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The map label for this gene is pyrP [H]

Identifier: 238917184

GI number: 238917184

Start: 1286124

End: 1287551

Strand: Reverse

Name: pyrP [H]

Synonym: EUBELI_01257

Alternate gene names: 238917184

Gene position: 1287551-1286124 (Counterclockwise)

Preceding gene: 238917185

Following gene: 238917183

Centisome position: 60.05

GC content: 38.24

Gene sequence:

>1428_bases
ATGGAACAAAAGAAAATCGAACCTATTCGTGATGCCAGAAAGCTTGGTAAAGCGAAGATGCTGATTCTTGGTATTCAGCA
TATGTTTGCCATGTTTGGCGCAACTATTCTTGTACCTATTCTCGTATCAGGATATTTTCAGGCTGCCTGCGGTGAGGAGC
TTACCAGAGGTCTGTCTGTATCAGTAACACTTTTCTGTGCAGGCTTTGGTACATTGATATTCCACCTGTGTACTAAATTC
AAAGTACCTGCATTCTTAGGATCTTCCTTTGCATTTCTTGGTGGATTCTACACAGTAGCTAATCTTGACAGCGGTATGTA
TGCTGGAATGTCAGCTAATGATAAAGCTGCTTATGCATGTGGTGGTATATTTGTTGCCGGAATGCTTTACTTTGTACTTG
CACTTATAATTAAGCTTGTTGGAGTCAACAGAGTTATGAAATTCCTTCCACCTGTAGTTACAGGACCTATCATTATATGT
ATTGGCCTTTCACTTGCAGGTTCAGCTATTACAAATGCTTCAACTAACTGGTTACTTGCATTTGTTGCACTTGCTGTAAT
TATTATATTCAATATATGGGGCAAGGGGCTTTTCAAGATTATTCCTATTCTTATGGGCGTAGTAATTTCATATGTATTTG
CACTTATTCTTAATGCATGCGGCGTACATAATCCTGATGGTTCAGCAATACTTAATTTCTCATCAATTGCATCTGCTTCA
TGGGTTGGAATTCCAAAGTTCCAGTTTATGAAATTTGATGTAACAGCAATCCTTGTAATGGCACCTATTGCTATTGCAAC
AATGATGGAACATATCGGAGATATGTCAGCTATTTCGGCTACAGTTGAAGAAAACTATTTAGCAGATCCAGGTCTTCACA
GAACACTTATTGGTGATGGTGTTGCAACAGCATTTGCAGGTGCAATTGGAGGTCCGGCTAATACTACATATGGTGAGAAC
ACAGGAGTTCTTGAACTTTCTAAGGTATATGACCCAAGAGTAATCAGAATCGCAGCAGTATTTGCAATTATACTTTCATT
CATACCTAAGTTTTCATCAGTTATATCAACTATGCCAACAGCAATTATCGGTGGTATATCATTCATGCTTTATGGTATGA
TTTCAGCTATCGGTGTAAGAAATGTTGTTGAGAACAAGGTTGACCTTACTAAGTCAAGAAACCTTATTATTGCAGGTGTT
ATATTTGTATGTGGTTTAGGCTTCGGTGGTGGACTTACATTTACAATCGGTGGAACATCTATAACACTTACAGCACTTGC
AATCGCTGCTATAGCAGGTATTCTTCTTAATGCTATATTACCTGGTAATGATTATGAATTCGGTAAGAATCCAGCAGGTG
ACAGCAGCCGTGGAGTTTATGTTATGAACACAGACTCTGAAAAAGAAGAATCAGAAGATAATAAGTAA

Upstream 100 bases:

>100_bases
TTTCATGCCCCGAAATGTTTAAAATGGAATATTTTTTCATTGCCCTAAATCTTATTATGTTCTATAATAATATGAAAATA
TATATTGATTGGAGCGTATT

Downstream 100 bases:

>100_bases
ATAACAATAAAATTTGGAGGTACTTAATAATGATGGATTTTGAGAATGAGAAGAATATAACAATATTTACACATCCACTT
ATCCAGCATAAGATTTCAAT

Product: nucleobase:cation symporter-2

Products: NA

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MEQKKIEPIRDARKLGKAKMLILGIQHMFAMFGATILVPILVSGYFQAACGEELTRGLSVSVTLFCAGFGTLIFHLCTKF
KVPAFLGSSFAFLGGFYTVANLDSGMYAGMSANDKAAYACGGIFVAGMLYFVLALIIKLVGVNRVMKFLPPVVTGPIIIC
IGLSLAGSAITNASTNWLLAFVALAVIIIFNIWGKGLFKIIPILMGVVISYVFALILNACGVHNPDGSAILNFSSIASAS
WVGIPKFQFMKFDVTAILVMAPIAIATMMEHIGDMSAISATVEENYLADPGLHRTLIGDGVATAFAGAIGGPANTTYGEN
TGVLELSKVYDPRVIRIAAVFAIILSFIPKFSSVISTMPTAIIGGISFMLYGMISAIGVRNVVENKVDLTKSRNLIIAGV
IFVCGLGFGGGLTFTIGGTSITLTALAIAAIAGILLNAILPGNDYEFGKNPAGDSSRGVYVMNTDSEKEESEDNK

Sequences:

>Translated_475_residues
MEQKKIEPIRDARKLGKAKMLILGIQHMFAMFGATILVPILVSGYFQAACGEELTRGLSVSVTLFCAGFGTLIFHLCTKF
KVPAFLGSSFAFLGGFYTVANLDSGMYAGMSANDKAAYACGGIFVAGMLYFVLALIIKLVGVNRVMKFLPPVVTGPIIIC
IGLSLAGSAITNASTNWLLAFVALAVIIIFNIWGKGLFKIIPILMGVVISYVFALILNACGVHNPDGSAILNFSSIASAS
WVGIPKFQFMKFDVTAILVMAPIAIATMMEHIGDMSAISATVEENYLADPGLHRTLIGDGVATAFAGAIGGPANTTYGEN
TGVLELSKVYDPRVIRIAAVFAIILSFIPKFSSVISTMPTAIIGGISFMLYGMISAIGVRNVVENKVDLTKSRNLIIAGV
IFVCGLGFGGGLTFTIGGTSITLTALAIAAIAGILLNAILPGNDYEFGKNPAGDSSRGVYVMNTDSEKEESEDNK
>Mature_475_residues
MEQKKIEPIRDARKLGKAKMLILGIQHMFAMFGATILVPILVSGYFQAACGEELTRGLSVSVTLFCAGFGTLIFHLCTKF
KVPAFLGSSFAFLGGFYTVANLDSGMYAGMSANDKAAYACGGIFVAGMLYFVLALIIKLVGVNRVMKFLPPVVTGPIIIC
IGLSLAGSAITNASTNWLLAFVALAVIIIFNIWGKGLFKIIPILMGVVISYVFALILNACGVHNPDGSAILNFSSIASAS
WVGIPKFQFMKFDVTAILVMAPIAIATMMEHIGDMSAISATVEENYLADPGLHRTLIGDGVATAFAGAIGGPANTTYGEN
TGVLELSKVYDPRVIRIAAVFAIILSFIPKFSSVISTMPTAIIGGISFMLYGMISAIGVRNVVENKVDLTKSRNLIIAGV
IFVCGLGFGGGLTFTIGGTSITLTALAIAAIAGILLNAILPGNDYEFGKNPAGDSSRGVYVMNTDSEKEESEDNK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=494, Percent_Identity=24.6963562753036, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI40316845, Length=494, Percent_Identity=24.6963562753036, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI44680145, Length=433, Percent_Identity=25.8660508083141, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI44680143, Length=434, Percent_Identity=25.8064516129032, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI87081818, Length=432, Percent_Identity=34.0277777777778, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1788843, Length=428, Percent_Identity=33.8785046728972, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87082181, Length=432, Percent_Identity=25.462962962963, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87082178, Length=324, Percent_Identity=27.4691358024691, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790087, Length=447, Percent_Identity=24.3847874720358, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=438, Percent_Identity=24.6575342465753, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17541904, Length=522, Percent_Identity=22.4137931034483, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17542262, Length=424, Percent_Identity=23.5849056603774, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71993493, Length=423, Percent_Identity=22.9314420803783, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17542260, Length=224, Percent_Identity=25.4464285714286, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356175, Length=498, Percent_Identity=25.3012048192771, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 50047; Mature: 50047

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]