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The map label for this gene is adk

Identifier: 238919055

GI number: 238919055

Start: 1120571

End: 1121215

Strand: Direct

Name: adk

Synonym: NT01EI_1123

Alternate gene names: 238919055

Gene position: 1120571-1121215 (Clockwise)

Preceding gene: 238919054

Following gene: 238919056

Centisome position: 29.39

GC content: 57.05

Gene sequence:

>645_bases
ATGCGTATTATTCTGCTGGGCGCTCCGGGCGCCGGTAAGGGCACACAGGCACAGTTTATCATGGAGAAATACGGTATTCC
GCAGATCTCCACCGGTGACATGCTACGCGCTGCGGTGAAGGCAGGCAGTGAGCTGGGCAAACAGGCTAAAGCGATCATGG
ACGCCGGTAAGCTGGTGACCGATGAGCTGGTTATCGCGCTGGTCAAAGAGCGTATCGCTCAGGAAGATTGCCACAACGGT
TTTCTGCTCGATGGTTTCCCGCGCACCATTCCGCAGGCGGATGCCATGAAAGAGGCCGGGATCAACGTCGATTATGTTCT
GGAGTTTGCCGTACCGGACGAACTGATCGTCGATCGCATCATTGGCCGTCGCGTTCACCCGGGATCCGGGCGGGTTTATC
ACGTTAAGTTCAACCCGCCGCAGGTTGAAGGTAAGGATGACGTGACCGGTGAAGATCTGATGACCCGTAAGGACGATCAG
GAAGAGACCGTGCGTAAGCGTCTGGTTGAATACCATCAGCAGACCGCGCCGCTGATTGGCTACTATGGCCAGGAAGCGCA
GGCGGGCAATACCCGCTATGTGAAGATCGATGGTACCCAGAGCGTCGATAGCGTGCGCGCCGAGCTGGAAAACGTGCTGG
GCTAA

Upstream 100 bases:

>100_bases
ACGCTTCAGCCATATGGCGTTGCCTTGAGCCGGTGCCCGTTATAATGGTAAGGTTTAGCGTTTTTTAAATCTTAGGTAAT
AATTTGAGGGGAATTACGCG

Downstream 100 bases:

>100_bases
TGCCGAAAGCCACGCGATGAAGCGGCCGATGGGCCGCTTTTTTGTCGCCGTTATCCGGGGTGCTCGGCCGATGTCAGCGA
TTGGTGGGACGCCGCCGTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKAIMDAGKLVTDELVIALVKERIAQEDCHNG
FLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRIIGRRVHPGSGRVYHVKFNPPQVEGKDDVTGEDLMTRKDDQ
EETVRKRLVEYHQQTAPLIGYYGQEAQAGNTRYVKIDGTQSVDSVRAELENVLG

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKAIMDAGKLVTDELVIALVKERIAQEDCHNG
FLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRIIGRRVHPGSGRVYHVKFNPPQVEGKDDVTGEDLMTRKDDQ
EETVRKRLVEYHQQTAPLIGYYGQEAQAGNTRYVKIDGTQSVDSVRAELENVLG
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKAIMDAGKLVTDELVIALVKERIAQEDCHNG
FLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRIIGRRVHPGSGRVYHVKFNPPQVEGKDDVTGEDLMTRKDDQ
EETVRKRLVEYHQQTAPLIGYYGQEAQAGNTRYVKIDGTQSVDSVRAELENVLG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=50.2347417840376, Blast_Score=217, Evalue=7e-57,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=50.2347417840376, Blast_Score=217, Evalue=7e-57,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=45.1612903225806, Blast_Score=167, Evalue=5e-42,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=41.2087912087912, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=41.2087912087912, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=41.2087912087912, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=41.2087912087912, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=33.6538461538462, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=29.0322580645161, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=30.1369863013699, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=30.1075268817204, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=28.021978021978, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI237858799, Length=147, Percent_Identity=27.2108843537415, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=88.785046728972, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=47.2477064220183, Blast_Score=210, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17537943, Length=190, Percent_Identity=32.6315789473684, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=207, Percent_Identity=34.7826086956522, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=31.5217391304348, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=219, Percent_Identity=44.7488584474886, Blast_Score=202, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=42.2680412371134, Blast_Score=148, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=27.1028037383178, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=46.2616822429907, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=45.0549450549451, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=45.0549450549451, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=32.5966850828729, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=32.5966850828729, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=26.9767441860465, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=26.9767441860465, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_EDWI9 (C5BD16)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932569.1
- GeneID:   7960708
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1123
- OMA:   RTYHVKY
- ProtClustDB:   CLSK2812965
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23493; Mature: 23493

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKAIMDAGKLVT
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DELVIALVKERIAQEDCHNGFLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRI
HHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHH
IGRRVHPGSGRVYHVKFNPPQVEGKDDVTGEDLMTRKDDQEETVRKRLVEYHQQTAPLIG
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
YYGQEAQAGNTRYVKIDGTQSVDSVRAELENVLG
ECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKAIMDAGKLVT
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DELVIALVKERIAQEDCHNGFLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRI
HHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHH
IGRRVHPGSGRVYHVKFNPPQVEGKDDVTGEDLMTRKDDQEETVRKRLVEYHQQTAPLIG
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
YYGQEAQAGNTRYVKIDGTQSVDSVRAELENVLG
ECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA