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The map label for this gene is hda [H]

Identifier: 238919123

GI number: 238919123

Start: 1188103

End: 1188819

Strand: Direct

Name: hda [H]

Synonym: NT01EI_1194

Alternate gene names: 238919123

Gene position: 1188103-1188819 (Clockwise)

Preceding gene: 238919122

Following gene: 238919126

Centisome position: 31.16

GC content: 59.55

Gene sequence:

>717_bases
ATGTCTGAGGTGAATCTGAACACGCCCACCCAGCTTTCATTGCCGCTCTATCTGCCCGACGATGAAACCTTTTCCAGTTT
CTACGCGGGGGAGAATGCCGCGCTGCTCGCTGCGTTGCAGAATGCGTTACGTCAAGAGCACGGATCCTATATCTATTTCT
GGTCACGCGAGGGCGGCGGGCGCAGCCATCTGCTGCATGCGGCCTGCGCCGAGCTATCGCAGCGTGGTGAGGCGGTCGGG
TTTGTGCCGCTCGATAAGCGGGCCTACTTTGTGCCTGAAGTCCTGGATGGCATGGAGCAACTGGCGCTGGTCTGTATTGA
TAATATTGAATGTATCGCCGGCGATGGGGCCTGGGAGATGGCCATCTTCAATCTGTATAACCGCATTCAGGAGAGCGGGC
GCACCCGCCTGCTGATCACCGGCGATCGTCCGCCGCGTCAGCTCAATCTGCGTCTGCCCGATCTGGCCTCGCGCCTGGAT
TGGGGGCAGATTTATAAGCTGCAGCCGCTGGGAGATGAAGAGAAGCTGCAGGCACTGCAGCTGCGCGCCCGCCTACGAGG
CTTTGAGCTGCCGGAGGACGTGGGGCGTTTCCTGCTGAAGCGTCTGGATCGTGAGATGCGCACCCTGTTTATGACCCTGG
ATCAGCTCGATCGGGCCTCTATCGCCGCCCAGCGTAAGCTGACCATCCCCTTCGTTAAAGAGACGCTGCTGCTGTAA

Upstream 100 bases:

>100_bases
CGGCGTGGGTAGCCTGGGCGTGGGTTTTTAGTGCAGCGGCGTGATTAGCGCATGCCTGTGCTCATTTCTGTGTTAAACTG
AAAAAGTTTTTTGCAAGTTT

Downstream 100 bases:

>100_bases
CCGTGCGGCGGTCTATGTTGCGCGCCGGGCTTGCCCGGCGCCAACGCCGTTTACAGAATCTCCAGCACTTGCTGTGGCGG
GCGGCCCAGGCGCGCCCGTA

Product: DNA replication initiation factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSEVNLNTPTQLSLPLYLPDDETFSSFYAGENAALLAALQNALRQEHGSYIYFWSREGGGRSHLLHAACAELSQRGEAVG
FVPLDKRAYFVPEVLDGMEQLALVCIDNIECIAGDGAWEMAIFNLYNRIQESGRTRLLITGDRPPRQLNLRLPDLASRLD
WGQIYKLQPLGDEEKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASIAAQRKLTIPFVKETLLL

Sequences:

>Translated_238_residues
MSEVNLNTPTQLSLPLYLPDDETFSSFYAGENAALLAALQNALRQEHGSYIYFWSREGGGRSHLLHAACAELSQRGEAVG
FVPLDKRAYFVPEVLDGMEQLALVCIDNIECIAGDGAWEMAIFNLYNRIQESGRTRLLITGDRPPRQLNLRLPDLASRLD
WGQIYKLQPLGDEEKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASIAAQRKLTIPFVKETLLL
>Mature_237_residues
SEVNLNTPTQLSLPLYLPDDETFSSFYAGENAALLAALQNALRQEHGSYIYFWSREGGGRSHLLHAACAELSQRGEAVGF
VPLDKRAYFVPEVLDGMEQLALVCIDNIECIAGDGAWEMAIFNLYNRIQESGRTRLLITGDRPPRQLNLRLPDLASRLDW
GQIYKLQPLGDEEKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASIAAQRKLTIPFVKETLLL

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=233, Percent_Identity=86.6952789699571, Blast_Score=419, Evalue=1e-119,
Organism=Escherichia coli, GI2367267, Length=247, Percent_Identity=25.1012145748988, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 27036; Mature: 26905

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVNLNTPTQLSLPLYLPDDETFSSFYAGENAALLAALQNALRQEHGSYIYFWSREGGG
CCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCC
RSHLLHAACAELSQRGEAVGFVPLDKRAYFVPEVLDGMEQLALVCIDNIECIAGDGAWEM
HHHHHHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHCCCEEEECCCHHHH
AIFNLYNRIQESGRTRLLITGDRPPRQLNLRLPDLASRLDWGQIYKLQPLGDEEKLQALQ
HHHHHHHHHHHCCCEEEEEECCCCCCEEEEECHHHHHHCCCCCEEEECCCCCHHHHHHHH
LRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASIAAQRKLTIPFVKETLLL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
SEVNLNTPTQLSLPLYLPDDETFSSFYAGENAALLAALQNALRQEHGSYIYFWSREGGG
CCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCC
RSHLLHAACAELSQRGEAVGFVPLDKRAYFVPEVLDGMEQLALVCIDNIECIAGDGAWEM
HHHHHHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHCCCEEEECCCHHHH
AIFNLYNRIQESGRTRLLITGDRPPRQLNLRLPDLASRLDWGQIYKLQPLGDEEKLQALQ
HHHHHHHHHHHCCCEEEEEECCCCCCEEEEECHHHHHHCCCCCEEEECCCCCHHHHHHHH
LRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASIAAQRKLTIPFVKETLLL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA