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The map label for this gene is clpP

Identifier: 238919011

GI number: 238919011

Start: 1074323

End: 1074943

Strand: Direct

Name: clpP

Synonym: NT01EI_1078

Alternate gene names: 238919011

Gene position: 1074323-1074943 (Clockwise)

Preceding gene: 238919010

Following gene: 238919012

Centisome position: 28.18

GC content: 54.91

Gene sequence:

>621_bases
ATGTCATACAGTGACCAGCGTGAGTTAGCACCGCACATGGCATTGGTGCCCATGGTTGTTGAGCAGACTTCGCGCGGCGA
GCGTTCATACGATATTTTTTCCCGTCTGCTCAAAGAACGCATTATCTTTCTGACAGGGCAGGTCGAGGACCATATGGCCA
ACCTGATCGTGGCCCAGATGCTGTTCCTGGAAGCAGAAAATCCGGAGAAAGATATCCACTTATATATCAACTCACCGGGT
GGGGTGATCACCGCCGGGATGTCCATCTATGACACCATGCAGTTTATTAAACCGGATGTCAGTACCATCTGTATGGGACA
GGCCTGCTCAATGGGGTCATTCCTGTTGGCGGCTGGCGCGCAGGGTAAACGTTTCTGTCTGCCGAACTCCCGGGTGATGA
TCCATCAGCCGTTGGGCGGCTTCCAGGGGCAGGCGACCGATATTGAGATCCATGCCAAAGAGATCCTCAGCATCAAGGCG
CGCATGAATACCCTGATGGCCAAGCACTCCGGGCAGCCGATTGAGGTTATTGAGCGCGATACCGAGCGCGATCGTTTCAT
GTCTGCACAGGACGCGGTGGAGTACGGCCTGGTTGATGCCGTATTGACCCAGCGCGCCTGA

Upstream 100 bases:

>100_bases
GGACGGCAGGAGAGGGCCCGATTGCGCATAGTCAATCTGGCCTATCTCAAGTAGAATCAAAACGTACTACTGCTGAAGAG
ATTTCTATAGGAGACGGTTA

Downstream 100 bases:

>100_bases
TTTGTGCGGCGAACCGACCCTCATGCTGCCTGTCTGGCCATTCGCCGATATACTATAGTGATGCAAAGCGCCCCCGGGCG
CTTTCGTTCGGATATCGCTG

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSYSDQRELAPHMALVPMVVEQTSRGERSYDIFSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAENPEKDIHLYINSPG
GVITAGMSIYDTMQFIKPDVSTICMGQACSMGSFLLAAGAQGKRFCLPNSRVMIHQPLGGFQGQATDIEIHAKEILSIKA
RMNTLMAKHSGQPIEVIERDTERDRFMSAQDAVEYGLVDAVLTQRA

Sequences:

>Translated_206_residues
MSYSDQRELAPHMALVPMVVEQTSRGERSYDIFSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAENPEKDIHLYINSPG
GVITAGMSIYDTMQFIKPDVSTICMGQACSMGSFLLAAGAQGKRFCLPNSRVMIHQPLGGFQGQATDIEIHAKEILSIKA
RMNTLMAKHSGQPIEVIERDTERDRFMSAQDAVEYGLVDAVLTQRA
>Mature_205_residues
SYSDQRELAPHMALVPMVVEQTSRGERSYDIFSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAENPEKDIHLYINSPGG
VITAGMSIYDTMQFIKPDVSTICMGQACSMGSFLLAAGAQGKRFCLPNSRVMIHQPLGGFQGQATDIEIHAKEILSIKAR
MNTLMAKHSGQPIEVIERDTERDRFMSAQDAVEYGLVDAVLTQRA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=57.8947368421053, Blast_Score=243, Evalue=9e-65,
Organism=Escherichia coli, GI1786641, Length=206, Percent_Identity=84.9514563106796, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=51.3089005235602, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=60.2094240837696, Blast_Score=251, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_EDWI9 (C5BCJ6)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932525.1
- GeneID:   7960664
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1078
- OMA:   KFGLVDN
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22952; Mature: 22821

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 110-110 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSDQRELAPHMALVPMVVEQTSRGERSYDIFSRLLKERIIFLTGQVEDHMANLIVAQM
CCCCCCHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHHHH
LFLEAENPEKDIHLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQACSMGSFLLAAGA
HHHHCCCCCCEEEEEEECCCCEEEECHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHCCC
QGKRFCLPNSRVMIHQPLGGFQGQATDIEIHAKEILSIKARMNTLMAKHSGQPIEVIERD
CCCEEECCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
TERDRFMSAQDAVEYGLVDAVLTQRA
CHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYSDQRELAPHMALVPMVVEQTSRGERSYDIFSRLLKERIIFLTGQVEDHMANLIVAQM
CCCCCHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHHHH
LFLEAENPEKDIHLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQACSMGSFLLAAGA
HHHHCCCCCCEEEEEEECCCCEEEECHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHCCC
QGKRFCLPNSRVMIHQPLGGFQGQATDIEIHAKEILSIKARMNTLMAKHSGQPIEVIERD
CCCEEECCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
TERDRFMSAQDAVEYGLVDAVLTQRA
CHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA