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The map label for this gene is lon [H]

Identifier: 238917375

GI number: 238917375

Start: 1504708

End: 1507062

Strand: Reverse

Name: lon [H]

Synonym: EUBELI_01452

Alternate gene names: 238917375

Gene position: 1507062-1504708 (Counterclockwise)

Preceding gene: 238917376

Following gene: 238917374

Centisome position: 70.29

GC content: 37.96

Gene sequence:

>2355_bases
ATGAGTAACAAATATGATAGACATTATCCAGCTATTCCATTAAGAAATGTCACTGTTTTTCCGGGGATGGTAATGCACTT
TGATGTGAGCAGAAAGAAGTCTGTAAAAGCTGTAGAAGCAAGTATGGCAGCTGATGAACTTATATATCTTGTAACACAGA
GAGATTCGCAGGTGAGCGAACCAGGGATAGCAGATTTATATACAGTAGGAACAATTGCTAAGATAAAACAGATAATAAAG
ATGCCAGGCAAAATTTTAAGGGTTCAGGTAGAAGGGCTTGAAAAGGCACTTGTAAATAGATTTGAAGAAGCGTCAGGAAT
GATGCTTGCTGATGTAAGTGTTATGCAAGGATTTGAGAAGCCTGATAAAATGGTGTCGAGAGCTATAATTGTAGGAATGA
GAGAACTTTTGACACAGTATGCACATGTTAATCCGAAGTTTGCAAAGGATACAGTCAAGAGATGGCTTTCTTATAATGAT
GCAGAAAAACTGATGACGGAATTTGCTCAGGAATTTATGATGGATTTTGATAAAAGACAGCAGTTTCTGGAGGCAGAAGA
CTATGAGCAGATGTATACATTTGCTGCAACATTGCTTGTAAATGAGATAAATGCTTATACTATTAAAGAAGAACTTGGCA
ATATTGTAAGAGAAAGAGTAGATAAGAACCAGAAGGATTACATATTAAGAGAAGAACTTGCAGCGATTAATGAAGAACTT
GATGGAGGAACCATAACAGAGGCTGAAGAATATGAGGCGGACGTTGAAAAGCTTGATTCACCGCAGTATGTAAAGGATAA
GCTAAAAAGGGAGATTAAGAGACTGAAATCACTTGCTGGTAATAATGCTGAGGCTAATGTTGAGAGAACATATATAGAGA
CATGTCTTGAATTACCATGGAATGTGTCGACTGAAGATAACAAAGATATAGATAATGCTGCAAAAGTGCTTGATTCGGAC
CACTATGGAATGAAAGATATTAAGGAAAGAATTCTGGAATCACTTGCGGTAAGAAACATAACAGGTAGTGGAAAAGCACC
TGTCATATGTCTTGCAGGACCTCCGGGAACAGGTAAGACATCTATAGCAAGATCAGTTGCAAAGGCACTTGGCAAGGAGT
ATGTAAGAATCTGTCTGGGTGGTGTAAGAGATGAGGCTGAGATAAGAGGACACAGGAAAACATATATTGGAGCTATGCCT
GGAAGAATTATTGAGGGACTTAAGAGTGCCGGAGTTAATAATCCTCTTATGCTTCTTGATGAGATAGATAAGATAAGCAG
TGATTATAAGGGCGATACATCAGCTGCACTTCTTGAAGTATTAGACAGCGAACAGAATGTTAATTTTGTCGACCACTATA
TAGAGATGCCGGTTGATTTGTCAAATGTGCTTTTTATTGCAACAGCTAATGATCTGTCTAATATAAGCCGTCCATTGCTT
GACAGAATGGAAATTATTGAAGTTGGTTCATACACAGCTAATGAAAAGTTTCATATTGCTAAGGAACACCTTATTAAGAA
ACAGATTAAAGAGAATGGTCTGCTTGTATCTGATGTAAAGTTCACTGATAAAGTTATAAGAACAATTATTAATTCGTATA
CAAGAGAAGCTGGTGTGAGAGGTCTTGAAAGGCAGATTGCAAAGATTGTAAGAAAAGCGGTTAGAGAATTATACAAAGCC
GGAGTGTTCACATCTGATGGAACAAGAGATAAGACTGTAAAGAAAACAGTTAATATATCTGATAAGAATATTACAGATTA
TCTTGGAAAAGTTAAATACAGACCGGACAAAAAGAATACAAAGGGTGAAGTTGGTATAGTAAGAGGGCTTGCATGGACAC
AGGCAGGTGGAGATACTCTTGAGATAGAGGTTATAACAATGCCGGGCAAAGGCGAGTTCAAGCTTACAGGTAACATGGGT
GATGTAATGAAAGAATCAGCAAGCATAGCTGTTTCTTATATCAGATCAGTAACAGAAAAAGGCAGATATAAAGTGGATGC
TGAATATTTCCAGAATCATGCATTCCATCTTCATATACCAGAGGGTGCAACTCCGAAAGACGGACCTTCTGCTGGCATTA
CAATGGCAACGGCAGTATTGTCTGCGGTTACTGGAATTCCTGTAAGAGCAGATGTTGCAATGACTGGAGAGCTTACATTA
AGAGGTAAGGTTCTTCCGATAGGAGGTCTTAAAGAAAAGCTTCTTGCAAGTAAGACAGCGGGTATAACAAATGTTTTTGT
ACCTCGGGATAACAGGTCGGATGTTGAAGAACTTGACACAGAGATAACTGAAGGGATGAATATAATATATGTGAATAATG
CTATTGAAGTATTTGCACAGGCATTAATGCGTTAA

Upstream 100 bases:

>100_bases
TAGAATACAGAACGGATGCTGTAAAAAAAGCACAGTAACGAAATTAATTCAGGCGGGCTGTTCATGATGGACGGTCCGTT
TTTTAGATAGAGAGGAATAT

Downstream 100 bases:

>100_bases
ATGAAAGGAGCAGCGGATTATGGTTATAAAAAAAGTTAATCTGGATATAGTAGTCGGAGTTACAAGTACACTTCCTGAAA
CCCCATTTCCGGAGGTTGCA

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MSNKYDRHYPAIPLRNVTVFPGMVMHFDVSRKKSVKAVEASMAADELIYLVTQRDSQVSEPGIADLYTVGTIAKIKQIIK
MPGKILRVQVEGLEKALVNRFEEASGMMLADVSVMQGFEKPDKMVSRAIIVGMRELLTQYAHVNPKFAKDTVKRWLSYND
AEKLMTEFAQEFMMDFDKRQQFLEAEDYEQMYTFAATLLVNEINAYTIKEELGNIVRERVDKNQKDYILREELAAINEEL
DGGTITEAEEYEADVEKLDSPQYVKDKLKREIKRLKSLAGNNAEANVERTYIETCLELPWNVSTEDNKDIDNAAKVLDSD
HYGMKDIKERILESLAVRNITGSGKAPVICLAGPPGTGKTSIARSVAKALGKEYVRICLGGVRDEAEIRGHRKTYIGAMP
GRIIEGLKSAGVNNPLMLLDEIDKISSDYKGDTSAALLEVLDSEQNVNFVDHYIEMPVDLSNVLFIATANDLSNISRPLL
DRMEIIEVGSYTANEKFHIAKEHLIKKQIKENGLLVSDVKFTDKVIRTIINSYTREAGVRGLERQIAKIVRKAVRELYKA
GVFTSDGTRDKTVKKTVNISDKNITDYLGKVKYRPDKKNTKGEVGIVRGLAWTQAGGDTLEIEVITMPGKGEFKLTGNMG
DVMKESASIAVSYIRSVTEKGRYKVDAEYFQNHAFHLHIPEGATPKDGPSAGITMATAVLSAVTGIPVRADVAMTGELTL
RGKVLPIGGLKEKLLASKTAGITNVFVPRDNRSDVEELDTEITEGMNIIYVNNAIEVFAQALMR

Sequences:

>Translated_784_residues
MSNKYDRHYPAIPLRNVTVFPGMVMHFDVSRKKSVKAVEASMAADELIYLVTQRDSQVSEPGIADLYTVGTIAKIKQIIK
MPGKILRVQVEGLEKALVNRFEEASGMMLADVSVMQGFEKPDKMVSRAIIVGMRELLTQYAHVNPKFAKDTVKRWLSYND
AEKLMTEFAQEFMMDFDKRQQFLEAEDYEQMYTFAATLLVNEINAYTIKEELGNIVRERVDKNQKDYILREELAAINEEL
DGGTITEAEEYEADVEKLDSPQYVKDKLKREIKRLKSLAGNNAEANVERTYIETCLELPWNVSTEDNKDIDNAAKVLDSD
HYGMKDIKERILESLAVRNITGSGKAPVICLAGPPGTGKTSIARSVAKALGKEYVRICLGGVRDEAEIRGHRKTYIGAMP
GRIIEGLKSAGVNNPLMLLDEIDKISSDYKGDTSAALLEVLDSEQNVNFVDHYIEMPVDLSNVLFIATANDLSNISRPLL
DRMEIIEVGSYTANEKFHIAKEHLIKKQIKENGLLVSDVKFTDKVIRTIINSYTREAGVRGLERQIAKIVRKAVRELYKA
GVFTSDGTRDKTVKKTVNISDKNITDYLGKVKYRPDKKNTKGEVGIVRGLAWTQAGGDTLEIEVITMPGKGEFKLTGNMG
DVMKESASIAVSYIRSVTEKGRYKVDAEYFQNHAFHLHIPEGATPKDGPSAGITMATAVLSAVTGIPVRADVAMTGELTL
RGKVLPIGGLKEKLLASKTAGITNVFVPRDNRSDVEELDTEITEGMNIIYVNNAIEVFAQALMR
>Mature_783_residues
SNKYDRHYPAIPLRNVTVFPGMVMHFDVSRKKSVKAVEASMAADELIYLVTQRDSQVSEPGIADLYTVGTIAKIKQIIKM
PGKILRVQVEGLEKALVNRFEEASGMMLADVSVMQGFEKPDKMVSRAIIVGMRELLTQYAHVNPKFAKDTVKRWLSYNDA
EKLMTEFAQEFMMDFDKRQQFLEAEDYEQMYTFAATLLVNEINAYTIKEELGNIVRERVDKNQKDYILREELAAINEELD
GGTITEAEEYEADVEKLDSPQYVKDKLKREIKRLKSLAGNNAEANVERTYIETCLELPWNVSTEDNKDIDNAAKVLDSDH
YGMKDIKERILESLAVRNITGSGKAPVICLAGPPGTGKTSIARSVAKALGKEYVRICLGGVRDEAEIRGHRKTYIGAMPG
RIIEGLKSAGVNNPLMLLDEIDKISSDYKGDTSAALLEVLDSEQNVNFVDHYIEMPVDLSNVLFIATANDLSNISRPLLD
RMEIIEVGSYTANEKFHIAKEHLIKKQIKENGLLVSDVKFTDKVIRTIINSYTREAGVRGLERQIAKIVRKAVRELYKAG
VFTSDGTRDKTVKKTVNISDKNITDYLGKVKYRPDKKNTKGEVGIVRGLAWTQAGGDTLEIEVITMPGKGEFKLTGNMGD
VMKESASIAVSYIRSVTEKGRYKVDAEYFQNHAFHLHIPEGATPKDGPSAGITMATAVLSAVTGIPVRADVAMTGELTLR
GKVLPIGGLKEKLLASKTAGITNVFVPRDNRSDVEELDTEITEGMNIIYVNNAIEVFAQALMR

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=613, Percent_Identity=41.4355628058728, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI31377667, Length=555, Percent_Identity=45.045045045045, Blast_Score=477, Evalue=1e-134,
Organism=Escherichia coli, GI1786643, Length=780, Percent_Identity=44.1025641025641, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=637, Percent_Identity=38.3045525902669, Blast_Score=454, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17556486, Length=528, Percent_Identity=40.1515151515151, Blast_Score=408, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=654, Percent_Identity=39.2966360856269, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24666867, Length=622, Percent_Identity=42.443729903537, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI221513036, Length=622, Percent_Identity=42.443729903537, Blast_Score=503, Evalue=1e-142,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87321; Mature: 87190

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKYDRHYPAIPLRNVTVFPGMVMHFDVSRKKSVKAVEASMAADELIYLVTQRDSQVSE
CCCCCCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
PGIADLYTVGTIAKIKQIIKMPGKILRVQVEGLEKALVNRFEEASGMMLADVSVMQGFEK
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCC
PDKMVSRAIIVGMRELLTQYAHVNPKFAKDTVKRWLSYNDAEKLMTEFAQEFMMDFDKRQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QFLEAEDYEQMYTFAATLLVNEINAYTIKEELGNIVRERVDKNQKDYILREELAAINEEL
HHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
DGGTITEAEEYEADVEKLDSPQYVKDKLKREIKRLKSLAGNNAEANVERTYIETCLELPW
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
NVSTEDNKDIDNAAKVLDSDHYGMKDIKERILESLAVRNITGSGKAPVICLAGPPGTGKT
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHH
SIARSVAKALGKEYVRICLGGVRDEAEIRGHRKTYIGAMPGRIIEGLKSAGVNNPLMLLD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCCHHHH
EIDKISSDYKGDTSAALLEVLDSEQNVNFVDHYIEMPVDLSNVLFIATANDLSNISRPLL
HHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
DRMEIIEVGSYTANEKFHIAKEHLIKKQIKENGLLVSDVKFTDKVIRTIINSYTREAGVR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHH
GLERQIAKIVRKAVRELYKAGVFTSDGTRDKTVKKTVNISDKNITDYLGKVKYRPDKKNT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECCCCCHHHHHHHCCEECCCCCCC
KGEVGIVRGLAWTQAGGDTLEIEVITMPGKGEFKLTGNMGDVMKESASIAVSYIRSVTEK
CCCEEEEECEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHC
GRYKVDAEYFQNHAFHLHIPEGATPKDGPSAGITMATAVLSAVTGIPVRADVAMTGELTL
CCEEEEHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECEEEECCEEE
RGKVLPIGGLKEKLLASKTAGITNVFVPRDNRSDVEELDTEITEGMNIIYVNNAIEVFAQ
EEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHH
ALMR
HHCC
>Mature Secondary Structure 
SNKYDRHYPAIPLRNVTVFPGMVMHFDVSRKKSVKAVEASMAADELIYLVTQRDSQVSE
CCCCCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
PGIADLYTVGTIAKIKQIIKMPGKILRVQVEGLEKALVNRFEEASGMMLADVSVMQGFEK
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCC
PDKMVSRAIIVGMRELLTQYAHVNPKFAKDTVKRWLSYNDAEKLMTEFAQEFMMDFDKRQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QFLEAEDYEQMYTFAATLLVNEINAYTIKEELGNIVRERVDKNQKDYILREELAAINEEL
HHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
DGGTITEAEEYEADVEKLDSPQYVKDKLKREIKRLKSLAGNNAEANVERTYIETCLELPW
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
NVSTEDNKDIDNAAKVLDSDHYGMKDIKERILESLAVRNITGSGKAPVICLAGPPGTGKT
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHH
SIARSVAKALGKEYVRICLGGVRDEAEIRGHRKTYIGAMPGRIIEGLKSAGVNNPLMLLD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCCHHHH
EIDKISSDYKGDTSAALLEVLDSEQNVNFVDHYIEMPVDLSNVLFIATANDLSNISRPLL
HHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
DRMEIIEVGSYTANEKFHIAKEHLIKKQIKENGLLVSDVKFTDKVIRTIINSYTREAGVR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHH
GLERQIAKIVRKAVRELYKAGVFTSDGTRDKTVKKTVNISDKNITDYLGKVKYRPDKKNT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECCCCCHHHHHHHCCEECCCCCCC
KGEVGIVRGLAWTQAGGDTLEIEVITMPGKGEFKLTGNMGDVMKESASIAVSYIRSVTEK
CCCEEEEECEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHC
GRYKVDAEYFQNHAFHLHIPEGATPKDGPSAGITMATAVLSAVTGIPVRADVAMTGELTL
CCEEEEHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECEEEECCEEE
RGKVLPIGGLKEKLLASKTAGITNVFVPRDNRSDVEELDTEITEGMNIIYVNNAIEVFAQ
EEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHH
ALMR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA