTAGAAATGGCGCACCTGGCACGGGAGAACGATGCGACGGTGATCGCCATCACCTCGCGCGACACAC
CGCTGGCCCTGGAAGCCTCTCTGGCTCTGCTGCTGGATGTGCCGGAGGATACCGATGTCTATATGCCCATGGTCTCACGT
CTGGCGCAGCTGACCCTGGTGGATGCACTGGCAACCGGCTTTACCCTGCGCCGCGGAGCGAAATTCCGGGATAACTTGAA
GCGGGTCAAGGAAGCCTTGAAGGAATCGCGCTTTGATAAAAGCATCGCCCTGCCCGCACACTTTGAGTAA

Upstream 100 bases:

>100_bases
TGGGCTGCAAAGCCGTTATCTGTCGTTGTATATTTTCAACAAACGTTCATAGATTTCTCCTCTTTATGAAATCGTCCAAC
CCCATAAGTGGCCCTCTCCT

Downstream 100 bases:

>100_bases
GGGAAGCAGCCACCCCGCCAACAGACTGAATAATACACGCCGGGCGCCTGCAGTTTAGCCAACCGGCGTCCCCCGCCGGC
GACGCTGCCAGTGGGGCTAT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNTLEKIQANLDQLSKSERKVAEVILAVPQTAIHSSIATLAKMADVSEPTVNRFCRRLETKGFPDFKLHLAQSLANGTPY
VNRNVEENDSVDAYTSKIFESAMAGLEMAKNHLDMVTINRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYF
DDIVMQRMSCMNSNEGDVVVLISHTGRTKSLVEMAHLARENDATVIAITSRDTPLALEASLALLLDVPEDTDVYMPMVSR
LAQLTLVDALATGFTLRRGAKFRDNLKRVKEALKESRFDKSIALPAHFE

Sequences:

>Translated_289_residues
MNTLEKIQANLDQLSKSERKVAEVILAVPQTAIHSSIATLAKMADVSEPTVNRFCRRLETKGFPDFKLHLAQSLANGTPY
VNRNVEENDSVDAYTSKIFESAMAGLEMAKNHLDMVTINRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYF
DDIVMQRMSCMNSNEGDVVVLISHTGRTKSLVEMAHLARENDATVIAITSRDTPLALEASLALLLDVPEDTDVYMPMVSR
LAQLTLVDALATGFTLRRGAKFRDNLKRVKEALKESRFDKSIALPAHFE
>Mature_289_residues
MNTLEKIQANLDQLSKSERKVAEVILAVPQTAIHSSIATLAKMADVSEPTVNRFCRRLETKGFPDFKLHLAQSLANGTPY
VNRNVEENDSVDAYTSKIFESAMAGLEMAKNHLDMVTINRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYF
DDIVMQRMSCMNSNEGDVVVLISHTGRTKSLVEMAHLARENDATVIAITSRDTPLALEASLALLLDVPEDTDVYMPMVSR
LAQLTLVDALATGFTLRRGAKFRDNLKRVKEALKESRFDKSIALPAHFE

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=282, Percent_Identity=79.7872340425532, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=24.5833333333333, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=27.0992366412214, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082130, Length=222, Percent_Identity=29.2792792792793, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32020; Mature: 32020

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLEKIQANLDQLSKSERKVAEVILAVPQTAIHSSIATLAKMADVSEPTVNRFCRRLET
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
KGFPDFKLHLAQSLANGTPYVNRNVEENDSVDAYTSKIFESAMAGLEMAKNHLDMVTINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYFDDIVMQRMSCMNSNEGDVVV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSLVEMAHLARENDATVIAITSRDTPLALEASLALLLDVPEDTDVYMPMVSR
EEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHCEEEEEECCCCCCHHHHHHHH
LAQLTLVDALATGFTLRRGAKFRDNLKRVKEALKESRFDKSIALPAHFE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNTLEKIQANLDQLSKSERKVAEVILAVPQTAIHSSIATLAKMADVSEPTVNRFCRRLET
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
KGFPDFKLHLAQSLANGTPYVNRNVEENDSVDAYTSKIFESAMAGLEMAKNHLDMVTINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYFDDIVMQRMSCMNSNEGDVVV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSLVEMAHLARENDATVIAITSRDTPLALEASLALLLDVPEDTDVYMPMVSR
EEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHCEEEEEECCCCCCHHHHHHHH
LAQLTLVDALATGFTLRRGAKFRDNLKRVKEALKESRFDKSIALPAHFE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]