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The map label for this gene is ypnP [H]

Identifier: 238917262

GI number: 238917262

Start: 1369373

End: 1370734

Strand: Reverse

Name: ypnP [H]

Synonym: EUBELI_01336

Alternate gene names: 238917262

Gene position: 1370734-1369373 (Counterclockwise)

Preceding gene: 238917263

Following gene: 238917261

Centisome position: 63.93

GC content: 37.74

Gene sequence:

>1362_bases
ATGGAAAATGCCAACACTATGGATAATGCAAAAATGACTAATGGACCAATAACAAGGATTTTATTATCATTTGCAGGTCC
GGTGCTTTTAGGTCAGTTACTGCAGCAGCTTTATAATATTGCTGATGCAGCTATTGTCGGACAGTTCTTAAGTTCTAAGG
CACTTGCAGCGGTTGGTGCAACATCTTCTCTTACATATATAGTATGTTATTTCTGTATAGGTTCATGTATAGGAATAAGT
GTTCCTGTGTCACAGGCATTTGGAGCAGGAAAGAATGATGATTTAAGAAAATATTTTGTTAATGGAGTCTACTTTGCGCT
TGCAATCGCGGTTATTATGACAGCAGTTACAGCGTCTATGAGTGGACTCTTTTTAACGTGGTTAAAGACACCTGAAAATA
TATTTAAGGATGCACATGTGTATCTTGTTATTATATTCTTAGGACTTCCGTTGACGGTTCTGTATAACTTCTGTTTTGGG
ATTCTGATGGCATTTGGAGACAGCAAAAAGTCAACAATGTTTATGGCAGTATCAACTGTTATTAATATATTTCTTGATCT
GTTTCTGGTTGTTGTTGTGAAATGGGGTGTTGCCGGAGCTGCAGTTGCTACTATATTTTCACAGGGAATTGCAGGCGTTC
TTAGTGCTGTATACATCTTTAAGAAGTACAAACTGTTATTTCCAGTTAATGCAGATGAAAGAAAGTTCCATCCGTATTAC
ATGAAGAACATTATTAAAATGTGCATGCCAATGGGACTGCAGTATTCTATTACTGCAATTGGCGCAATTATTCTGCAATT
TTATGTAAATGCACTTGGAGAAGACGCCATTGCAGGATTTACATCCGGATATAAGATTAAGAATCTGATTCTGTGTCCGT
TAAATGCGTTGGGAACAGCTCTTTCATCATTTATCGGACAGAATTTCGGAGCTAAGAGATTTGACCGTATCAGTGAAGGA
TTTAAGAGAACTTTGGAGATAGGTCTTATCTATTCTGTAATTACTATGGTTGTATGCTTTTTTACAGGTAAATATATGGC
GCTTATATTCGTAGATGCAGCCGATACGGTTGTTGTCGGTTACACTGTGAAATTCATAAAATATATAAGTGTGTTTAATG
CGGAGCTTGCACTTTTGTTTACTGCGAGATACTCTGTTCAGGGTATGGGATATGGCAAATATTCTATCCTCTCAGGACTT
GCTGAGATGGCTGGTAGGGCGGCTGTTGCTGTGCTTCTGATACCGCATTTTGGCTTTGATGCAGTGTGCTGGAATGAGGG
ACTTACATTCCTTGCAGGAATTGCAGTTATTCTGCCAATTTATATTAAACTATTTTGCCATTTGCGTAAAAGTATGATAT
AA

Upstream 100 bases:

>100_bases
TCTGATTCATAAAAAGAAAAAATGATTATCAGTTGCAAATCTTTTCATAAGGACTATAATGGTTAAGAATTATTAGTAAT
TATGATGGGATGGAAGAAAA

Downstream 100 bases:

>100_bases
TTTTTACAATTTTGGGATGAGGAAAGGTGGCGCTTATGTCTAAGATTATATTAACAGGTGACAGACCAACCGGAAGACTT
CACTTAGGTCATTATGTTGG

Product: MATE family multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MENANTMDNAKMTNGPITRILLSFAGPVLLGQLLQQLYNIADAAIVGQFLSSKALAAVGATSSLTYIVCYFCIGSCIGIS
VPVSQAFGAGKNDDLRKYFVNGVYFALAIAVIMTAVTASMSGLFLTWLKTPENIFKDAHVYLVIIFLGLPLTVLYNFCFG
ILMAFGDSKKSTMFMAVSTVINIFLDLFLVVVVKWGVAGAAVATIFSQGIAGVLSAVYIFKKYKLLFPVNADERKFHPYY
MKNIIKMCMPMGLQYSITAIGAIILQFYVNALGEDAIAGFTSGYKIKNLILCPLNALGTALSSFIGQNFGAKRFDRISEG
FKRTLEIGLIYSVITMVVCFFTGKYMALIFVDAADTVVVGYTVKFIKYISVFNAELALLFTARYSVQGMGYGKYSILSGL
AEMAGRAAVAVLLIPHFGFDAVCWNEGLTFLAGIAVILPIYIKLFCHLRKSMI

Sequences:

>Translated_453_residues
MENANTMDNAKMTNGPITRILLSFAGPVLLGQLLQQLYNIADAAIVGQFLSSKALAAVGATSSLTYIVCYFCIGSCIGIS
VPVSQAFGAGKNDDLRKYFVNGVYFALAIAVIMTAVTASMSGLFLTWLKTPENIFKDAHVYLVIIFLGLPLTVLYNFCFG
ILMAFGDSKKSTMFMAVSTVINIFLDLFLVVVVKWGVAGAAVATIFSQGIAGVLSAVYIFKKYKLLFPVNADERKFHPYY
MKNIIKMCMPMGLQYSITAIGAIILQFYVNALGEDAIAGFTSGYKIKNLILCPLNALGTALSSFIGQNFGAKRFDRISEG
FKRTLEIGLIYSVITMVVCFFTGKYMALIFVDAADTVVVGYTVKFIKYISVFNAELALLFTARYSVQGMGYGKYSILSGL
AEMAGRAAVAVLLIPHFGFDAVCWNEGLTFLAGIAVILPIYIKLFCHLRKSMI
>Mature_453_residues
MENANTMDNAKMTNGPITRILLSFAGPVLLGQLLQQLYNIADAAIVGQFLSSKALAAVGATSSLTYIVCYFCIGSCIGIS
VPVSQAFGAGKNDDLRKYFVNGVYFALAIAVIMTAVTASMSGLFLTWLKTPENIFKDAHVYLVIIFLGLPLTVLYNFCFG
ILMAFGDSKKSTMFMAVSTVINIFLDLFLVVVVKWGVAGAAVATIFSQGIAGVLSAVYIFKKYKLLFPVNADERKFHPYY
MKNIIKMCMPMGLQYSITAIGAIILQFYVNALGEDAIAGFTSGYKIKNLILCPLNALGTALSSFIGQNFGAKRFDRISEG
FKRTLEIGLIYSVITMVVCFFTGKYMALIFVDAADTVVVGYTVKFIKYISVFNAELALLFTARYSVQGMGYGKYSILSGL
AEMAGRAAVAVLLIPHFGFDAVCWNEGLTFLAGIAVILPIYIKLFCHLRKSMI

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49327; Mature: 49327

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]