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The map label for this gene is gne [H]

Identifier: 238919226

GI number: 238919226

Start: 1300239

End: 1301210

Strand: Direct

Name: gne [H]

Synonym: NT01EI_1309

Alternate gene names: 238919226

Gene position: 1300239-1301210 (Clockwise)

Preceding gene: 238919225

Following gene: 238919227

Centisome position: 34.11

GC content: 41.05

Gene sequence:

>972_bases
ATGAAATTAGCAATCATTGGCGGTTCTGGTTTTATCGGTACGCGTCTGGCTACGCAGTTAAAAAATAATAATGTTGAATT
TACTATTGTTGATAAACGAAACAGCGAAACGTTTCCGGAGTGTTGGCAATATGGAGATGTTACTAAGCCTGAATCACTTG
AAGAACCATTGAAAGGCGCAGATGTCATCATTAATCTCGCCGCAGAGCACAAAGATAATGTCCATCCAATCAGCCTTTAC
TATGATGTAAATGTCCAAGGTGCTAAAAATGTTTGTGATGTCGCTGAAAAGCTAAACATACAACATATTGTATTTACTTC
ATCAGTTGCAGTTTATGGTTTTGTGGAAAAAGAAACCGGAGAAGATGGGAAGTATAATCCTTTCAATGATTATGGTAAGT
CAAAATTAGAGGCTGAGTTTGCGTATGATGCCTGGCAAGCGAAAGTACCAGAGAGAACATTGGTAACAGTCAGACCAACC
GTTGTCTTCGGTGAAAATAATCGCGGGAACGTATATAACTTATTCCGCCAGATAGCATCAGGTAAGTTTTTGATGATTGG
CCCAGGGCTGAATCAAAAATCAATGGCGTATGTTGAAAATATGGCCGCCTTCTTGAGGTTTTCGACCACGATGGGAGCGG
GGCGTCATGTTTTTAACTATATAGATAAACCAGACTTTAGTATGAATGATTTAACTGGGGTGATTTGTACAGCATTACAT
CGCCATAAAAACAATATTCGTATTCCTTATGCGGTTGGCCTGTTAGGTGGCTATTGCTTCGATATCCTGGCAAAGGTTAC
CGGTCGAGAGTTCCCCGTAAGCAGCATTCGTGTGAAGAAGTTTTGTGCTCGTACTCAGTTTAAGTCAAACCATATCGCGC
AAACGGGATTTAAAGCGCCGGTAACGTTAGAGCAGGGTATCGCCAATACGGTTCGTTACGAGTTTTTGGAGAAGCATGAT
GACAAGTCTTAA

Upstream 100 bases:

>100_bases
TTGAATATGATAAATATTTTTCATCTGCTCAGGTTGTAAGCGGTTGCTTTGATATAAACAATCTTGCTGAAAAATATATT
GAATTAATTGAGGGTGATAA

Downstream 100 bases:

>100_bases
AGCCGTTATCCCCGTCGCCGGACTGGGGATGAAGATGTTGCCGGCCACCAAGGCCATCCCGAAAGAGATGCTGCCCATTG
TTGATAAGCCGCTGATTCAG

Product: UDP-N-acetylglucosamine 4-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc 4-epimerase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKLAIIGGSGFIGTRLATQLKNNNVEFTIVDKRNSETFPECWQYGDVTKPESLEEPLKGADVIINLAAEHKDNVHPISLY
YDVNVQGAKNVCDVAEKLNIQHIVFTSSVAVYGFVEKETGEDGKYNPFNDYGKSKLEAEFAYDAWQAKVPERTLVTVRPT
VVFGENNRGNVYNLFRQIASGKFLMIGPGLNQKSMAYVENMAAFLRFSTTMGAGRHVFNYIDKPDFSMNDLTGVICTALH
RHKNNIRIPYAVGLLGGYCFDILAKVTGREFPVSSIRVKKFCARTQFKSNHIAQTGFKAPVTLEQGIANTVRYEFLEKHD
DKS

Sequences:

>Translated_323_residues
MKLAIIGGSGFIGTRLATQLKNNNVEFTIVDKRNSETFPECWQYGDVTKPESLEEPLKGADVIINLAAEHKDNVHPISLY
YDVNVQGAKNVCDVAEKLNIQHIVFTSSVAVYGFVEKETGEDGKYNPFNDYGKSKLEAEFAYDAWQAKVPERTLVTVRPT
VVFGENNRGNVYNLFRQIASGKFLMIGPGLNQKSMAYVENMAAFLRFSTTMGAGRHVFNYIDKPDFSMNDLTGVICTALH
RHKNNIRIPYAVGLLGGYCFDILAKVTGREFPVSSIRVKKFCARTQFKSNHIAQTGFKAPVTLEQGIANTVRYEFLEKHD
DKS
>Mature_323_residues
MKLAIIGGSGFIGTRLATQLKNNNVEFTIVDKRNSETFPECWQYGDVTKPESLEEPLKGADVIINLAAEHKDNVHPISLY
YDVNVQGAKNVCDVAEKLNIQHIVFTSSVAVYGFVEKETGEDGKYNPFNDYGKSKLEAEFAYDAWQAKVPERTLVTVRPT
VVFGENNRGNVYNLFRQIASGKFLMIGPGLNQKSMAYVENMAAFLRFSTTMGAGRHVFNYIDKPDFSMNDLTGVICTALH
RHKNNIRIPYAVGLLGGYCFDILAKVTGREFPVSSIRVKKFCARTQFKSNHIAQTGFKAPVTLEQGIANTVRYEFLEKHD
DKS

Specific function: Converts UDP-GlcNAc to UDP-GalNAc. Essential for O antigen synthesis [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI193211614, Length=267, Percent_Identity=28.0898876404494, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI8393516, Length=267, Percent_Identity=28.0898876404494, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321437, Length=346, Percent_Identity=28.0346820809249, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.7 [H]

Molecular weight: Translated: 36160; Mature: 36160

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAIIGGSGFIGTRLATQLKNNNVEFTIVDKRNSETFPECWQYGDVTKPESLEEPLKGA
CEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHCCCC
DVIINLAAEHKDNVHPISLYYDVNVQGAKNVCDVAEKLNIQHIVFTSSVAVYGFVEKETG
EEEEEEEHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCEEEEEEEECCCC
EDGKYNPFNDYGKSKLEAEFAYDAWQAKVPERTLVTVRPTVVFGENNRGNVYNLFRQIAS
CCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHC
GKFLMIGPGLNQKSMAYVENMAAFLRFSTTMGAGRHVFNYIDKPDFSMNDLTGVICTALH
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
RHKNNIRIPYAVGLLGGYCFDILAKVTGREFPVSSIRVKKFCARTQFKSNHIAQTGFKAP
HCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCC
VTLEQGIANTVRYEFLEKHDDKS
CCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLAIIGGSGFIGTRLATQLKNNNVEFTIVDKRNSETFPECWQYGDVTKPESLEEPLKGA
CEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHCCCC
DVIINLAAEHKDNVHPISLYYDVNVQGAKNVCDVAEKLNIQHIVFTSSVAVYGFVEKETG
EEEEEEEHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCEEEEEEEECCCC
EDGKYNPFNDYGKSKLEAEFAYDAWQAKVPERTLVTVRPTVVFGENNRGNVYNLFRQIAS
CCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHC
GKFLMIGPGLNQKSMAYVENMAAFLRFSTTMGAGRHVFNYIDKPDFSMNDLTGVICTALH
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
RHKNNIRIPYAVGLLGGYCFDILAKVTGREFPVSSIRVKKFCARTQFKSNHIAQTGFKAP
HCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCC
VTLEQGIANTVRYEFLEKHDDKS
CCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11976290; 11206551; 11258796 [H]