The gene/protein map for NC_012778 is currently unavailable.
Definition Eubacterium eligens ATCC 27750 chromosome, complete genome.
Accession NC_012778
Length 2,144,190

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The map label for this gene is ppiA [C]

Identifier: 238917034

GI number: 238917034

Start: 1115414

End: 1116031

Strand: Direct

Name: ppiA [C]

Synonym: EUBELI_01104

Alternate gene names: 238917034

Gene position: 1115414-1116031 (Clockwise)

Preceding gene: 238917031

Following gene: 238917044

Centisome position: 52.02

GC content: 38.51

Gene sequence:

>618_bases
ATGAAGAAAAAACATTTATTATTAAGCATAATCCTATTATGTATTTTATTCAGCCTGACTGCATGTGGCAGACAGAATTC
TGGTAATTCATCAACTTCCGATGGAAACACTCAGTTATCCGGCAAGCACCATGTTGCCATTGAAGTAAACAATTATGGAA
CGATTGAGGTAGAACTTGATGCAGATACTGCCCCAATTACTGTTACTAATTTTATTAATCTTGCCAATTCAGGATTTTAT
AACGGTCTGACTTTTCATCGCGTAATTGATGGATTTATGATTCAGGGTGGAGACCCTAATGGTGACGGAACTGGTGGCTC
TTCTGAGAAAATCAAGGGTGAATTCAAGTCAAATGGCGTCCAAAATAATATAAGCCATATAAGAGGCACTATATCTATGG
CACGCTCTTCTGCTAATAATTCTGCAAGTTCTCAGTTTTTCATTATGCAAAAGGACACTCCAAGCCTTGACGGACAATAC
GCAGCTTTCGGAACTGTCACGAGCGGCATGGACATTGTCGATAAGATATGTAAAGACTGCACTGATACTAATCAGAATGG
TGTGATTACAGATAAGAGTAAACAGCCTGTGATTAGTACTATAAGGGTTGTGGATTAA

Upstream 100 bases:

>100_bases
TTTATATACATTTTAATTGTTTATATGCATATTAGATGTTTAACATACCGGCTGATAATGTTATACTTGATTCACTAATT
CTAGAAAGGAATATTTTAAA

Downstream 100 bases:

>100_bases
CGAATAACCGCACCGTCTTACGACGGTGCGGTTATTATATTAAAACATATTCTATTTATCAAAATCATAACTATTCTCAT
ATATATCTAAAACCTGAGTC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MKKKHLLLSIILLCILFSLTACGRQNSGNSSTSDGNTQLSGKHHVAIEVNNYGTIEVELDADTAPITVTNFINLANSGFY
NGLTFHRVIDGFMIQGGDPNGDGTGGSSEKIKGEFKSNGVQNNISHIRGTISMARSSANNSASSQFFIMQKDTPSLDGQY
AAFGTVTSGMDIVDKICKDCTDTNQNGVITDKSKQPVISTIRVVD

Sequences:

>Translated_205_residues
MKKKHLLLSIILLCILFSLTACGRQNSGNSSTSDGNTQLSGKHHVAIEVNNYGTIEVELDADTAPITVTNFINLANSGFY
NGLTFHRVIDGFMIQGGDPNGDGTGGSSEKIKGEFKSNGVQNNISHIRGTISMARSSANNSASSQFFIMQKDTPSLDGQY
AAFGTVTSGMDIVDKICKDCTDTNQNGVITDKSKQPVISTIRVVD
>Mature_205_residues
MKKKHLLLSIILLCILFSLTACGRQNSGNSSTSDGNTQLSGKHHVAIEVNNYGTIEVELDADTAPITVTNFINLANSGFY
NGLTFHRVIDGFMIQGGDPNGDGTGGSSEKIKGEFKSNGVQNNISHIRGTISMARSSANNSASSQFFIMQKDTPSLDGQY
AAFGTVTSGMDIVDKICKDCTDTNQNGVITDKSKQPVISTIRVVD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=43.75, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI19557636, Length=127, Percent_Identity=40.9448818897638, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7706339, Length=124, Percent_Identity=38.7096774193548, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=44.6153846153846, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4758950, Length=140, Percent_Identity=41.4285714285714, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4505991, Length=182, Percent_Identity=38.4615384615385, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI10863927, Length=137, Percent_Identity=41.6058394160584, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI64276486, Length=118, Percent_Identity=38.135593220339, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI310110104, Length=136, Percent_Identity=41.1764705882353, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI6631100, Length=176, Percent_Identity=33.5227272727273, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310129267, Length=136, Percent_Identity=40.4411764705882, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI310120620, Length=136, Percent_Identity=40.4411764705882, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI5454154, Length=164, Percent_Identity=36.5853658536585, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45439316, Length=131, Percent_Identity=41.2213740458015, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI5174637, Length=151, Percent_Identity=39.0728476821192, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI303305009, Length=129, Percent_Identity=41.0852713178295, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310127646, Length=136, Percent_Identity=36.7647058823529, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310114371, Length=136, Percent_Identity=36.7647058823529, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310119221, Length=136, Percent_Identity=36.7647058823529, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4826932, Length=134, Percent_Identity=40.2985074626866, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI22547215, Length=127, Percent_Identity=44.0944881889764, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22547212, Length=127, Percent_Identity=44.0944881889764, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7657473, Length=127, Percent_Identity=44.0944881889764, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI256017253, Length=129, Percent_Identity=41.0852713178295, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI221139811, Length=129, Percent_Identity=41.0852713178295, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI256017251, Length=129, Percent_Identity=41.0852713178295, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI42560244, Length=153, Percent_Identity=36.6013071895425, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI178057341, Length=139, Percent_Identity=37.410071942446, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI20911035, Length=133, Percent_Identity=34.5864661654135, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI169163387, Length=137, Percent_Identity=37.2262773722628, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI209417936, Length=139, Percent_Identity=37.410071942446, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI30102944, Length=139, Percent_Identity=37.410071942446, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI219842199, Length=139, Percent_Identity=37.410071942446, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI150418007, Length=130, Percent_Identity=40.7692307692308, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI169214050, Length=139, Percent_Identity=37.410071942446, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI169164185, Length=137, Percent_Identity=37.2262773722628, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI169163623, Length=137, Percent_Identity=37.2262773722628, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI239751853, Length=139, Percent_Identity=36.6906474820144, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI113428306, Length=139, Percent_Identity=36.6906474820144, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI310127745, Length=136, Percent_Identity=33.0882352941176, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI310119290, Length=136, Percent_Identity=33.0882352941176, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1789763, Length=178, Percent_Identity=40.4494382022472, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786736, Length=158, Percent_Identity=43.0379746835443, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506311, Length=132, Percent_Identity=44.6969696969697, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17539496, Length=153, Percent_Identity=40.5228758169935, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17532641, Length=131, Percent_Identity=39.6946564885496, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506307, Length=151, Percent_Identity=43.7086092715232, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=124, Percent_Identity=41.1290322580645, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=124, Percent_Identity=41.1290322580645, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=150, Percent_Identity=40.6666666666667, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997782, Length=117, Percent_Identity=40.1709401709402, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17552780, Length=130, Percent_Identity=43.0769230769231, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=147, Percent_Identity=40.1360544217687, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552784, Length=162, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=38.8535031847134, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=136, Percent_Identity=40.4411764705882, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=136, Percent_Identity=40.4411764705882, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=136, Percent_Identity=38.9705882352941, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=123, Percent_Identity=37.3983739837398, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551282, Length=123, Percent_Identity=37.3983739837398, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32563659, Length=139, Percent_Identity=30.9352517985612, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=135, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320359, Length=129, Percent_Identity=42.6356589147287, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=206, Percent_Identity=33.9805825242718, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=140, Percent_Identity=39.2857142857143, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323246, Length=155, Percent_Identity=34.8387096774194, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17986117, Length=147, Percent_Identity=42.1768707482993, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922376, Length=130, Percent_Identity=40.7692307692308, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21357249, Length=118, Percent_Identity=40.6779661016949, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20130249, Length=142, Percent_Identity=42.9577464788732, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24652460, Length=130, Percent_Identity=40, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647301, Length=132, Percent_Identity=45.4545454545455, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=43.8461538461538, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664125, Length=130, Percent_Identity=43.8461538461538, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357783, Length=130, Percent_Identity=43.8461538461538, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922912, Length=127, Percent_Identity=47.244094488189, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136360, Length=200, Percent_Identity=33.5, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650807, Length=157, Percent_Identity=33.1210191082803, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355677, Length=158, Percent_Identity=32.2784810126582, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24586038, Length=164, Percent_Identity=37.1951219512195, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21885; Mature: 21885

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKKKHLLLSIILLCILFSLTACGRQNSGNSSTSDGNTQLSGKHHVAIEVNNYGTIEVELD
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCEEEEEEECCCEEEEEEEC
ADTAPITVTNFINLANSGFYNGLTFHRVIDGFMIQGGDPNGDGTGGSSEKIKGEFKSNGV
CCCCCEEHHHHHHHHCCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCHHCCCHHHCCCC
QNNISHIRGTISMARSSANNSASSQFFIMQKDTPSLDGQYAAFGTVTSGMDIVDKICKDC
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEECHHCCHHHHHHHHHHH
TDTNQNGVITDKSKQPVISTIRVVD
CCCCCCCEEECCCCCCCCCEEEECC
>Mature Secondary Structure
MKKKHLLLSIILLCILFSLTACGRQNSGNSSTSDGNTQLSGKHHVAIEVNNYGTIEVELD
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCEEEEEEECCCEEEEEEEC
ADTAPITVTNFINLANSGFYNGLTFHRVIDGFMIQGGDPNGDGTGGSSEKIKGEFKSNGV
CCCCCEEHHHHHHHHCCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCHHCCCHHHCCCC
QNNISHIRGTISMARSSANNSASSQFFIMQKDTPSLDGQYAAFGTVTSGMDIVDKICKDC
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEECHHCCHHHHHHHHHHH
TDTNQNGVITDKSKQPVISTIRVVD
CCCCCCCEEECCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]