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The map label for this gene is putP [H]

Identifier: 238917075

GI number: 238917075

Start: 1158442

End: 1159971

Strand: Reverse

Name: putP [H]

Synonym: EUBELI_01145

Alternate gene names: 238917075

Gene position: 1159971-1158442 (Counterclockwise)

Preceding gene: 238917076

Following gene: 238917074

Centisome position: 54.1

GC content: 37.97

Gene sequence:

>1530_bases
ATGTCAAACATTATTATTTTAGCAGCAATTATACTTTACCTCGGAATGGTGGTATGGATAGGAGTAATCTGTTCTAAGAA
GAACAGTGATGTAGGAGACTTCTATCTTGGTGGAAGAAAGTTAGGACCTGTTGTTACTGCAATGAGTGCAGAAGCGTCAG
ACATGAGCAGTTACCTGCTTATGGGTGTTCCGGGACTGGCATACCTTACAGGTCTTGCTGACGCAACATGGACAGCAATT
GGTCTTGCACTTGGTACATACCTTAACTGGCTTATTGTTGCCAAGAAGATAAGATTATATTCACATGGTTATCAGGCAAT
AACACTTCCTGATTATTTTTCTAAGAGATTCGGGGATGACAAGCATGTAATTACATTAATATCAGCAGCACTTATTGTAA
TATTCTTTATACCATACACAGCATCAGGCTTTGCTGCCTGCGGAAAGCTGTTTAACAGTCTTTTAGGTTTTGATTATCAT
GCAGCAATGATTGTCAGTGCTGTTGTTATTGTACTTTACTGCACAATGGGTGGATTCCTTGCAGCAAGTACATCAGATCT
TGTACAGAGTATTATTATGACATTCGCACTTGCTGTCGTTGTAATATTCGGAATTGTGCAGGCTGGAGGAATGGGAGCTG
TACTTGATAATGCCAAGGCACTTCCTGGATATCTTGATATGTTCCATACACATATTGCAGAGACTAATACATCTGGAGAC
TATGGATTCTTTAAGATTGTTTCAACACTTGCATGGGGACTCGGATACTTCGGTATGCCACATATCCTTTTAAGATTCAT
GGCTATTGAAGATGAGAACAAGTTAAAGATTTCAAGAAGAATTGCTACTGTATGGGTATTCATATCACTTATTGTTGCAA
CTGGAATCGGTGTAATAGGACTTACACTTTCAAAGAATGGTATTATTGATACCCTTACAGGTTCAGAATCAGAGACAATT
ATTGTTAAGATATCACATTATCTTTCAACATTTAACCCTGTAGCAGCATTTATAGCAGGAATTATCCTTGCAGGTATTCT
TGCAGCAACCATGTCAACAGCAGATTCACAGCTTCTTGCAGCTTCATCTGCTATATCACAGAACCTTGCGGTTGAGGTGT
TACATATTAATATGTCTAAGAAGACATCAATGCTTGTTGCAAGACTTACAGTTGTTGTTATATCAGTTATATCAATATTC
TTTGCACTTGATCCTACAAGCTCAGTATTTAAGATTGTTTCATTTGCATGGGCAGGTTTCGGTGCAGCATTCGGTCCTGT
AGTTCTATGCTCACTTTTCTGGAAGAGAGCCAATAAGTATGGAATTATATCGGGCATGATTGCAGGTGGAGCAATGATAT
TTATATGGAAATTCGGAATTGCAAAGCTTGGAGGAATATTTGCTGTATATGAGCTTTTACCAGCATTTATCTTCGCAACA
TTAGTTATTATTGTTGTAAGTCTTGCTACAGGAAAGCCATCTAAGGAAGTTATGGATAAGTTTGAAGAAGTTAAGAATAT
GAGCAAATAA

Upstream 100 bases:

>100_bases
AGTTATATGCAATAATTTAATCCCTTTTCGCTTTTTATAAAGCCGAATGTATGCTATAATAGGTACATTCGCGTATTTAT
GAAAGGAAAAGGGATTTTTT

Downstream 100 bases:

>100_bases
TTCATGTCTCTTAATGTAATATGTAGAAGAGAGTTTTATATAATATGGGATATAATATAGCAATATGTGATGATGATAAT
TTAATGGCTCAGAATATTAA

Product: solute:Na+ symporter

Products: NA

Alternate protein names: Proline permease [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSNIIILAAIILYLGMVVWIGVICSKKNSDVGDFYLGGRKLGPVVTAMSAEASDMSSYLLMGVPGLAYLTGLADATWTAI
GLALGTYLNWLIVAKKIRLYSHGYQAITLPDYFSKRFGDDKHVITLISAALIVIFFIPYTASGFAACGKLFNSLLGFDYH
AAMIVSAVVIVLYCTMGGFLAASTSDLVQSIIMTFALAVVVIFGIVQAGGMGAVLDNAKALPGYLDMFHTHIAETNTSGD
YGFFKIVSTLAWGLGYFGMPHILLRFMAIEDENKLKISRRIATVWVFISLIVATGIGVIGLTLSKNGIIDTLTGSESETI
IVKISHYLSTFNPVAAFIAGIILAGILAATMSTADSQLLAASSAISQNLAVEVLHINMSKKTSMLVARLTVVVISVISIF
FALDPTSSVFKIVSFAWAGFGAAFGPVVLCSLFWKRANKYGIISGMIAGGAMIFIWKFGIAKLGGIFAVYELLPAFIFAT
LVIIVVSLATGKPSKEVMDKFEEVKNMSK

Sequences:

>Translated_509_residues
MSNIIILAAIILYLGMVVWIGVICSKKNSDVGDFYLGGRKLGPVVTAMSAEASDMSSYLLMGVPGLAYLTGLADATWTAI
GLALGTYLNWLIVAKKIRLYSHGYQAITLPDYFSKRFGDDKHVITLISAALIVIFFIPYTASGFAACGKLFNSLLGFDYH
AAMIVSAVVIVLYCTMGGFLAASTSDLVQSIIMTFALAVVVIFGIVQAGGMGAVLDNAKALPGYLDMFHTHIAETNTSGD
YGFFKIVSTLAWGLGYFGMPHILLRFMAIEDENKLKISRRIATVWVFISLIVATGIGVIGLTLSKNGIIDTLTGSESETI
IVKISHYLSTFNPVAAFIAGIILAGILAATMSTADSQLLAASSAISQNLAVEVLHINMSKKTSMLVARLTVVVISVISIF
FALDPTSSVFKIVSFAWAGFGAAFGPVVLCSLFWKRANKYGIISGMIAGGAMIFIWKFGIAKLGGIFAVYELLPAFIFAT
LVIIVVSLATGKPSKEVMDKFEEVKNMSK
>Mature_508_residues
SNIIILAAIILYLGMVVWIGVICSKKNSDVGDFYLGGRKLGPVVTAMSAEASDMSSYLLMGVPGLAYLTGLADATWTAIG
LALGTYLNWLIVAKKIRLYSHGYQAITLPDYFSKRFGDDKHVITLISAALIVIFFIPYTASGFAACGKLFNSLLGFDYHA
AMIVSAVVIVLYCTMGGFLAASTSDLVQSIIMTFALAVVVIFGIVQAGGMGAVLDNAKALPGYLDMFHTHIAETNTSGDY
GFFKIVSTLAWGLGYFGMPHILLRFMAIEDENKLKISRRIATVWVFISLIVATGIGVIGLTLSKNGIIDTLTGSESETII
VKISHYLSTFNPVAAFIAGIILAGILAATMSTADSQLLAASSAISQNLAVEVLHINMSKKTSMLVARLTVVVISVISIFF
ALDPTSSVFKIVSFAWAGFGAAFGPVVLCSLFWKRANKYGIISGMIAGGAMIFIWKFGIAKLGGIFAVYELLPAFIFATL
VIIVVSLATGKPSKEVMDKFEEVKNMSK

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=487, Percent_Identity=41.4784394250513, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI11141885, Length=458, Percent_Identity=25.764192139738, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI14140236, Length=485, Percent_Identity=22.4742268041237, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507035, Length=374, Percent_Identity=24.331550802139, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4507031, Length=473, Percent_Identity=23.6786469344609, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI167466278, Length=273, Percent_Identity=26.3736263736264, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787251, Length=492, Percent_Identity=39.8373983739837, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI87082237, Length=459, Percent_Identity=27.2331154684096, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790503, Length=453, Percent_Identity=23.3995584988962, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539284, Length=478, Percent_Identity=23.0125523012552, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54404; Mature: 54273

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIIILAAIILYLGMVVWIGVICSKKNSDVGDFYLGGRKLGPVVTAMSAEASDMSSYLL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHCHHHHHHCCCHHHHHHHHH
MGVPGLAYLTGLADATWTAIGLALGTYLNWLIVAKKIRLYSHGYQAITLPDYFSKRFGDD
HCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHCCCC
KHVITLISAALIVIFFIPYTASGFAACGKLFNSLLGFDYHAAMIVSAVVIVLYCTMGGFL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHH
AASTSDLVQSIIMTFALAVVVIFGIVQAGGMGAVLDNAKALPGYLDMFHTHIAETNTSGD
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCC
YGFFKIVSTLAWGLGYFGMPHILLRFMAIEDENKLKISRRIATVWVFISLIVATGIGVIG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
LTLSKNGIIDTLTGSESETIIVKISHYLSTFNPVAAFIAGIILAGILAATMSTADSQLLA
EEECCCCCEEEECCCCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
ASSAISQNLAVEVLHINMSKKTSMLVARLTVVVISVISIFFALDPTSSVFKIVSFAWAGF
HHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GAAFGPVVLCSLFWKRANKYGIISGMIAGGAMIFIWKFGIAKLGGIFAVYELLPAFIFAT
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVIIVVSLATGKPSKEVMDKFEEVKNMSK
HHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNIIILAAIILYLGMVVWIGVICSKKNSDVGDFYLGGRKLGPVVTAMSAEASDMSSYLL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHCHHHHHHCCCHHHHHHHHH
MGVPGLAYLTGLADATWTAIGLALGTYLNWLIVAKKIRLYSHGYQAITLPDYFSKRFGDD
HCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHCCCC
KHVITLISAALIVIFFIPYTASGFAACGKLFNSLLGFDYHAAMIVSAVVIVLYCTMGGFL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHH
AASTSDLVQSIIMTFALAVVVIFGIVQAGGMGAVLDNAKALPGYLDMFHTHIAETNTSGD
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCC
YGFFKIVSTLAWGLGYFGMPHILLRFMAIEDENKLKISRRIATVWVFISLIVATGIGVIG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
LTLSKNGIIDTLTGSESETIIVKISHYLSTFNPVAAFIAGIILAGILAATMSTADSQLLA
EEECCCCCEEEECCCCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
ASSAISQNLAVEVLHINMSKKTSMLVARLTVVVISVISIFFALDPTSSVFKIVSFAWAGF
HHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GAAFGPVVLCSLFWKRANKYGIISGMIAGGAMIFIWKFGIAKLGGIFAVYELLPAFIFAT
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVIIVVSLATGKPSKEVMDKFEEVKNMSK
HHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]