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The map label for this gene is uvrB [H]

Identifier: 238917729

GI number: 238917729

Start: 1869784

End: 1871853

Strand: Reverse

Name: uvrB [H]

Synonym: EUBELI_01809

Alternate gene names: 238917729

Gene position: 1871853-1869784 (Counterclockwise)

Preceding gene: 238917730

Following gene: 238917728

Centisome position: 87.3

GC content: 41.45

Gene sequence:

>2070_bases
ATGTTTGTTCTGTACTTTTTGGCTGTTATATTGTATAATGAGAAAAATGTTGGAAAACAAGGAGGGATTATGGACAGATT
TGTATTACATTCGGATTTTAAGCCTATGGGCGACCAGCCGCAGGCTATTGAAGCACTTACAAAGGGCTTTGAGGAAGGCA
ATCAGTTTGAGACTCTAGTTGGTGTAACTGGTTCTGGTAAAACATTTACAATGGCGAACATTATACAGAATGTTCAGAAA
CCTACACTTATTATAAGCCATAATAAGACACTGGCAGCGCAGTTGTATGGGGAGATGAAGGAGTTCTTTCCAGAGAATGC
GGTTGAGTACTTTGTCTCCTATTATGATTATTACCAGCCAGAGGCCTATGTACCTCAGAGTGACACTTATATTGCGAAGG
ATTCATCTATTAATGATGAAATTGATAAATTAAGACATTCGGCAACAGCGGCACTTTCTGAAAGAAATGATGTTATTATC
GTTGCTTCGGTTTCATGTATATATGGATTAGGTGCGCCGGTTGATTATAAGAACATGGTTATTTCACTTCGTCCGGGAAT
GGAGAAGGACAGGGATGATTGCATAAGAAAGCTTATTGATATCCAGTATGTAAGGAACGACCAGGATTTTAAGCGAGGAA
CCTTCAGGGTAAGAGGCGATGTTGTTGAAGTGTATCCTTCATCATCATCAGGTGATGCCATAAGAGTTGAATTCTTTGGT
GATGAAGTGGACAGAATAAGTGAGATAGATTCCCTTACAGGCGAAGTTAAAGGCGTTCTTGAACATATTGCGATATTCCC
TAACTCACATTATGTTGTTGAGAAGGAGAAGATGGACGCTGCTATTGAGAACATCAAGGCAGAGCTTGCCGAGAGAGTGA
AGTATTTCAAGAGTGAGGATAAGCTTTTAGAGGCACAGAGAATTGAAGAGAGAACGAATTTTGATATAGAGATGATGCAG
GAGACAGGCTTTTGTTCAGGAATAGAGAATTATTCAAGACATCTGGCAGGACTTCCGGCAGGGTGTCCTCCGTATACGCT
GATGGATTATTTTCCAGATGATTTTCTTATTATTGTGGATGAGTCGCATATCACTATTCCGCAGATTCGAGGCATGTATG
CCGGTGACCAGTCAAGAAAGACTACGCTTGTAGATTATGGCTTCAGACTGCCATCTGCGAAGGACAACAGACCGCTTAAT
TTCAGCGAGTTTGAGAGCAAGATTTCACAGATGCTTTTCGTATCAGCAACACCAAGCACATACGAGGCAGAGCATGAGCT
TATGAGAACTGAGCAGGTTATCAGACCTACCGGACTTCTTGACCCGGAGATAACTGTTAAGCCGATTGAAGGACAGATTG
ATGACCTTATATCTGAGATTAACAAGGAAACTGCCAAGAAGAACAAGGTGCTTGTTACTACACTTACCAAGAGAATGGCG
GAGGACCTTACTGATTATCTTAAAGAGGCAGGAATCCGGGTTAAATATCTTCATGCAGATATTGATACGCTTGAGCGTCA
GAAGATTATAAGAGATATGCGTCTTGATGGTTTTGATGTTCTTGTCGGAATCAACCTGCTGCGAGAAGGTCTGGATATTC
CTGAAATCAGCCTTGTTGCAATACTTGATGCTGATAAGGAAGGCTTCTTAAGAACAGAGACATCGCTTATACAGACGATT
GGCCGGGCTGCGAGAAATGCAGAGGGACATGTTATCATGTATGCAGACAAGATTACTGAATCTATGGAAAAGGCTATTTC
AGAGACTGAACGAAGAAGAAAGATTCAGCAGGATTATAATGATGAGCATGGAATTACTCCACAGACAATCAAGAAGGCAG
TAAGAGATCTTATAAGCATAAGCAAGGCAGCGGAGCCGGGTGACGCTTCAGGAAAGCTTAAGGTTGATTATGAATCTATG
AGCATCAAAGAGCTTGAGAAAGTTAAGACGCAGGTTGAGAAGAACATGCGTAAGGCAGCAGCAGAGCTTAACTTTGAGGA
GGCTGCACAGCTTCGTGACAAGATGATTGAGATTAATAAATATATTTATGAAGGAAAGAAACATGGCTGA

Upstream 100 bases:

>100_bases
GCAGTTGAAGGCAGCAGTAGAGTATCTCAATGGGAAAATGAGTGTCAGCGCGGCAGAATAAAGATTATAGAAGTATGGAA
TAAAGTACAGGACAAATCGA

Downstream 100 bases:

>100_bases
TAGTAAGTTAAAGAAAGAGATTGAAAGAGGCAGTTATAAGAACTGTATAAGGATAAAGGGCGCAAGAGAGCATAATCTTA
AGGGAATAGACGTTGATATT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MFVLYFLAVILYNEKNVGKQGGIMDRFVLHSDFKPMGDQPQAIEALTKGFEEGNQFETLVGVTGSGKTFTMANIIQNVQK
PTLIISHNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPQSDTYIAKDSSINDEIDKLRHSATAALSERNDVII
VASVSCIYGLGAPVDYKNMVISLRPGMEKDRDDCIRKLIDIQYVRNDQDFKRGTFRVRGDVVEVYPSSSSGDAIRVEFFG
DEVDRISEIDSLTGEVKGVLEHIAIFPNSHYVVEKEKMDAAIENIKAELAERVKYFKSEDKLLEAQRIEERTNFDIEMMQ
ETGFCSGIENYSRHLAGLPAGCPPYTLMDYFPDDFLIIVDESHITIPQIRGMYAGDQSRKTTLVDYGFRLPSAKDNRPLN
FSEFESKISQMLFVSATPSTYEAEHELMRTEQVIRPTGLLDPEITVKPIEGQIDDLISEINKETAKKNKVLVTTLTKRMA
EDLTDYLKEAGIRVKYLHADIDTLERQKIIRDMRLDGFDVLVGINLLREGLDIPEISLVAILDADKEGFLRTETSLIQTI
GRAARNAEGHVIMYADKITESMEKAISETERRRKIQQDYNDEHGITPQTIKKAVRDLISISKAAEPGDASGKLKVDYESM
SIKELEKVKTQVEKNMRKAAAELNFEEAAQLRDKMIEINKYIYEGKKHG

Sequences:

>Translated_689_residues
MFVLYFLAVILYNEKNVGKQGGIMDRFVLHSDFKPMGDQPQAIEALTKGFEEGNQFETLVGVTGSGKTFTMANIIQNVQK
PTLIISHNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPQSDTYIAKDSSINDEIDKLRHSATAALSERNDVII
VASVSCIYGLGAPVDYKNMVISLRPGMEKDRDDCIRKLIDIQYVRNDQDFKRGTFRVRGDVVEVYPSSSSGDAIRVEFFG
DEVDRISEIDSLTGEVKGVLEHIAIFPNSHYVVEKEKMDAAIENIKAELAERVKYFKSEDKLLEAQRIEERTNFDIEMMQ
ETGFCSGIENYSRHLAGLPAGCPPYTLMDYFPDDFLIIVDESHITIPQIRGMYAGDQSRKTTLVDYGFRLPSAKDNRPLN
FSEFESKISQMLFVSATPSTYEAEHELMRTEQVIRPTGLLDPEITVKPIEGQIDDLISEINKETAKKNKVLVTTLTKRMA
EDLTDYLKEAGIRVKYLHADIDTLERQKIIRDMRLDGFDVLVGINLLREGLDIPEISLVAILDADKEGFLRTETSLIQTI
GRAARNAEGHVIMYADKITESMEKAISETERRRKIQQDYNDEHGITPQTIKKAVRDLISISKAAEPGDASGKLKVDYESM
SIKELEKVKTQVEKNMRKAAAELNFEEAAQLRDKMIEINKYIYEGKKHG
>Mature_689_residues
MFVLYFLAVILYNEKNVGKQGGIMDRFVLHSDFKPMGDQPQAIEALTKGFEEGNQFETLVGVTGSGKTFTMANIIQNVQK
PTLIISHNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPQSDTYIAKDSSINDEIDKLRHSATAALSERNDVII
VASVSCIYGLGAPVDYKNMVISLRPGMEKDRDDCIRKLIDIQYVRNDQDFKRGTFRVRGDVVEVYPSSSSGDAIRVEFFG
DEVDRISEIDSLTGEVKGVLEHIAIFPNSHYVVEKEKMDAAIENIKAELAERVKYFKSEDKLLEAQRIEERTNFDIEMMQ
ETGFCSGIENYSRHLAGLPAGCPPYTLMDYFPDDFLIIVDESHITIPQIRGMYAGDQSRKTTLVDYGFRLPSAKDNRPLN
FSEFESKISQMLFVSATPSTYEAEHELMRTEQVIRPTGLLDPEITVKPIEGQIDDLISEINKETAKKNKVLVTTLTKRMA
EDLTDYLKEAGIRVKYLHADIDTLERQKIIRDMRLDGFDVLVGINLLREGLDIPEISLVAILDADKEGFLRTETSLIQTI
GRAARNAEGHVIMYADKITESMEKAISETERRRKIQQDYNDEHGITPQTIKKAVRDLISISKAAEPGDASGKLKVDYESM
SIKELEKVKTQVEKNMRKAAAELNFEEAAQLRDKMIEINKYIYEGKKHG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=58.974358974359, Blast_Score=773, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78185; Mature: 78185

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVLYFLAVILYNEKNVGKQGGIMDRFVLHSDFKPMGDQPQAIEALTKGFEEGNQFETLV
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
GVTGSGKTFTMANIIQNVQKPTLIISHNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQP
EECCCCCEEHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
EAYVPQSDTYIAKDSSINDEIDKLRHSATAALSERNDVIIVASVSCIYGLGAPVDYKNMV
CCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCEE
ISLRPGMEKDRDDCIRKLIDIQYVRNDQDFKRGTFRVRGDVVEVYPSSSSGDAIRVEFFG
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEECCCCCCCEEEEEECC
DEVDRISEIDSLTGEVKGVLEHIAIFPNSHYVVEKEKMDAAIENIKAELAERVKYFKSED
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHH
KLLEAQRIEERTNFDIEMMQETGFCSGIENYSRHLAGLPAGCPPYTLMDYFPDDFLIIVD
HHHHHHHHHHHCCCCCEEHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEC
ESHITIPQIRGMYAGDQSRKTTLVDYGFRLPSAKDNRPLNFSEFESKISQMLFVSATPST
CCCEEHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCC
YEAEHELMRTEQVIRPTGLLDPEITVKPIEGQIDDLISEINKETAKKNKVLVTTLTKRMA
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
EDLTDYLKEAGIRVKYLHADIDTLERQKIIRDMRLDGFDVLVGINLLREGLDIPEISLVA
HHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEE
ILDADKEGFLRTETSLIQTIGRAARNAEGHVIMYADKITESMEKAISETERRRKIQQDYN
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
DEHGITPQTIKKAVRDLISISKAAEPGDASGKLKVDYESMSIKELEKVKTQVEKNMRKAA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AELNFEEAAQLRDKMIEINKYIYEGKKHG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFVLYFLAVILYNEKNVGKQGGIMDRFVLHSDFKPMGDQPQAIEALTKGFEEGNQFETLV
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
GVTGSGKTFTMANIIQNVQKPTLIISHNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQP
EECCCCCEEHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
EAYVPQSDTYIAKDSSINDEIDKLRHSATAALSERNDVIIVASVSCIYGLGAPVDYKNMV
CCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCEE
ISLRPGMEKDRDDCIRKLIDIQYVRNDQDFKRGTFRVRGDVVEVYPSSSSGDAIRVEFFG
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEECCCCCCCEEEEEECC
DEVDRISEIDSLTGEVKGVLEHIAIFPNSHYVVEKEKMDAAIENIKAELAERVKYFKSED
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHH
KLLEAQRIEERTNFDIEMMQETGFCSGIENYSRHLAGLPAGCPPYTLMDYFPDDFLIIVD
HHHHHHHHHHHCCCCCEEHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEC
ESHITIPQIRGMYAGDQSRKTTLVDYGFRLPSAKDNRPLNFSEFESKISQMLFVSATPST
CCCEEHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCC
YEAEHELMRTEQVIRPTGLLDPEITVKPIEGQIDDLISEINKETAKKNKVLVTTLTKRMA
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
EDLTDYLKEAGIRVKYLHADIDTLERQKIIRDMRLDGFDVLVGINLLREGLDIPEISLVA
HHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEE
ILDADKEGFLRTETSLIQTIGRAARNAEGHVIMYADKITESMEKAISETERRRKIQQDYN
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
DEHGITPQTIKKAVRDLISISKAAEPGDASGKLKVDYESMSIKELEKVKTQVEKNMRKAA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AELNFEEAAQLRDKMIEINKYIYEGKKHG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA