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The map label for this gene is pheP [H]

Identifier: 238919494

GI number: 238919494

Start: 1552568

End: 1553935

Strand: Direct

Name: pheP [H]

Synonym: NT01EI_1590

Alternate gene names: 238919494

Gene position: 1552568-1553935 (Clockwise)

Preceding gene: 238919491

Following gene: 238919497

Centisome position: 40.73

GC content: 60.31

Gene sequence:

>1368_bases
ATGGGCGATTCGCAGCACATCAGTACGACTCTTGAGAGAGGATTAAAAAACCGGCATATCCAGCTGATCGCCCTGGGCGG
CGCGGTGGGCACCGGTCTGTTTCTGGGGATCGGTCCGGCCATTCAGCTGGCCGGACCGGCGGTTTTACTGGGCTATGCCA
TCGGCGGCGCAATCGCGTTTCTGATCATGCGCCAGCTGGGGGAGATGGTGGTGCAGGAGCCGGTTGCCGGTTCGTTTGCC
CACTTTGCCCATAAATATTGGGGACCGTTTGCCGGTTTTGTCTCCGGCTGGAACTATTGGGTCATGTTCGTGCTGGTCGG
CATGGCCGAGCTGACCGCGGCCGGTATCTATATGCAGTATTGGTGGCCGGATGTGCCGACCTGGATGTGGGCCAGCCTGT
TCTTTGTCCTGATCAACGCGCTGAATATGGTGAACGTGCGTCTGTACGGTGAAACCGAGTTCTGGTTCGCCCTGATCAAG
GTGGCGGCGATCCTCGGGATGATCGTGTTCGGCAGCTGGCTGCTGCTGTCCGGTGACGCCGGGCCCCAGGCGGGGCTGGC
GAATCTGTGGGTGCACGGCGGCTTTTTACCGCATGGCTGGGGGGGACTGATCATGGCGATGGCGGTGATCATGTTCTCCT
TCGGCGGCCTTGAGCTGATCGGGATCACCGCCGCGGAGGCCAGCGAGCCGGAAAAGAGCATTCCCAAGGCAACCAATCAG
GTGGTCTACCGTATCCTGATCTTTTATATCGGCTCCCTGCTGGTACTGCTGGCCCTGTACCCCTGGTCGCAGATCGGCGC
CAGCAGCAGTCCGTTTGTGATGATCTTCCATCACTTGAACAGCAACACGGTAGCGGCGGTATTGAATGTGGTGATCCTGA
CCGCCGCGCTGTCGGTATATAACAGCTGTGTCTACTCCAATAGCCGTATGCTGTACGGGCTGTCGCTGCAGGGTAATGCG
CCGCGCCGCCTGACCCGGGTCAATCGCCGCGGGATCCCGGTGTGGTCAATCGGCCTTTCGGGGCTCACGACCTCTCTGGT
GATCCTGATTAACTATCTGATGCCGGGTAAGGCGTTCGGGCTACTGATGGCGCTGGTGGTCTCTACGCTGGTGATCAACT
GGGTGATGATCTGCATGGCGCATCTGAAGTTCAGGGCGGTGCAGAATCGTCTGGGCGTGACGGCACGGTTCCGCGCGCTG
TGGTATCCCTATGGTAACTACCTGTGCCTGGCGTTTCTTGGCCTGATCTTGGTGATTATGGTGCTGACGCCGGGGATCCG
GATATCGGTGCTGCTGCTGCCGCTGTGGCTGGGCGTGCTGTGGGGCGGATTCTGCCTGGCGCGGATGCGCCGCGGAAAAT
CGGCGTAG

Upstream 100 bases:

>100_bases
GGGTGATACAAACCCATGCGCGTTGTAAACAAAATAATACGATGCGCCACGGAGACCGCAGTTAATTCAGTTGCCATGAC
GCTATCGCACAGAGGAAAAA

Downstream 100 bases:

>100_bases
TGTCACGCAAGGCGACCCGCACACAGCGGGCCGCCTTGTGGTTTAATAACCGGTCTGTAGCAACTGTCCCCAGGGCAGAT
AGTAGAGATTGGCCACCACC

Product: phenylalanine-specific permease

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MGDSQHISTTLERGLKNRHIQLIALGGAVGTGLFLGIGPAIQLAGPAVLLGYAIGGAIAFLIMRQLGEMVVQEPVAGSFA
HFAHKYWGPFAGFVSGWNYWVMFVLVGMAELTAAGIYMQYWWPDVPTWMWASLFFVLINALNMVNVRLYGETEFWFALIK
VAAILGMIVFGSWLLLSGDAGPQAGLANLWVHGGFLPHGWGGLIMAMAVIMFSFGGLELIGITAAEASEPEKSIPKATNQ
VVYRILIFYIGSLLVLLALYPWSQIGASSSPFVMIFHHLNSNTVAAVLNVVILTAALSVYNSCVYSNSRMLYGLSLQGNA
PRRLTRVNRRGIPVWSIGLSGLTTSLVILINYLMPGKAFGLLMALVVSTLVINWVMICMAHLKFRAVQNRLGVTARFRAL
WYPYGNYLCLAFLGLILVIMVLTPGIRISVLLLPLWLGVLWGGFCLARMRRGKSA

Sequences:

>Translated_455_residues
MGDSQHISTTLERGLKNRHIQLIALGGAVGTGLFLGIGPAIQLAGPAVLLGYAIGGAIAFLIMRQLGEMVVQEPVAGSFA
HFAHKYWGPFAGFVSGWNYWVMFVLVGMAELTAAGIYMQYWWPDVPTWMWASLFFVLINALNMVNVRLYGETEFWFALIK
VAAILGMIVFGSWLLLSGDAGPQAGLANLWVHGGFLPHGWGGLIMAMAVIMFSFGGLELIGITAAEASEPEKSIPKATNQ
VVYRILIFYIGSLLVLLALYPWSQIGASSSPFVMIFHHLNSNTVAAVLNVVILTAALSVYNSCVYSNSRMLYGLSLQGNA
PRRLTRVNRRGIPVWSIGLSGLTTSLVILINYLMPGKAFGLLMALVVSTLVINWVMICMAHLKFRAVQNRLGVTARFRAL
WYPYGNYLCLAFLGLILVIMVLTPGIRISVLLLPLWLGVLWGGFCLARMRRGKSA
>Mature_454_residues
GDSQHISTTLERGLKNRHIQLIALGGAVGTGLFLGIGPAIQLAGPAVLLGYAIGGAIAFLIMRQLGEMVVQEPVAGSFAH
FAHKYWGPFAGFVSGWNYWVMFVLVGMAELTAAGIYMQYWWPDVPTWMWASLFFVLINALNMVNVRLYGETEFWFALIKV
AAILGMIVFGSWLLLSGDAGPQAGLANLWVHGGFLPHGWGGLIMAMAVIMFSFGGLELIGITAAEASEPEKSIPKATNQV
VYRILIFYIGSLLVLLALYPWSQIGASSSPFVMIFHHLNSNTVAAVLNVVILTAALSVYNSCVYSNSRMLYGLSLQGNAP
RRLTRVNRRGIPVWSIGLSGLTTSLVILINYLMPGKAFGLLMALVVSTLVINWVMICMAHLKFRAVQNRLGVTARFRALW
YPYGNYLCLAFLGLILVIMVLTPGIRISVLLLPLWLGVLWGGFCLARMRRGKSA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=353, Percent_Identity=24.0793201133144, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI181337167, Length=352, Percent_Identity=25.2840909090909, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=72.2595078299776, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=65.6387665198238, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI48994972, Length=441, Percent_Identity=40.8163265306122, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=42.4507658643326, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1790653, Length=449, Percent_Identity=37.1937639198218, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=35.4347826086957, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=36.8663594470046, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI87081915, Length=438, Percent_Identity=35.1598173515982, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1788480, Length=385, Percent_Identity=37.4025974025974, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI87081869, Length=324, Percent_Identity=22.5308641975309, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082023, Length=199, Percent_Identity=26.1306532663317, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=377, Percent_Identity=21.4854111405836, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=452, Percent_Identity=32.5221238938053, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=31.8284424379233, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324924, Length=445, Percent_Identity=32.5842696629214, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324059, Length=451, Percent_Identity=35.0332594235033, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=443, Percent_Identity=33.8600451467269, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6324553, Length=392, Percent_Identity=33.6734693877551, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=407, Percent_Identity=31.6953316953317, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=447, Percent_Identity=31.7673378076063, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6321629, Length=401, Percent_Identity=30.6733167082294, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=424, Percent_Identity=31.8396226415094, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319608, Length=460, Percent_Identity=30.6521739130435, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322967, Length=434, Percent_Identity=29.4930875576037, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=28.2555282555283, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324981, Length=440, Percent_Identity=30.2272727272727, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=27.3399014778325, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=28.8557213930348, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=27.6119402985075, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=475, Percent_Identity=24.4210526315789, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24667468, Length=423, Percent_Identity=24.5862884160757, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161077963, Length=187, Percent_Identity=31.0160427807487, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24666159, Length=301, Percent_Identity=22.2591362126246, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221512776, Length=301, Percent_Identity=22.2591362126246, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49706; Mature: 49575

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDSQHISTTLERGLKNRHIQLIALGGAVGTGLFLGIGPAIQLAGPAVLLGYAIGGAIAF
CCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHH
LIMRQLGEMVVQEPVAGSFAHFAHKYWGPFAGFVSGWNYWVMFVLVGMAELTAAGIYMQY
HHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEE
WWPDVPTWMWASLFFVLINALNMVNVRLYGETEFWFALIKVAAILGMIVFGSWLLLSGDA
ECCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEECCC
GPQAGLANLWVHGGFLPHGWGGLIMAMAVIMFSFGGLELIGITAAEASEPEKSIPKATNQ
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHH
VVYRILIFYIGSLLVLLALYPWSQIGASSSPFVMIFHHLNSNTVAAVLNVVILTAALSVY
HHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
NSCVYSNSRMLYGLSLQGNAPRRLTRVNRRGIPVWSIGLSGLTTSLVILINYLMPGKAFG
HHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCHHHH
LLMALVVSTLVINWVMICMAHLKFRAVQNRLGVTARFRALWYPYGNYLCLAFLGLILVIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHH
VLTPGIRISVLLLPLWLGVLWGGFCLARMRRGKSA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GDSQHISTTLERGLKNRHIQLIALGGAVGTGLFLGIGPAIQLAGPAVLLGYAIGGAIAF
CCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHH
LIMRQLGEMVVQEPVAGSFAHFAHKYWGPFAGFVSGWNYWVMFVLVGMAELTAAGIYMQY
HHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEE
WWPDVPTWMWASLFFVLINALNMVNVRLYGETEFWFALIKVAAILGMIVFGSWLLLSGDA
ECCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEECCC
GPQAGLANLWVHGGFLPHGWGGLIMAMAVIMFSFGGLELIGITAAEASEPEKSIPKATNQ
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHH
VVYRILIFYIGSLLVLLALYPWSQIGASSSPFVMIFHHLNSNTVAAVLNVVILTAALSVY
HHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
NSCVYSNSRMLYGLSLQGNAPRRLTRVNRRGIPVWSIGLSGLTTSLVILINYLMPGKAFG
HHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCHHHH
LLMALVVSTLVINWVMICMAHLKFRAVQNRLGVTARFRALWYPYGNYLCLAFLGLILVIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHH
VLTPGIRISVLLLPLWLGVLWGGFCLARMRRGKSA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]