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The map label for this gene is hisA [H]

Identifier: 238916951

GI number: 238916951

Start: 1033381

End: 1034469

Strand: Reverse

Name: hisA [H]

Synonym: EUBELI_01020

Alternate gene names: 238916951

Gene position: 1034469-1033381 (Counterclockwise)

Preceding gene: 238916952

Following gene: 238916950

Centisome position: 48.25

GC content: 40.77

Gene sequence:

>1089_bases
ATGCGATTATATCCAGCAATTGATGTTAAAGACGGGCAGTGTGTCCGCTTAAAGAAGGGACTTTTTAATGAAGTTACTGT
ATATTCTGAAAGACCTTACGAGATCGCTAAAGGCTTTGAAGAGGCAGGAGCACAGTTTATACATACTGTTGACCTTGATG
GCGCTTTGAAAGGACACGGCGTTAATGCAGAAACTATTAAGAAGATATGTTCAAGTGTTAATGTTCCTGTACAGATGGGC
GGTGGAATCCGTACTCTTGAGAACATTCAGGAGGTTCTTGACCTCGGCGTATACAGAGTTATTATCGGTACTAAGGCTGT
TGAGAATCCTGATTTTATTAAGGCTGCCATTGACAGATTCGGTGCTGAACATATTGTTGTAGGTGTTGATGCAAAAGATG
GTCTTGTGGCTATCGAGGGCTGGGAAAAGGTCAGTGATAAGACCGCACTTTCACTTGCACTTGCAATGAAGGATATCGGC
GTACAGACTATTGTGTACACTGATATATCAAAGGATGGTATGCTTGCCGGTCCTAATGTTGAACAGACTAAGATTCTTTC
TGATAAAACAGGTATTGATATTATTGCTTCAGGCGGCATGAGCTGCATGGATGATCTTACACATATTAATGATGCCGGTA
TCCATGGTGCAATTATCGGTAAGGCAATATATGAAAAACGTATTGACCTTAAGGAGGCTGTTAATCTTTTTGAATCCGGA
GCATCTTACAGCAAGGCATCATCAATGCCTAAGGCTGATATTTCGTTTAAGGATTTAAAGCTTGATGCCAATGGTCTTAT
TCCAGTTGTTGTACAGGATTATGTCAATGATGAAGTCCTTATGCTTGCTTACATGAATGAGGAAGCCTACAATAAAACTT
TAGAGACTGGCATCATGACTTATTATAGCCGAAGCCGTCAGGAGCTCTGGGTTAAAGGTCTTACATCAGGTCATTTCCAG
TATGTTGGTTCTCTTGACATCGACTGTGACAATGATACTATTCTTGCAAAGGTTCGTCAGGTTGGTGCTGCATGCCACAC
TGGAAACAGAACATGCTTCTATAGAAATATTAAAACATGGAACAGATAA

Upstream 100 bases:

>100_bases
TTTGCAAAGGCATTGGATGAGGCAACTGTTAAAGATACAAGAATCAAGACAATTCTCTCTACTAAGGGAAGTCTCTAAAT
ATACTTAAGGAGTTACATAT

Downstream 100 bases:

>100_bases
TTTATGGAATATAAATATATAATCACAGATATTAACAATAAAATCTTCTGTTGCATATATACTTCTGATAATACCTGCCA
CTATCTTAAGCCTTTAGATA

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVNAETIKKICSSVNVPVQMG
GGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFGAEHIVVGVDAKDGLVAIEGWEKVSDKTALSLALAMKDIG
VQTIVYTDISKDGMLAGPNVEQTKILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNLFESG
ASYSKASSMPKADISFKDLKLDANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQ
YVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWNR

Sequences:

>Translated_362_residues
MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVNAETIKKICSSVNVPVQMG
GGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFGAEHIVVGVDAKDGLVAIEGWEKVSDKTALSLALAMKDIG
VQTIVYTDISKDGMLAGPNVEQTKILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNLFESG
ASYSKASSMPKADISFKDLKLDANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQ
YVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWNR
>Mature_362_residues
MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVNAETIKKICSSVNVPVQMG
GGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFGAEHIVVGVDAKDGLVAIEGWEKVSDKTALSLALAMKDIG
VQTIVYTDISKDGMLAGPNVEQTKILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNLFESG
ASYSKASSMPKADISFKDLKLDANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQ
YVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWNR

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.9218106995885, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=51.0204081632653, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788336, Length=242, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 39629; Mature: 39629

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHG
CCCCCCEECCCCCEEEEHHCCCCCEEEECCCCHHHHCCHHHCCCEEEEEEECCCCCCCCC
VNAETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRF
CCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHC
GAEHIVVGVDAKDGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDISKDGMLAGPNV
CCCEEEEEECCCCCEEEEECCHHHCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCC
EQTKILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNLFESG
CHHEEECCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCC
ASYSKASSMPKADISFKDLKLDANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMT
CCHHHHCCCCCCCCCCEEEEECCCCCEEEEEHHHCCCCEEEEEEECCHHHHHHHHHHHHH
YYSRSRQELWVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTW
HHHHCHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCC
NR
CC
>Mature Secondary Structure
MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHG
CCCCCCEECCCCCEEEEHHCCCCCEEEECCCCHHHHCCHHHCCCEEEEEEECCCCCCCCC
VNAETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRF
CCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHC
GAEHIVVGVDAKDGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDISKDGMLAGPNV
CCCEEEEEECCCCCEEEEECCHHHCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCC
EQTKILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNLFESG
CHHEEECCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCC
ASYSKASSMPKADISFKDLKLDANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMT
CCHHHHCCCCCCCCCCEEEEECCCCCEEEEEHHHCCCCEEEEEEECCHHHHHHHHHHHHH
YYSRSRQELWVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTW
HHHHCHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCC
NR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA