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The map label for this gene is vanR [H]

Identifier: 238917425

GI number: 238917425

Start: 1558758

End: 1559441

Strand: Reverse

Name: vanR [H]

Synonym: EUBELI_01503

Alternate gene names: 238917425

Gene position: 1559441-1558758 (Counterclockwise)

Preceding gene: 238917426

Following gene: 238917424

Centisome position: 72.73

GC content: 35.53

Gene sequence:

>684_bases
ATGGCATCTGTTTTAGTGGTTGATGATGAAGAAGATATTAGAGAGCTTGTCGGAATCTATATAAAAAATGAGGGCTATCA
GGTATATAAGGCGGCTAATGGCAAAGATGCTCTTGATATTATTGATAACATGAGCATAGATATTACGATTCTTGATGTTA
TGATGGCTGATATGGACGGAATAACCCTCTGTATGGAAATCAGAAAAAAGAGCAATATTCCGATAATTATGCTGTCTGCA
AAAGACCAGGATATGGACAAGGTTATAGGTCTTAGTGCAGGTGCAGATGATTATCTTGCAAAACCATTTAACCCGGTTGA
GCTTATAGCGAGGGTCAAGGCGCAGCTGAGAAGATATAAGGATTTTAACAATCAGAAACAGAGTAATATATTGGAGTATC
TTGACCTTACTATGAATATAGACACTCACAGGGTATTTCTTTCTTCTAAAGAAATACTGCTTACACCAAAGGAATTTGCG
ATACTTGAGCTTTTATGGAAGAATAAAGGAAATGTTTTCTCAACGGAGCATATATATGATATGCTGTGGAGTGAAGAGGA
GGCATATGACATTAATAATGTAATTATGGTGCATATAAGAAATATCCGCTCAAAGATAGAAACAGATTTAAAGAATCCTA
AATACATAAAAACTGTATGGGGAGTTGGATATAAGTTTTCGTGA

Upstream 100 bases:

>100_bases
CGGAAGAGTATGGGCTGAGTATAATGATGGAATATTTGCAATTAATATAGAACTTAAGAAGAATGATATGTGAATCTGAT
TATGAAATGAGGAGGATATT

Downstream 100 bases:

>100_bases
TTTAATGTAGAATTAAACATGATAATGTAGTATTATGTTTATACATTTTTATAAATATCTGGAGGACTTATGAAAAAGAT
TAAAGCACTTATGCCGGAAG

Product: two-component system OmpR family phosphate regulon response regulator OmpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MASVLVVDDEEDIRELVGIYIKNEGYQVYKAANGKDALDIIDNMSIDITILDVMMADMDGITLCMEIRKKSNIPIIMLSA
KDQDMDKVIGLSAGADDYLAKPFNPVELIARVKAQLRRYKDFNNQKQSNILEYLDLTMNIDTHRVFLSSKEILLTPKEFA
ILELLWKNKGNVFSTEHIYDMLWSEEEAYDINNVIMVHIRNIRSKIETDLKNPKYIKTVWGVGYKFS

Sequences:

>Translated_227_residues
MASVLVVDDEEDIRELVGIYIKNEGYQVYKAANGKDALDIIDNMSIDITILDVMMADMDGITLCMEIRKKSNIPIIMLSA
KDQDMDKVIGLSAGADDYLAKPFNPVELIARVKAQLRRYKDFNNQKQSNILEYLDLTMNIDTHRVFLSSKEILLTPKEFA
ILELLWKNKGNVFSTEHIYDMLWSEEEAYDINNVIMVHIRNIRSKIETDLKNPKYIKTVWGVGYKFS
>Mature_226_residues
ASVLVVDDEEDIRELVGIYIKNEGYQVYKAANGKDALDIIDNMSIDITILDVMMADMDGITLCMEIRKKSNIPIIMLSAK
DQDMDKVIGLSAGADDYLAKPFNPVELIARVKAQLRRYKDFNNQKQSNILEYLDLTMNIDTHRVFLSSKEILLTPKEFAI
LELLWKNKGNVFSTEHIYDMLWSEEEAYDINNVIMVHIRNIRSKIETDLKNPKYIKTVWGVGYKFS

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=35.5555555555556, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=31.858407079646, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=32.15859030837, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=33.9285714285714, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=30.9734513274336, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.9775784753363, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=32, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.9344978165939, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=34.2342342342342, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.695652173913, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=30.2222222222222, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=32.5892857142857, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.5423728813559, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=178, Percent_Identity=28.0898876404494, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=29.4573643410853, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=163, Percent_Identity=28.8343558282209, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=31.6831683168317, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=34.3137254901961, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26151; Mature: 26019

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVLVVDDEEDIRELVGIYIKNEGYQVYKAANGKDALDIIDNMSIDITILDVMMADMDG
CCEEEEECCHHHHHHHHCEEEECCCEEEEEECCCCCHHHHHCCCCEEEEEEEHHHHCCCC
ITLCMEIRKKSNIPIIMLSAKDQDMDKVIGLSAGADDYLAKPFNPVELIARVKAQLRRYK
HHHHEEHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHH
DFNNQKQSNILEYLDLTMNIDTHRVFLSSKEILLTPKEFAILELLWKNKGNVFSTEHIYD
CCCCHHHHHHHHHHHHEECCCCEEEEECCCEEEECCHHHHHHHHHHCCCCCEEEHHHHHH
MLWSEEEAYDINNVIMVHIRNIRSKIETDLKNPKYIKTVWGVGYKFS
HHCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEHHHCCCEECC
>Mature Secondary Structure 
ASVLVVDDEEDIRELVGIYIKNEGYQVYKAANGKDALDIIDNMSIDITILDVMMADMDG
CEEEEECCHHHHHHHHCEEEECCCEEEEEECCCCCHHHHHCCCCEEEEEEEHHHHCCCC
ITLCMEIRKKSNIPIIMLSAKDQDMDKVIGLSAGADDYLAKPFNPVELIARVKAQLRRYK
HHHHEEHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHH
DFNNQKQSNILEYLDLTMNIDTHRVFLSSKEILLTPKEFAILELLWKNKGNVFSTEHIYD
CCCCHHHHHHHHHHHHEECCCCEEEEECCCEEEECCHHHHHHHHHHCCCCCEEEHHHHHH
MLWSEEEAYDINNVIMVHIRNIRSKIETDLKNPKYIKTVWGVGYKFS
HHCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]