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The map label for this gene is glmS [H]

Identifier: 238917172

GI number: 238917172

Start: 1264018

End: 1265856

Strand: Reverse

Name: glmS [H]

Synonym: EUBELI_01245

Alternate gene names: 238917172

Gene position: 1265856-1264018 (Counterclockwise)

Preceding gene: 238917173

Following gene: 238917171

Centisome position: 59.04

GC content: 38.01

Gene sequence:

>1839_bases
GTGAAAGGAATTAAATATATGTGCGGAATTGCAGGATATGTAGGAGACAGAGAAAGCGCAGATGTACTTGTAGATGCATT
GTCTAAGCTTGAATACAGGGGATATGACTCAGCAGGTATTGCGGTATTTGATCATGGCAATATTAAGGTTAAGAAATGCA
AGGGAAGACTTGCCAACCTTGTTGAGAAGATGGATGAAGAGGGAAAACCACAAGGACATGTTGGAATTGGTCATACAAGA
TGGGCTACACATGGAGAACCATCAGATATCAATTCACATCCACATGGTAATAAGAGAGTTACTATTGTACATAACGGTAT
TATTGAGAACTACAAGAAGCTTAAGGATTTTCTTATCGGAGAGGGATATAGCTTTGCAAGTGAAACAGATACTGAAGTTG
CAGCAAAGCTGCTTGACTACTACTATGATGGCGATCCTATGAAGACTATTGCAAAGGTGTTATCAGAGATTAAGGGTTCA
TACGCACTTGGAATTATGTTCAGAGATTTCCCTGATGAAATATTTGCAGTAAGAAAGGACAGTCCTCTTATTGTTGGTGT
TGGAGAACATGAGAATTTTATAGCATCTGATGTACCGGCTATTATTCATTATACAAGAGATTATTATCTTCTTGACCAGA
ATGAGATTGCAGTTATTAAGAAGGATTCAGTTAAGATATATGATGTTCATGGCAATGAGATACATAAGGAATTAAATACT
GCTGACTGGGATGTTGATGCTGCAGAAAAGGGCGGTTATGCGCACTTTATGCTTAAGGAAATCCATGAGCAGCCAGATTC
TGTAAAGAGAACAATCATGCCAAGAATCATGGACGATATGCCTGATTTCAGTGCAGAAGGATTCAATCCTGACAAGTTAA
AGAATTATAAGAATATATATATTGTTGCCTGTGGTACTGCAATGCATGCCGGAATGGTAGGAAAATATATAATAGAAAAG
ATGGCAAGAGTATCTGTAACTGTTGATATTGCATCAGAATTCAGATACAGAGATCCTCTTATCAGTGAAGATGATCTTAT
GATTGTTATATCACAGTCAGGTGAGACTGCTGATACTAAGGCTGCACTTGAACTTGCAAAACAGGCAGGTGCTGATACTA
TGGCAATTGTTAATGTTAAGGGTTCATCAATTGCAAGAGAAGCAGATATGGTTGTATATACACATGCGGGTCCTGAGATT
TCAGTTGCTTCAACAAAGGCATATATGGTTCAGATATCAATTATGTATTTAATTGCATTTGAATTAGCTTATGCTAATGG
TAAGATGGATGAGGCAGAATGCAGCAGATACACTAAGATGCTTGAAGAAATACCTGAGGTTATTGAAGAAGCCATTGCAC
TTGAGAGTAAGTGTCAGTTTGCAGCTTCTAAGCTTATTAATGCAGACAGTCTTCTTTATATAGGACGAGGTCTTGATTAT
GCACTCAGTATGGAAGGCTCTCTTAAGTTAAAGGAGATATCTTATATTCATTCTGAATCATATGCAGCAGGAGAGCTTAA
GCATGGAACTATCTCGCTTATTACAGAACAGATGCCTGTAATTGCAATTGCAACACAGAAGAATCTTGAGGAAAAGACTA
TAAGTAATATTAAGGAAGTTAAGTCAAGAGGAGCATTTGTAGTGCTTATTGCAGAACCAGAGCTTGATATTGAGGATGGA
GTGGCAGATATTGTTATTAAGCTTCCACAGGCAGACCAGCTTCTTATGCCTATGGTTGCGGCAGTTCCATTACAGCTTAT
TGCCTACTATACAGCAGTTCTTAAGGGTAACGATGTTGATAAGCCAAGAAACCTTGCAAAATCTGTTACGGTTGAATAA

Upstream 100 bases:

>100_bases
GGTTTTGTTTCAAGAAGAACAAGGGCTGTTATGGCATTAAGGAATCAGGTGGGGCTTGTAGGGCTTTTTAACGAGACTGC
TAAGAATTATAAGTAAATGA

Downstream 100 bases:

>100_bases
TTGATATAAAGAGGATATTAGATATGAATAATGATGCATTAAAGATAAGTAATCTGTATGACCTTAATGAAACTATTGCA
GCAAAGGTATTTGAAGGCTG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MKGIKYMCGIAGYVGDRESADVLVDALSKLEYRGYDSAGIAVFDHGNIKVKKCKGRLANLVEKMDEEGKPQGHVGIGHTR
WATHGEPSDINSHPHGNKRVTIVHNGIIENYKKLKDFLIGEGYSFASETDTEVAAKLLDYYYDGDPMKTIAKVLSEIKGS
YALGIMFRDFPDEIFAVRKDSPLIVGVGEHENFIASDVPAIIHYTRDYYLLDQNEIAVIKKDSVKIYDVHGNEIHKELNT
ADWDVDAAEKGGYAHFMLKEIHEQPDSVKRTIMPRIMDDMPDFSAEGFNPDKLKNYKNIYIVACGTAMHAGMVGKYIIEK
MARVSVTVDIASEFRYRDPLISEDDLMIVISQSGETADTKAALELAKQAGADTMAIVNVKGSSIAREADMVVYTHAGPEI
SVASTKAYMVQISIMYLIAFELAYANGKMDEAECSRYTKMLEEIPEVIEEAIALESKCQFAASKLINADSLLYIGRGLDY
ALSMEGSLKLKEISYIHSESYAAGELKHGTISLITEQMPVIAIATQKNLEEKTISNIKEVKSRGAFVVLIAEPELDIEDG
VADIVIKLPQADQLLMPMVAAVPLQLIAYYTAVLKGNDVDKPRNLAKSVTVE

Sequences:

>Translated_612_residues
MKGIKYMCGIAGYVGDRESADVLVDALSKLEYRGYDSAGIAVFDHGNIKVKKCKGRLANLVEKMDEEGKPQGHVGIGHTR
WATHGEPSDINSHPHGNKRVTIVHNGIIENYKKLKDFLIGEGYSFASETDTEVAAKLLDYYYDGDPMKTIAKVLSEIKGS
YALGIMFRDFPDEIFAVRKDSPLIVGVGEHENFIASDVPAIIHYTRDYYLLDQNEIAVIKKDSVKIYDVHGNEIHKELNT
ADWDVDAAEKGGYAHFMLKEIHEQPDSVKRTIMPRIMDDMPDFSAEGFNPDKLKNYKNIYIVACGTAMHAGMVGKYIIEK
MARVSVTVDIASEFRYRDPLISEDDLMIVISQSGETADTKAALELAKQAGADTMAIVNVKGSSIAREADMVVYTHAGPEI
SVASTKAYMVQISIMYLIAFELAYANGKMDEAECSRYTKMLEEIPEVIEEAIALESKCQFAASKLINADSLLYIGRGLDY
ALSMEGSLKLKEISYIHSESYAAGELKHGTISLITEQMPVIAIATQKNLEEKTISNIKEVKSRGAFVVLIAEPELDIEDG
VADIVIKLPQADQLLMPMVAAVPLQLIAYYTAVLKGNDVDKPRNLAKSVTVE
>Mature_612_residues
MKGIKYMCGIAGYVGDRESADVLVDALSKLEYRGYDSAGIAVFDHGNIKVKKCKGRLANLVEKMDEEGKPQGHVGIGHTR
WATHGEPSDINSHPHGNKRVTIVHNGIIENYKKLKDFLIGEGYSFASETDTEVAAKLLDYYYDGDPMKTIAKVLSEIKGS
YALGIMFRDFPDEIFAVRKDSPLIVGVGEHENFIASDVPAIIHYTRDYYLLDQNEIAVIKKDSVKIYDVHGNEIHKELNT
ADWDVDAAEKGGYAHFMLKEIHEQPDSVKRTIMPRIMDDMPDFSAEGFNPDKLKNYKNIYIVACGTAMHAGMVGKYIIEK
MARVSVTVDIASEFRYRDPLISEDDLMIVISQSGETADTKAALELAKQAGADTMAIVNVKGSSIAREADMVVYTHAGPEI
SVASTKAYMVQISIMYLIAFELAYANGKMDEAECSRYTKMLEEIPEVIEEAIALESKCQFAASKLINADSLLYIGRGLDY
ALSMEGSLKLKEISYIHSESYAAGELKHGTISLITEQMPVIAIATQKNLEEKTISNIKEVKSRGAFVVLIAEPELDIEDG
VADIVIKLPQADQLLMPMVAAVPLQLIAYYTAVLKGNDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=36.2573099415205, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=36.0058309037901, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI29570798, Length=208, Percent_Identity=31.7307692307692, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=43.2078559738134, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI87082251, Length=316, Percent_Identity=21.5189873417722, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788651, Length=206, Percent_Identity=30.0970873786408, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532899, Length=436, Percent_Identity=35.7798165137615, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17532897, Length=459, Percent_Identity=35.2941176470588, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17539970, Length=434, Percent_Identity=35.2534562211982, Blast_Score=259, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=35.796766743649, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=30.5936073059361, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.5365853658537, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=35.5072463768116, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28573187, Length=212, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67625; Mature: 67625

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIKYMCGIAGYVGDRESADVLVDALSKLEYRGYDSAGIAVFDHGNIKVKKCKGRLANL
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEHHHHHHHHH
VEKMDEEGKPQGHVGIGHTRWATHGEPSDINSHPHGNKRVTIVHNGIIENYKKLKDFLIG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHC
EGYSFASETDTEVAAKLLDYYYDGDPMKTIAKVLSEIKGSYALGIMFRDFPDEIFAVRKD
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHEEEECC
SPLIVGVGEHENFIASDVPAIIHYTRDYYLLDQNEIAVIKKDSVKIYDVHGNEIHKELNT
CCEEEEECCCCCCHHHCCCCCEEEECCEEEECCCCEEEEEECCEEEEECCCHHHHHHCCC
ADWDVDAAEKGGYAHFMLKEIHEQPDSVKRTIMPRIMDDMPDFSAEGFNPDKLKNYKNIY
CCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEE
IVACGTAMHAGMVGKYIIEKMARVSVTVDIASEFRYRDPLISEDDLMIVISQSGETADTK
EEEECCHHHHHHHHHHHHHHHHHHEEEEEEHHHHHCCCCCCCCCCEEEEEECCCCCCHHH
AALELAKQAGADTMAIVNVKGSSIAREADMVVYTHAGPEISVASTKAYMVQISIMYLIAF
HHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCEEEEEHHHHHHHHHH
ELAYANGKMDEAECSRYTKMLEEIPEVIEEAIALESKCQFAASKLINADSLLYIGRGLDY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCE
ALSMEGSLKLKEISYIHSESYAAGELKHGTISLITEQMPVIAIATQKNLEEKTISNIKEV
EEECCCCEEEEHHHHHHCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHH
KSRGAFVVLIAEPELDIEDGVADIVIKLPQADQLLMPMVAAVPLQLIAYYTAVLKGNDVD
HHCCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC
>Mature Secondary Structure
MKGIKYMCGIAGYVGDRESADVLVDALSKLEYRGYDSAGIAVFDHGNIKVKKCKGRLANL
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEHHHHHHHHH
VEKMDEEGKPQGHVGIGHTRWATHGEPSDINSHPHGNKRVTIVHNGIIENYKKLKDFLIG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHC
EGYSFASETDTEVAAKLLDYYYDGDPMKTIAKVLSEIKGSYALGIMFRDFPDEIFAVRKD
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHEEEECC
SPLIVGVGEHENFIASDVPAIIHYTRDYYLLDQNEIAVIKKDSVKIYDVHGNEIHKELNT
CCEEEEECCCCCCHHHCCCCCEEEECCEEEECCCCEEEEEECCEEEEECCCHHHHHHCCC
ADWDVDAAEKGGYAHFMLKEIHEQPDSVKRTIMPRIMDDMPDFSAEGFNPDKLKNYKNIY
CCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEE
IVACGTAMHAGMVGKYIIEKMARVSVTVDIASEFRYRDPLISEDDLMIVISQSGETADTK
EEEECCHHHHHHHHHHHHHHHHHHEEEEEEHHHHHCCCCCCCCCCEEEEEECCCCCCHHH
AALELAKQAGADTMAIVNVKGSSIAREADMVVYTHAGPEISVASTKAYMVQISIMYLIAF
HHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCEEEEEHHHHHHHHHH
ELAYANGKMDEAECSRYTKMLEEIPEVIEEAIALESKCQFAASKLINADSLLYIGRGLDY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCE
ALSMEGSLKLKEISYIHSESYAAGELKHGTISLITEQMPVIAIATQKNLEEKTISNIKEV
EEECCCCEEEEHHHHHHCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHH
KSRGAFVVLIAEPELDIEDGVADIVIKLPQADQLLMPMVAAVPLQLIAYYTAVLKGNDVD
HHCCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]