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The map label for this gene is tdcA [H]

Identifier: 238919381

GI number: 238919381

Start: 1448098

End: 1449024

Strand: Direct

Name: tdcA [H]

Synonym: NT01EI_1475

Alternate gene names: 238919381

Gene position: 1448098-1449024 (Clockwise)

Preceding gene: 238919378

Following gene: 238919384

Centisome position: 37.98

GC content: 52.1

Gene sequence:

>927_bases
ATGCGCTATTTGCCAAAAATACAACAGCTGAAGGTGTTTAATGAGGTTATTCGCAGCGGAAGCATCCGGGCGGCGGCGCG
TAAAATGGATCAGTCTCAGCCTGCTTTAACCCGTACACTCAAAGAGTTAGAACACCATATGGGAGCAATGCTGCTGATCC
GCAGCAACGAGGGAGTGACCCTGACTGACGCCGGAAAATCCTTTGCCATCCGGGCACATTTGATCTTGGAGGAGCTGGAA
AAGGCGGCAGAGGAGGTGGAGCAAATAACCAAAAATGGCCATGGACATGTCGCTTTCGGTATTTCCTCTTTATTCGGGGT
GACAGTGTTAAATAAAGTGTTGAATGATTTTAAACAGGGATTTCCGGCTACCGTAATTAATGTTAAGGAAGCGCAGCTTT
CTACCTTGTTACCCAGTTTACGTGATGGAAGACTCGATTTCGCGCTGGGGACATTGACAGATGAGATGCCGCTGGGGGAC
TTTATTTCTATTCCCCTGTTCGATGCGCCATTTTGTATTGTTGCCAGAAAAGATCATCCGTTAGCCACTTGTTCAGCGCT
GGAGGGGTTACGCCAGGCGAAGTGGGTAATGCCGGAAACGGATATGGGATATTATCATAACATCCGGCATATTATTCCCT
TTGACCACCCGGATAATCCACACTATCCCATTCTGACGGACTCCACGGTGTGCATCATGAATCTGGTGATGCACGGTGAC
TACCTGACCATCCTGTCGCGTGCACGCCTGCGCGAGGCCCGTTTCGGTGGCGTACTGACGGCGCTGCCCATCGGGCTGCA
GTTCCTGCCGGTGGGGCACTATGGCTTGATCTATCCGCGAAAACGCCCGCTGACGCAGGCCTCACAGGCGCTGGTGGAAC
AGTTTCGCTGGCACTGTCGGCATCATGACTGGCAGCACCCGCAGTGA

Upstream 100 bases:

>100_bases
ATAAAGCCAGTGTCATGACTATTGATTTAACGCAAAAATTGATGGCAGGGTAATATGCTATTAGTTTCACGATGATAAAA
AAAACTGATAGGGTGGAGCG

Downstream 100 bases:

>100_bases
CGGGCGCTGTCACACTTTTTGCAGGAGGCGATATGGACTTTTCCACCGCATATCACAGGTTCCGGCAGAGTCTGGACGGC
ACGGACAGCGGCATGACCCC

Product: hypothetical protein

Products: NA

Alternate protein names: Tdc operon transcriptional activator [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRYLPKIQQLKVFNEVIRSGSIRAAARKMDQSQPALTRTLKELEHHMGAMLLIRSNEGVTLTDAGKSFAIRAHLILEELE
KAAEEVEQITKNGHGHVAFGISSLFGVTVLNKVLNDFKQGFPATVINVKEAQLSTLLPSLRDGRLDFALGTLTDEMPLGD
FISIPLFDAPFCIVARKDHPLATCSALEGLRQAKWVMPETDMGYYHNIRHIIPFDHPDNPHYPILTDSTVCIMNLVMHGD
YLTILSRARLREARFGGVLTALPIGLQFLPVGHYGLIYPRKRPLTQASQALVEQFRWHCRHHDWQHPQ

Sequences:

>Translated_308_residues
MRYLPKIQQLKVFNEVIRSGSIRAAARKMDQSQPALTRTLKELEHHMGAMLLIRSNEGVTLTDAGKSFAIRAHLILEELE
KAAEEVEQITKNGHGHVAFGISSLFGVTVLNKVLNDFKQGFPATVINVKEAQLSTLLPSLRDGRLDFALGTLTDEMPLGD
FISIPLFDAPFCIVARKDHPLATCSALEGLRQAKWVMPETDMGYYHNIRHIIPFDHPDNPHYPILTDSTVCIMNLVMHGD
YLTILSRARLREARFGGVLTALPIGLQFLPVGHYGLIYPRKRPLTQASQALVEQFRWHCRHHDWQHPQ
>Mature_308_residues
MRYLPKIQQLKVFNEVIRSGSIRAAARKMDQSQPALTRTLKELEHHMGAMLLIRSNEGVTLTDAGKSFAIRAHLILEELE
KAAEEVEQITKNGHGHVAFGISSLFGVTVLNKVLNDFKQGFPATVINVKEAQLSTLLPSLRDGRLDFALGTLTDEMPLGD
FISIPLFDAPFCIVARKDHPLATCSALEGLRQAKWVMPETDMGYYHNIRHIIPFDHPDNPHYPILTDSTVCIMNLVMHGD
YLTILSRARLREARFGGVLTALPIGLQFLPVGHYGLIYPRKRPLTQASQALVEQFRWHCRHHDWQHPQ

Specific function: Transcriptional activator for the tdcABCDE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789506, Length=310, Percent_Identity=35.8064516129032, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1787601, Length=299, Percent_Identity=32.4414715719064, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1790399, Length=299, Percent_Identity=26.7558528428094, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788481, Length=261, Percent_Identity=24.904214559387, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788887, Length=248, Percent_Identity=28.6290322580645, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788748, Length=200, Percent_Identity=27.5, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=262, Percent_Identity=25.1908396946565, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693105, Length=183, Percent_Identity=25.1366120218579, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787879, Length=306, Percent_Identity=25.1633986928105, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788297, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI157672245, Length=243, Percent_Identity=23.8683127572016, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786401, Length=174, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI2367136, Length=218, Percent_Identity=26.1467889908257, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787949, Length=176, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790262, Length=177, Percent_Identity=24.2937853107345, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34752; Mature: 34752

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPKIQQLKVFNEVIRSGSIRAAARKMDQSQPALTRTLKELEHHMGAMLLIRSNEGVT
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCEE
LTDAGKSFAIRAHLILEELEKAAEEVEQITKNGHGHVAFGISSLFGVTVLNKVLNDFKQG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
FPATVINVKEAQLSTLLPSLRDGRLDFALGTLTDEMPLGDFISIPLFDAPFCIVARKDHP
CCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCC
LATCSALEGLRQAKWVMPETDMGYYHNIRHIIPFDHPDNPHYPILTDSTVCIMNLVMHGD
CHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCCCCCCCCCEECCCHHHHHHHHHCCC
YLTILSRARLREARFGGVLTALPIGLQFLPVGHYGLIYPRKRPLTQASQALVEQFRWHCR
HHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHC
HHDWQHPQ
CCCCCCCC
>Mature Secondary Structure
MRYLPKIQQLKVFNEVIRSGSIRAAARKMDQSQPALTRTLKELEHHMGAMLLIRSNEGVT
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCEE
LTDAGKSFAIRAHLILEELEKAAEEVEQITKNGHGHVAFGISSLFGVTVLNKVLNDFKQG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
FPATVINVKEAQLSTLLPSLRDGRLDFALGTLTDEMPLGDFISIPLFDAPFCIVARKDHP
CCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCC
LATCSALEGLRQAKWVMPETDMGYYHNIRHIIPFDHPDNPHYPILTDSTVCIMNLVMHGD
CHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCCCCCCCCCEECCCHHHHHHHHHCCC
YLTILSRARLREARFGGVLTALPIGLQFLPVGHYGLIYPRKRPLTQASQALVEQFRWHCR
HHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHC
HHDWQHPQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]