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The map label for this gene is garR [H]

Identifier: 238917189

GI number: 238917189

Start: 1294881

End: 1295756

Strand: Reverse

Name: garR [H]

Synonym: EUBELI_01262

Alternate gene names: 238917189

Gene position: 1295756-1294881 (Counterclockwise)

Preceding gene: 238917190

Following gene: 238917188

Centisome position: 60.43

GC content: 38.47

Gene sequence:

>876_bases
ATGGTTATAGGCTTTGTTGGATTGGGAATAATGGGAAAACCGATGGCAAAGAATCTTTGCAGAGCTGGATACACATTGAT
TGTTAATGACCATCATAAGGAAAATGTCGATGAACTTGTACAGGCAGGTGCGAGAAGTGGTGATTTAAAACAGATTGGCA
TGGAAAGTGATGTGGTTATAACAATGCTTCCAAACAGTCCTCAGGTAAAGGATGTAATGCTTGGGGAAAATGGTATTGCG
GGTTATATGAAAAAAGGAACATGTTTTATAGATATGAGTTCAATTAATCCTGTCGACAGCAGATATATTGGTGATGTATT
AAAAGAAAAAGGAATTGATATGCTTGATGCACCTGTGTCAGGAGGAGAACCTAAAGCAATAGATGGAACAGTTGCATTTA
TGGTTGGTGGAGATGAGAAAACATTTGATAAGTATAAACAGATTCTTACACATATGGGTTCATCAGTTACAAGATGTGGT
GAACTTGGAGCAGGAAATACAACAAAACTTGCCAATCAGATAATTGTTGCATGTAATATCCAGGCAGTTTCTGAAAGCTT
CATTCTGGCAAAAAAAGCCGGAGTAGACCCTGAGCGTGTATTTGAGGCAATAAAAGGCGGACTAGCAGGGTCTACTGTTA
TGAATGCCAAAGTTCCAATGATGATAGAGGACAATGTTGAACCAGGATTCAGAGTAGATTTGCATATTAAAGATTTGAAT
AATGCACTTGAGTGTGCTCATAGTGTTGGAGCTCCAGTACCGATGACGGCACAGGTTCAGGAAATAATGCAGTATCTGCA
TAATAATGGAGATGGAAGCAGCGACCACAGTGCAATTATACATTATTATGAAAAACTGGCAGACACAAAATTATAA

Upstream 100 bases:

>100_bases
ACTTATGAGAACTATATGGACTTATCAGTATGGTCGCATTATTATATAAAAGAAAGGTTATAATAACAATACATTTAGAA
CAATATCAGGAGGATTATAT

Downstream 100 bases:

>100_bases
ATGTTGTTGACAGGTTATTATAATGTCAGGAAGGAGAATCTTATGAATAAAGAATTAAGAGCGGTTGCAGACAATATAAT
TGATGCGGCAATTAAAGCAG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MVIGFVGLGIMGKPMAKNLCRAGYTLIVNDHHKENVDELVQAGARSGDLKQIGMESDVVITMLPNSPQVKDVMLGENGIA
GYMKKGTCFIDMSSINPVDSRYIGDVLKEKGIDMLDAPVSGGEPKAIDGTVAFMVGGDEKTFDKYKQILTHMGSSVTRCG
ELGAGNTTKLANQIIVACNIQAVSESFILAKKAGVDPERVFEAIKGGLAGSTVMNAKVPMMIEDNVEPGFRVDLHIKDLN
NALECAHSVGAPVPMTAQVQEIMQYLHNNGDGSSDHSAIIHYYEKLADTKL

Sequences:

>Translated_291_residues
MVIGFVGLGIMGKPMAKNLCRAGYTLIVNDHHKENVDELVQAGARSGDLKQIGMESDVVITMLPNSPQVKDVMLGENGIA
GYMKKGTCFIDMSSINPVDSRYIGDVLKEKGIDMLDAPVSGGEPKAIDGTVAFMVGGDEKTFDKYKQILTHMGSSVTRCG
ELGAGNTTKLANQIIVACNIQAVSESFILAKKAGVDPERVFEAIKGGLAGSTVMNAKVPMMIEDNVEPGFRVDLHIKDLN
NALECAHSVGAPVPMTAQVQEIMQYLHNNGDGSSDHSAIIHYYEKLADTKL
>Mature_291_residues
MVIGFVGLGIMGKPMAKNLCRAGYTLIVNDHHKENVDELVQAGARSGDLKQIGMESDVVITMLPNSPQVKDVMLGENGIA
GYMKKGTCFIDMSSINPVDSRYIGDVLKEKGIDMLDAPVSGGEPKAIDGTVAFMVGGDEKTFDKYKQILTHMGSSVTRCG
ELGAGNTTKLANQIIVACNIQAVSESFILAKKAGVDPERVFEAIKGGLAGSTVMNAKVPMMIEDNVEPGFRVDLHIKDLN
NALECAHSVGAPVPMTAQVQEIMQYLHNNGDGSSDHSAIIHYYEKLADTKL

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=32.5342465753425, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=25.886524822695, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=59.9315068493151, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=44.8630136986301, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=33.2155477031802, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=29.4736842105263, Blast_Score=124, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17557316, Length=293, Percent_Identity=30.7167235494881, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=36.3013698630137, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=36.3013698630137, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=22.4199288256228, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31172; Mature: 31172

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIGFVGLGIMGKPMAKNLCRAGYTLIVNDHHKENVDELVQAGARSGDLKQIGMESDVVI
CEEEEEECCCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCCCHHHCCCCCCEEE
TMLPNSPQVKDVMLGENGIAGYMKKGTCFIDMSSINPVDSRYIGDVLKEKGIDMLDAPVS
EECCCCCCCEEEEECCCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCC
GGEPKAIDGTVAFMVGGDEKTFDKYKQILTHMGSSVTRCGELGAGNTTKLANQIIVACNI
CCCCCEECCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHCEEEEEEEH
QAVSESFILAKKAGVDPERVFEAIKGGLAGSTVMNAKVPMMIEDNVEPGFRVDLHIKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEEECCCCCCCEEEEEEHHHH
NALECAHSVGAPVPMTAQVQEIMQYLHNNGDGSSDHSAIIHYYEKLADTKL
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVIGFVGLGIMGKPMAKNLCRAGYTLIVNDHHKENVDELVQAGARSGDLKQIGMESDVVI
CEEEEEECCCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCCCHHHCCCCCCEEE
TMLPNSPQVKDVMLGENGIAGYMKKGTCFIDMSSINPVDSRYIGDVLKEKGIDMLDAPVS
EECCCCCCCEEEEECCCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCC
GGEPKAIDGTVAFMVGGDEKTFDKYKQILTHMGSSVTRCGELGAGNTTKLANQIIVACNI
CCCCCEECCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHCEEEEEEEH
QAVSESFILAKKAGVDPERVFEAIKGGLAGSTVMNAKVPMMIEDNVEPGFRVDLHIKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEEECCCCCCCEEEEEEHHHH
NALECAHSVGAPVPMTAQVQEIMQYLHNNGDGSSDHSAIIHYYEKLADTKL
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]