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The map label for this gene is hemH

Identifier: 238919056

GI number: 238919056

Start: 1121357

End: 1122325

Strand: Direct

Name: hemH

Synonym: NT01EI_1124

Alternate gene names: 238919056

Gene position: 1121357-1122325 (Clockwise)

Preceding gene: 238919055

Following gene: 238919057

Centisome position: 29.41

GC content: 63.67

Gene sequence:

>969_bases
ATGATGGCAGAAAAACATGGGGTACTGCTGGTGAATCTGGGCACACCGTCGGCGGCGACGCCTGCGGCGGTCAAGGCCTA
CCTGGCGGAGTTTCTTAGCGATCGGCGGGTGGTGGATCTGCCATCCTGGCAGTGGCAGCCGCTGCTGCGTGGGCTTATCC
TGCCGCGCCGGGCGCCGCGGGTCGCCCGTCTGTATCAGTCTATCTGGACGGCGCAGGGGTCGCCGCTGTTGTACTATAGC
CAACGCCTGTGCGACGGGCTGCAGGCGCGTCTGGGCGAGGCGATCCCGGTTGTGCTGGGTATGAGCTACGGTGAGCCGTC
GCTGGACCGCGCGCTGTCCGCGCTGTCCGACGCGGGGGTGACCCAGCTGACGGTGGTTCCGCTGTATCCACAGTACTCCT
GTTCGACCAGCGCCGCCGTGTTTGACGGTGTGGCGGCCTGGCTGGCACGGCAGCGGTGTATACCGGCACTGCGCTTCGTG
CGCGACTACGCGCAGCACCCGGCCTATATTGCCGCGCTGTGTCAGCGTATCCGCTGCAGCATAGCTGAACACGGACAGCC
TGACATATTGCTGTTTTCCTACCACGGCATTCCGCAGCGCTATGCCGCTGAAGGGGATGATTATCCGCAACGCTGCCTGG
CGACCACGCAGGCGGTGGTTCAGGCGTTAGGGCTGATGCCGTCCCAGTATGCCGTCAGCTTTCAGTCGCGCTTTGGCCGG
GAGCCTTGGCTGACACCCTATACCGATGAGACCGTGGTCGCCCTGGCCACCGGTGGTGTGCGTCATTTGCAAGTGATTTG
TCCCGGTTTTGCCGCCGATTGCCTGGAGACGCTGGAGGAGATCGCGGTACAGAATCGTGAGGCCTTTTTGGCTGCTGGCG
GCCACCATTTTGCCTATATTCCGGCGCTGAACGATGACGACATGCAGATAACGCTGCTGCAGCAGCTGGTCGCGGCGACG
CCAGCGTAG

Upstream 100 bases:

>100_bases
TTGTCGCCGTTATCCGGGGTGCTCGGCCGATGTCAGCGATTGGTGGGACGCCGCCGTTTATCCTTTACAATAGGGGTAAG
CGAATGGGGGGAGCGAAGAG

Downstream 100 bases:

>100_bases
GATGCCCGCTGACGAGGCCGGGGGGAGTGTGCTATTCTAGCCCGCTCCCTTTTCTTTTTGCCGATAACTCAGATGAAATT
CCCCGGTCAACGCAAGTCTA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MMAEKHGVLLVNLGTPSAATPAAVKAYLAEFLSDRRVVDLPSWQWQPLLRGLILPRRAPRVARLYQSIWTAQGSPLLYYS
QRLCDGLQARLGEAIPVVLGMSYGEPSLDRALSALSDAGVTQLTVVPLYPQYSCSTSAAVFDGVAAWLARQRCIPALRFV
RDYAQHPAYIAALCQRIRCSIAEHGQPDILLFSYHGIPQRYAAEGDDYPQRCLATTQAVVQALGLMPSQYAVSFQSRFGR
EPWLTPYTDETVVALATGGVRHLQVICPGFAADCLETLEEIAVQNREAFLAAGGHHFAYIPALNDDDMQITLLQQLVAAT
PA

Sequences:

>Translated_322_residues
MMAEKHGVLLVNLGTPSAATPAAVKAYLAEFLSDRRVVDLPSWQWQPLLRGLILPRRAPRVARLYQSIWTAQGSPLLYYS
QRLCDGLQARLGEAIPVVLGMSYGEPSLDRALSALSDAGVTQLTVVPLYPQYSCSTSAAVFDGVAAWLARQRCIPALRFV
RDYAQHPAYIAALCQRIRCSIAEHGQPDILLFSYHGIPQRYAAEGDDYPQRCLATTQAVVQALGLMPSQYAVSFQSRFGR
EPWLTPYTDETVVALATGGVRHLQVICPGFAADCLETLEEIAVQNREAFLAAGGHHFAYIPALNDDDMQITLLQQLVAAT
PA
>Mature_322_residues
MMAEKHGVLLVNLGTPSAATPAAVKAYLAEFLSDRRVVDLPSWQWQPLLRGLILPRRAPRVARLYQSIWTAQGSPLLYYS
QRLCDGLQARLGEAIPVVLGMSYGEPSLDRALSALSDAGVTQLTVVPLYPQYSCSTSAAVFDGVAAWLARQRCIPALRFV
RDYAQHPAYIAALCQRIRCSIAEHGQPDILLFSYHGIPQRYAAEGDDYPQRCLATTQAVVQALGLMPSQYAVSFQSRFGR
EPWLTPYTDETVVALATGGVRHLQVICPGFAADCLETLEEIAVQNREAFLAAGGHHFAYIPALNDDDMQITLLQQLVAAT
PA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=302, Percent_Identity=26.8211920529801, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI60499025, Length=302, Percent_Identity=26.8211920529801, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786681, Length=319, Percent_Identity=59.8746081504702, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324750, Length=290, Percent_Identity=26.2068965517241, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17864156, Length=293, Percent_Identity=28.6689419795222, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=29.8850574712644, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45552018, Length=126, Percent_Identity=29.3650793650794, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_EDWI9 (C5BD17)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932570.1
- GeneID:   7960709
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1124
- OMA:   GLPERHL
- ProtClustDB:   CLSK2812966
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35258; Mature: 35258

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAEKHGVLLVNLGTPSAATPAAVKAYLAEFLSDRRVVDLPSWQWQPLLRGLILPRRAPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCHH
VARLYQSIWTAQGSPLLYYSQRLCDGLQARLGEAIPVVLGMSYGEPSLDRALSALSDAGV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCC
TQLTVVPLYPQYSCSTSAAVFDGVAAWLARQRCIPALRFVRDYAQHPAYIAALCQRIRCS
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IAEHGQPDILLFSYHGIPQRYAAEGDDYPQRCLATTQAVVQALGLMPSQYAVSFQSRFGR
HHHCCCCCEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
EPWLTPYTDETVVALATGGVRHLQVICPGFAADCLETLEEIAVQNREAFLAAGGHHFAYI
CCCCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHEEEECCCCEEEE
PALNDDDMQITLLQQLVAATPA
ECCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MMAEKHGVLLVNLGTPSAATPAAVKAYLAEFLSDRRVVDLPSWQWQPLLRGLILPRRAPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCHH
VARLYQSIWTAQGSPLLYYSQRLCDGLQARLGEAIPVVLGMSYGEPSLDRALSALSDAGV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCC
TQLTVVPLYPQYSCSTSAAVFDGVAAWLARQRCIPALRFVRDYAQHPAYIAALCQRIRCS
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IAEHGQPDILLFSYHGIPQRYAAEGDDYPQRCLATTQAVVQALGLMPSQYAVSFQSRFGR
HHHCCCCCEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
EPWLTPYTDETVVALATGGVRHLQVICPGFAADCLETLEEIAVQNREAFLAAGGHHFAYI
CCCCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHEEEECCCCEEEE
PALNDDDMQITLLQQLVAATPA
ECCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA