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The map label for this gene is murC

Identifier: 238917838

GI number: 238917838

Start: 1986447

End: 1987826

Strand: Direct

Name: murC

Synonym: EUBELI_01919

Alternate gene names: 238917838

Gene position: 1986447-1987826 (Clockwise)

Preceding gene: 238917829

Following gene: 238917839

Centisome position: 92.64

GC content: 40.0

Gene sequence:

>1380_bases
ATGTACAAGATTGATTTCAACAACCCTATCCATATTCACTTCATTGGCATAGGTGGTATAAGTATGAGTGGGCTTGCCAA
GATTCTTTTATCTAAAGGTTTTTCTGTTTCAGGTTCCGATTCACACTCATCAGCACTTACTGACGAACTCATTGGGGACG
GATGTCTGGTATCTGTTCCACAAAGTGCCGGTAACATAACTAATGATATAGATCTTGTTGTATATACAGCAGCAATTCAT
CCTGATAATCCAGAATTCAAGGCAGCTAAAGAAGCAGGACTTCCTATGCTTACCCGTGCAGAGCTTCTTGGCCAGATTAT
GACCGTCTATAAGAATGCAATTAATATTGCCGGTACTCATGGAAAGACAACAACTACTTCCATGGTCTCTGAGATACTGC
TTGCTGCCAGCATGGATCCTACTATATCTGTGGGCGGTATACTTAACAGCATTGGTGGCAACACCAGAGTAGGCGGTGAT
AATTATTTTGTAGCAGAAGCCTGCGAATATACTAACAGCTTTTTATCATTTAATCCAACTATGAACATTATTCTCAATGT
CAAGGAAGATCATCTTGATTTCTTCAAGGATATTGATGATATCCGTCATTCTTTTAAGCTTTTTACTGAAAAGCTGCCTT
CTGACGGAACTCTTATCATCAACACTGACATTGATAATTATGAATATTTCTATCAGGATACTGACTGCGAGGTCATTACA
TTTGGCTCTGACCCTGCAAAGAGCATGTACAGTGCTTCTGATATCGCTTATGACGAGCTTGGAAGATGCACTTATTCTCT
TCTTATTAATGGAGAGAAGGCTGACACTATAACTCTTGGTGTACCGGGGCTTCACAATGTTTACAATTCTCTTGCTGCTA
TTGCCGCTACAAGAAAGCTATCTGTTGATATGGAGCATATCAAGGCAGGTCTTTCTAACTTTAAGGGTACTAACAGAAGA
TTTGAGAAGAAAGGCACATTTAACGGTGTTACTGTCATTGATGATTATGCCCATCACCCTGATGAAATCCGTGCTACTTT
AAGTTCTGCCGCACACTATCCACATAACCGTGTATGGGTAGTTTTCCAGCCTCATACATATTCGCGTACGAAGCTTTTAT
TTAATGAGTTTGCTGATGCATTAAGCCACGCTGACAAAGTTGTCCTCGCCAAGATATACGCTGCAAGAGAGACTGATACG
CTTGGAATCAGCTCTGCTGACCTGTGCGAGAAGATTAAATCTCTCGGTAAGGAATGTGTATACATTGACAATTTTGAGGA
CATTGAAAAATATTTATTAAAAAATTGTATCAACGGTGACTTGTTAATAACTATGGGGGCCGGTGACATATATAAAGTCG
GTGAGGACTTGCTTAAATAG

Upstream 100 bases:

>100_bases
ACATTTTCTAAATCGTATATTATATAATAAGAAAGGTTTGAAAAATAAGCCGATAAGACATACAATATAACAAACAATAA
TTTCAAGGAAGGAAAATATC

Downstream 100 bases:

>100_bases
TCGGTTTTCCACCTGCCTGAATTTTTTCAACAAAGTTATCCACATTATCCACAATTTTCTGTTACTTAATTGTGCAGAAT
GGTTGTGGATAATTTTTTAT

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MYKIDFNNPIHIHFIGIGGISMSGLAKILLSKGFSVSGSDSHSSALTDELIGDGCLVSVPQSAGNITNDIDLVVYTAAIH
PDNPEFKAAKEAGLPMLTRAELLGQIMTVYKNAINIAGTHGKTTTTSMVSEILLAASMDPTISVGGILNSIGGNTRVGGD
NYFVAEACEYTNSFLSFNPTMNIILNVKEDHLDFFKDIDDIRHSFKLFTEKLPSDGTLIINTDIDNYEYFYQDTDCEVIT
FGSDPAKSMYSASDIAYDELGRCTYSLLINGEKADTITLGVPGLHNVYNSLAAIAATRKLSVDMEHIKAGLSNFKGTNRR
FEKKGTFNGVTVIDDYAHHPDEIRATLSSAAHYPHNRVWVVFQPHTYSRTKLLFNEFADALSHADKVVLAKIYAARETDT
LGISSADLCEKIKSLGKECVYIDNFEDIEKYLLKNCINGDLLITMGAGDIYKVGEDLLK

Sequences:

>Translated_459_residues
MYKIDFNNPIHIHFIGIGGISMSGLAKILLSKGFSVSGSDSHSSALTDELIGDGCLVSVPQSAGNITNDIDLVVYTAAIH
PDNPEFKAAKEAGLPMLTRAELLGQIMTVYKNAINIAGTHGKTTTTSMVSEILLAASMDPTISVGGILNSIGGNTRVGGD
NYFVAEACEYTNSFLSFNPTMNIILNVKEDHLDFFKDIDDIRHSFKLFTEKLPSDGTLIINTDIDNYEYFYQDTDCEVIT
FGSDPAKSMYSASDIAYDELGRCTYSLLINGEKADTITLGVPGLHNVYNSLAAIAATRKLSVDMEHIKAGLSNFKGTNRR
FEKKGTFNGVTVIDDYAHHPDEIRATLSSAAHYPHNRVWVVFQPHTYSRTKLLFNEFADALSHADKVVLAKIYAARETDT
LGISSADLCEKIKSLGKECVYIDNFEDIEKYLLKNCINGDLLITMGAGDIYKVGEDLLK
>Mature_459_residues
MYKIDFNNPIHIHFIGIGGISMSGLAKILLSKGFSVSGSDSHSSALTDELIGDGCLVSVPQSAGNITNDIDLVVYTAAIH
PDNPEFKAAKEAGLPMLTRAELLGQIMTVYKNAINIAGTHGKTTTTSMVSEILLAASMDPTISVGGILNSIGGNTRVGGD
NYFVAEACEYTNSFLSFNPTMNIILNVKEDHLDFFKDIDDIRHSFKLFTEKLPSDGTLIINTDIDNYEYFYQDTDCEVIT
FGSDPAKSMYSASDIAYDELGRCTYSLLINGEKADTITLGVPGLHNVYNSLAAIAATRKLSVDMEHIKAGLSNFKGTNRR
FEKKGTFNGVTVIDDYAHHPDEIRATLSSAAHYPHNRVWVVFQPHTYSRTKLLFNEFADALSHADKVVLAKIYAARETDT
LGISSADLCEKIKSLGKECVYIDNFEDIEKYLLKNCINGDLLITMGAGDIYKVGEDLLK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=34.341252699784, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=26.6666666666667, Blast_Score=162, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_EUBE2 (C4Z4L9)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002931355.1
- ProteinModelPortal:   C4Z4L9
- GeneID:   7957660
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01919
- OMA:   YQPHRYS
- ProtClustDB:   CLSK2505997
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50225; Mature: 50225

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKIDFNNPIHIHFIGIGGISMSGLAKILLSKGFSVSGSDSHSSALTDELIGDGCLVSVP
CEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECC
QSAGNITNDIDLVVYTAAIHPDNPEFKAAKEAGLPMLTRAELLGQIMTVYKNAINIAGTH
CCCCCCCCCCEEEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECCC
GKTTTTSMVSEILLAASMDPTISVGGILNSIGGNTRVGGDNYFVAEACEYTNSFLSFNPT
CCCHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCEECCCCEEEEHHHHHCCCCEEECCC
MNIILNVKEDHLDFFKDIDDIRHSFKLFTEKLPSDGTLIINTDIDNYEYFYQDTDCEVIT
EEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCEEEE
FGSDPAKSMYSASDIAYDELGRCTYSLLINGEKADTITLGVPGLHNVYNSLAAIAATRKL
ECCCCHHHHHHHHCCCHHHHCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHH
SVDMEHIKAGLSNFKGTNRRFEKKGTFNGVTVIDDYAHHPDEIRATLSSAAHYPHNRVWV
CCCHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEE
VFQPHTYSRTKLLFNEFADALSHADKVVLAKIYAARETDTLGISSADLCEKIKSLGKECV
EECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEE
YIDNFEDIEKYLLKNCINGDLLITMGAGDIYKVGEDLLK
EECCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MYKIDFNNPIHIHFIGIGGISMSGLAKILLSKGFSVSGSDSHSSALTDELIGDGCLVSVP
CEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECC
QSAGNITNDIDLVVYTAAIHPDNPEFKAAKEAGLPMLTRAELLGQIMTVYKNAINIAGTH
CCCCCCCCCCEEEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECCC
GKTTTTSMVSEILLAASMDPTISVGGILNSIGGNTRVGGDNYFVAEACEYTNSFLSFNPT
CCCHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCEECCCCEEEEHHHHHCCCCEEECCC
MNIILNVKEDHLDFFKDIDDIRHSFKLFTEKLPSDGTLIINTDIDNYEYFYQDTDCEVIT
EEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCEEEE
FGSDPAKSMYSASDIAYDELGRCTYSLLINGEKADTITLGVPGLHNVYNSLAAIAATRKL
ECCCCHHHHHHHHCCCHHHHCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHH
SVDMEHIKAGLSNFKGTNRRFEKKGTFNGVTVIDDYAHHPDEIRATLSSAAHYPHNRVWV
CCCHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEE
VFQPHTYSRTKLLFNEFADALSHADKVVLAKIYAARETDTLGISSADLCEKIKSLGKECV
EECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEE
YIDNFEDIEKYLLKNCINGDLLITMGAGDIYKVGEDLLK
EECCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA