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The map label for this gene is upp [H]

Identifier: 238917183

GI number: 238917183

Start: 1285447

End: 1286094

Strand: Reverse

Name: upp [H]

Synonym: EUBELI_01256

Alternate gene names: 238917183

Gene position: 1286094-1285447 (Counterclockwise)

Preceding gene: 238917184

Following gene: 238917182

Centisome position: 59.98

GC content: 40.9

Gene sequence:

>648_bases
ATGATGGATTTTGAGAATGAGAAGAATATAACAATATTTACACATCCACTTATCCAGCATAAGATTTCAATTCTTAGAGA
TAAGAAAACAGGAACTAATGAATTTAGAAAGCTCGTTGAAGAAATAGCTATGCTTGAAGGTTTTGAGGCATTATCAGATC
TTCCAACAGAAGATGTAGAGATTGAGACACCTATTGAGACTTGTATGACACCTATGATTTCAGGACGTAAGCTTGCAATT
GTTCCTATCTTAAGGGCAGGCCTTGGCATGGTTCCTGGTGTACTTTCACTTGTACCAACAGCTAAGGTTGGACATATTGG
AATGTACCGTAATGAAGAGACACATGAGCCGGTACCATATTACTGCAAGCTTCCACATCCAATTGAGGAAAGAACTATTG
TTGTAACAGATCCGATGCTTGCAACAGGTGGTTCGGCAGTTGATGCAATTGACCAGATAAAGAAGGTTGGCGGAAAGCAG
ATTAAGTTCATGTGTATCATAGCTGCCCCAGAGGGAGTTGAAAAGCTTCATAAGGCACATCCGGATGTTCAGATATACAT
TGGACATCTTGACAGAGAGCTTAATGCAGATGCTTATATCTGCCCAGGACTTGGGGATGCCGGAGACCGAATCTTCGGAA
CTAAGTAA

Upstream 100 bases:

>100_bases
GTGACAGCAGCCGTGGAGTTTATGTTATGAACACAGACTCTGAAAAAGAAGAATCAGAAGATAATAAGTAAATAACAATA
AAATTTGGAGGTACTTAATA

Downstream 100 bases:

>100_bases
ATAATTATGGGCATGTAATTGCTTTGCGCTAAGAGATATGATAGTGTGTAAAATGCGGCTCCCAACGGGAGCCGTTTTTG
TAACTTATATTATTTAATTA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MMDFENEKNITIFTHPLIQHKISILRDKKTGTNEFRKLVEEIAMLEGFEALSDLPTEDVEIETPIETCMTPMISGRKLAI
VPILRAGLGMVPGVLSLVPTAKVGHIGMYRNEETHEPVPYYCKLPHPIEERTIVVTDPMLATGGSAVDAIDQIKKVGGKQ
IKFMCIIAAPEGVEKLHKAHPDVQIYIGHLDRELNADAYICPGLGDAGDRIFGTK

Sequences:

>Translated_215_residues
MMDFENEKNITIFTHPLIQHKISILRDKKTGTNEFRKLVEEIAMLEGFEALSDLPTEDVEIETPIETCMTPMISGRKLAI
VPILRAGLGMVPGVLSLVPTAKVGHIGMYRNEETHEPVPYYCKLPHPIEERTIVVTDPMLATGGSAVDAIDQIKKVGGKQ
IKFMCIIAAPEGVEKLHKAHPDVQIYIGHLDRELNADAYICPGLGDAGDRIFGTK
>Mature_215_residues
MMDFENEKNITIFTHPLIQHKISILRDKKTGTNEFRKLVEEIAMLEGFEALSDLPTEDVEIETPIETCMTPMISGRKLAI
VPILRAGLGMVPGVLSLVPTAKVGHIGMYRNEETHEPVPYYCKLPHPIEERTIVVTDPMLATGGSAVDAIDQIKKVGGKQ
IKFMCIIAAPEGVEKLHKAHPDVQIYIGHLDRELNADAYICPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.6930693069307, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.6930693069307, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI87082118, Length=201, Percent_Identity=52.2388059701493, Blast_Score=220, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17539892, Length=210, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=210, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.0625, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=32.0197044334975, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=32.0197044334975, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=32.0197044334975, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=32.0197044334975, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23741; Mature: 23741

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDFENEKNITIFTHPLIQHKISILRDKKTGTNEFRKLVEEIAMLEGFEALSDLPTEDVE
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IETPIETCMTPMISGRKLAIVPILRAGLGMVPGVLSLVPTAKVGHIGMYRNEETHEPVPY
EECCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCE
YCKLPHPIEERTIVVTDPMLATGGSAVDAIDQIKKVGGKQIKFMCIIAAPEGVEKLHKAH
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCC
PDVQIYIGHLDRELNADAYICPGLGDAGDRIFGTK
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMDFENEKNITIFTHPLIQHKISILRDKKTGTNEFRKLVEEIAMLEGFEALSDLPTEDVE
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IETPIETCMTPMISGRKLAIVPILRAGLGMVPGVLSLVPTAKVGHIGMYRNEETHEPVPY
EECCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCE
YCKLPHPIEERTIVVTDPMLATGGSAVDAIDQIKKVGGKQIKFMCIIAAPEGVEKLHKAH
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCC
PDVQIYIGHLDRELNADAYICPGLGDAGDRIFGTK
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA