Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 238919014

GI number: 238919014

Start: 1076622

End: 1078976

Strand: Direct

Name: lon [H]

Synonym: NT01EI_1081

Alternate gene names: 238919014

Gene position: 1076622-1078976 (Clockwise)

Preceding gene: 238919012

Following gene: 238919015

Centisome position: 28.24

GC content: 56.9

Gene sequence:

>2355_bases
ATGAATCCTGAGCGTTCCGAACGCATAGAAATCCCCGTATTGCCGCTGCGCGATGTGGTGGTTTATCCGCATATGGTGAT
TCCGTTGTTTGTAGGCCGGGAAAAATCGATCCGTTGCCTGGAAGCCGCAATGGATCACGATAAGAAGATCATGCTGGTGG
CACAGAAAGAGGCCTCGACCGATGAGCCGGGGATCAGCGATCTGTTTACGGTCGGTACGGTGGCCTCCATTCTGCAGATG
TTGAAGCTGCCCGATGGTACGGTAAAAGTACTGGTAGAAGGGATCCAGCGTGCGCGTATTACCACGCTGTCTGACGGCGG
CGAACACTTTGCGGCTCAGGCTGAGTACCTGGATACGCCGGAGATGGATGAGCGCGAGCAAGAAGTTTTGGTCCGCACCG
CCATCAATCAGTTTGAAGGCTATATCAAGCTGAACAAAAAAATTCCGCCGGAGGTGCTGACGTCGCTGAACAGCATCGAC
GATGCTGCCCGTCTGGCCGATACCATTGCTGCCCATATGCCGCTGAAGCTGAACGATAAACAGACGGTGCTGGAGATGTC
CGACGTGGCGGAGCGTCTGGAATACCTGATGGCGATGATGGAGTCCGAGATCGATCTGCTGCAGGTGGAAAAGCGCATCC
GTAACCGGGTGAAGAAGCAGATGGAGAAGAGCCAGCGCGAGTACTATCTGAATGAGCAGATGAAGGCGATTCAGAAAGAG
CTCGGCGAAATGGACGATGCACCGGATGAGTTTGAGGCCCTGAAGCGCAAGATCGAAGCGGCCAAAATGCCGAAAGAGGC
GCGCGCAAAGGCGGAGTCCGAGCTGCAGAAGCTGAAGATGATGTCGCCGATGTCAGCGGAAGCTACCGTGGTACGCAGCT
ACATCGACTGGATTGTACAGGTACCGTGGCACGCTCGCAGCAAGGTGAAAAAAGATCTGTGCAAGGCGCAGGAGACGCTG
GACGCCGACCACTATGGCCTTGAGCGGGTCAAGGATCGCATCCTGGAATACCTGGCGGTACAGAGCCGGGTCAGCAAAAT
TAAAGGGCCGATCCTATGTCTGGTTGGACCGCCGGGGGTAGGTAAAACCTCGCTGGGGCAATCTATCGCCCGGGCGACCG
GACGTCAGTATGTACGTATGGCGTTGGGCGGGGTACGCGACGAGGCGGAGATCCGTGGTCACCGTCGGACCTATATCGGG
TCTATGCCGGGTAAACTGATCCAGAAGATGGCTAAAGTGGGAGTTCGTAACCCGCTGTTCCTGTTAGATGAAATCGATAA
AATGTCCTCTGACATGCGCGGCGATCCGGCCTCGGCCCTGCTGGAGGTCCTAGATCCGGAGCAGAATGTCGCCTTTAACG
ATCACTATCTGGAAGTGGACTACGATCTGTCCGATGTAATGTTCGTCGCCACCTCTAACTCCATGAATATTCCGGCGCCG
CTGCTGGACCGTATGGAGGTGATTCGCCTGTCCGGCTATACCGAAGACGAGAAGCTTAACATTGCCCGCCAGCACCTGCT
GCCGAAGCAGATTGAGCGTAATGCGCTGAAGAAAGGCGAGTTAACGGTGGATGATAGCGCTATTATCGGGATTATTCGCT
ATTACACCCGTGAGGCCGGGGTGCGCGCGCTGGAGCGTGAAATCTCCAAGCTGTGTCGTAAGGCGGTGAAACAGCTGCTA
CTGGATAAGTCGCTGCGCCATATTGTGATCAATGGCGATAGCCTGAAAGACTATCTGGGCGTTCAGCGCTGTGATTATGG
CCGTGCCGACAGCGAAAACCGCGTAGGTCAGGTCACCGGCCTGGCTTGGACCGAGGTGGGTGGTGATCTGCTGACCATTG
AAACCGCCTGTGTCCCGGGTAAGGGAAAACTGACCTATACCGGCTCACTGGGAGAGGTGATGCAGGAGTCGATTCAGGCG
GCGTTGACCGTGGTGCGCGCGCGCGCTGACAAGCTGGGGATCAACCCGGACTTCTATGAGAAGCGCGATATCCACGTGCA
CGTACCGGAGGGGGCGACCCCGAAAGATGGCCCGAGCGCCGGTATTGCCATGTGTACGGCGCTGGTCTCCTGCCTGACCG
GTAATCCGGTGCGCGCCGATGTGGCGATGACTGGGGAGATTACGCTGCGAGGTCAGGTACTGCCGATCGGCGGGCTGAAG
GAGAAGCTGCTGGCGGCCCACCGTGGTGGGATTAAGACCGTGCTGATCCCGGACGACAACAAGCGTGATCTGGAGGAGAT
GCCGGAGAACGTTCTGCGCGATCTCGATATCCATCCGGTGAAGTGGATCGATGAGGTTTTGGCCCTGGCGCTGCAGAGTT
CCCCGTTTGGGATGGACGTTGTTACGGCAAAATAG

Upstream 100 bases:

>100_bases
TCCCCATATACTCAGATAATCCTCTGGCGAAGCAGCCGTTGTCCGTTGTGCGGTGCTGTTTCTCCATAACCTGGCGGAAG
CTAAACAAAGAGAGAGCTCT

Downstream 100 bases:

>100_bases
TGATATATCGCAAAATACGTTGATAAAACACCGGCTGGCAGCGTATTTCGGGCTTGCCAGCCTTTTTTTGTACGGCTAAC
GTAGAACTCTGTCAGCCGTA

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGISDLFTVGTVASILQM
LKLPDGTVKVLVEGIQRARITTLSDGGEHFAAQAEYLDTPEMDEREQEVLVRTAINQFEGYIKLNKKIPPEVLTSLNSID
DAARLADTIAAHMPLKLNDKQTVLEMSDVAERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDEFEALKRKIEAAKMPKEARAKAESELQKLKMMSPMSAEATVVRSYIDWIVQVPWHARSKVKKDLCKAQETL
DADHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIARATGRQYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVRNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIARQHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRALEREISKLCRKAVKQLL
LDKSLRHIVINGDSLKDYLGVQRCDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPDDNKRDLEEMPENVLRDLDIHPVKWIDEVLALALQSSPFGMDVVTAK

Sequences:

>Translated_784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGISDLFTVGTVASILQM
LKLPDGTVKVLVEGIQRARITTLSDGGEHFAAQAEYLDTPEMDEREQEVLVRTAINQFEGYIKLNKKIPPEVLTSLNSID
DAARLADTIAAHMPLKLNDKQTVLEMSDVAERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDEFEALKRKIEAAKMPKEARAKAESELQKLKMMSPMSAEATVVRSYIDWIVQVPWHARSKVKKDLCKAQETL
DADHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIARATGRQYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVRNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIARQHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRALEREISKLCRKAVKQLL
LDKSLRHIVINGDSLKDYLGVQRCDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPDDNKRDLEEMPENVLRDLDIHPVKWIDEVLALALQSSPFGMDVVTAK
>Mature_784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGISDLFTVGTVASILQM
LKLPDGTVKVLVEGIQRARITTLSDGGEHFAAQAEYLDTPEMDEREQEVLVRTAINQFEGYIKLNKKIPPEVLTSLNSID
DAARLADTIAAHMPLKLNDKQTVLEMSDVAERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDEFEALKRKIEAAKMPKEARAKAESELQKLKMMSPMSAEATVVRSYIDWIVQVPWHARSKVKKDLCKAQETL
DADHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIARATGRQYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVRNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIARQHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRALEREISKLCRKAVKQLL
LDKSLRHIVINGDSLKDYLGVQRCDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPDDNKRDLEEMPENVLRDLDIHPVKWIDEVLALALQSSPFGMDVVTAK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=777, Percent_Identity=37.5804375804376, Blast_Score=501, Evalue=1e-141,
Organism=Homo sapiens, GI21396489, Length=624, Percent_Identity=40.8653846153846, Blast_Score=494, Evalue=1e-139,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=92.7295918367347, Blast_Score=1470, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=663, Percent_Identity=40.7239819004525, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=547, Percent_Identity=38.9396709323583, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=677, Percent_Identity=39.7341211225997, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=45.1510333863275, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=629, Percent_Identity=45.1510333863275, Blast_Score=530, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87413; Mature: 87413

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01046 LON_SER ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST
CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DEPGISDLFTVGTVASILQMLKLPDGTVKVLVEGIQRARITTLSDGGEHFAAQAEYLDTP
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCC
EMDEREQEVLVRTAINQFEGYIKLNKKIPPEVLTSLNSIDDAARLADTIAAHMPLKLNDK
CCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCH
QTVLEMSDVAERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEMDDAPDEFEALKRKIEAAKMPKEARAKAESELQKLKMMSPMSAEATVVRSYIDWIVQ
HCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWHARSKVKKDLCKAQETLDADHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIARATGRQYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVRNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIARQHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
VRALEREISKLCRKAVKQLLLDKSLRHIVINGDSLKDYLGVQRCDYGRADSENRVGQVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEEC
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYE
EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH
EKLLAAHRGGIKTVLIPDDNKRDLEEMPENVLRDLDIHPVKWIDEVLALALQSSPFGMDV
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEE
VTAK
EECC
>Mature Secondary Structure
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST
CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DEPGISDLFTVGTVASILQMLKLPDGTVKVLVEGIQRARITTLSDGGEHFAAQAEYLDTP
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCC
EMDEREQEVLVRTAINQFEGYIKLNKKIPPEVLTSLNSIDDAARLADTIAAHMPLKLNDK
CCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCH
QTVLEMSDVAERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEMDDAPDEFEALKRKIEAAKMPKEARAKAESELQKLKMMSPMSAEATVVRSYIDWIVQ
HCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWHARSKVKKDLCKAQETLDADHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIARATGRQYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVRNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIARQHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
VRALEREISKLCRKAVKQLLLDKSLRHIVINGDSLKDYLGVQRCDYGRADSENRVGQVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEEC
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYE
EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH
EKLLAAHRGGIKTVLIPDDNKRDLEEMPENVLRDLDIHPVKWIDEVLALALQSSPFGMDV
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEE
VTAK
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA