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The map label for this gene is icd [H]

Identifier: 238917202

GI number: 238917202

Start: 1312195

End: 1313403

Strand: Reverse

Name: icd [H]

Synonym: EUBELI_01275

Alternate gene names: 238917202

Gene position: 1313403-1312195 (Counterclockwise)

Preceding gene: 238917204

Following gene: 238917201

Centisome position: 61.25

GC content: 38.63

Gene sequence:

>1209_bases
ATGGACAAAATTAAGATGACAACTCCACTTGTAGAGATGGACGGAGATGAGATGACAAGAGTATTGTGGAAGCTTATCAA
GGACGAGCTGCTCACTCCTTTTATTGACCTTAACACAGAATACTATGATTTGGGTCTTGTACATAGAAATGAGACTAATG
ATCAGGTAACTATAGATTCAGCAGAAGCTACTAAGAAGTATGGTGTTGCAGTAAAGTGTGCAACAATTACACCTAATGCG
GCAAGAATGACAGAATATAATCTCAAAGAGATGTATAAGAGTCCTAACGGAACAATAAGAGCCATGCTTGATGGTACAGT
ATTCAGAGCTCCTATTATCGTTAAGGGTATTGAGCCATATGTTAAGACATGGAAGAAGCCTATCACAATTGCAAGACATG
CATATGGTGATGTATATAAGGCATCTGAGATGAAGGTTTCTGAGGCTGGTAAGGCAGAGCTTGTATTTACTAACGAGGCT
GGTGAGGAGACAAGAGAGCTTATTCATAACTTCAAGGGTGCAGGAGTTCTACAGGGAATGCACAACCTCAATGATTCTAT
TGAGAGCTTTGCAAGAAGCTGCTTTAATTTTGCGCTTGAGACAAAGCAGGATCTCTGGTTTGCAACTAAGGATACAATCT
CTAAAAAGTATGACCATACATTTAAGGACATATTCCAGGAAATATTCGATGCTGAGTATAAGACTAAGTTCGAGGAATCT
GGCATAACATATTTCTATACACTTATAGATGATGCAGTAGCAAGAGTTATCCGTTCAGAGGGTGGATATATCTGGGCTTG
TAAGAACTATGATGGAGATGTTATGAGTGATATGGTAGCCACAGCATTTGGTTCACTTTCAATGATGACTTCTGTTCTTG
TATCACCTAATGGATACTATGAGTATGAAGCTGCACACGGAACAGTACAGAGACATTATTATAAGCATCTTAAGGGTGAA
GAAACATCTACTAACCCTATCGCTACTATATTCGCATGGACAGGCGCTTTAAGAAAAAGAGGAGAGTTGGATAACATTCC
TGAGCTTGGAAAATTTGCTGATACTCTTGAGCGTGCATGTATTAAAACTATTGAAGATGGAAAGATGACAAAGGATCTTG
CACTTATTACAACAATGGAGAATCCTGTAACACTTAATACACAGGATTTCATCAGTGCAATAAGAAAGACTCTTGAGGAA
CTTCTTTAA

Upstream 100 bases:

>100_bases
AAGTAATCAGGCTAATACAAGTCAGTTTCTGTTTACAAAACATTTGAAATAAATTATAATAATTAATCAGGTAAGAAAAG
AAAGAGAGGTTCTTTATATT

Downstream 100 bases:

>100_bases
TTAATGGGTTCTGGATTTTCCATTTGATGATGGAGGGGGACATTATGTCACATATAATGGGTATAACATTTAGAAGCATG
AATATAAGCCAGCTGGTTAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDKIKMTTPLVEMDGDEMTRVLWKLIKDELLTPFIDLNTEYYDLGLVHRNETNDQVTIDSAEATKKYGVAVKCATITPNA
ARMTEYNLKEMYKSPNGTIRAMLDGTVFRAPIIVKGIEPYVKTWKKPITIARHAYGDVYKASEMKVSEAGKAELVFTNEA
GEETRELIHNFKGAGVLQGMHNLNDSIESFARSCFNFALETKQDLWFATKDTISKKYDHTFKDIFQEIFDAEYKTKFEES
GITYFYTLIDDAVARVIRSEGGYIWACKNYDGDVMSDMVATAFGSLSMMTSVLVSPNGYYEYEAAHGTVQRHYYKHLKGE
ETSTNPIATIFAWTGALRKRGELDNIPELGKFADTLERACIKTIEDGKMTKDLALITTMENPVTLNTQDFISAIRKTLEE
LL

Sequences:

>Translated_402_residues
MDKIKMTTPLVEMDGDEMTRVLWKLIKDELLTPFIDLNTEYYDLGLVHRNETNDQVTIDSAEATKKYGVAVKCATITPNA
ARMTEYNLKEMYKSPNGTIRAMLDGTVFRAPIIVKGIEPYVKTWKKPITIARHAYGDVYKASEMKVSEAGKAELVFTNEA
GEETRELIHNFKGAGVLQGMHNLNDSIESFARSCFNFALETKQDLWFATKDTISKKYDHTFKDIFQEIFDAEYKTKFEES
GITYFYTLIDDAVARVIRSEGGYIWACKNYDGDVMSDMVATAFGSLSMMTSVLVSPNGYYEYEAAHGTVQRHYYKHLKGE
ETSTNPIATIFAWTGALRKRGELDNIPELGKFADTLERACIKTIEDGKMTKDLALITTMENPVTLNTQDFISAIRKTLEE
LL
>Mature_402_residues
MDKIKMTTPLVEMDGDEMTRVLWKLIKDELLTPFIDLNTEYYDLGLVHRNETNDQVTIDSAEATKKYGVAVKCATITPNA
ARMTEYNLKEMYKSPNGTIRAMLDGTVFRAPIIVKGIEPYVKTWKKPITIARHAYGDVYKASEMKVSEAGKAELVFTNEA
GEETRELIHNFKGAGVLQGMHNLNDSIESFARSCFNFALETKQDLWFATKDTISKKYDHTFKDIFQEIFDAEYKTKFEES
GITYFYTLIDDAVARVIRSEGGYIWACKNYDGDVMSDMVATAFGSLSMMTSVLVSPNGYYEYEAAHGTVQRHYYKHLKGE
ETSTNPIATIFAWTGALRKRGELDNIPELGKFADTLERACIKTIEDGKMTKDLALITTMENPVTLNTQDFISAIRKTLEE
LL

Specific function: Catalyzes The Oxidation Of 3-Carboxy-2-Hydroxy-4- Methylpentanoate (3-Isopropylmalate) To 3-Carboxy-4-Methyl-2- Oxopentanoate. The Product Decarboxylates To 4-Methyl-2 Oxopentanoate. [C]

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=55.5282555282555, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI28178825, Length=397, Percent_Identity=54.911838790932, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=51.8427518427518, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17540874, Length=385, Percent_Identity=55.0649350649351, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=54.7911547911548, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320137, Length=404, Percent_Identity=53.7128712871287, Blast_Score=443, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=53.5802469135802, Blast_Score=435, Evalue=1e-123,
Organism=Drosophila melanogaster, GI21356561, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24660856, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221330983, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221330987, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221330985, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI28574947, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24660849, Length=400, Percent_Identity=53.25, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24660868, Length=400, Percent_Identity=53.25, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24660860, Length=400, Percent_Identity=53.25, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45544; Mature: 45544

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIKMTTPLVEMDGDEMTRVLWKLIKDELLTPFIDLNTEYYDLGLVHRNETNDQVTIDS
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCCCCEEEEEC
AEATKKYGVAVKCATITPNAARMTEYNLKEMYKSPNGTIRAMLDGTVFRAPIIVKGIEPY
HHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCEEEECCCHH
VKTWKKPITIARHAYGDVYKASEMKVSEAGKAELVFTNEAGEETRELIHNFKGAGVLQGM
HHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHH
HNLNDSIESFARSCFNFALETKQDLWFATKDTISKKYDHTFKDIFQEIFDAEYKTKFEES
HHHHHHHHHHHHHHHHHHHCCCHHHEEECHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHC
GITYFYTLIDDAVARVIRSEGGYIWACKNYDGDVMSDMVATAFGSLSMMTSVLVSPNGYY
CCEEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
EYEAAHGTVQRHYYKHLKGEETSTNPIATIFAWTGALRKRGELDNIPELGKFADTLERAC
EEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
IKTIEDGKMTKDLALITTMENPVTLNTQDFISAIRKTLEELL
HHHHCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDKIKMTTPLVEMDGDEMTRVLWKLIKDELLTPFIDLNTEYYDLGLVHRNETNDQVTIDS
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCCCCEEEEEC
AEATKKYGVAVKCATITPNAARMTEYNLKEMYKSPNGTIRAMLDGTVFRAPIIVKGIEPY
HHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCEEEECCCHH
VKTWKKPITIARHAYGDVYKASEMKVSEAGKAELVFTNEAGEETRELIHNFKGAGVLQGM
HHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHH
HNLNDSIESFARSCFNFALETKQDLWFATKDTISKKYDHTFKDIFQEIFDAEYKTKFEES
HHHHHHHHHHHHHHHHHHHCCCHHHEEECHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHC
GITYFYTLIDDAVARVIRSEGGYIWACKNYDGDVMSDMVATAFGSLSMMTSVLVSPNGYY
CCEEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
EYEAAHGTVQRHYYKHLKGEETSTNPIATIFAWTGALRKRGELDNIPELGKFADTLERAC
EEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
IKTIEDGKMTKDLALITTMENPVTLNTQDFISAIRKTLEELL
HHHHCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]